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NPHP4 ,NPHP4 ,O75161
  • Uniprot Accession= O75161
  • Ensembl Transcript= ENST00000378156.8
  • Uniprot Name= NPHP4
  • Name= Nephrocystin-4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 39
  • Number of Interaction partner in biogrid: 13
  • Number of Interaction partner in hippie: 65
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AIP AIP O00170 AH receptor-interacting protein chr11 Not Cancer Driver No 1 hippie 32 64 9 9 1
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 17 112 9 9 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
CACYBP CACYBP Q9HB71 Calcyclin-binding protein chr1 Not Cancer Driver No 1 hippie 27 92 10 10 0
CCDC140 CCDC140 Q96MF4 Coiled-coil domain-containing protein 140 chr2 Not Cancer Driver No 1 hippie, biogrid 36 163 36 36 0
CEP128_ENST00000281129 CEP128 Q6ZU80 Centrosomal protein of 128 kDa chr14 Not Cancer Driver No 1 hippie 195 897 167 167 0
CEP164 CEP164 Q9UPV0 Centrosomal protein of 164 kDa chr11 Not Cancer Driver No 1 hippie 161 1198 124 124 2
CEP89 CEP89 Q96ST8 Centrosomal protein of 89 kDa chr19 Census Yes 1 hippie 96 540 72 72 0
CLUH_ENST00000435359 CLUH O75153 Clustered mitochondria protein homolog chr17 Not Cancer Driver No 2 intact, hippie 164 339 48 48 0
DAAM1 DAAM1 Q9Y4D1 Disheveled-associated activator of morphogenesis 1 chr14 Not Cancer Driver No 1 intact, hippie 152 391 47 47 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 1 intact 126 50 8 8 4
DNAJC7 DNAJC7 Q99615 DnaJ homolog subfamily C member 7 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 41 102 9 9 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
FKBP4 FKBP4 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 chr12 Not Cancer Driver No 1 hippie 46 134 12 12 0
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 hippie, biogrid 19 36 7 7 2
GKAP1 GKAP1 Q5VSY0 G kinase-anchoring protein 1 chr9 Not Cancer Driver No 1 hippie 39 279 29 29 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 intact, hippie 24 200 13 13 0
HSPA1L HSPA1L P34931 Heat shock 70 kDa protein 1-like chr6 Not Cancer Driver No 1 intact, hippie 119 141 28 28 0
HSPA2_ENST00000247207 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 Not Cancer Driver No 1 intact, hippie 93 286 38 38 0
HSPA6 HSPA6 P17066 Heat shock 70 kDa protein 6 chr1 Not Cancer Driver No 1 intact, hippie 112 235 27 27 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 intact, hippie 149 251 52 52 0
INTU INTU Q9ULD6 Protein inturned chr4 Not Cancer Driver No 1 intact, hippie 146 282 52 52 0
INVS INVS Q9Y283 Inversin chr9 Not Cancer Driver No 1 hippie 125 487 64 64 2
IRS4 IRS4 O14654 Insulin receptor substrate 4 chrX Census, Compendium Yes 1 intact, hippie 297 798 203 203 0
JADE1_ENST00000512960 JADE1 Q6IE81 Protein Jade-1 chr4 Not Cancer Driver No 1 intact, hippie 94 409 47 47 0
LATS1 LATS1 O95835 Serine/threonine-protein kinase LATS1 chr6 Census, Compendium Yes 1 hippie 161 788 100 100 0
LCN1 LCN1 P31025 Lipocalin-1 chr9 Not Cancer Driver No 1 hippie, biogrid 31 69 17 17 0
NEK4 NEK4 P51957 Serine/threonine-protein kinase Nek4 chr3 Not Cancer Driver No 1 hippie 78 492 49 49 0
NPHP1_ENST00000393272 NPHP1 O15259 Nephrocystin-1 chr2 Not Cancer Driver No 4 intact, hippie, biogrid 108 259 32 32 1
NPHP4 NPHP4 O75161 Nephrocystin-4 chr1 Not Cancer Driver No 1 hippie 176 469 54 54 17
NUDC NUDC Q9Y266 Nuclear migration protein nudC chr1 Not Cancer Driver No 1 intact, hippie 36 235 29 29 0
NUDCD2 NUDCD2 Q8WVJ2 NudC domain-containing protein 2 chr5 Not Cancer Driver No 1 intact, hippie 12 39 6 6 0
NUDCD3 NUDCD3 Q8IVD9 NudC domain-containing protein 3 chr7 Not Cancer Driver No 1 intact, hippie 30 199 16 16 0
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 30 157 13 13 0
PNMA2 PNMA2 Q9UL42 Paraneoplastic antigen Ma2 chr8 Not Cancer Driver No 1 hippie, biogrid 52 45 5 5 0
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 26 23 4 4 0
PPP4R2 PPP4R2 Q9NY27 Serine/threonine-protein phosphatase 4 regulatory subunit 2 chr3 Not Cancer Driver No 1 intact, hippie 32 314 26 26 0
PRPS2_ENST00000380668 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 chrX Not Cancer Driver No 1 hippie, biogrid 56 4 1 1 0
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 Not Cancer Driver No 1 hippie, biogrid 11 52 3 3 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 Not Cancer Driver No 1 intact, hippie 161 261 37 37 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 2 intact, hippie 89 169 38 38 22
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RPAP3 RPAP3 Q9H6T3 RNA polymerase II-associated protein 3 chr12 Not Cancer Driver No 1 intact, hippie 59 334 37 37 0
RPGRIP1 RPGRIP1 Q96KN7 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 chr14 Not Cancer Driver No 3 intact, hippie 219 680 110 110 6
RPGRIP1L_ENST00000379925 RPGRIP1L Q68CZ1 Protein fantom chr16 Not Cancer Driver No 4 intact, hippie 177 586 94 94 8
RPGR_ENST00000339363 RPGR Q92834 X-linked retinitis pigmentosa GTPase regulator chrX Not Cancer Driver No 5 intact, hippie, biogrid 115 639 64 64 25
RPP25L RPP25L Q8N5L8 Ribonuclease P protein subunit p25-like protein chr9 Not Cancer Driver No 2 intact, hippie 31 113 18 18 0
RUVBL1 RUVBL1 Q9Y265 RuvB-like 1 chr3 Not Cancer Driver No 1 intact, hippie 54 67 7 7 0
SKAP1_ENST00000584924 SKAP1 Q86WV1 Src kinase-associated phosphoprotein 1 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 67 130 27 27 0
SPATA7 SPATA7 Q9P0W8 Spermatogenesis-associated protein 7 chr14 Not Cancer Driver No 1 hippie 89 408 70 70 0
SPIRE1 SPIRE1 Q08AE8 Protein spire homolog 1 chr18 Not Cancer Driver No 1 hippie 78 414 48 48 0
SSSCA1 ZNRD2 O60232 Protein ZNRD2 chr11 Not Cancer Driver No 1 intact 19 103 12 12 0
STIP1_ENST00000305218 STIP1 P31948 Stress-induced-phosphoprotein 1 chr11 Not Cancer Driver No 1 hippie 74 270 39 39 0
SUGT1 SUGT1 Q9Y2Z0 Protein SGT1 homolog chr13 Not Cancer Driver No 1 intact, hippie 31 119 5 5 0
SULT1C4 SULT1C4 O75897 Sulfotransferase 1C4 chr2 Not Cancer Driver No 1 hippie, biogrid 57 19 5 5 0
TEFM TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 2 intact, hippie 37 26 5 5 0
TRIM37 TRIM37 O94972 E3 ubiquitin-protein ligase TRIM37 chr17 Not Cancer Driver No 1 hippie 119 492 60 60 3
TRIM52 TRIM52 Q96A61 E3 ubiquitin-protein ligase TRIM52 chr5 Not Cancer Driver No 1 hippie, biogrid 23 147 13 13 0
TTC4 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 intact, hippie 45 100 12 12 0
TUBAL3 TUBAL3 A6NHL2 Tubulin alpha chain-like 3 chr10 Not Cancer Driver No 1 intact, hippie 85 25 3 3 0
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 intact, hippie 40 63 11 11 5
TUBB1 TUBB1 Q9H4B7 Tubulin beta-1 chain chr20 Not Cancer Driver No 2 intact, hippie 71 38 4 4 1
TUBB2B TUBB2B Q9BVA1 Tubulin beta-2B chain chr6 Not Cancer Driver No 1 intact, hippie 43 68 10 10 10
TUBB4B TUBB4B P68371 Tubulin beta-4B chain chr9 Not Cancer Driver No 1 intact, hippie 52 65 11 11 2