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NLRP3_ENST00000391828 ,NLRP3 ,Q96P20
  • Uniprot Accession= Q96P20
  • Ensembl Transcript= ENST00000391828.7
  • Uniprot Name= NLRP3
  • Name= NACHT, LRR and PYD domains-containing protein 3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 38
  • Number of Interaction partner in biogrid: 3
  • Number of Interaction partner in hippie: 92
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABRAXAS2 ABRAXAS2 Q15018 BRISC complex subunit Abraxas 2 chr10 Not Cancer Driver No 1 hippie 47 207 26 26 0
AP3B1 AP3B1 O00203 AP-3 complex subunit beta-1 chr5 Not Cancer Driver No 1 hippie 126 316 31 31 1
ARHGAP17 ARHGAP17 Q68EM7 Rho GTPase-activating protein 17 chr16 Not Cancer Driver No 1 hippie, biogrid 123 547 72 72 0
ARIH2 ARIH2 O95376 E3 ubiquitin-protein ligase ARIH2 chr3 Not Cancer Driver No 1 hippie 64 85 11 11 0
ATP1B3 ATP1B3 P54709 Sodium/potassium-transporting ATPase subunit beta-3 chr3 Not Cancer Driver No 1 hippie 36 6 1 1 0
BRCC3 BRCC3 P46736 Lys-63-specific deubiquitinase BRCC36 chrX Not Cancer Driver No 1 hippie 39 74 7 7 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 hippie 80 45 4 4 0
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie 45 245 31 31 0
CARD8_ENST00000519940 CARD8 Q9Y2G2 Caspase recruitment domain-containing protein 8 chr19 Not Cancer Driver No 2 intact, hippie 53 126 7 7 1
CASP1 CASP1 P29466 Caspase-1 chr11 Not Cancer Driver No 1 hippie 79 87 18 18 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 142 106 12 12 1
CBLB CBLB Q13191 E3 ubiquitin-protein ligase CBL-B chr3 Census Yes 1 hippie 160 562 104 104 0
CBX3_ENST00000396386 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 1 intact, hippie 23 119 18 18 0
CBX5 CBX5 P45973 Chromobox protein homolog 5 chr12 Not Cancer Driver No 1 intact, hippie 21 116 12 12 0
CCDC86 CCDC86 Q9H6F5 Coiled-coil domain-containing protein 86 chr11 Not Cancer Driver No 1 hippie 36 360 36 36 0
COPS7A_ENST00000534947 COPS7A Q9UBW8 COP9 signalosome complex subunit 7a chr12 Not Cancer Driver No 1 hippie 32 74 10 10 0
CUL1_ENST00000602748 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 hippie 151 65 9 9 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 intact, hippie 64 102 2 2 0
CUL4B CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 1 intact, hippie 138 207 38 38 2
DCAF4 DCAF4 Q8WV16 DDB1- and CUL4-associated factor 4 chr14 Not Cancer Driver No 1 intact 59 114 11 11 0
DHX33 DHX33 Q9H6R0 ATP-dependent RNA helicase DHX33 chr17 Not Cancer Driver No 1 hippie 53 125 12 12 0
DLST DLST P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial chr14 Not Cancer Driver No 1 intact, hippie 53 190 32 32 1
DMAP1_ENST00000315913 DMAP1 Q9NPF5 DNA methyltransferase 1-associated protein 1 chr1 Not Cancer Driver No 1 intact, hippie 49 269 28 28 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 intact, hippie 50 174 27 27 0
EIF2AK2_ENST00000395127 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase chr2 Not Cancer Driver No 1 hippie 59 188 22 22 0
EIF3F_ENST00000309828 EIF3F O00303 Eukaryotic translation initiation factor 3 subunit F chr11 Not Cancer Driver No 1 hippie 29 125 8 8 1
FAF1 FAF1 Q9UNN5 FAS-associated factor 1 chr1 Not Cancer Driver No 1 hippie 83 241 34 34 0
FBXL2 FBXL2 Q9UKC9 F-box/LRR-repeat protein 2 chr3 Not Cancer Driver No 1 hippie 48 0 0 0 0
FBXL6 FBXL6 Q8N531 F-box/LRR-repeat protein 6 chr8 Not Cancer Driver No 1 intact, hippie 48 114 5 5 0
FBXO28 FBXO28 Q9NVF7 F-box only protein 28 chr1 Not Cancer Driver No 1 intact, hippie 49 230 30 30 0
FEM1A FEM1A Q9BSK4 Protein fem-1 homolog A chr19 Not Cancer Driver No 1 intact, hippie 68 162 22 22 0
GEMIN2 GEMIN2 O14893 Gem-associated protein 2 chr14 Not Cancer Driver No 1 intact, hippie 39 99 6 6 0
GPATCH4_ENST00000368232 GPATCH4 A0A0A0MRK1 G patch domain-containing protein 4 chr1 Not Cancer Driver No 1 intact, hippie 42 359 39 39 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX Not Cancer Driver No 1 hippie 178 409 59 59 0
HERC5 HERC5 Q9UII4 E3 ISG15--protein ligase HERC5 chr4 Not Cancer Driver No 1 hippie 124 118 12 12 0
HIST1H1B H1-5 P16401 Histone H1.5 chr6 Not Cancer Driver No 1 intact 66 224 66 66 0
HNRNPC_ENST00000420743 HNRNPC P07910 Heterogeneous nuclear ribonucleoproteins C1/C2 chr14 Not Cancer Driver No 1 intact, hippie 42 227 35 35 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 61 82 6 6 2
IL1B IL1B P01584 Interleukin-1 beta chr2 Not Cancer Driver No 1 hippie 39 16 3 3 0
KIAA2013_ENST00000616327 KIAA2013 Q8IYS2 Uncharacterized protein KIAA2013 chr1 Not Cancer Driver No 1 intact, hippie 35 78 5 5 0
LTBP4 LTBP4 Q8N2S1 Latent-transforming growth factor beta-binding protein 4 chr19 Not Cancer Driver No 1 intact, hippie 191 432 42 42 1
LUC7L LUC7L Q9NQ29 Putative RNA-binding protein Luc7-like 1 chr16 Not Cancer Driver No 1 hippie 50 254 41 41 0
LUC7L3_ENST00000240304 LUC7L3 O95232 Luc7-like protein 3 chr17 Not Cancer Driver No 1 intact, hippie 59 323 47 47 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 22 24 1 1 0
MARK4 MARK4 Q96L34 MAP/microtubule affinity-regulating kinase 4 chr19 Not Cancer Driver No 1 hippie 94 403 46 46 0
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 2 intact, hippie 70 411 58 58 0
MCFD2_ENST00000409973 MCFD2 Q8NI22 Multiple coagulation factor deficiency protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 16 90 11 11 4
MEFV MEFV O15553 Pyrin chr16 Not Cancer Driver No 1 hippie 196 397 119 119 47
MTCH1 MTCH1 Q9NZJ7 Mitochondrial carrier homolog 1 chr6 Not Cancer Driver No 1 intact, hippie 31 102 2 2 0
NECTIN3 NECTIN3 Q9NQS3 Nectin-3 chr3 Not Cancer Driver No 1 intact, hippie 72 106 9 9 0
NEK7 NEK7 Q8TDX7 Serine/threonine-protein kinase Nek7 chr1 Not Cancer Driver No 3 intact, hippie 35 23 0 0 0
NLRC4_ENST00000360906 NLRC4 Q9NPP4 NLR family CARD domain-containing protein 4 chr2 Not Cancer Driver No 1 hippie 205 15 2 2 3
NLRP3_ENST00000391828 NLRP3 Q96P20 NACHT, LRR and PYD domains-containing protein 3 chr1 Not Cancer Driver No 2 intact, hippie 339 64 33 33 37
NLRP5 NLRP5 P59047 NACHT, LRR and PYD domains-containing protein 5 chr19 Not Cancer Driver No 1 intact, hippie 369 144 35 35 0
P2RY2_ENST00000393596 P2RY2 P41231 P2Y purinoceptor 2 chr11 Not Cancer Driver No 1 hippie 67 60 13 13 0
PCGF5 PCGF5 Q86SE9 Polycomb group RING finger protein 5 chr10 Not Cancer Driver No 1 intact, hippie 31 52 5 5 0
PGM1_ENST00000371084 PGM1 P36871 Phosphoglucomutase-1 chr1 Not Cancer Driver No 1 hippie 62 31 3 3 13
PHF14 PHF14 O94880 PHD finger protein 14 chr7 Not Cancer Driver No 1 intact, hippie 102 565 56 56 0
PHRF1 PHRF1 Q9P1Y6 PHD and RING finger domain-containing protein 1 chr11 Not Cancer Driver No 1 intact, hippie 238 1414 194 194 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PSMB8 PSMB8 P28062 Proteasome subunit beta type-8 chr6 Not Cancer Driver No 1 hippie 43 62 7 7 3
PXN_ENST00000228307 PXN P49023 Paxillin chr12 Not Cancer Driver No 1 hippie 62 341 24 24 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 Not Cancer Driver No 1 hippie 16 39 4 4 0
RBBP7_ENST00000380087 RBBP7 Q16576 Histone-binding protein RBBP7 chrX Not Cancer Driver No 1 intact, hippie 67 138 19 19 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 hippie 10 18 1 1 0
RNF125 RNF125 Q96EQ8 E3 ubiquitin-protein ligase RNF125 chr18 Not Cancer Driver No 1 hippie 35 26 1 1 3
SH3BP1 SH3BP1 Q9Y3L3 SH3 domain-binding protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 57 430 31 31 0
SMARCA5 SMARCA5 O60264 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 chr4 Not Cancer Driver No 1 intact, hippie 116 363 48 48 0
SNRPB SNRPB P14678 Small nuclear ribonucleoprotein-associated proteins B and B' chr20 Not Cancer Driver No 1 intact, hippie 39 182 34 34 4
SPAST SPAST Q9UBP0 Spastin chr2 Not Cancer Driver No 1 intact, hippie 73 270 25 25 77
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie 54 267 32 32 30
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 Census Yes 1 hippie 53 130 11 11 1
STAMBP_ENST00000339566 STAMBP O95630 STAM-binding protein chr2 Not Cancer Driver No 1 hippie 51 139 16 16 6
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
SUGT1 SUGT1 Q9Y2Z0 Protein SGT1 homolog chr13 Not Cancer Driver No 1 hippie 31 119 5 5 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 Census Yes 1 intact, hippie 96 131 27 27 5
TGOLN2_ENST00000377386 TGOLN2 O43493 Trans-Golgi network integral membrane protein 2 chr2 Not Cancer Driver No 1 intact, hippie 51 399 46 46 0
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 Census, Compendium Yes 1 hippie 93 391 53 53 0
TRIM24 TRIM24 O15164 Transcription intermediary factor 1-alpha chr7 Census, Compendium Yes 1 hippie 120 537 61 61 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIM31 TRIM31 Q9BZY9 E3 ubiquitin-protein ligase TRIM31 chr6 Not Cancer Driver No 1 hippie 55 152 21 21 0
TRIM65 TRIM65 Q6PJ69 Tripartite motif-containing protein 65 chr17 Not Cancer Driver No 1 hippie 53 127 13 13 0
TXNIP TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie 61 77 14 14 0
UBR5 UBR5 O95071 E3 ubiquitin-protein ligase UBR5 chr8 Census, Compendium Yes 1 hippie 340 1296 162 162 0
ULK1 ULK1 O75385 Serine/threonine-protein kinase ULK1 chr12 Not Cancer Driver No 1 hippie 142 588 77 77 0
UQCRQ_ENST00000378665 UQCRQ O14949 Cytochrome b-c1 complex subunit 8 chr5 Not Cancer Driver No 1 hippie 9 12 1 1 1
URB1 URB1 O60287 Nucleolar pre-ribosomal-associated protein 1 chr21 Not Cancer Driver No 1 intact, hippie 93 180 2 2 0
USP13 USP13 Q92995 Ubiquitin carboxyl-terminal hydrolase 13 chr3 Not Cancer Driver No 1 hippie 121 224 42 42 0
USP5 USP5 P45974 Ubiquitin carboxyl-terminal hydrolase 5 chr12 Not Cancer Driver No 1 hippie 117 262 38 38 0
USP50 USP50 Q70EL3 Inactive ubiquitin carboxyl-terminal hydrolase 50 chr15 Not Cancer Driver No 1 hippie 33 2 0 0 0
VDR_ENST00000549336 VDR P11473 Vitamin D3 receptor chr12 Not Cancer Driver No 1 hippie 64 102 16 16 14
YBX3 YBX3 P16989 Y-box-binding protein 3 chr12 Not Cancer Driver No 1 intact, hippie 49 359 47 47 0
ZC3H8 ZC3H8 Q8N5P1 Zinc finger CCCH domain-containing protein 8 chr2 Not Cancer Driver No 1 intact, hippie 22 187 17 17 0