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NKX2-5 ,NKX2-5 ,P52952
  • Uniprot Accession= P52952
  • Ensembl Transcript= ENST00000329198.4
  • Uniprot Name= NKX2-5
  • Name= Homeobox protein Nkx-2.5
  • Chromosome= chr5
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 34
  • Number of Interaction partner in biogrid: 4
  • Number of Interaction partner in hippie: 73
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
APBA1 APBA1 Q02410 Amyloid-beta A4 precursor protein-binding family A member 1 chr9 Not Cancer Driver No 1 hippie, biogrid 149 556 103 103 0
C1QBP C1QBP Q07021 Complement component 1 Q subcomponent-binding protein, mitochondrial chr17 Not Cancer Driver No 1 intact, hippie 14 103 6 6 2
CALM1 CALM1 P0DP23 Calmodulin-1 chr14 Not Cancer Driver No 1 intact, hippie 19 115 15 15 7
CAMTA2_ENST00000348066 CAMTA2 O94983 Calmodulin-binding transcription activator 2 chr17 Not Cancer Driver No 1 intact, hippie 148 613 84 84 0
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
CLPX CLPX O76031 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial chr15 Not Cancer Driver No 1 intact, hippie 66 195 22 22 1
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 hippie 71 75 8 8 4
DBN1_ENST00000309007 DBN1 Q16643 Drebrin chr5 Not Cancer Driver No 1 intact, hippie 84 510 73 73 0
DNAH10 DNAH10 Q8IVF4 Dynein axonemal heavy chain 10 chr12 Not Cancer Driver No 1 intact, hippie 802 220 31 31 0
ELF5 ELF5 Q9UKW6 ETS-related transcription factor Elf-5 chr11 Not Cancer Driver No 1 hippie 49 0 0 0 0
EMD EMD P50402 Emerin chrX Not Cancer Driver No 1 hippie 42 160 28 28 4
EWSR1_ENST00000397938 EWSR1 Q01844 RNA-binding protein EWS chr22 Census, Compendium Yes 1 hippie 94 646 93 93 0
FBLIM1_ENST00000375771 FBLIM1 Q8WUP2 Filamin-binding LIM protein 1 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 54 176 28 28 0
FBXO25 FBXO25 Q8TCJ0 F-box only protein 25 chr8 Not Cancer Driver No 1 hippie 33 20 0 0 0
FLOT2 FLOT2 Q14254 Flotillin-2 chr17 Not Cancer Driver No 2 intact, hippie 56 20 3 3 0
FOXA1 FOXA1 P55317 Hepatocyte nuclear factor 3-alpha chr14 Census, Compendium Yes 1 intact, hippie 100 295 53 53 0
FOXE1 FOXE1 O00358 Forkhead box protein E1 chr9 Not Cancer Driver No 1 hippie 38 133 5 5 4
FOXH1 FOXH1 O75593 Forkhead box protein H1 chr8 Not Cancer Driver No 1 hippie 47 215 25 25 0
GATA4_ENST00000335135 GATA4 P43694 Transcription factor GATA-4 chr8 Not Cancer Driver No 2 intact, hippie 48 301 34 34 18
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact, hippie, biogrid 28 10 1 1 0
HAGH HAGH Q16775 Hydroxyacylglutathione hydrolase, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie 26 41 1 1 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 hippie 47 135 10 10 0
HIPK1_ENST00000426820 HIPK1 Q86Z02 Homeodomain-interacting protein kinase 1 chr1 Not Cancer Driver No 1 hippie 158 565 89 89 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 Not Cancer Driver No 1 hippie 154 686 96 96 0
ID1 ID1 P41134 DNA-binding protein inhibitor ID-1 chr20 Not Cancer Driver No 1 hippie 20 17 6 6 0
ID2_ENST00000396290 ID2 Q02363 DNA-binding protein inhibitor ID-2 chr2 Not Cancer Driver No 1 hippie 14 52 7 7 0
ID3 ID3 Q02535 DNA-binding protein inhibitor ID-3 chr1 Census, Compendium Yes 1 hippie 14 34 4 4 0
ILF2 ILF2 Q12905 Interleukin enhancer-binding factor 2 chr1 Not Cancer Driver No 1 hippie 36 92 9 9 0
IRF4 IRF4 Q15306 Interferon regulatory factor 4 chr6 Census, Compendium Yes 1 hippie 99 155 45 45 0
JARID2 JARID2 Q92833 Protein Jumonji chr6 Not Cancer Driver No 1 hippie 190 724 113 113 0
JMJD1C JMJD1C Q15652 Probable JmjC domain-containing histone demethylation protein 2C chr10 Not Cancer Driver No 1 intact, hippie 305 1640 200 200 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KDM6A KDM6A O15550 Lysine-specific demethylase 6A chrX Census, Compendium Yes 1 hippie 173 648 71 71 0
KPNA4 KPNA4 O00629 Importin subunit alpha-3 chr3 Not Cancer Driver No 1 intact 59 112 12 12 0
KRTAP8-1 KRTAP8-1 Q8IUC2 Keratin-associated protein 8-1 chr21 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
KSR2_ENST00000339824 KSR2 Q6VAB6 Kinase suppressor of Ras 2 chr12 Not Cancer Driver No 1 intact, hippie 231 434 120 120 0
LBR_ENST00000272163 LBR Q14739 Delta(14)-sterol reductase LBR chr1 Not Cancer Driver No 1 hippie 95 130 15 15 5
LONP1 LONP1 P36776 Lon protease homolog, mitochondrial chr19 Not Cancer Driver No 1 hippie 99 175 15 15 10
MAGED2 MAGED2 Q9UNF1 Melanoma-associated antigen D2 chrX Not Cancer Driver No 1 hippie 99 326 53 53 1
NKX2-4 NKX2-4 Q9H2Z4 Homeobox protein Nkx-2.4 chr20 Not Cancer Driver No 1 intact, hippie 22 242 21 21 0
NOP2_ENST00000322166 NOP2 P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase chr12 Not Cancer Driver No 1 intact, hippie 116 510 72 72 0
PAX9 PAX9 P55771 Paired box protein Pax-9 chr14 Not Cancer Driver No 1 intact, hippie 52 198 32 32 1
POLDIP2 POLDIP2 Q9Y2S7 Polymerase delta-interacting protein 2 chr17 Not Cancer Driver No 1 hippie 36 94 13 13 0
PPP1R13L_ENST00000360957 PPP1R13L Q8WUF5 RelA-associated inhibitor chr19 Not Cancer Driver No 1 hippie, biogrid 117 657 90 90 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 Not Cancer Driver No 1 hippie 49 151 19 19 2
RBPMS_ENST00000320203 RBPMS Q93062 RNA-binding protein with multiple splicing chr8 Not Cancer Driver No 1 intact, hippie 23 87 11 11 0
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 Not Cancer Driver No 1 hippie 51 98 6 6 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 Not Cancer Driver No 1 hippie 28 114 16 16 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 Not Cancer Driver No 1 hippie 13 4 1 1 0
RPL37 RPL37 P61927 60S ribosomal protein L37 chr5 Not Cancer Driver No 1 hippie 12 83 10 10 0
RPL39 RPL39 P62891 60S ribosomal protein L39 chrX Not Cancer Driver No 1 hippie 9 51 9 9 0
SHOX SHOX O15266 Short stature homeobox protein chrX Not Cancer Driver No 1 intact, hippie 78 169 58 58 4
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 3 intact, hippie 198 195 17 17 8
SMG1 SMG1 Q96Q15 Serine/threonine-protein kinase SMG1 chr16 Not Cancer Driver No 1 hippie 348 605 73 73 0
SOX10_ENST00000360880 SOX10 P56693 Transcription factor SOX-10 chr22 Not Cancer Driver No 1 intact, hippie 66 421 62 62 14
SRF SRF P11831 Serum response factor chr6 Not Cancer Driver No 1 hippie 44 443 42 42 0
SRRM2 SRRM2 Q9UQ35 Serine/arginine repetitive matrix protein 2 chr16 Not Cancer Driver No 1 hippie 433 2748 431 431 0
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 intact, hippie 27 0 0 0 6
TBX2 TBX2 Q13207 T-box transcription factor TBX2 chr17 Not Cancer Driver No 1 hippie 74 401 36 36 1
TBX5 TBX5 Q99593 T-box transcription factor TBX5 chr12 Not Cancer Driver No 1 hippie 155 351 113 113 5
TCEAL1_ENST00000372626 TCEAL1 Q15170 Transcription elongation factor A protein-like 1 chrX Not Cancer Driver No 1 intact, hippie 18 147 18 18 0
TFAM TFAM Q00059 Transcription factor A, mitochondrial chr10 Not Cancer Driver No 1 hippie 25 110 15 15 1
TLE1 TLE1 Q04724 Transducin-like enhancer protein 1 chr9 Not Cancer Driver No 1 intact, hippie 111 381 53 53 0
TLE3 TLE3 Q04726 Transducin-like enhancer protein 3 chr15 Not Cancer Driver No 1 hippie 87 381 50 50 0
TLX3 TLX3 O43711 T-cell leukemia homeobox protein 3 chr5 Census Yes 1 intact, hippie 40 179 24 24 0
TMED1 TMED1 Q13445 Transmembrane emp24 domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 26 26 3 3 0
TMED10 TMED10 P49755 Transmembrane emp24 domain-containing protein 10 chr14 Not Cancer Driver No 1 hippie 24 15 3 3 0
TMED9 TMED9 Q9BVK6 Transmembrane emp24 domain-containing protein 9 chr5 Not Cancer Driver No 1 intact, hippie 16 22 2 2 0
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 Not Cancer Driver No 1 intact, hippie 33 234 29 29 8
TPM3 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 intact, hippie 35 230 27 27 21
TPM4_ENST00000300933 TPM4 P67936 Tropomyosin alpha-4 chain chr19 Census Yes 1 intact, hippie 28 216 28 28 0
TRIP10 TRIP10 Q15642 Cdc42-interacting protein 4 chr19 Not Cancer Driver No 1 hippie 72 460 61 61 0
USP11 USP11 P51784 Ubiquitin carboxyl-terminal hydrolase 11 chrX Not Cancer Driver No 1 intact, hippie 140 210 28 28 0
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 Not Cancer Driver No 1 intact, hippie 87 118 11 11 0