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NIPBL ,NIPBL ,Q6KC79
  • Uniprot Accession= Q6KC79
  • Ensembl Transcript= ENST00000282516.12
  • Uniprot Name= NIPBL
  • Name= Nipped-B-like protein
  • Chromosome= chr5
  • Driver status= Compendium
  • Number of Interaction partner in intact: 1
  • Number of Interaction partner in biogrid: 23
  • Number of Interaction partner in hippie: 149
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADAR ADAR P55265 Double-stranded RNA-specific adenosine deaminase chr1 Not Cancer Driver No 1 hippie 149 675 83 83 12
AKAP8 AKAP8 O43823 A-kinase anchor protein 8 chr19 Not Cancer Driver No 1 hippie 88 566 78 78 0
ANO7 ANO7 Q6IWH7 Anoctamin-7 chr2 Not Cancer Driver No 1 hippie 144 147 32 32 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie, biogrid 34 103 14 14 0
AR AR P10275 Androgen receptor chrX Census, Compendium Yes 1 hippie, biogrid 196 443 88 88 169
ARFGAP1_ENST00000370283 ARFGAP1 Q8N6T3 ADP-ribosylation factor GTPase-activating protein 1 chr20 Not Cancer Driver No 2 intact, hippie, biogrid 60 264 37 37 0
ATXN7L1 ATXN7L1 Q9ULK2 Ataxin-7-like protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 60 710 48 48 0
AZGP1 AZGP1 P25311 Zinc-alpha-2-glycoprotein chr7 Not Cancer Driver No 1 hippie 59 41 10 10 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
BRD3 BRD3 Q15059 Bromodomain-containing protein 3 chr9 Census Yes 1 hippie 87 566 68 68 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
CBX3_ENST00000396386 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 2 hippie, biogrid 23 119 18 18 0
CBX5 CBX5 P45973 Chromobox protein homolog 5 chr12 Not Cancer Driver No 1 hippie 21 116 12 12 0
CCDC8 CCDC8 Q9H0W5 Coiled-coil domain-containing protein 8 chr19 Not Cancer Driver No 1 hippie 96 505 91 91 0
CDC5L CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 hippie 100 618 77 77 0
CDK6 CDK6 Q00534 Cyclin-dependent kinase 6 chr7 Census Yes 1 hippie 40 24 3 3 1
CDK8 CDK8 P49336 Cyclin-dependent kinase 8 chr13 Not Cancer Driver No 1 hippie 76 152 18 18 7
CENPA CENPA P49450 Histone H3-like centromeric protein A chr2 Not Cancer Driver No 1 hippie, biogrid 15 50 4 4 0
CEP63 CEP63 Q96MT8 Centrosomal protein of 63 kDa chr3 Not Cancer Driver No 1 hippie 100 507 68 68 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
CKAP5 CKAP5 Q14008 Cytoskeleton-associated protein 5 chr11 Not Cancer Driver No 1 hippie 198 634 64 64 0
COIL COIL P38432 Coilin chr17 Not Cancer Driver No 1 hippie, biogrid 61 385 42 42 0
CTDSPL2 CTDSPL2 Q05D32 CTD small phosphatase-like protein 2 chr15 Not Cancer Driver No 1 hippie 47 256 27 27 0
DBN1_ENST00000309007 DBN1 Q16643 Drebrin chr5 Not Cancer Driver No 1 hippie 84 510 73 73 0
DCAF7 DCAF7 P61962 DDB1- and CUL4-associated factor 7 chr17 Not Cancer Driver No 1 hippie 48 0 0 0 0
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 hippie 48 53 6 6 1
DDX17_ENST00000640332 DDX17 Q92841 Probable ATP-dependent RNA helicase DDX17 chr22 Not Cancer Driver No 1 hippie 91 362 48 48 0
DDX47 DDX47 Q9H0S4 Probable ATP-dependent RNA helicase DDX47 chr12 Not Cancer Driver No 1 hippie 51 98 7 7 0
EED_ENST00000263360 EED O75530 Polycomb protein EED chr11 Census Yes 1 hippie 64 79 11 11 6
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 hippie 109 100 14 14 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
EN1 EN1 Q05925 Homeobox protein engrailed-1 chr2 Not Cancer Driver No 1 hippie 42 357 30 30 0
ERG_ENST00000288319 ERG P11308 Transcriptional regulator ERG chr21 Census, Compendium Yes 1 hippie 95 296 54 54 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EWSR1_ENST00000397938 EWSR1 Q01844 RNA-binding protein EWS chr22 Census, Compendium Yes 1 hippie 94 646 93 93 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FAXC FAXC Q5TGI0 Failed axon connections homolog chr6 Not Cancer Driver No 1 hippie, biogrid 47 54 11 11 0
FEV FEV Q99581 Protein FEV chr2 Census Yes 1 hippie 15 55 0 0 0
FLNA FLNA P21333 Filamin-A chrX Census Yes 1 hippie 416 1456 214 214 28
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 hippie 39 24 3 3 0
GATA2_ENST00000487848 GATA2 P23769 Endothelial transcription factor GATA-2 chr3 Census, Compendium Yes 1 hippie 72 370 49 49 6
GPSM3_ENST00000375043 GPSM3 Q9Y4H4 G-protein-signaling modulator 3 chr6 Not Cancer Driver No 1 hippie, biogrid 26 160 26 26 0
HINFP HINFP Q9BQA5 Histone H4 transcription factor chr11 Not Cancer Driver No 1 hippie 65 154 24 24 0
HNF4A HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 135 127 48 48 5
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
HNRNPK_ENST00000351839 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K chr9 Not Cancer Driver No 1 hippie 75 302 59 59 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
IL31 IL31 Q6EBC2 Interleukin-31 chr12 Not Cancer Driver No 1 hippie, biogrid 19 25 4 4 0
IRF4 IRF4 Q15306 Interferon regulatory factor 4 chr6 Census, Compendium Yes 1 hippie 99 155 45 45 0
KDM6B_ENST00000448097 KDM6B O15054 Lysine-specific demethylase 6B chr17 Not Cancer Driver No 1 hippie 189 1278 142 142 2
KHSRP KHSRP Q92945 Far upstream element-binding protein 2 chr19 Not Cancer Driver No 1 hippie 84 684 81 81 0
KLF15 KLF15 Q9UIH9 Krueppel-like factor 15 chr3 Not Cancer Driver No 1 hippie 66 273 48 48 0
KLF16 KLF16 Q9BXK1 Krueppel-like factor 16 chr19 Not Cancer Driver No 1 hippie 13 204 8 8 0
KLF5 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 77 366 40 40 0
KLF8 KLF8 O95600 Krueppel-like factor 8 chrX Not Cancer Driver No 1 hippie 71 270 53 53 0
KPNA1 KPNA1 P52294 Importin subunit alpha-5 chr3 Not Cancer Driver No 1 hippie, biogrid 65 121 18 18 0
KPNA5 KPNA5 O15131 Importin subunit alpha-6 chr6 Not Cancer Driver No 1 hippie, biogrid 65 133 13 13 0
KPRP KPRP Q5T749 Keratinocyte proline-rich protein chr1 Not Cancer Driver No 1 hippie 198 193 68 68 0
KSR2_ENST00000339824 KSR2 Q6VAB6 Kinase suppressor of Ras 2 chr12 Not Cancer Driver No 1 hippie 231 434 120 120 0
LDHD LDHD Q86WU2 Probable D-lactate dehydrogenase, mitochondrial chr16 Not Cancer Driver No 1 hippie 55 48 6 6 2
LHX3_ENST00000371748 LHX3 Q9UBR4 LIM/homeobox protein Lhx3 chr9 Not Cancer Driver No 1 hippie 38 232 14 14 2
LMNA LMNA P02545 Prelamin-A/C chr1 Census Yes 1 hippie 68 544 49 49 131
MAU2 MAU2 Q9Y6X3 MAU2 chromatid cohesion factor homolog chr19 Not Cancer Driver No 2 hippie, biogrid 68 36 1 1 0
MED12 MED12 Q93074 Mediator of RNA polymerase II transcription subunit 12 chrX Census, Compendium Yes 1 hippie 409 974 175 175 5
MED13 MED13 Q9UHV7 Mediator of RNA polymerase II transcription subunit 13 chr17 Not Cancer Driver No 1 hippie 288 905 127 127 3
MED13L MED13L Q71F56 Mediator of RNA polymerase II transcription subunit 13-like chr12 Not Cancer Driver No 1 hippie 274 1074 142 142 0
MED23 MED23 Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 chr6 Not Cancer Driver No 1 hippie 158 28 2 2 1
MGA MGA Q8IWI9 MAX gene-associated protein chr15 Compendium Yes 1 hippie 341 2317 259 259 0
MKI67 MKI67 P46013 Proliferation marker protein Ki-67 chr10 Not Cancer Driver No 1 hippie, biogrid 540 3169 529 529 0
MLLT3 MLLT3 P42568 Protein AF-9 chr9 Census, Compendium Yes 1 hippie 69 414 58 58 0
MYB_ENST00000367814 MYB P10242 Transcriptional activator Myb chr6 Census Yes 1 hippie 82 528 69 69 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYOD1 MYOD1 P15172 Myoblast determination protein 1 chr11 Census Yes 1 hippie 45 246 33 33 0
NAA40 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 22 30 3 3 0
NFATC1 NFATC1 O95644 Nuclear factor of activated T-cells, cytoplasmic 1 chr18 Not Cancer Driver No 1 hippie 173 713 130 130 0
NFIL3 NFIL3 Q16649 Nuclear factor interleukin-3-regulated protein chr9 Not Cancer Driver No 1 hippie 57 333 41 41 0
NFIX_ENST00000592199 NFIX Q14938 Nuclear factor 1 X-type chr19 Not Cancer Driver No 1 hippie 60 305 40 40 6
NIPBL NIPBL Q6KC79 Nipped-B-like protein chr5 Compendium Yes 1 hippie 353 1528 184 184 37
NMB_ENST00000360476 NMB P08949 Neuromedin-B chr15 Not Cancer Driver No 1 hippie, biogrid 6 30 2 2 0
NONO NONO Q15233 Non-POU domain-containing octamer-binding protein chrX Census, Compendium Yes 1 hippie 101 349 64 64 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
NR3C1_ENST00000343796 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 92 362 37 37 12
OBSL1 OBSL1 O75147 Obscurin-like protein 1 chr2 Not Cancer Driver No 1 hippie 233 553 60 60 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 119 320 34 34 0
PAX6_ENST00000241001 PAX6 P26367 Paired box protein Pax-6 chr11 Not Cancer Driver No 1 hippie 72 337 56 56 38
PAX8 PAX8 Q06710 Paired box protein Pax-8 chr2 Census Yes 1 hippie 84 291 55 55 4
PAX9 PAX9 P55771 Paired box protein Pax-9 chr14 Not Cancer Driver No 1 hippie 52 198 32 32 1
PCBP2_ENST00000439930 PCBP2 Q15366 Poly(rC)-binding protein 2 chr12 Not Cancer Driver No 1 hippie 40 200 24 24 0
PKP3 PKP3 Q9Y446 Plakophilin-3 chr11 Not Cancer Driver No 1 hippie 72 357 22 22 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POLDIP3_ENST00000252115 POLDIP3 Q9BY77 Polymerase delta-interacting protein 3 chr22 Not Cancer Driver No 1 hippie 39 301 29 29 0
PPT1 PPT1 P50897 Palmitoyl-protein thioesterase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 37 0 0 0 23
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie 83 72 6 6 0
PRPF31 PRPF31 Q8WWY3 U4/U6 small nuclear ribonucleoprotein Prp31 chr19 Not Cancer Driver No 1 hippie 58 213 17 17 2
PRSS23 PRSS23 O95084 Serine protease 23 chr11 Not Cancer Driver No 1 hippie, biogrid 53 51 4 4 0
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 Census, Compendium Yes 1 hippie, biogrid 115 421 74 74 3
RBM10_ENST00000377604 RBM10 P98175 RNA-binding protein 10 chrX Census, Compendium Yes 1 hippie 112 777 99 99 0
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 Not Cancer Driver No 1 hippie 51 98 6 6 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 Not Cancer Driver No 1 hippie 28 114 16 16 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 Not Cancer Driver No 1 hippie 13 4 1 1 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 hippie 46 9 3 3 4
RUVBL1 RUVBL1 Q9Y265 RuvB-like 1 chr3 Not Cancer Driver No 1 hippie 54 67 7 7 0
RUVBL2 RUVBL2 Q9Y230 RuvB-like 2 chr19 Not Cancer Driver No 1 hippie 62 100 13 13 0
SETX SETX Q7Z333 Probable helicase senataxin chr9 Not Cancer Driver No 1 hippie 342 1240 156 156 20
SF3A2 SF3A2 Q15428 Splicing factor 3A subunit 2 chr19 Not Cancer Driver No 1 hippie, biogrid 30 382 21 21 0
SF3B1 SF3B1 O75533 Splicing factor 3B subunit 1 chr2 Census, Compendium Yes 1 hippie 244 477 80 80 0
SF3B3 SF3B3 Q15393 Splicing factor 3B subunit 3 chr16 Not Cancer Driver No 1 hippie 154 145 19 19 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SMC1A SMC1A Q14683 Structural maintenance of chromosomes protein 1A chrX Census, Compendium Yes 1 hippie 200 717 114 114 21
SMC3 SMC3 Q9UQE7 Structural maintenance of chromosomes protein 3 chr10 Not Cancer Driver No 1 hippie 149 605 70 70 0
SNIP1 SNIP1 Q8TAD8 Smad nuclear-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 58 285 40 40 1
SNRNP200 SNRNP200 O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase chr2 Not Cancer Driver No 1 hippie 237 270 37 37 11
SNW1_ENST00000261531 SNW1 Q13573 SNW domain-containing protein 1 chr14 Not Cancer Driver No 1 hippie 62 488 56 56 0
SNX9 SNX9 Q9Y5X1 Sorting nexin-9 chr6 Not Cancer Driver No 1 hippie 71 231 23 23 0
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 hippie 39 312 39 39 0
SP100_ENST00000264052 SP100 P23497 Nuclear autoantigen Sp-100 chr2 Not Cancer Driver No 1 hippie 136 680 101 101 0
SP7 SP7 Q8TDD2 Transcription factor Sp7 chr12 Not Cancer Driver No 1 hippie 63 332 44 44 0
SPINDOC SPINDOC Q9BUA3 Spindlin interactor and repressor of chromatin-binding protein chr11 Not Cancer Driver No 1 hippie 56 364 54 54 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie 54 267 32 32 30
STAG1 STAG1 Q8WVM7 Cohesin subunit SA-1 chr3 Census Yes 1 hippie 226 391 66 66 8
STAG2_ENST00000371157 STAG2 Q8N3U4 Cohesin subunit SA-2 chrX Census, Compendium Yes 1 hippie 179 330 46 46 3
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
STK38 STK38 Q15208 Serine/threonine-protein kinase 38 chr6 Not Cancer Driver No 1 hippie 57 77 6 6 0
STK38L STK38L Q9Y2H1 Serine/threonine-protein kinase 38-like chr12 Not Cancer Driver No 1 hippie 51 86 12 12 0
SUCO_ENST00000263688 SUCO Q9UBS9 SUN domain-containing ossification factor chr1 Not Cancer Driver No 1 hippie 164 785 99 99 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
SUPT5H SUPT5H O00267 Transcription elongation factor SPT5 chr19 Not Cancer Driver No 1 hippie 165 572 87 87 0
TBXT TBXT O15178 T-box transcription factor T chr6 Not Cancer Driver No 1 hippie 110 253 69 69 1
TEAD1_ENST00000638666 TEAD1 P28347 Transcriptional enhancer factor TEF-1 chr11 Not Cancer Driver No 1 hippie 52 157 24 24 1
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 Not Cancer Driver No 1 hippie, biogrid 28 310 16 16 0
TET2 TET2 Q6N021 Methylcytosine dioxygenase TET2 chr4 Census, Compendium Yes 1 hippie 191 1663 176 176 1
TFG TFG Q92734 Protein TFG chr3 Census, Compendium Yes 1 hippie 45 290 34 34 3
THRAP3_ENST00000469141 THRAP3 Q9Y2W1 Thyroid hormone receptor-associated protein 3 chr1 Census Yes 1 hippie 137 955 137 137 0
TLX1 TLX1 P31314 T-cell leukemia homeobox protein 1 chr10 Census Yes 1 hippie 28 223 17 17 0
TLX2 TLX2 O43763 T-cell leukemia homeobox protein 2 chr2 Not Cancer Driver No 1 hippie 24 220 15 15 0
TLX3 TLX3 O43711 T-cell leukemia homeobox protein 3 chr5 Census Yes 1 hippie 40 179 24 24 0
TOMM40_ENST00000405636 TOMM40 O96008 Mitochondrial import receptor subunit TOM40 homolog chr19 Not Cancer Driver No 1 hippie, biogrid 17 98 1 1 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TUBB3 TUBB3 Q13509 Tubulin beta-3 chain chr16 Not Cancer Driver No 1 hippie 67 53 10 10 12
TUBB8 TUBB8 Q3ZCM7 Tubulin beta-8 chain chr10 Not Cancer Driver No 1 hippie 103 53 18 18 13
USP37_ENST00000454775 USP37 Q86T82 Ubiquitin carboxyl-terminal hydrolase 37 chr2 Not Cancer Driver No 1 hippie 112 530 62 62 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WAPL_ENST00000618527 WAPL Q7Z5K2 Wings apart-like protein homolog chr10 Not Cancer Driver No 1 hippie 140 621 68 68 0
ZDBF2 ZDBF2 Q9HCK1 DBF4-type zinc finger-containing protein 2 chr2 Not Cancer Driver No 1 hippie 510 1664 380 380 0
ZNF330 ZNF330 Q9Y3S2 Zinc finger protein 330 chr4 Not Cancer Driver No 1 hippie, biogrid 44 127 19 19 0