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NES ,NES ,P48681
  • Uniprot Accession= P48681
  • Ensembl Transcript= ENST00000368223.3
  • Uniprot Name= NES
  • Name= Nestin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 54
  • Number of Interaction partner in biogrid: 49
  • Number of Interaction partner in hippie: 120
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCF3 ABCF3 Q9NUQ8 ATP-binding cassette sub-family F member 3 chr3 Not Cancer Driver No 1 hippie, biogrid 109 136 19 19 0
ADD1_ENST00000398129 ADD1 P35611 Alpha-adducin chr4 Not Cancer Driver No 1 hippie 106 439 64 64 0
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 Not Cancer Driver No 1 intact, hippie 173 788 103 103 0
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie 144 767 104 104 2
ARHGEF19 ARHGEF19 Q8IW93 Rho guanine nucleotide exchange factor 19 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 82 365 36 36 0
ASCL1 ASCL1 P50553 Achaete-scute homolog 1 chr12 Not Cancer Driver No 1 hippie, biogrid 33 182 24 24 0
ATP9A ATP9A O75110 Probable phospholipid-transporting ATPase IIA chr20 Not Cancer Driver No 1 intact, hippie 175 69 18 18 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 50 150 30 30 0
BTF3 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 hippie 27 192 24 24 0
CAPN1_ENST00000533129 CAPN1 P07384 Calpain-1 catalytic subunit chr11 Not Cancer Driver No 1 intact, hippie, biogrid 68 32 2 2 1
CCDC71 CCDC71 Q8IV32 Coiled-coil domain-containing protein 71 chr3 Not Cancer Driver No 1 hippie, biogrid 61 374 47 47 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 Not Cancer Driver No 1 intact, hippie 226 1481 173 173 0
CCSER2_ENST00000224756 CCSER2 Q9H7U1 Serine-rich coiled-coil domain-containing protein 2 chr10 Not Cancer Driver No 1 intact, hippie 104 752 98 98 0
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 Not Cancer Driver No 1 hippie 48 5 1 1 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 Not Cancer Driver No 1 hippie 35 103 16 16 0
CEP162 CEP162 Q5TB80 Centrosomal protein of 162 kDa chr6 Not Cancer Driver No 1 intact, hippie 162 1056 128 128 0
CGAS CGAS Q8N884 Cyclic GMP-AMP synthase chr6 Not Cancer Driver No 1 hippie 50 173 7 7 0
CHD7 CHD7 Q9P2D1 Chromodomain-helicase-DNA-binding protein 7 chr8 Not Cancer Driver No 1 intact, hippie 464 1872 299 299 50
CHMP4C CHMP4C Q96CF2 Charged multivesicular body protein 4c chr8 Not Cancer Driver No 1 hippie 33 224 31 31 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
CLTA CLTA P09496 Clathrin light chain A chr9 Not Cancer Driver No 1 intact, hippie 20 192 12 12 0
CLTB CLTB P09497 Clathrin light chain B chr5 Not Cancer Driver No 1 intact, hippie 33 193 28 28 0
CMSS1 CMSS1 Q9BQ75 Protein CMSS1 chr3 Not Cancer Driver No 1 intact, hippie 52 98 16 16 0
COL5A2 COL5A2 P05997 Collagen alpha-2(V) chain chr2 Not Cancer Driver No 1 intact, hippie 350 1276 297 297 2
COQ3 COQ3 Q9NZJ6 Ubiquinone biosynthesis O-methyltransferase, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 47 22 5 5 0
CTBP1 CTBP1 Q13363 C-terminal-binding protein 1 chr4 Not Cancer Driver No 1 intact, hippie 42 123 9 9 1
CTCFL_ENST00000371196 CTCFL Q8NI51 Transcriptional repressor CTCFL chr20 Not Cancer Driver No 1 hippie, biogrid 136 266 61 61 0
DEPDC1B DEPDC1B Q8WUY9 DEP domain-containing protein 1B chr5 Not Cancer Driver No 1 intact, hippie, biogrid 76 52 6 6 0
DES DES P17661 Desmin chr2 Not Cancer Driver No 1 hippie, biogrid 71 264 41 41 35
DNAH12_ENST00000351747 DNAH12 Q6ZR08 Dynein axonemal heavy chain 12 chr3 Not Cancer Driver No 1 intact, hippie 243 174 22 22 0
EBF2 EBF2 Q9HAK2 Transcription factor COE2 chr8 Not Cancer Driver No 1 intact, hippie 158 261 71 71 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EGR1 EGR1 P18146 Early growth response protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 78 501 72 72 0
EIF3I EIF3I Q13347 Eukaryotic translation initiation factor 3 subunit I chr1 Not Cancer Driver No 1 intact, hippie 47 46 6 6 0
FAM167A FAM167A Q96KS9 Protein FAM167A chr8 Not Cancer Driver No 2 intact, hippie, biogrid 33 116 17 17 0
FAM81B FAM81B Q96LP2 Protein FAM81B chr5 Not Cancer Driver No 1 intact, hippie 85 178 29 29 0
FERD3L FERD3L Q96RJ6 Fer3-like protein chr7 Not Cancer Driver No 1 intact, hippie, biogrid 79 59 23 23 0
FIGLA FIGLA Q6QHK4 Factor in the germline alpha chr2 Not Cancer Driver No 1 hippie, biogrid 22 154 17 17 0
FLII FLII Q13045 Protein flightless-1 homolog chr17 Not Cancer Driver No 1 intact, hippie 128 206 32 32 0
FTSJ3 FTSJ3 Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 chr17 Not Cancer Driver No 1 hippie, biogrid 103 533 66 66 0
GART_ENST00000381815 GART P22102 Trifunctional purine biosynthetic protein adenosine-3 chr21 Not Cancer Driver No 1 intact, hippie 96 50 6 6 0
GFAP_ENST00000588735 GFAP P14136 Glial fibrillary acidic protein chr17 Not Cancer Driver No 3 intact, hippie, biogrid 65 288 42 42 62
GKAP1 GKAP1 Q5VSY0 G kinase-anchoring protein 1 chr9 Not Cancer Driver No 1 intact, hippie 39 279 29 29 0
GOLGA2_ENST00000611957 GOLGA2 Q08379 Golgin subfamily A member 2 chr9 Not Cancer Driver No 1 intact, hippie 115 854 96 96 0
GPATCH4_ENST00000368232 GPATCH4 A0A0A0MRK1 G patch domain-containing protein 4 chr1 Not Cancer Driver No 1 intact, hippie 42 359 39 39 0
GRIN3B GRIN3B O60391 Glutamate receptor ionotropic, NMDA 3B chr19 Not Cancer Driver No 1 hippie, biogrid 90 299 23 23 0
GRTP1_ENST00000375431 GRTP1 Q5TC63 Growth hormone-regulated TBC protein 1 chr13 Not Cancer Driver No 1 intact, hippie 58 39 3 3 0
HADHB HADHB P55084 Trifunctional enzyme subunit beta, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 71 41 9 9 14
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 106 257 37 37 0
IDE IDE P14735 Insulin-degrading enzyme chr10 Not Cancer Driver No 3 intact, hippie, biogrid 90 96 8 8 0
IMPDH2 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 chr3 Not Cancer Driver No 1 intact, hippie 70 6 1 1 0
INA INA Q16352 Alpha-internexin chr10 Not Cancer Driver No 1 hippie, biogrid 62 256 43 43 0
KEAP1_ENST00000393623 KEAP1 Q14145 Kelch-like ECH-associated protein 1 chr19 Census, Compendium Yes 1 hippie 237 57 12 12 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KIF20A KIF20A O95235 Kinesin-like protein KIF20A chr5 Not Cancer Driver No 1 hippie 79 340 40 40 1
KRT18_ENST00000388837 KRT18 P05783 Keratin, type I cytoskeletal 18 chr12 Not Cancer Driver No 1 hippie, biogrid 57 179 21 21 4
KRT23 KRT23 Q9C075 Keratin, type I cytoskeletal 23 chr17 Not Cancer Driver No 1 hippie, biogrid 69 259 47 47 0
KRT31 KRT31 Q15323 Keratin, type I cuticular Ha1 chr17 Not Cancer Driver No 1 hippie, biogrid 116 64 16 16 0
KRT7 KRT7 P08729 Keratin, type II cytoskeletal 7 chr12 Not Cancer Driver No 1 intact, hippie 63 158 28 28 0
KRT8_ENST00000546897 KRT8 P05787 Keratin, type II cytoskeletal 8 chr12 Not Cancer Driver No 2 hippie, biogrid 65 221 37 37 3
LAMA1 LAMA1 P25391 Laminin subunit alpha-1 chr18 Not Cancer Driver No 1 hippie 600 329 71 71 0
LAS1L LAS1L Q9Y4W2 Ribosomal biogenesis protein LAS1L chrX Not Cancer Driver No 1 intact, hippie 100 279 49 49 0
LMNB1 LMNB1 P20700 Lamin-B1 chr5 Not Cancer Driver No 1 intact, hippie 60 404 42 42 4
MCM5 MCM5 P33992 DNA replication licensing factor MCM5 chr22 Not Cancer Driver No 1 hippie 88 109 20 20 1
MICALL2 MICALL2 Q8IY33 MICAL-like protein 2 chr7 Not Cancer Driver No 1 intact, hippie 110 675 88 88 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYF6 MYF6 P23409 Myogenic factor 6 chr12 Not Cancer Driver No 2 hippie, biogrid 89 118 44 44 0
MYOG MYOG P15173 Myogenin chr1 Not Cancer Driver No 2 intact, hippie, biogrid 36 132 20 20 0
NACA_ENST00000356769 NACA Q13765 Nascent polypeptide-associated complex subunit alpha chr12 Census Yes 1 hippie 37 143 26 26 0
NCAPD3 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie 193 304 42 42 1
NEFL NEFL P07196 Neurofilament light polypeptide chr8 Not Cancer Driver No 1 hippie, biogrid 92 285 39 39 12
NEFM NEFM P07197 Neurofilament medium polypeptide chr8 Not Cancer Driver No 3 intact, hippie, biogrid 182 767 147 147 0
NEUROG1 NEUROG1 Q92886 Neurogenin-1 chr5 Not Cancer Driver No 1 hippie, biogrid 27 178 18 18 0
NPAS1_ENST00000449844 NPAS1 Q99742 Neuronal PAS domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 53 309 23 23 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OBSL1 OBSL1 O75147 Obscurin-like protein 1 chr2 Not Cancer Driver No 1 hippie 233 553 60 60 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 57 99 13 13 23
PKP4 PKP4 Q99569 Plakophilin-4 chr2 Not Cancer Driver No 1 hippie 172 756 119 119 0
POLRMT POLRMT O00411 DNA-directed RNA polymerase, mitochondrial chr19 Not Cancer Driver No 1 intact, hippie 188 253 31 31 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRDX2 PRDX2 P32119 Peroxiredoxin-2 chr19 Not Cancer Driver No 1 intact, hippie 24 30 4 4 0
PRPH PRPH P41219 Peripherin chr12 Not Cancer Driver No 1 hippie, biogrid 37 239 20 20 0
RALBP1 RALBP1 Q15311 RalA-binding protein 1 chr18 Not Cancer Driver No 1 hippie 65 381 46 46 0
RAMP1 RAMP1 O60894 Receptor activity-modifying protein 1 chr2 Not Cancer Driver No 1 hippie, biogrid 16 0 0 0 0
RNF13_ENST00000392894 RNF13 O43567 E3 ubiquitin-protein ligase RNF13 chr3 Not Cancer Driver No 1 intact, hippie 45 107 17 17 2
RNF145_ENST00000519865 RNF145 Q96MT1 RING finger protein 145 chr5 Not Cancer Driver No 1 hippie, biogrid 94 78 10 10 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 intact, hippie 46 9 3 3 4
RRP9 RRP9 O43818 U3 small nucleolar RNA-interacting protein 2 chr3 Not Cancer Driver No 1 intact, hippie 53 146 9 9 0
RSPRY1_ENST00000394420 RSPRY1 Q96DX4 RING finger and SPRY domain-containing protein 1 chr16 Not Cancer Driver No 2 intact, hippie, biogrid 64 98 18 18 1
S100A2_ENST00000368709 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie, biogrid 16 6 2 2 0
SCRT1 SCRT1 Q9BWW7 Transcriptional repressor scratch 1 chr8 Not Cancer Driver No 1 hippie, biogrid 26 173 8 8 0
SF3B1 SF3B1 O75533 Splicing factor 3B subunit 1 chr2 Census, Compendium Yes 1 intact, hippie 244 477 80 80 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SLC25A22_ENST00000628067 SLC25A22 Q9H936 Mitochondrial glutamate carrier 1 chr11 Not Cancer Driver No 1 hippie 34 22 2 2 1
SLC35F6 SLC35F6 Q8N357 Solute carrier family 35 member F6 chr2 Not Cancer Driver No 1 intact, hippie 33 13 0 0 0
SLC35G1 SLC35G1 Q2M3R5 Solute carrier family 35 member G1 chr10 Not Cancer Driver No 1 hippie, biogrid 37 36 0 0 0
SLU7 SLU7 O95391 Pre-mRNA-splicing factor SLU7 chr5 Not Cancer Driver No 1 hippie, biogrid 75 436 63 63 0
SRRM1 SRRM1 Q8IYB3 Serine/arginine repetitive matrix protein 1 chr1 Not Cancer Driver No 1 hippie 129 795 122 122 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 hippie, biogrid 75 135 14 14 9
SUMO3_ENST00000332859 SUMO3 P55854 Small ubiquitin-related modifier 3 chr21 Not Cancer Driver No 1 hippie 7 87 5 5 0
SVIL SVIL O95425 Supervillin chr10 Not Cancer Driver No 1 hippie 308 1423 192 192 0
SYNC SYNC Q9H7C4 Syncoilin chr1 Not Cancer Driver No 1 intact, hippie, biogrid 30 358 22 22 0
SYNM SYNM O15061 Synemin chr15 Not Cancer Driver No 1 hippie, biogrid 156 1244 131 131 0
TCF4_ENST00000564999 TCF4 P15884 Transcription factor 4 chr18 Compendium Yes 1 hippie, biogrid 141 662 136 136 13
TMEM132A_ENST00000453848 TMEM132A Q24JP5 Transmembrane protein 132A chr11 Not Cancer Driver No 1 intact, hippie 137 529 71 71 0
TNIP3_ENST00000057513 TNIP3 Q96KP6 TNFAIP3-interacting protein 3 chr4 Not Cancer Driver No 1 intact, hippie 97 249 72 72 0
TNRC6A TNRC6A Q8NDV7 Trinucleotide repeat-containing gene 6A protein chr16 Not Cancer Driver No 1 hippie 284 1830 265 265 0
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 Not Cancer Driver No 1 hippie, biogrid 33 234 29 29 8
TPM3 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 hippie, biogrid 35 230 27 27 21
TRAK2 TRAK2 O60296 Trafficking kinesin-binding protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 112 576 70 70 0
UBR1 UBR1 Q8IWV7 E3 ubiquitin-protein ligase UBR1 chr15 Not Cancer Driver No 2 hippie, biogrid 170 165 15 15 18
UBR2 UBR2 Q8IWV8 E3 ubiquitin-protein ligase UBR2 chr6 Not Cancer Driver No 1 intact, hippie 172 228 30 30 0
UBR5 UBR5 O95071 E3 ubiquitin-protein ligase UBR5 chr8 Census, Compendium Yes 1 intact, hippie 340 1296 162 162 0
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 4 intact, hippie, biogrid 84 316 57 57 1
XPNPEP3 XPNPEP3 Q9NQH7 Xaa-Pro aminopeptidase 3 chr22 Not Cancer Driver No 1 hippie, biogrid 64 128 14 14 1
ZBTB18_ENST00000622512 ZBTB18 Q99592 Zinc finger and BTB domain-containing protein 18 chr1 Not Cancer Driver No 1 intact 78 236 25 25 0
ZBTB44_ENST00000357899 ZBTB44 Q8NCP5 Zinc finger and BTB domain-containing protein 44 chr11 Not Cancer Driver No 1 hippie, biogrid 68 266 35 35 0
ZNF10 ZNF10 P21506 Zinc finger protein 10 chr12 Not Cancer Driver No 1 hippie, biogrid 78 78 15 15 0