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NEK2 ,NEK2 ,P51955
  • Uniprot Accession= P51955
  • Ensembl Transcript= ENST00000366999.8
  • Uniprot Name= NEK2
  • Name= Serine/threonine-protein kinase Nek2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 10
  • Number of Interaction partner in hippie: 121
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTBL2 ACTBL2 Q562R1 Beta-actin-like protein 2 chr5 Not Cancer Driver No 1 hippie 73 29 5 5 0
ANAPC1 ANAPC1 Q9H1A4 Anaphase-promoting complex subunit 1 chr2 Not Cancer Driver No 1 hippie 206 263 33 33 0
ANAPC15_ENST00000538393 ANAPC15 P60006 Anaphase-promoting complex subunit 15 chr11 Not Cancer Driver No 2 hippie, biogrid 15 117 14 14 0
ANAPC2 ANAPC2 Q9UJX6 Anaphase-promoting complex subunit 2 chr9 Not Cancer Driver No 1 hippie 104 146 26 26 0
ANAPC4_ENST00000315368 ANAPC4 Q9UJX5 Anaphase-promoting complex subunit 4 chr4 Not Cancer Driver No 1 hippie 70 54 1 1 0
ANAPC5 ANAPC5 Q9UJX4 Anaphase-promoting complex subunit 5 chr12 Not Cancer Driver No 1 hippie, biogrid 94 41 4 4 0
ANAPC7 ANAPC7 A0A024RBJ3 Anaphase promoting complex subunit 7, isoform CRA_b chr12 Not Cancer Driver No 1 hippie 74 98 17 17 0
ANKFY1_ENST00000341657 ANKFY1 Q9P2R3 Rabankyrin-5 chr17 Not Cancer Driver No 1 hippie 109 185 29 29 0
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie 144 767 104 104 2
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
APOD APOD P05090 Apolipoprotein D chr3 Not Cancer Driver No 1 hippie 34 13 2 2 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BFSP2 BFSP2 Q13515 Phakinin chr3 Not Cancer Driver No 2 hippie, biogrid 69 211 28 28 1
BUB1B BUB1B O60566 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta chr15 Census Yes 1 hippie 96 480 35 35 7
C16orf87 C16orf87 Q6PH81 UPF0547 protein C16orf87 chr16 Not Cancer Driver No 1 hippie, biogrid 17 103 8 8 0
CALML5 CALML5 Q9NZT1 Calmodulin-like protein 5 chr10 Not Cancer Driver No 1 hippie 34 98 21 21 0
CAPZA1 CAPZA1 P52907 F-actin-capping protein subunit alpha-1 chr1 Not Cancer Driver No 1 hippie 40 41 2 2 0
CAPZA2 CAPZA2 P47755 F-actin-capping protein subunit alpha-2 chr7 Not Cancer Driver No 1 hippie 37 19 0 0 0
CAT CAT P04040 Catalase chr11 Not Cancer Driver No 1 hippie 70 176 18 18 0
CCDC85A CCDC85A Q96PX6 Coiled-coil domain-containing protein 85A chr2 Not Cancer Driver No 2 hippie, biogrid 146 399 116 116 0
CDC16_ENST00000356221 CDC16 Q13042 Cell division cycle protein 16 homolog chr13 Not Cancer Driver No 1 hippie 68 54 7 7 0
CDC20 CDC20 Q12834 Cell division cycle protein 20 homolog chr1 Not Cancer Driver No 1 hippie 44 198 15 15 0
CDC23 CDC23 Q9UJX2 Cell division cycle protein 23 homolog chr5 Not Cancer Driver No 1 hippie 57 45 6 6 0
CDC26 CDC26 Q8NHZ8 Anaphase-promoting complex subunit CDC26 chr9 Not Cancer Driver No 1 hippie 5 85 5 5 0
CDC27_ENST00000066544 CDC27 P30260 Cell division cycle protein 27 homolog chr17 Not Cancer Driver No 1 hippie 179 289 75 75 0
CDH1 CDH1 P12830 Cadherin-1 chr16 Census, Compendium Yes 1 hippie 150 400 82 82 5
CDSN CDSN Q15517 Corneodesmosin chr6 Not Cancer Driver No 1 hippie 56 469 52 52 0
CEP250 CEP250 Q9BV73 Centrosome-associated protein CEP250 chr20 Not Cancer Driver No 1 hippie 250 1859 195 195 0
CFAP97 CFAP97 Q9P2B7 Cilia- and flagella-associated protein 97 chr4 Not Cancer Driver No 1 hippie 63 530 63 63 0
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 Not Cancer Driver No 1 hippie 58 86 16 16 0
CHGA CHGA P10645 Chromogranin-A chr14 Not Cancer Driver No 1 hippie 46 421 44 44 0
CLEC4C_ENST00000360345 CLEC4C Q8WTT0 C-type lectin domain family 4 member C chr12 Not Cancer Driver No 1 hippie 58 5 1 1 0
CORO1A CORO1A P31146 Coronin-1A chr16 Not Cancer Driver No 1 hippie 51 126 15 15 1
CORO1C_ENST00000541050 CORO1C Q9ULV4 Coronin-1C chr12 Not Cancer Driver No 1 hippie 61 84 13 13 0
CSN2 CSN2 P05814 Beta-casein chr4 Not Cancer Driver No 1 hippie 49 41 12 12 0
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 415 288 301 301 14
DCTN1 DCTN1 Q14203 Dynactin subunit 1 chr2 Census Yes 1 hippie 172 817 111 111 11
DPP9_ENST00000598800 DPP9 Q86TI2 Dipeptidyl peptidase 9 chr19 Not Cancer Driver No 1 hippie, biogrid 94 83 15 15 0
DSC1 DSC1 Q08554 Desmocollin-1 chr18 Not Cancer Driver No 1 hippie 219 265 65 65 0
DSG1 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 1 hippie 250 496 130 130 0
DTD1 DTD1 Q8TEA8 D-aminoacyl-tRNA deacylase 1 chr20 Not Cancer Driver No 2 hippie, biogrid 45 93 26 26 0
EDRF1 EDRF1 Q3B7T1 Erythroid differentiation-related factor 1 chr10 Not Cancer Driver No 1 hippie 139 270 36 36 0
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 hippie 109 100 14 14 0
EEF2 EEF2 P13639 Elongation factor 2 chr19 Not Cancer Driver No 1 hippie 111 78 14 14 1
EIF4A1 EIF4A1 P60842 Eukaryotic initiation factor 4A-I chr17 Not Cancer Driver No 1 hippie 48 35 7 7 0
EIF4A2 EIF4A2 Q14240 Eukaryotic initiation factor 4A-II chr3 Census Yes 1 hippie 77 27 14 14 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
FANCA FANCA O15360 Fanconi anemia group A protein chr16 Census, Compendium Yes 1 hippie 160 154 15 15 27
FLG2 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 hippie 613 2252 577 577 0
FUNDC2 FUNDC2 Q9BWH2 FUN14 domain-containing protein 2 chrX Not Cancer Driver No 1 hippie 28 34 3 3 0
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 hippie 39 24 3 3 0
GIT1_ENST00000225394 GIT1 Q9Y2X7 ARF GTPase-activating protein GIT1 chr17 Not Cancer Driver No 1 hippie 67 434 42 42 0
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 Census, Compendium Yes 1 hippie 68 255 41 41 0
HNRNPDL HNRNPDL O14979 Heterogeneous nuclear ribonucleoprotein D-like chr4 Not Cancer Driver No 1 hippie 51 297 36 36 2
HNRNPF_ENST00000356053 HNRNPF P52597 Heterogeneous nuclear ribonucleoprotein F chr10 Not Cancer Driver No 1 hippie 65 105 18 18 0
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
HNRNPK_ENST00000351839 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K chr9 Not Cancer Driver No 1 hippie 75 302 59 59 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 hippie 100 254 43 43 0
HSPA1L HSPA1L P34931 Heat shock 70 kDa protein 1-like chr6 Not Cancer Driver No 1 hippie 119 141 28 28 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 Not Cancer Driver No 1 hippie 73 282 35 35 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
HSPA9 HSPA9 P38646 Stress-70 protein, mitochondrial chr5 Not Cancer Driver No 1 hippie 67 283 26 26 2
IFT140 IFT140 Q96RY7 Intraflagellar transport protein 140 homolog chr16 Not Cancer Driver No 1 hippie 176 161 27 27 10
IMMT IMMT Q16891 MICOS complex subunit MIC60 chr2 Not Cancer Driver No 1 hippie 97 400 50 50 0
JUP JUP P14923 Junction plakoglobin chr17 Not Cancer Driver No 1 hippie 112 241 37 37 0
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 28 24 2 2 0
KIF24 KIF24 Q5T7B8 Kinesin-like protein KIF24 chr9 Not Cancer Driver No 1 hippie 126 898 90 90 0
LRRC15_ENST00000347624 LRRC15 Q8TF66 Leucine-rich repeat-containing protein 15 chr3 Not Cancer Driver No 1 hippie 124 37 11 11 0
MAD1L1_ENST00000399654 MAD1L1 Q9Y6D9 Mitotic spindle assembly checkpoint protein MAD1 chr7 Not Cancer Driver No 1 hippie 117 526 77 77 0
MAD2L1 MAD2L1 Q13257 Mitotic spindle assembly checkpoint protein MAD2A chr4 Not Cancer Driver No 1 hippie 26 12 1 1 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MCC_ENST00000302475 MCC P23508 Colorectal mutant cancer protein chr5 Not Cancer Driver No 2 hippie, biogrid 136 589 92 92 0
MYH9 MYH9 P35579 Myosin-9 chr22 Census, Compendium Yes 1 hippie 310 1120 160 160 17
MYO5A MYO5A Q9Y4I1 Unconventional myosin-Va chr15 Census, Compendium Yes 1 hippie 224 497 58 58 0
NDC80 NDC80 O14777 Kinetochore protein NDC80 homolog chr18 Not Cancer Driver No 1 hippie 80 313 45 45 0
NEK11 NEK11 Q8NG66 Serine/threonine-protein kinase Nek11 chr3 Not Cancer Driver No 1 hippie 91 264 45 45 0
NEK2 NEK2 P51955 Serine/threonine-protein kinase Nek2 chr1 Not Cancer Driver No 1 hippie 61 92 19 19 0
NMRK2_ENST00000168977 NMRK2 Q9NPI5 Nicotinamide riboside kinase 2 chr19 Not Cancer Driver No 1 hippie 25 53 9 9 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 hippie 29 249 22 22 0
ODF2 ODF2 Q5BJF6 Outer dense fiber protein 2 chr9 Not Cancer Driver No 1 hippie 123 607 90 90 0
PDE4DIP_ENST00000369354 PDE4DIP Q5VU43 Myomegalin chr1 Census, Compendium Yes 1 hippie 555 1633 395 395 0
PKP1 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie 106 190 26 26 0
PPP1CA_ENST00000376745 PPP1CA P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit chr11 Not Cancer Driver No 1 hippie 38 27 6 6 0
PPP1CB_ENST00000358506 PPP1CB P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit chr2 Not Cancer Driver No 1 hippie 47 25 5 5 5
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 26 23 4 4 0
PPP1R12A_ENST00000261207 PPP1R12A O14974 Protein phosphatase 1 regulatory subunit 12A chr12 Not Cancer Driver No 1 hippie 107 821 89 89 0
PPP1R2 PPP1R2 P41236 Protein phosphatase inhibitor 2 chr3 Not Cancer Driver No 1 hippie 19 205 19 19 0
PRDX2 PRDX2 P32119 Peroxiredoxin-2 chr19 Not Cancer Driver No 1 hippie 24 30 4 4 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PRMT1 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie 50 18 1 1 0
PRSS3 PRSS3 P35030 Trypsin-3 chr9 Not Cancer Driver No 1 hippie 50 30 0 0 0
PSMC2_ENST00000292644 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie 63 120 13 13 0
PSMC3_ENST00000298852 PSMC3 P17980 26S proteasome regulatory subunit 6A chr11 Not Cancer Driver No 1 hippie 55 131 10 10 0
PSMC4 PSMC4 P43686 26S proteasome regulatory subunit 6B chr19 Not Cancer Driver No 1 hippie 51 21 3 3 0
PSMC6_ENST00000606149 PSMC6 P62333 26S proteasome regulatory subunit 10B chr14 Not Cancer Driver No 1 hippie 49 69 8 8 0
PSMD2 PSMD2 Q13200 26S proteasome non-ATPase regulatory subunit 2 chr3 Not Cancer Driver No 1 hippie 100 135 14 14 0
PTPRD PTPRD P23468 Receptor-type tyrosine-protein phosphatase delta chr9 Census, Compendium Yes 1 hippie 577 747 219 219 0
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 52 19 2 2 0
RITA1_ENST00000548278 RITA1 Q96K30 RBPJ-interacting and tubulin-associated protein 1 chr12 Not Cancer Driver No 1 hippie 27 271 28 28 0
RNF41_ENST00000615206 RNF41 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 chr12 Not Cancer Driver No 1 hippie 44 33 2 2 0
RPLP0_ENST00000228306 RPLP0 P05388 60S acidic ribosomal protein P0 chr12 Not Cancer Driver No 1 hippie 44 36 4 4 0
RUVBL2 RUVBL2 Q9Y230 RuvB-like 2 chr19 Not Cancer Driver No 1 hippie 62 100 13 13 0
S100A7_ENST00000368722 S100A7 P31151 Protein S100-A7 chr1 Census Yes 1 hippie 39 28 14 14 0
SEMG1 SEMG1 P04279 Semenogelin-1 chr20 Not Cancer Driver No 1 hippie 101 442 98 98 0
SEMG2 SEMG2 Q02383 Semenogelin-2 chr20 Not Cancer Driver No 1 hippie 147 561 145 145 0
SETD1A SETD1A O15047 Histone-lysine N-methyltransferase SETD1A chr16 Not Cancer Driver No 1 hippie 223 1327 188 188 5
SF3B3 SF3B3 Q15393 Splicing factor 3B subunit 3 chr16 Not Cancer Driver No 1 hippie 154 145 19 19 0
SMURF1 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 chr7 Not Cancer Driver No 1 hippie 89 256 31 31 0
SPTBN4_ENST00000598249 SPTBN4 Q9H254 Spectrin beta chain, non-erythrocytic 4 chr19 Not Cancer Driver No 1 hippie 312 866 103 103 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 Not Cancer Driver No 1 hippie 42 302 26 26 0
TCEAL7 TCEAL7 Q9BRU2 Transcription elongation factor A protein-like 7 chrX Not Cancer Driver No 1 hippie, biogrid 14 92 12 12 0
TCF25 TCF25 Q9BQ70 Transcription factor 25 chr16 Not Cancer Driver No 1 hippie 82 280 35 35 0
THRAP3_ENST00000469141 THRAP3 Q9Y2W1 Thyroid hormone receptor-associated protein 3 chr1 Census Yes 1 hippie 137 955 137 137 0
TMOD3 TMOD3 Q9NYL9 Tropomodulin-3 chr15 Not Cancer Driver No 1 hippie 40 190 24 24 0
TPM3 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 hippie 35 230 27 27 21
TRIM21 TRIM21 P19474 E3 ubiquitin-protein ligase TRIM21 chr11 Not Cancer Driver No 1 hippie 85 49 7 7 0
TRIM27 TRIM27 P14373 Zinc finger protein RFP chr6 Census Yes 1 hippie 59 87 11 11 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 hippie 170 215 45 45 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 hippie 84 316 57 57 1