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MTHFR_ENST00000376590 ,MTHFR ,P42898
  • Uniprot Accession= P42898
  • Ensembl Transcript= ENST00000376590.8
  • Uniprot Name= MTHFR
  • Name= Methylenetetrahydrofolate reductase
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 14
  • Number of Interaction partner in biogrid: 35
  • Number of Interaction partner in hippie: 43
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ANKLE2 ANKLE2 Q86XL3 Ankyrin repeat and LEM domain-containing protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 127 521 71 71 2
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 42 130 17 17 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie, biogrid 24 72 5 5 0
BTN3A1 BTN3A1 O00481 Butyrophilin subfamily 3 member A1 chr6 Not Cancer Driver No 1 hippie, biogrid 77 72 18 18 0
C18orf25 C18orf25 Q96B23 Uncharacterized protein C18orf25 chr18 Not Cancer Driver No 1 hippie, biogrid 30 393 27 27 0
CDCA8_ENST00000327331 CDCA8 Q53HL2 Borealin chr1 Not Cancer Driver No 3 hippie, biogrid 23 170 13 13 0
COX4I2 COX4I2 Q96KJ9 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial chr20 Not Cancer Driver No 1 hippie, biogrid 26 36 4 4 1
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CXorf66 CXorf66 Q5JRM2 Uncharacterized protein CXorf66 chrX Not Cancer Driver No 1 hippie, biogrid 93 248 72 72 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 Not Cancer Driver No 1 intact, hippie, biogrid 76 277 26 26 3
EPHA1 EPHA1 P21709 Ephrin type-A receptor 1 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 147 211 38 38 0
EPHA8 EPHA8 P29322 Ephrin type-A receptor 8 chr1 Not Cancer Driver No 1 intact 197 121 17 17 0
G0S2 G0S2 P27469 G0/G1 switch protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 8 28 5 5 0
GNAI1 GNAI1 P63096 Guanine nucleotide-binding protein G(i) subunit alpha-1 chr7 Not Cancer Driver No 3 intact, hippie, biogrid 52 11 3 3 0
GNAZ GNAZ P19086 Guanine nucleotide-binding protein G(z) subunit alpha chr22 Not Cancer Driver No 3 hippie, biogrid 84 30 13 13 0
HSD3B2_ENST00000369416 HSD3B2 P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 83 24 9 9 28
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KCNF1 KCNF1 Q9H3M0 Potassium voltage-gated channel subfamily F member 1 chr2 Not Cancer Driver No 1 hippie, biogrid 116 73 13 13 0
KCNV2 KCNV2 Q8TDN2 Potassium voltage-gated channel subfamily V member 2 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 104 120 22 22 5
KPNA6 KPNA6 O60684 Importin subunit alpha-7 chr1 Not Cancer Driver No 1 hippie, biogrid 70 97 17 17 0
LSM8 LSM8 O95777 U6 snRNA-associated Sm-like protein LSm8 chr7 Not Cancer Driver No 1 intact, hippie 14 3 1 1 0
MTHFR_ENST00000376590 MTHFR P42898 Methylenetetrahydrofolate reductase chr1 Not Cancer Driver No 1 hippie 95 125 22 22 53
NOX5 NOX5 Q96PH1 NADPH oxidase 5 chr15 Not Cancer Driver No 2 intact, hippie, biogrid 118 95 9 9 0
PCDHB16 PCDHB16 Q9NRJ7 Protocadherin beta-16 chr5 Not Cancer Driver No 2 hippie, biogrid 214 247 70 70 0
PRPF31 PRPF31 Q8WWY3 U4/U6 small nuclear ribonucleoprotein Prp31 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 58 213 17 17 2
RASSF1 RASSF1 Q9NS23 Ras association domain-containing protein 1 chr3 Not Cancer Driver No 3 hippie, biogrid 36 79 3 3 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RFX1 RFX1 P22670 MHC class II regulatory factor RFX1 chr19 Not Cancer Driver No 1 hippie 114 536 66 66 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 70 435 31 31 0
SMPD2 SMPD2 O60906 Sphingomyelin phosphodiesterase 2 chr6 Not Cancer Driver No 3 intact, hippie, biogrid 45 48 5 5 0
SP110_ENST00000358662 SP110 Q9HB58 Sp110 nuclear body protein chr2 Not Cancer Driver No 1 hippie, biogrid 92 368 54 54 0
SPATA19_ENST00000532889 SPATA19 Q7Z5L4 Spermatogenesis-associated protein 19, mitochondrial chr11 Not Cancer Driver No 2 hippie, biogrid 49 85 24 24 0
SYT2_ENST00000367268 SYT2 Q8N9I0 Synaptotagmin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 73 141 24 24 3
TIGD6_ENST00000515406 TIGD6 Q17RP2 Tigger transposable element-derived protein 6 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 30 64 4 4 0
TLR10_ENST00000508334 TLR10 Q9BXR5 Toll-like receptor 10 chr4 Not Cancer Driver No 1 hippie, biogrid 122 9 1 1 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 Not Cancer Driver No 1 hippie, biogrid 141 35 3 3 0
TMEM223 TMEM223 A0PJW6 Transmembrane protein 223 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 19 6 0 0 0
TMPRSS4_ENST00000437212 TMPRSS4 Q9NRS4 Transmembrane protease serine 4 chr11 Not Cancer Driver No 1 hippie, biogrid 47 35 4 4 0
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 66 218 29 29 0
TYROBP TYROBP O43914 TYRO protein tyrosine kinase-binding protein chr19 Not Cancer Driver No 1 hippie, biogrid 24 28 8 8 0
UBA52_ENST00000595683 UBA52 P62987 Ubiquitin-60S ribosomal protein L40 chr19 Not Cancer Driver No 1 hippie, biogrid 19 45 8 8 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
ZNF263 ZNF263 O14978 Zinc finger protein 263 chr16 Not Cancer Driver No 1 hippie, biogrid 90 403 58 58 0
ZNF556 ZNF556 Q9HAH1 Zinc finger protein 556 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 107 177 36 36 0