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MFN2_ENST00000444836 ,MFN2 ,O95140
  • Uniprot Accession= O95140
  • Ensembl Transcript= ENST00000444836.5
  • Uniprot Name= MFN2
  • Name= Mitofusin-2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 9
  • Number of Interaction partner in biogrid: 96
  • Number of Interaction partner in hippie: 124
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTBL2 ACTBL2 Q562R1 Beta-actin-like protein 2 chr5 Not Cancer Driver No 1 hippie, biogrid 73 29 5 5 0
ADSL ADSL P30566 Adenylosuccinate lyase chr22 Not Cancer Driver No 1 hippie, biogrid 68 36 9 9 27
AIP AIP O00170 AH receptor-interacting protein chr11 Not Cancer Driver No 1 hippie, biogrid 32 64 9 9 1
AKAP1_ENST00000539273 AKAP1 Q92667 A-kinase anchor protein 1, mitochondrial chr17 Not Cancer Driver No 3 hippie, biogrid 107 537 67 67 0
ALDH3A2_ENST00000579855 ALDH3A2 P51648 Aldehyde dehydrogenase family 3 member A2 chr17 Not Cancer Driver No 1 hippie, biogrid 47 5 2 2 26
ATXN3 ATXN3 P54252 Ataxin-3 chr14 Not Cancer Driver No 1 hippie, biogrid 46 181 24 24 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie, biogrid 17 112 9 9 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 Not Cancer Driver No 1 hippie 38 58 9 9 0
C3orf18_ENST00000426034 C3orf18 Q9UK00 Uncharacterized protein C3orf18 chr3 Not Cancer Driver No 1 hippie, biogrid 24 111 19 19 0
C9orf72 C9orf72 Q96LT7 Guanine nucleotide exchange factor C9orf72 chr9 Not Cancer Driver No 1 hippie, biogrid 64 11 0 0 0
CACYBP CACYBP Q9HB71 Calcyclin-binding protein chr1 Not Cancer Driver No 1 hippie, biogrid 27 92 10 10 0
CDC34 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 26 95 11 11 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 hippie, biogrid 52 214 31 31 0
CFAP36_ENST00000349456 CFAP36 Q96G28 Cilia- and flagella-associated protein 36 chr2 Not Cancer Driver No 1 hippie, biogrid 44 227 25 25 0
CIP2A CIP2A Q8TCG1 Protein CIP2A chr3 Not Cancer Driver No 1 hippie 118 240 31 31 0
CLTC_ENST00000269122 CLTC Q00610 Clathrin heavy chain 1 chr17 Census, Compendium Yes 1 hippie, biogrid 190 71 6 6 1
CRYBG3 CRYBG3 Q68DQ2 Very large A-kinase anchor protein chr3 Not Cancer Driver No 1 hippie, biogrid 179 1770 71 71 0
CYP2C19 CYP2C19 P33261 Cytochrome P450 2C19 chr10 Not Cancer Driver No 1 hippie, biogrid 157 32 12 12 0
DIP2A DIP2A Q14689 Disco-interacting protein 2 homolog A chr21 Not Cancer Driver No 1 hippie, biogrid 204 396 53 53 0
DIPK2A DIPK2A Q8NDZ4 Divergent protein kinase domain 2A chr3 Not Cancer Driver No 1 hippie 56 9 0 0 0
DNM1L_ENST00000549701 DNM1L O00429 Dynamin-1-like protein chr12 Not Cancer Driver No 1 hippie, biogrid 67 212 23 23 7
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie 54 141 5 5 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EXD2 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 58 176 15 15 0
FKBP4 FKBP4 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 chr12 Not Cancer Driver No 1 hippie, biogrid 46 134 12 12 0
FKBP8_ENST00000222308 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie, biogrid 71 160 25 25 0
GHITM GHITM Q9H3K2 Growth hormone-inducible transmembrane protein chr10 Not Cancer Driver No 2 intact, hippie, biogrid 50 8 0 0 0
GLMN GLMN Q92990 Glomulin chr1 Not Cancer Driver No 1 hippie, biogrid 49 37 6 6 0
GOLGA3_ENST00000450791 GOLGA3 Q08378 Golgin subfamily A member 3 chr12 Not Cancer Driver No 1 hippie, biogrid 221 1272 189 189 0
GYPA_ENST00000360771 GYPA P02724 Glycophorin-A chr4 Not Cancer Driver No 1 hippie, biogrid 46 94 31 31 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX Not Cancer Driver No 1 hippie 178 409 59 59 0
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 intact, hippie 36 25 6 6 0
HUWE1_ENST00000262854 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX Not Cancer Driver No 1 hippie 669 2091 329 329 21
IBTK IBTK Q9P2D0 Inhibitor of Bruton tyrosine kinase chr6 Not Cancer Driver No 1 hippie, biogrid 146 364 39 39 0
IPO5_ENST00000490680 IPO5 O00410 Importin-5 chr13 Not Cancer Driver No 1 hippie, biogrid 128 52 3 3 0
KDF1 KDF1 Q8NAX2 Keratinocyte differentiation factor 1 chr1 Not Cancer Driver No 1 hippie 61 277 50 50 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
LARP4_ENST00000398473 LARP4 Q71RC2 La-related protein 4 chr12 Not Cancer Driver No 1 hippie, biogrid 86 486 53 53 0
LRRC49_ENST00000260382 LRRC49 Q8IUZ0 Leucine-rich repeat-containing protein 49 chr15 Not Cancer Driver No 1 hippie, biogrid 117 124 21 21 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
MAPK9 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 Not Cancer Driver No 1 hippie 59 90 8 8 0
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 2 hippie, biogrid 70 411 58 58 0
MFN1 MFN1 Q8IWA4 Mitofusin-1 chr3 Not Cancer Driver No 2 hippie, biogrid 90 64 5 5 0
MFN2_ENST00000444836 MFN2 O95140 Mitofusin-2 chr1 Not Cancer Driver No 2 intact, hippie 80 81 9 9 20
MTCH1 MTCH1 Q9NZJ7 Mitochondrial carrier homolog 1 chr6 Not Cancer Driver No 1 hippie, biogrid 31 102 2 2 0
MYH10_ENST00000269243 MYH10 P35580 Myosin-10 chr17 Not Cancer Driver No 1 hippie, biogrid 258 1134 136 136 0
NAA15 NAA15 Q9BXJ9 N-alpha-acetyltransferase 15, NatA auxiliary subunit chr4 Not Cancer Driver No 1 hippie, biogrid 95 115 17 17 0
NAXE NAXE Q8NCW5 NAD(P)H-hydrate epimerase chr1 Not Cancer Driver No 1 hippie 22 5 0 0 2
NBR1 NBR1 Q14596 Next to BRCA1 gene 1 protein chr17 Not Cancer Driver No 1 hippie, biogrid 101 560 51 51 0
NIPSNAP1 NIPSNAP1 Q9BPW8 Protein NipSnap homolog 1 chr22 Not Cancer Driver No 1 hippie, biogrid 31 9 0 0 0
NIPSNAP2 NIPSNAP2 O75323 Protein NipSnap homolog 2 chr7 Not Cancer Driver No 1 hippie 30 6 1 1 0
NSFL1C_ENST00000216879 NSFL1C Q9UNZ2 NSFL1 cofactor p47 chr20 Not Cancer Driver No 1 hippie, biogrid 56 266 39 39 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUDC NUDC Q9Y266 Nuclear migration protein nudC chr1 Not Cancer Driver No 1 hippie, biogrid 36 235 29 29 0
NUDCD3 NUDCD3 Q8IVD9 NudC domain-containing protein 3 chr7 Not Cancer Driver No 1 hippie, biogrid 30 199 16 16 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OCIAD1 OCIAD1 Q9NX40 OCIA domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 37 169 25 25 0
OCRL OCRL Q01968 Inositol polyphosphate 5-phosphatase OCRL chrX Not Cancer Driver No 1 hippie, biogrid 151 126 24 24 41
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 30 157 13 13 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 57 99 13 13 23
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PRKAR2A PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 Not Cancer Driver No 1 hippie, biogrid 37 149 13 13 0
PRKAR2B PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 Not Cancer Driver No 1 hippie, biogrid 60 125 4 4 0
PRKCI PRKCI P41743 Protein kinase C iota type chr3 Not Cancer Driver No 1 hippie, biogrid 110 120 16 16 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 2 intact, hippie 110 78 15 15 31
PSMA1_ENST00000396394 PSMA1 P25786 Proteasome subunit alpha type-1 chr11 Not Cancer Driver No 1 hippie, biogrid 48 51 9 9 0
PSMA2 PSMA2 P25787 Proteasome subunit alpha type-2 chr7 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 0
PSMA3 PSMA3 P25788 Proteasome subunit alpha type-3 chr14 Not Cancer Driver No 1 hippie, biogrid 27 30 5 5 0
PSMA5 PSMA5 P28066 Proteasome subunit alpha type-5 chr1 Not Cancer Driver No 1 hippie, biogrid 24 23 1 1 0
PSMA6 PSMA6 P60900 Proteasome subunit alpha type-6 chr14 Not Cancer Driver No 1 hippie, biogrid 37 2 1 1 0
PSMA7 PSMA7 O14818 Proteasome subunit alpha type-7 chr20 Not Cancer Driver No 1 hippie, biogrid 24 23 1 1 0
PSMB1 PSMB1 P20618 Proteasome subunit beta type-1 chr6 Not Cancer Driver No 1 hippie, biogrid 25 14 2 2 0
PSMB4 PSMB4 P28070 Proteasome subunit beta type-4 chr1 Not Cancer Driver No 1 hippie, biogrid 23 18 2 2 0
PSMB5 PSMB5 P28074 Proteasome subunit beta type-5 chr14 Not Cancer Driver No 1 hippie, biogrid 39 9 0 0 0
PSMB6 PSMB6 P28072 Proteasome subunit beta type-6 chr17 Not Cancer Driver No 1 hippie, biogrid 19 22 1 1 0
PSMB7 PSMB7 Q99436 Proteasome subunit beta type-7 chr9 Not Cancer Driver No 1 hippie, biogrid 25 26 3 3 0
PSMC1 PSMC1 P62191 26S proteasome regulatory subunit 4 chr14 Not Cancer Driver No 1 hippie, biogrid 36 165 10 10 0
PSMC2_ENST00000292644 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie, biogrid 63 120 13 13 0
PSMC3_ENST00000298852 PSMC3 P17980 26S proteasome regulatory subunit 6A chr11 Not Cancer Driver No 1 hippie, biogrid 55 131 10 10 0
PSMC4 PSMC4 P43686 26S proteasome regulatory subunit 6B chr19 Not Cancer Driver No 1 hippie, biogrid 51 21 3 3 0
PSMC5 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 hippie, biogrid 52 64 6 6 0
PSMC6_ENST00000606149 PSMC6 P62333 26S proteasome regulatory subunit 10B chr14 Not Cancer Driver No 1 hippie, biogrid 49 69 8 8 0
PSMD1 PSMD1 Q99460 26S proteasome non-ATPase regulatory subunit 1 chr2 Not Cancer Driver No 1 hippie, biogrid 110 201 19 19 0
PSMD11_ENST00000457654 PSMD11 O00231 26S proteasome non-ATPase regulatory subunit 11 chr17 Not Cancer Driver No 1 hippie, biogrid 51 0 0 0 0
PSMD13_ENST00000532097 PSMD13 Q9UNM6 26S proteasome non-ATPase regulatory subunit 13 chr11 Not Cancer Driver No 1 hippie, biogrid 30 13 3 3 0
PSMD2 PSMD2 Q13200 26S proteasome non-ATPase regulatory subunit 2 chr3 Not Cancer Driver No 1 hippie, biogrid 100 135 14 14 0
PSMD4_ENST00000368884 PSMD4 P55036 26S proteasome non-ATPase regulatory subunit 4 chr1 Not Cancer Driver No 1 hippie, biogrid 43 243 25 25 0
PSMD6_ENST00000295901 PSMD6 Q15008 26S proteasome non-ATPase regulatory subunit 6 chr3 Not Cancer Driver No 1 hippie, biogrid 33 40 3 3 0
PSMD7 PSMD7 P51665 26S proteasome non-ATPase regulatory subunit 7 chr16 Not Cancer Driver No 1 hippie, biogrid 39 70 4 4 0
REEP5 REEP5 Q00765 Receptor expression-enhancing protein 5 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 34 0 0 0 0
RHOT2 RHOT2 Q8IXI1 Mitochondrial Rho GTPase 2 chr16 Not Cancer Driver No 1 hippie, biogrid 52 79 5 5 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RTL5 RTL5 Q5HYW3 Retrotransposon Gag-like protein 5 chrX Not Cancer Driver No 1 hippie 99 311 59 59 0
SAMM50 SAMM50 Q9Y512 Sorting and assembly machinery component 50 homolog chr22 Not Cancer Driver No 1 intact, hippie 51 34 1 1 0
SLC25A38 SLC25A38 Q96DW6 Mitochondrial glycine transporter chr3 Not Cancer Driver No 1 hippie 46 0 0 0 4
SLC25A46 SLC25A46 Q96AG3 Mitochondrial outer membrane protein SLC25A46 chr5 Not Cancer Driver No 2 hippie, biogrid 37 96 2 2 4
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 79 137 12 12 0
SMCR8 SMCR8 Q8TEV9 Guanine nucleotide exchange protein SMCR8 chr17 Not Cancer Driver No 1 hippie, biogrid 107 357 38 38 0
SNAP47_ENST00000366759 SNAP47 Q5SQN1 Synaptosomal-associated protein 47 chr1 Not Cancer Driver No 1 hippie, biogrid 51 192 20 20 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 2 hippie, biogrid 54 267 32 32 30
ST13 ST13 P50502 Hsc70-interacting protein chr22 Not Cancer Driver No 1 hippie, biogrid 38 297 29 29 0
STIP1_ENST00000305218 STIP1 P31948 Stress-induced-phosphoprotein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 74 270 39 39 0
TCHP_ENST00000405876 TCHP Q9BT92 Trichoplein keratin filament-binding protein chr12 Not Cancer Driver No 1 hippie 60 356 50 50 0
TDRKH_ENST00000368827 TDRKH Q9Y2W6 Tudor and KH domain-containing protein chr1 Not Cancer Driver No 1 hippie, biogrid 76 185 27 27 0
THY1 THY1 P04216 Thy-1 membrane glycoprotein chr11 Not Cancer Driver No 1 hippie, biogrid 24 5 0 0 0
TMEM160 TMEM160 Q9NX00 Transmembrane protein 160 chr19 Not Cancer Driver No 1 hippie, biogrid 8 46 1 1 0
TPGS1 TPGS1 Q6ZTW0 Tubulin polyglutamylase complex subunit 1 chr19 Not Cancer Driver No 1 hippie, biogrid 6 62 2 2 0
TPM3 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 hippie, biogrid 35 230 27 27 21
TPM4_ENST00000300933 TPM4 P67936 Tropomyosin alpha-4 chain chr19 Census Yes 1 hippie, biogrid 28 216 28 28 0
TRAK2 TRAK2 O60296 Trafficking kinesin-binding protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 112 576 70 70 0
TTC1 TTC1 Q99614 Tetratricopeptide repeat protein 1 chr5 Not Cancer Driver No 1 hippie, biogrid 28 211 21 21 0
TTC4 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 hippie, biogrid 45 100 12 12 0
TXNL1_ENST00000590954 TXNL1 O43396 Thioredoxin-like protein 1 chr18 Not Cancer Driver No 1 hippie, biogrid 41 89 4 4 0
UBB_ENST00000614404 UBB P0CG47 Polyubiquitin-B chr17 Not Cancer Driver No 1 hippie, biogrid 20 102 8 8 0
UBE2N UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 Not Cancer Driver No 1 hippie 25 24 3 3 0
UBR4 UBR4 Q5T4S7 E3 ubiquitin-protein ligase UBR4 chr1 Not Cancer Driver No 1 hippie, biogrid 565 1066 119 119 0
UBXN4 UBXN4 Q92575 UBX domain-containing protein 4 chr2 Not Cancer Driver No 1 hippie, biogrid 69 302 41 41 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 2 intact, hippie, biogrid 88 186 16 16 16
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 Not Cancer Driver No 1 hippie, biogrid 133 543 61 61 0
VPS13D VPS13D Q5THJ4 Intermembrane lipid transfer protein VPS13D chr1 Not Cancer Driver No 1 hippie, biogrid 501 973 118 118 8
VSIG1_ENST00000217957 VSIG1 Q86XK7 V-set and immunoglobulin domain-containing protein 1 chrX Not Cancer Driver No 2 hippie, biogrid 55 137 20 20 0
WDR41 WDR41 Q9HAD4 WD repeat-containing protein 41 chr5 Not Cancer Driver No 1 hippie, biogrid 48 23 2 2 0
YKT6 YKT6 O15498 Synaptobrevin homolog YKT6 chr7 Not Cancer Driver No 1 hippie, biogrid 19 21 2 2 0
ZZEF1 ZZEF1 O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 292 580 69 69 0