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MED8_ENST00000372457 ,MED8 ,Q96G25
  • Uniprot Accession= Q96G25
  • Ensembl Transcript= ENST00000372457.8
  • Uniprot Name= MED8
  • Name= Mediator of RNA polymerase II transcription subunit 8
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 29
  • Number of Interaction partner in biogrid: 70
  • Number of Interaction partner in hippie: 102
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD11 ACAD11 Q709F0 Acyl-CoA dehydrogenase family member 11 chr3 Not Cancer Driver No 1 hippie, biogrid 108 33 4 4 0
ACTL6A ACTL6A O96019 Actin-like protein 6A chr3 Not Cancer Driver No 1 biogrid 61 74 15 15 0
APOA2 APOA2 P02652 Apolipoprotein A-II chr1 Not Cancer Driver No 1 hippie, biogrid 13 0 0 0 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
AR AR P10275 Androgen receptor chrX Census, Compendium Yes 1 hippie, biogrid 196 443 88 88 169
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 46 122 22 22 0
ATG16L1 ATG16L1 Q676U5 Autophagy-related protein 16-1 chr2 Not Cancer Driver No 1 hippie 79 239 25 25 1
BIRC5_ENST00000350051 BIRC5 O15392 Baculoviral IAP repeat-containing protein 5 chr17 Not Cancer Driver No 2 hippie, biogrid 20 49 6 6 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
BRD9 BRD9 Q9H8M2 Bromodomain-containing protein 9 chr5 Not Cancer Driver No 1 biogrid 77 385 44 44 0
CCNC CCNC P24863 Cyclin-C chr6 Census Yes 5 intact, hippie, biogrid 32 33 3 3 0
CCNH CCNH P51946 Cyclin-H chr5 Not Cancer Driver No 1 hippie 40 28 4 4 0
CDK19 CDK19 Q9BWU1 Cyclin-dependent kinase 19 chr6 Not Cancer Driver No 8 intact, hippie, biogrid 63 191 28 28 8
CDK8 CDK8 P49336 Cyclin-dependent kinase 8 chr13 Not Cancer Driver No 10 intact, hippie, biogrid 76 152 18 18 7
CPSF1 CPSF1 Q10570 Cleavage and polyadenylation specificity factor subunit 1 chr8 Not Cancer Driver No 1 hippie, biogrid 177 298 42 42 0
CSN3 CSN3 P07498 Kappa-casein chr4 Not Cancer Driver No 1 intact 49 87 24 24 0
CTDP1 CTDP1 Q9Y5B0 RNA polymerase II subunit A C-terminal domain phosphatase chr18 Not Cancer Driver No 1 hippie 121 624 87 87 0
CUL2_ENST00000374748 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 hippie 87 66 3 3 0
CXXC1_ENST00000285106 CXXC1 Q9P0U4 CXXC-type zinc finger protein 1 chr18 Not Cancer Driver No 1 biogrid 115 366 65 65 0
DISC1_ENST00000439617 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 132 514 82 82 0
ELOB_ENST00000409906 ELOB Q15370 Elongin-B chr16 Not Cancer Driver No 1 intact, hippie 13 69 10 10 0
ELOC ELOC Q15369 Elongin-C chr8 Not Cancer Driver No 1 intact, hippie 22 25 5 5 0
EPAS1 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 Census, Compendium Yes 1 hippie 120 449 53 53 6
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 121 195 27 27 2
EWSR1_ENST00000397938 EWSR1 Q01844 RNA-binding protein EWS chr22 Census, Compendium Yes 1 hippie 94 646 93 93 0
FBXL19 FBXL19 Q6PCT2 F-box/LRR-repeat protein 19 chr16 Not Cancer Driver No 1 hippie, biogrid 67 350 38 38 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FOS FOS P01100 Protein c-Fos chr14 Not Cancer Driver No 1 hippie 45 245 33 33 0
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 intact, hippie 39 24 3 3 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 biogrid 47 135 10 10 0
HNF4A HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 135 127 48 48 5
HSPB3 HSPB3 Q12988 Heat shock protein beta-3 chr5 Not Cancer Driver No 1 hippie, biogrid 30 21 4 4 1
INO80E INO80E Q8NBZ0 INO80 complex subunit E chr16 Not Cancer Driver No 1 biogrid 21 210 21 21 0
INTS9 INTS9 Q9NV88 Integrator complex subunit 9 chr8 Not Cancer Driver No 1 biogrid 68 50 5 5 0
KMT2A_ENST00000389506 KMT2A Q03164 Histone-lysine N-methyltransferase 2A chr11 Census, Compendium Yes 1 biogrid 446 3145 338 338 0
KRT40_ENST00000398486 KRT40 Q6A162 Keratin, type I cytoskeletal 40 chr17 Not Cancer Driver No 1 intact, hippie 70 6 1 1 0
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 114 404 58 58 0
LMO2_ENST00000395833 LMO2 P25791 Rhombotin-2 chr11 Census Yes 1 hippie, biogrid 35 14 1 1 0
MED1 MED1 Q15648 Mediator of RNA polymerase II transcription subunit 1 chr17 Not Cancer Driver No 6 hippie, biogrid 162 1104 117 117 0
MED10 MED10 Q9BTT4 Mediator of RNA polymerase II transcription subunit 10 chr5 Not Cancer Driver No 9 intact, hippie, biogrid 14 13 3 3 0
MED11 MED11 Q9P086 Mediator of RNA polymerase II transcription subunit 11 chr17 Not Cancer Driver No 4 hippie, biogrid 12 24 4 4 0
MED12 MED12 Q93074 Mediator of RNA polymerase II transcription subunit 12 chrX Census, Compendium Yes 5 hippie, biogrid 409 974 175 175 5
MED12L MED12L Q86YW9 Mediator of RNA polymerase II transcription subunit 12-like protein chr3 Not Cancer Driver No 1 hippie, biogrid 372 822 153 153 0
MED13 MED13 Q9UHV7 Mediator of RNA polymerase II transcription subunit 13 chr17 Not Cancer Driver No 2 hippie, biogrid 288 905 127 127 3
MED13L MED13L Q71F56 Mediator of RNA polymerase II transcription subunit 13-like chr12 Not Cancer Driver No 1 hippie, biogrid 274 1074 142 142 0
MED14 MED14 O60244 Mediator of RNA polymerase II transcription subunit 14 chrX Not Cancer Driver No 4 hippie, biogrid 182 318 45 45 0
MED15 MED15 Q96RN5 Mediator of RNA polymerase II transcription subunit 15 chr22 Not Cancer Driver No 2 hippie, biogrid 95 558 72 72 0
MED16 MED16 Q9Y2X0 Mediator of RNA polymerase II transcription subunit 16 chr19 Not Cancer Driver No 3 hippie, biogrid 100 87 7 7 0
MED17 MED17 Q9NVC6 Mediator of RNA polymerase II transcription subunit 17 chr11 Not Cancer Driver No 4 hippie, biogrid 75 182 17 17 1
MED18_ENST00000398997 MED18 Q9BUE0 Mediator of RNA polymerase II transcription subunit 18 chr1 Not Cancer Driver No 6 intact, hippie, biogrid 35 10 2 2 0
MED20 MED20 Q9H944 Mediator of RNA polymerase II transcription subunit 20 chr6 Not Cancer Driver No 4 hippie, biogrid 22 0 0 0 0
MED21 MED21 Q13503 Mediator of RNA polymerase II transcription subunit 21 chr12 Not Cancer Driver No 4 hippie, biogrid 12 46 3 3 0
MED22_ENST00000343730 MED22 Q15528 Mediator of RNA polymerase II transcription subunit 22 chr9 Not Cancer Driver No 3 hippie, biogrid 26 98 12 12 0
MED23 MED23 Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 158 28 2 2 1
MED24_ENST00000394128 MED24 O75448 Mediator of RNA polymerase II transcription subunit 24 chr17 Not Cancer Driver No 4 hippie, biogrid 101 76 0 0 0
MED25 MED25 Q71SY5 Mediator of RNA polymerase II transcription subunit 25 chr19 Not Cancer Driver No 1 hippie 103 432 54 54 2
MED26 MED26 O95402 Mediator of RNA polymerase II transcription subunit 26 chr19 Not Cancer Driver No 2 hippie, biogrid 71 541 61 61 0
MED27 MED27 Q6P2C8 Mediator of RNA polymerase II transcription subunit 27 chr9 Not Cancer Driver No 3 hippie, biogrid 34 61 5 5 0
MED28 MED28 Q9H204 Mediator of RNA polymerase II transcription subunit 28 chr4 Not Cancer Driver No 2 hippie, biogrid 24 101 18 18 0
MED29_ENST00000599213 MED29 Q9NX70 Mediator of RNA polymerase II transcription subunit 29 chr19 Not Cancer Driver No 7 intact, hippie, biogrid 21 119 10 10 0
MED30 MED30 Q96HR3 Mediator of RNA polymerase II transcription subunit 30 chr8 Not Cancer Driver No 2 hippie, biogrid 20 93 8 8 0
MED31 MED31 Q9Y3C7 Mediator of RNA polymerase II transcription subunit 31 chr17 Not Cancer Driver No 2 hippie, biogrid 16 15 1 1 0
MED4 MED4 Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 chr13 Not Cancer Driver No 4 hippie, biogrid 29 161 17 17 0
MED6_ENST00000256379 MED6 O75586 Mediator of RNA polymerase II transcription subunit 6 chr14 Not Cancer Driver No 3 hippie, biogrid 21 79 4 4 0
MED7 MED7 O43513 Mediator of RNA polymerase II transcription subunit 7 chr5 Not Cancer Driver No 6 intact, hippie, biogrid 32 132 19 19 0
MED8_ENST00000372457 MED8 Q96G25 Mediator of RNA polymerase II transcription subunit 8 chr1 Not Cancer Driver No 1 hippie 29 191 24 24 0
MED9 MED9 Q9NWA0 Mediator of RNA polymerase II transcription subunit 9 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 16 127 15 15 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MRGBP MRGBP Q9NV56 MRG/MORF4L-binding protein chr20 Not Cancer Driver No 1 biogrid 27 147 23 23 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYOD1 MYOD1 P15172 Myoblast determination protein 1 chr11 Census Yes 1 hippie 45 246 33 33 0
NR3C1_ENST00000343796 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 92 362 37 37 12
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 75 38 4 4 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
PAF1 PAF1 Q8N7H5 RNA polymerase II-associated factor 1 homolog chr19 Not Cancer Driver No 1 biogrid 77 378 56 56 0
PEX14 PEX14 O75381 Peroxisomal membrane protein PEX14 chr1 Not Cancer Driver No 1 hippie, biogrid 38 266 28 28 0
PHYHIP PHYHIP Q92561 Phytanoyl-CoA hydroxylase-interacting protein chr8 Not Cancer Driver No 1 hippie, biogrid 44 25 4 4 0
PNMA1 PNMA1 Q8ND90 Paraneoplastic antigen Ma1 chr14 Not Cancer Driver No 1 intact, hippie 48 56 9 9 0
POLR2A POLR2A P24928-2 Isoform 2 of DNA-directed RNA polymerase II subunit RPB1 chr17 Census Yes 1 hippie, biogrid 56 230 20 20 0
POLR2B_ENST00000314595 POLR2B P30876 DNA-directed RNA polymerase II subunit RPB2 chr4 Not Cancer Driver No 1 hippie, biogrid 166 173 25 25 0
POLR2C POLR2C P19387 DNA-directed RNA polymerase II subunit RPB3 chr16 Not Cancer Driver No 1 hippie, biogrid 34 108 11 11 0
POLR2D POLR2D O15514 DNA-directed RNA polymerase II subunit RPB4 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 13 54 2 2 0
POLR2E POLR2E P19388 DNA-directed RNA polymerases I, II, and III subunit RPABC1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 31 36 3 3 0
POLR2F_ENST00000442738 POLR2F P61218 DNA-directed RNA polymerases I, II, and III subunit RPABC2 chr22 Not Cancer Driver No 1 hippie, biogrid 22 57 13 13 0
POLR2G POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 Not Cancer Driver No 1 hippie, biogrid 15 15 1 1 0
POLR2H_ENST00000456318 POLR2H P52434 DNA-directed RNA polymerases I, II, and III subunit RPABC3 chr3 Not Cancer Driver No 1 hippie, biogrid 16 14 1 1 0
POLR2I POLR2I P36954 DNA-directed RNA polymerase II subunit RPB9 chr19 Not Cancer Driver No 1 hippie, biogrid 21 22 5 5 0
POLR2J POLR2J P52435 DNA-directed RNA polymerase II subunit RPB11-a chr7 Not Cancer Driver No 1 hippie, biogrid 12 0 0 0 0
POLR2K POLR2K P53803 DNA-directed RNA polymerases I, II, and III subunit RPABC4 chr8 Not Cancer Driver No 1 hippie, biogrid 10 11 1 1 0
POLR2L POLR2L P62875 DNA-directed RNA polymerases I, II, and III subunit RPABC5 chr11 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 0
POLR2M_ENST00000464277 POLR2M Q6EEV4 DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 chr15 Not Cancer Driver No 1 intact, hippie, biogrid 4 121 4 4 0
PRKAR1B_ENST00000403562 PRKAR1B P31321 cAMP-dependent protein kinase type I-beta regulatory subunit chr7 Not Cancer Driver No 1 intact, hippie 53 71 13 13 0
PTBP3_ENST00000374255 PTBP3 O95758 Polypyrimidine tract-binding protein 3 chr9 Not Cancer Driver No 1 intact, hippie 61 114 9 9 0
RAVER1_ENST00000615032 RAVER1 Q8IY67 Ribonucleoprotein PTB-binding 1 chr19 Not Cancer Driver No 1 intact 61 330 22 22 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 intact, hippie 10 18 1 1 0
RECQL5 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 Not Cancer Driver No 1 hippie, biogrid 132 495 71 71 0
RPAP2 RPAP2 Q8IXW5 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 chr1 Not Cancer Driver No 1 hippie, biogrid 56 293 25 25 0
RPRD2 RPRD2 Q5VT52 Regulation of nuclear pre-mRNA domain-containing protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 184 1225 156 156 0
SCAF4 SCAF4 O95104 SR-related and CTD-associated factor 4 chr21 Not Cancer Driver No 1 hippie, biogrid 162 938 132 132 0
SNTA1 SNTA1 Q13424 Alpha-1-syntrophin chr20 Not Cancer Driver No 1 hippie 43 238 14 14 2
STN1 STN1 Q9H668 CST complex subunit STN1 chr10 Not Cancer Driver No 1 hippie 41 27 2 2 2
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
TBXT TBXT O15178 T-box transcription factor T chr6 Not Cancer Driver No 1 intact, hippie 110 253 69 69 1
TCL1B TCL1B O95988 T-cell leukemia/lymphoma protein 1B chr14 Not Cancer Driver No 3 hippie, biogrid 38 11 1 1 0
THOC7 THOC7 Q6I9Y2 THO complex subunit 7 homolog chr3 Not Cancer Driver No 1 hippie 26 63 5 5 0
THRA THRA P10827 Thyroid hormone receptor alpha chr17 Not Cancer Driver No 1 hippie 69 207 30 30 2
TNIP2 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 Not Cancer Driver No 1 hippie 43 316 36 36 0
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 Not Cancer Driver No 1 intact, hippie 227 1632 190 190 0
TRIP4 TRIP4 Q15650 Activating signal cointegrator 1 chr15 Not Cancer Driver No 1 hippie 71 176 27 27 0
UBALD1 UBALD1 Q8TB05 UBA-like domain-containing protein 1 chr16 Not Cancer Driver No 1 intact, hippie 6 127 6 6 0
USP49 USP49 Q70CQ1 Ubiquitin carboxyl-terminal hydrolase 49 chr6 Not Cancer Driver No 1 hippie 81 190 19 19 0
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 biogrid 30 35 3 3 0
ZC3H13 ZC3H13 Q5T200 Zinc finger CCCH domain-containing protein 13 chr13 Not Cancer Driver No 1 hippie 250 1443 224 224 0
ZCCHC10 ZCCHC10 Q8TBK6 Zinc finger CCHC domain-containing protein 10 chr5 Not Cancer Driver No 1 hippie, biogrid 12 144 11 11 0