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MDM4 ,MDM4 ,O15151
  • Uniprot Accession= O15151
  • Ensembl Transcript= ENST00000367182.7
  • Uniprot Name= MDM4
  • Name= Protein Mdm4
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of Interaction partner in intact: 32
  • Number of Interaction partner in biogrid: 15
  • Number of Interaction partner in hippie: 109
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
ALB ALB P02768 Albumin chr4 Compendium Yes 1 hippie 162 6 0 0 3
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie 34 103 14 14 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARF1_ENST00000272102 ARF1 P84077 ADP-ribosylation factor 1 chr1 Not Cancer Driver No 1 hippie 30 4 2 2 2
ASRGL1_ENST00000301776 ASRGL1 Q7L266 Isoaspartyl peptidase/L-asparaginase chr11 Not Cancer Driver No 2 hippie, biogrid 43 74 12 12 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 Census, Compendium Yes 1 hippie 469 225 39 39 41
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 intact, hippie 24 72 5 5 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
C1orf109 C1orf109 Q9NX04 Uncharacterized protein C1orf109 chr1 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
CAPN7 CAPN7 Q9Y6W3 Calpain-7 chr3 Not Cancer Driver No 1 intact, hippie 80 92 9 9 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 Census Yes 1 hippie 60 128 21 21 0
CCNDBP1 CCNDBP1 O95273 Cyclin-D1-binding protein 1 chr15 Not Cancer Driver No 2 hippie, biogrid 35 63 5 5 0
CD160_ENST00000369288 CD160 O95971 CD160 antigen chr1 Not Cancer Driver No 2 intact, hippie 20 2 0 0 0
CD44 CD44 P16070 CD44 antigen chr11 Not Cancer Driver No 1 hippie 75 542 60 60 0
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie 40 1 0 0 0
CDK4 CDK4 P11802 Cyclin-dependent kinase 4 chr12 Census, Compendium Yes 1 hippie 52 52 5 5 3
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 Census, Compendium Yes 1 hippie 48 121 30 30 0
CDKN2A_ENST00000304494 CDKN2A P42771 Cyclin-dependent kinase inhibitor 2A chr9 Census, Compendium Yes 1 hippie 166 83 88 88 36
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 Not Cancer Driver No 1 hippie 15 67 3 3 0
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 Not Cancer Driver No 2 intact, hippie 58 86 16 16 0
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 Census, Compendium Yes 1 hippie 335 157 130 130 13
COP1 COP1 Q8NHY2 E3 ubiquitin-protein ligase COP1 chr1 Not Cancer Driver No 1 hippie 106 147 11 11 0
CSNK1A1L CSNK1A1L Q8N752 Casein kinase I isoform alpha-like chr13 Not Cancer Driver No 1 hippie, biogrid 75 46 7 7 0
CSNK1A1_ENST00000377843 CSNK1A1 P48729 Casein kinase I isoform alpha chr5 Not Cancer Driver No 3 intact, hippie, biogrid 44 46 3 3 0
DAXX_ENST00000266000 DAXX Q9UER7 Death domain-associated protein 6 chr6 Census, Compendium Yes 1 intact, hippie 106 549 81 81 0
E2F1 E2F1 Q01094 Transcription factor E2F1 chr20 Not Cancer Driver No 1 hippie 49 272 23 23 0
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 Not Cancer Driver No 2 intact, hippie, biogrid 156 494 44 44 2
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
EPHA2 EPHA2 P29317 Ephrin type-A receptor 2 chr1 Compendium Yes 1 hippie 171 187 39 39 3
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FAM193A FAM193A P78312 Protein FAM193A chr4 Not Cancer Driver No 2 intact, hippie, biogrid 169 918 118 118 0
FGFR4 FGFR4 P22455 Fibroblast growth factor receptor 4 chr5 Census, Compendium Yes 1 hippie 113 162 28 28 0
GLIS2 GLIS2 Q9BZE0 Zinc finger protein GLIS2 chr16 Not Cancer Driver No 1 hippie 42 300 25 25 0
HBB HBB P68871 Hemoglobin subunit beta chr11 Not Cancer Driver No 2 hippie, biogrid 45 7 2 2 5
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 Compendium Yes 1 hippie 233 43 16 16 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 Not Cancer Driver No 1 hippie 154 686 96 96 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
KPNA3 KPNA3 O00505 Importin subunit alpha-4 chr13 Not Cancer Driver No 1 intact, hippie 65 108 11 11 0
LATS2 LATS2 Q9NRM7 Serine/threonine-protein kinase LATS2 chr13 Census, Compendium Yes 1 hippie 178 687 116 116 0
LRSAM1_ENST00000373322 LRSAM1 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 chr9 Not Cancer Driver No 1 hippie 86 240 30 30 1
MAGEA1 MAGEA1 P43355 Melanoma-associated antigen 1 chrX Not Cancer Driver No 1 hippie 68 71 15 15 0
MAGEB1_ENST00000397550 MAGEB1 P43366 Melanoma-associated antigen B1 chrX Not Cancer Driver No 1 hippie 106 173 45 45 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 Not Cancer Driver No 1 hippie 40 85 10 10 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 10 intact, hippie, biogrid 56 297 37 37 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 Census, Compendium Yes 2 intact, hippie 57 202 26 26 1
MKRN3 MKRN3 Q13064 Probable E3 ubiquitin-protein ligase makorin-3 chr15 Not Cancer Driver No 3 intact, hippie 197 201 99 99 4
MNAT1 MNAT1 P51948 CDK-activating kinase assembly factor MAT1 chr14 Not Cancer Driver No 1 hippie 23 64 2 2 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 Not Cancer Driver No 1 hippie 84 292 35 35 1
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 Census, Compendium Yes 1 hippie 379 296 37 37 18
NAA10 NAA10 P41227 N-alpha-acetyltransferase 10 chrX Not Cancer Driver No 1 hippie 33 117 17 17 3
NBN NBN O60934 Nibrin chr8 Census Yes 1 hippie 90 417 54 54 1
NF2 NF2 P35240 Merlin chr22 Census, Compendium Yes 1 hippie 69 252 26 26 16
PELI1 PELI1 Q96FA3 E3 ubiquitin-protein ligase pellino homolog 1 chr2 Not Cancer Driver No 2 hippie, biogrid 47 167 17 17 0
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 Not Cancer Driver No 3 intact, hippie, biogrid 72 69 7 7 0
PPP1CA_ENST00000376745 PPP1CA P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit chr11 Not Cancer Driver No 1 hippie 38 27 6 6 0
PPP1CB_ENST00000358506 PPP1CB P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit chr2 Not Cancer Driver No 1 hippie 47 25 5 5 5
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 26 23 4 4 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 Not Cancer Driver No 1 hippie 72 124 17 17 0
PSMC5 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 hippie 52 64 6 6 0
PSMD2 PSMD2 Q13200 26S proteasome non-ATPase regulatory subunit 2 chr3 Not Cancer Driver No 1 hippie 100 135 14 14 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 Not Cancer Driver No 1 hippie 157 730 84 84 0
RAD54B RAD54B Q9Y620 DNA repair and recombination protein RAD54B chr8 Not Cancer Driver No 1 hippie 112 120 16 16 0
RB1 RB1 P06400 Retinoblastoma-associated protein chr13 Census, Compendium Yes 1 hippie 140 282 32 32 22
RCHY1 RCHY1 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie 33 23 0 0 0
RNF115 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 intact, hippie 30 136 14 14 0
RNF2 RNF2 Q99496 E3 ubiquitin-protein ligase RING2 chr1 Not Cancer Driver No 1 hippie 40 203 22 22 0
RPL11 RPL11 P62913 60S ribosomal protein L11 chr1 Not Cancer Driver No 1 hippie, biogrid 27 12 1 1 1
RPL15_ENST00000413699 RPL15 P61313 60S ribosomal protein L15 chr3 Not Cancer Driver No 1 hippie, biogrid 18 84 9 9 0
RPL37 RPL37 P61927 60S ribosomal protein L37 chr5 Not Cancer Driver No 1 hippie 12 83 10 10 0
RPS15_ENST00000592588 RPS15 P62841 40S ribosomal protein S15 chr19 Not Cancer Driver No 1 hippie 13 59 7 7 0
RPS20_ENST00000521262 RPS20 P60866 40S ribosomal protein S20 chr8 Not Cancer Driver No 1 hippie 18 53 8 8 0
RPS27A_ENST00000404735 RPS27A P62979 Ubiquitin-40S ribosomal protein S27a chr2 Not Cancer Driver No 1 intact 18 47 2 2 0
S100A1 S100A1 P23297 Protein S100-A1 chr1 Not Cancer Driver No 1 hippie 13 9 0 0 0
S100A2_ENST00000368709 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie 16 6 2 2 0
S100A5 S100A5 P33763 Protein S100-A5 chr1 Not Cancer Driver No 1 hippie 12 7 1 1 0
S100B S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 intact, hippie 17 13 1 1 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie 27 75 9 9 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 Census, Compendium Yes 1 hippie 97 111 19 19 5
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SMARCA2 SMARCA2 P51531 Probable global transcription activator SNF2L2 chr9 Not Cancer Driver No 1 hippie 273 1009 160 160 42
SPATA46 SPATA46 Q5T0L3 Spermatogenesis-associated protein 46 chr1 Not Cancer Driver No 2 intact, hippie 30 68 6 6 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
TOP2A TOP2A P11388 DNA topoisomerase 2-alpha chr17 Compendium Yes 1 hippie 150 508 59 59 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 14 intact, hippie, biogrid 2891 282 1466 1466 83
TP63 TP63 Q9H3D4 Tumor protein 63 chr3 Census, Compendium Yes 1 hippie 229 398 143 143 28
TP73 TP73 O15350 Tumor protein p73 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 82 443 55 55 0
TRIM46 TRIM46 Q7Z4K8 Tripartite motif-containing protein 46 chr1 Not Cancer Driver No 1 hippie 115 173 30 30 0
TRIM55 TRIM55 Q9BYV6 Tripartite motif-containing protein 55 chr8 Not Cancer Driver No 1 intact, hippie 134 276 78 78 0
UBA1 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie 117 165 22 22 6
UBC UBC P0CG48 Polyubiquitin-C chr12 Not Cancer Driver No 1 intact 97 312 53 53 0
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 13 14 0 0 0
UBE2D2 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 19 13 1 1 0
UBE2D3_ENST00000394801 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 hippie 21 13 4 4 0
USP2 USP2 O75604 Ubiquitin carboxyl-terminal hydrolase 2 chr11 Not Cancer Driver No 1 hippie 88 213 39 39 0
USP22 USP22 Q9UPT9 Ubiquitin carboxyl-terminal hydrolase 22 chr17 Not Cancer Driver No 1 hippie 64 50 1 1 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 3 intact, hippie 170 215 45 45 0
VPS26C VPS26C O14972 Vacuolar protein sorting-associated protein 26C chr21 Not Cancer Driver No 1 intact, hippie 46 4 0 0 0
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie 30 35 3 3 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 intact, hippie 22 109 4 4 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 3 intact, hippie 32 41 3 3 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 intact, hippie 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 1 intact, hippie 15 55 3 3 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 intact, hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 2 intact, hippie, biogrid 30 81 10 10 0
ZKSCAN3_ENST00000252211 ZKSCAN3 Q9BRR0 Zinc finger protein with KRAB and SCAN domains 3 chr6 Not Cancer Driver No 1 hippie 70 267 30 30 0
ZKSCAN4 ZKSCAN4 Q969J2 Zinc finger protein with KRAB and SCAN domains 4 chr6 Not Cancer Driver No 1 intact, hippie 43 303 23 23 0