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MCL1 ,MCL1 ,Q07820
  • Uniprot Accession= Q07820
  • Ensembl Transcript= ENST00000369026.2
  • Uniprot Name= MCL1
  • Name= Induced myeloid leukemia cell differentiation protein Mcl-1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 48
  • Number of Interaction partner in hippie: 116
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 Not Cancer Driver No 1 hippie 112 43 5 5 5
ADAM32 ADAM32 Q8TC27 Disintegrin and metalloproteinase domain-containing protein 32 chr8 Not Cancer Driver No 1 hippie, biogrid 132 88 16 16 0
AGO2 AGO2 Q9UKV8 Protein argonaute-2 chr8 Not Cancer Driver No 1 hippie 126 141 15 15 11
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie 34 103 14 14 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 Not Cancer Driver No 1 hippie, biogrid 41 83 12 12 9
ASPRV1 ASPRV1 Q53RT3 Retroviral-like aspartic protease 1 chr2 Not Cancer Driver No 2 hippie, biogrid 66 85 18 18 3
ATG12 ATG12 O94817 Ubiquitin-like protein ATG12 chr5 Not Cancer Driver No 1 hippie 15 60 8 8 0
ATG2A ATG2A Q2TAZ0 Autophagy-related protein 2 homolog A chr11 Not Cancer Driver No 1 hippie 228 887 124 124 0
ATPAF1_ENST00000574428 ATPAF1 Q5TC12 ATP synthase mitochondrial F1 complex assembly factor 1 chr1 Not Cancer Driver No 1 hippie 33 47 8 8 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 Not Cancer Driver No 1 hippie 14 163 14 14 0
BAG3 BAG3 O95817 BAG family molecular chaperone regulator 3 chr10 Not Cancer Driver No 1 hippie 57 571 57 57 7
BAG4 BAG4 O95429 BAG family molecular chaperone regulator 4 chr8 Not Cancer Driver No 1 hippie 55 402 49 49 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie, biogrid 98 861 79 79 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 Not Cancer Driver No 4 hippie, biogrid 38 58 9 9 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 Census Yes 4 hippie, biogrid 30 39 2 2 0
BBC3 BBC3 Q96PG8 Bcl-2-binding component 3, isoforms 3/4 chr19 Not Cancer Driver No 4 hippie, biogrid 20 253 20 20 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 2 hippie, biogrid 29 55 3 3 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 Not Cancer Driver No 4 hippie, biogrid 42 130 17 17 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie 24 72 5 5 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BID_ENST00000551952 BID P55957 BH3-interacting domain death agonist chr22 Not Cancer Driver No 2 hippie, biogrid 23 74 9 9 0
BIK BIK Q13323 Bcl-2-interacting killer chr22 Not Cancer Driver No 1 hippie 16 21 4 4 0
BMF_ENST00000561360 BMF Q96LC9 Bcl-2-modifying factor chr15 Not Cancer Driver No 1 hippie 22 94 9 9 0
BOK BOK Q9UMX3 Bcl-2-related ovarian killer protein chr2 Not Cancer Driver No 1 hippie 7 0 0 0 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 hippie 80 45 4 4 0
C5AR2_ENST00000600626 C5AR2 Q9P296 C5a anaphylatoxin chemotactic receptor 2 chr19 Not Cancer Driver No 2 hippie, biogrid 60 11 3 3 0
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie 45 245 31 31 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie 30 2 0 0 0
CDC20 CDC20 Q12834 Cell division cycle protein 20 homolog chr1 Not Cancer Driver No 1 hippie 44 198 15 15 0
CHRM4 CHRM4 P08173 Muscarinic acetylcholine receptor M4 chr11 Not Cancer Driver No 1 hippie 75 143 27 27 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 hippie 17 5 1 1 1
CPT2 CPT2 P23786 Carnitine O-palmitoyltransferase 2, mitochondrial chr1 Not Cancer Driver No 2 hippie, biogrid 66 70 5 5 21
CUL1_ENST00000602748 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 hippie 151 65 9 9 0
DAD1 DAD1 P61803 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 chr14 Not Cancer Driver No 1 hippie 7 0 0 0 0
DBI_ENST00000355857 DBI P07108 Acyl-CoA-binding protein chr2 Not Cancer Driver No 1 hippie, biogrid 13 27 6 6 0
DDX58 DDX58 O95786 Antiviral innate immune response receptor RIG-I chr9 Not Cancer Driver No 1 hippie 118 61 10 10 2
DOT1L DOT1L Q8TEK3 Histone-lysine N-methyltransferase, H3 lysine-79 specific chr19 Compendium Yes 1 biogrid 178 988 118 118 0
DUSP22_ENST00000344450 DUSP22 Q9NRW4 Dual specificity protein phosphatase 22 chr6 Not Cancer Driver No 1 hippie 84 0 0 0 0
DYNLL1_ENST00000242577 DYNLL1 P63167 Dynein light chain 1, cytoplasmic chr12 Not Cancer Driver No 1 hippie, biogrid 9 0 0 0 0
DYNLL2 DYNLL2 Q96FJ2 Dynein light chain 2, cytoplasmic chr17 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 0
ECM1_ENST00000369047 ECM1 Q16610 Extracellular matrix protein 1 chr1 Not Cancer Driver No 2 hippie, biogrid 91 219 28 28 1
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie 54 141 5 5 0
EDEM2 EDEM2 Q9BV94 ER degradation-enhancing alpha-mannosidase-like protein 2 chr20 Not Cancer Driver No 2 hippie, biogrid 69 54 3 3 0
EDNRA EDNRA P25101 Endothelin-1 receptor chr4 Not Cancer Driver No 3 hippie, biogrid 62 21 6 6 2
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 1 hippie 275 314 41 41 1
FBXO4 FBXO4 Q9UKT5 F-box only protein 4 chr5 Not Cancer Driver No 1 hippie 55 68 7 7 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FLG FLG P20930 Filaggrin chr1 Not Cancer Driver No 2 hippie, biogrid 1612 3956 1593 1593 0
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 hippie 39 24 3 3 0
GBP5 GBP5 Q96PP8 Guanylate-binding protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 106 170 21 21 0
GSK3A GSK3A P49840 Glycogen synthase kinase-3 alpha chr19 Not Cancer Driver No 1 hippie 55 180 8 8 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 hippie 56 146 13 13 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie, biogrid 107 16 4 4 18
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 24 200 13 13 0
HSPA4 HSPA4 P34932 Heat shock 70 kDa protein 4 chr5 Not Cancer Driver No 1 hippie 80 351 24 24 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
HSPA9 HSPA9 P38646 Stress-70 protein, mitochondrial chr5 Not Cancer Driver No 1 hippie 67 283 26 26 2
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 hippie 61 82 6 6 2
HUWE1_ENST00000262854 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX Not Cancer Driver No 2 hippie, biogrid 669 2091 329 329 21
IER3 IER3 P46695 Radiation-inducible immediate-early gene IEX-1 chr6 Not Cancer Driver No 1 hippie 5 106 4 4 0
KCNF1 KCNF1 Q9H3M0 Potassium voltage-gated channel subfamily F member 1 chr2 Not Cancer Driver No 1 hippie 116 73 13 13 0
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie, biogrid 788 7 2 2 27
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie 95 84 12 12 0
MAGEA8_ENST00000542674 MAGEA8 P43361 Melanoma-associated antigen 8 chrX Not Cancer Driver No 1 hippie, biogrid 65 112 19 19 0
MAPK10_ENST00000515650 MAPK10 P53779 Mitogen-activated protein kinase 10 chr4 Not Cancer Driver No 1 hippie 88 107 16 16 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MCL1 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 Not Cancer Driver No 1 hippie 30 203 21 21 0
MLLT11 MLLT11 Q13015 Protein AF1q chr1 Census Yes 1 hippie, biogrid 15 18 5 5 0
NIPAL1 NIPAL1 Q6NVV3 Magnesium transporter NIPA3 chr4 Not Cancer Driver No 1 hippie, biogrid 51 2 0 0 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie, biogrid 284 10 0 0 14
NSFL1C_ENST00000216879 NSFL1C Q9UNZ2 NSFL1 cofactor p47 chr20 Not Cancer Driver No 1 hippie, biogrid 56 266 39 39 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OTUD1 OTUD1 Q5VV17 OTU domain-containing protein 1 chr10 Not Cancer Driver No 1 hippie 9 279 2 2 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 hippie 30 22 3 3 1
PDK2 PDK2 Q15119 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial chr17 Not Cancer Driver No 1 biogrid 45 35 4 4 0
PEBP1 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 23 76 13 13 0
PIN1 PIN1 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 chr19 Not Cancer Driver No 1 hippie 17 115 12 12 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 57 99 13 13 23
PMAIP1 PMAIP1 Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 chr18 Not Cancer Driver No 2 hippie, biogrid 2 23 1 1 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 Not Cancer Driver No 4 hippie, biogrid 72 124 17 17 0
PRKAB1 PRKAB1 Q9Y478 5'-AMP-activated protein kinase subunit beta-1 chr12 Not Cancer Driver No 3 hippie, biogrid 39 124 13 13 0
PRKAB2 PRKAB2 O43741 5'-AMP-activated protein kinase subunit beta-2 chr1 Not Cancer Driver No 3 hippie, biogrid 31 110 12 12 0
PRKAG1_ENST00000548065 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 Not Cancer Driver No 2 hippie, biogrid 35 25 2 2 0
PRKAR1A_ENST00000536854 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit chr17 Census, Compendium Yes 1 biogrid 39 66 11 11 17
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
RANBP6 RANBP6 O60518 Ran-binding protein 6 chr9 Not Cancer Driver No 2 hippie, biogrid 152 46 4 4 0
RBM10_ENST00000377604 RBM10 P98175 RNA-binding protein 10 chrX Census, Compendium Yes 1 hippie, biogrid 112 777 99 99 0
RTL10_ENST00000407472 RTL10 Q7L3V2 Protein Bop chr22 Not Cancer Driver No 1 hippie 52 196 31 31 0
SERPINB7 SERPINB7 O75635 Serpin B7 chr18 Not Cancer Driver No 2 hippie, biogrid 100 30 8 8 0
SKP1_ENST00000517625 SKP1 P63208 S-phase kinase-associated protein 1 chr5 Not Cancer Driver No 1 hippie 19 95 17 17 0
SLC5A6 SLC5A6 Q9Y289 Sodium-dependent multivitamin transporter chr2 Not Cancer Driver No 1 hippie, biogrid 87 28 0 0 2
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie 54 267 32 32 30
STARD9 STARD9 Q9P2P6 StAR-related lipid transfer protein 9 chr15 Not Cancer Driver No 3 hippie, biogrid 104 3390 76 76 0
STX8 STX8 Q9UNK0 Syntaxin-8 chr17 Not Cancer Driver No 1 hippie 32 98 10 10 0
TMPRSS5 TMPRSS5 Q9H3S3 Transmembrane protease serine 5 chr11 Not Cancer Driver No 1 hippie, biogrid 46 33 1 1 0
TNKS TNKS O95271 Poly [ADP-ribose] polymerase tankyrase-1 chr8 Not Cancer Driver No 1 hippie 163 480 59 59 0
TNKS2 TNKS2 Q9H2K2 Poly [ADP-ribose] polymerase tankyrase-2 chr10 Not Cancer Driver No 1 hippie 117 255 24 24 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TPT1_ENST00000530705 TPT1 P13693 Translationally-controlled tumor protein chr13 Not Cancer Driver No 1 hippie 17 43 6 6 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 67 62 7 7 0
TRIM11 TRIM11 Q96F44 E3 ubiquitin-protein ligase TRIM11 chr1 Not Cancer Driver No 1 hippie, biogrid 58 132 14 14 0
TXLNG TXLNG Q9NUQ3 Gamma-taxilin chrX Not Cancer Driver No 1 hippie, biogrid 50 374 35 35 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie 64 132 26 26 0
UHRF2 UHRF2 Q96PU4 E3 ubiquitin-protein ligase UHRF2 chr9 Not Cancer Driver No 1 hippie 88 253 22 22 0
UNK UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie 79 511 46 46 0
USP13 USP13 Q92995 Ubiquitin carboxyl-terminal hydrolase 13 chr3 Not Cancer Driver No 1 hippie 121 224 42 42 0
USP17L2 USP17L2 Q6R6M4 Ubiquitin carboxyl-terminal hydrolase 17 chr8 Not Cancer Driver No 1 hippie 105 201 54 54 0
USP9X_ENST00000378308 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 hippie 339 405 51 51 1
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 Not Cancer Driver No 1 hippie, biogrid 133 543 61 61 0
VDAC1_ENST00000395047 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 chr5 Not Cancer Driver No 1 hippie 38 36 4 4 0
YBEY_ENST00000397691 YBEY P58557 Endoribonuclease YbeY chr21 Not Cancer Driver No 1 hippie, biogrid 19 9 2 2 0
ZAR1L ZAR1L A6NP61 ZAR1-like protein chr13 Not Cancer Driver No 1 hippie, biogrid 29 178 17 17 0