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MAPKAPK2 ,MAPKAPK2 ,P49137
  • Uniprot Accession= P49137
  • Ensembl Transcript= ENST00000367103.3
  • Uniprot Name= MAPKAPK2
  • Name= MAP kinase-activated protein kinase 2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 12
  • Number of Interaction partner in biogrid: 48
  • Number of Interaction partner in hippie: 118
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACIN1 ACIN1 Q9UKV3 Apoptotic chromatin condensation inducer in the nucleus chr14 Not Cancer Driver No 1 hippie, biogrid 157 1294 155 155 0
AGO2 AGO2 Q9UKV8 Protein argonaute-2 chr8 Not Cancer Driver No 1 hippie 126 141 15 15 11
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 2 intact, hippie 108 158 24 24 4
AL662899.2_ENST00000375880 CSNK2B Q5SRQ3 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie 21 30 1 1 0
ALOX5 ALOX5 P09917 Polyunsaturated fatty acid 5-lipoxygenase chr10 Not Cancer Driver No 2 intact, hippie 129 16 2 2 0
ALPL ALPL P05186 Alkaline phosphatase, tissue-nonspecific isozyme chr1 Not Cancer Driver No 1 biogrid 80 184 39 39 113
ARPC5_ENST00000359856 ARPC5 O15511 Actin-related protein 2/3 complex subunit 5 chr1 Not Cancer Driver No 1 hippie 15 66 7 7 0
ATF1 ATF1 P18846 Cyclic AMP-dependent transcription factor ATF-1 chr12 Census Yes 1 hippie 31 240 28 28 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie 17 112 9 9 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 1 hippie 29 55 3 3 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BRD9 BRD9 Q9H8M2 Bromodomain-containing protein 9 chr5 Not Cancer Driver No 1 hippie, biogrid 77 385 44 44 0
CAMK2G_ENST00000423381 CAMK2G Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma chr10 Not Cancer Driver No 1 biogrid 68 145 14 14 1
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 Not Cancer Driver No 1 hippie 63 313 35 35 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 hippie 80 328 43 43 0
CDK11B CDK11B P21127 Cyclin-dependent kinase 11B chr1 Not Cancer Driver No 1 hippie, biogrid 74 501 35 35 0
CDK12 CDK12 Q9NYV4 Cyclin-dependent kinase 12 chr17 Census, Compendium Yes 1 hippie, biogrid 225 1202 160 160 0
CEP131 CEP131 Q9UPN4 Centrosomal protein of 131 kDa chr17 Not Cancer Driver No 1 hippie 126 948 113 113 0
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 25 201 22 22 2
CHMP4C CHMP4C Q96CF2 Charged multivesicular body protein 4c chr8 Not Cancer Driver No 1 hippie 33 224 31 31 0
CIR1 CIR1 Q86X95 Corepressor interacting with RBPJ 1 chr2 Not Cancer Driver No 1 hippie, biogrid 46 385 42 42 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
CPSF4 CPSF4 O95639 Cleavage and polyadenylation specificity factor subunit 4 chr7 Not Cancer Driver No 1 hippie, biogrid 36 89 11 11 0
CREB1_ENST00000430624 CREB1 P16220 Cyclic AMP-responsive element-binding protein 1 chr2 Census Yes 1 hippie 25 277 23 23 0
CSNK2B_ENST00000375866 CSNK2B P67870 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie 20 19 0 0 4
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 123 167 23 23 3
DDRGK1 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 34 181 23 23 0
DDX21 DDX21 Q9NR30 Nucleolar RNA helicase 2 chr10 Not Cancer Driver No 1 hippie, biogrid 72 342 30 30 0
DDX46_ENST00000354283 DDX46 Q7L014 Probable ATP-dependent RNA helicase DDX46 chr5 Not Cancer Driver No 1 hippie, biogrid 120 510 72 72 0
DDX5 DDX5 P17844 Probable ATP-dependent RNA helicase DDX5 chr17 Census Yes 1 hippie 74 225 23 23 0
DES DES P17661 Desmin chr2 Not Cancer Driver No 1 hippie 71 264 41 41 35
DHX8 DHX8 Q14562 ATP-dependent RNA helicase DHX8 chr17 Not Cancer Driver No 1 hippie, biogrid 138 490 72 72 0
DIDO1 DIDO1 Q9BTC0 Death-inducer obliterator 1 chr20 Not Cancer Driver No 1 hippie, biogrid 453 1917 400 400 0
EEF2K EEF2K O00418 Eukaryotic elongation factor 2 kinase chr16 Not Cancer Driver No 1 hippie 104 311 39 39 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
ETV1 ETV1 P50549 ETS translocation variant 1 chr7 Census Yes 1 hippie 100 282 66 66 0
HDGFL2 HDGFL2 Q7Z4V5 Hepatoma-derived growth factor-related protein 2 chr19 Not Cancer Driver No 1 hippie 59 622 57 57 0
HNRNPA0 HNRNPA0 Q13151 Heterogeneous nuclear ribonucleoprotein A0 chr5 Not Cancer Driver No 1 hippie 25 172 14 14 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 Not Cancer Driver No 1 hippie 59 335 37 37 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 24 200 13 13 0
HSPA1B HSPA1B P0DMV9 Heat shock 70 kDa protein 1B chr6 Not Cancer Driver No 1 intact 15 200 5 5 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 2 intact, hippie 10 118 8 8 20
INS INS P01308 Insulin chr11 Not Cancer Driver No 1 hippie 15 5 1 1 22
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
LIMK1 LIMK1 P53667 LIM domain kinase 1 chr7 Not Cancer Driver No 1 intact, hippie 110 170 30 30 0
LSP1_ENST00000311604 LSP1 P33241 Lymphocyte-specific protein 1 chr11 Not Cancer Driver No 1 hippie 44 337 43 43 0
LYAR_ENST00000452476 LYAR Q9NX58 Cell growth-regulating nucleolar protein chr4 Not Cancer Driver No 1 intact, hippie 50 249 31 31 0
MAGI1 MAGI1 Q96QZ7 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 260 1212 220 220 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 Not Cancer Driver No 1 hippie 48 55 11 11 0
MAPK11 MAPK11 Q15759 Mitogen-activated protein kinase 11 chr22 Not Cancer Driver No 2 intact, hippie, biogrid 23 64 2 2 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 Not Cancer Driver No 5 intact, hippie, biogrid 39 25 1 1 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie 38 49 5 5 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 Not Cancer Driver No 2 intact, hippie 43 92 5 5 0
MAPKAPK3 MAPKAPK3 Q16644 MAP kinase-activated protein kinase 3 chr3 Not Cancer Driver No 2 hippie, biogrid 35 117 12 12 1
MAPKAPK5 MAPKAPK5 Q8IW41 MAP kinase-activated protein kinase 5 chr12 Not Cancer Driver No 1 hippie 51 101 12 12 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MTHFD2 MTHFD2 P13995 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 39 39 3 3 0
MTHFD2L MTHFD2L Q9H903 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial chr4 Not Cancer Driver No 1 hippie, biogrid 45 59 6 6 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
PABPC1 PABPC1 P11940 Polyadenylate-binding protein 1 chr8 Census, Compendium Yes 1 hippie 100 317 55 55 0
PARN PARN O95453 Poly(A)-specific ribonuclease PARN chr16 Not Cancer Driver No 1 hippie 71 197 22 22 2
PAXBP1 PAXBP1 Q9Y5B6 PAX3- and PAX7-binding protein 1 chr21 Not Cancer Driver No 1 hippie, biogrid 96 532 55 55 0
PHC2 PHC2 Q8IXK0 Polyhomeotic-like protein 2 chr1 Not Cancer Driver No 1 hippie 101 674 67 67 0
PHF3 PHF3 Q92576 PHD finger protein 3 chr6 Not Cancer Driver No 1 hippie, biogrid 260 1718 217 217 0
PIAS2 PIAS2 O75928 E3 SUMO-protein ligase PIAS2 chr18 Not Cancer Driver No 1 hippie 78 209 28 28 0
PINX1 PINX1 Q96BK5 PIN2/TERF1-interacting telomerase inhibitor 1 chr8 Not Cancer Driver No 1 hippie 66 328 66 66 0
PKM_ENST00000335181 PKM P14618 Pyruvate kinase PKM chr15 Not Cancer Driver No 1 hippie 78 58 13 13 0
PLA2G2E PLA2G2E Q9NZK7 Group IIE secretory phospholipase A2 chr1 Not Cancer Driver No 1 biogrid 33 0 0 0 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 Not Cancer Driver No 1 hippie 87 119 13 13 0
PPP1R10 PPP1R10 Q96QC0 Serine/threonine-protein phosphatase 1 regulatory subunit 10 chr6 Not Cancer Driver No 1 hippie, biogrid 114 798 100 100 0
PRPF40A PRPF40A O75400 Pre-mRNA-processing factor 40 homolog A chr2 Not Cancer Driver No 1 hippie, biogrid 83 694 57 57 0
PRPF4B PRPF4B Q13523 Serine/threonine-protein kinase PRP4 homolog chr6 Not Cancer Driver No 1 hippie, biogrid 120 646 86 86 0
PRRC2A_ENST00000376007 PRRC2A P48634 Protein PRRC2A chr6 Not Cancer Driver No 1 hippie, biogrid 253 2119 249 249 0
PRRC2C PRRC2C Q9Y520-4 Isoform 4 of Protein PRRC2C chr1 Not Cancer Driver No 1 hippie, biogrid 296 2713 287 287 0
PTP4A3_ENST00000521578 PTP4A3 O75365 Protein tyrosine phosphatase type IVA 3 chr8 Not Cancer Driver No 1 biogrid 30 3 0 0 0
RBBP6 RBBP6 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 chr16 Not Cancer Driver No 1 hippie, biogrid 229 1626 212 212 0
RBM43 RBM43 Q6ZSC3 RNA-binding protein 43 chr2 Not Cancer Driver No 1 hippie, biogrid 50 28 4 4 0
RCSD1 RCSD1 Q6JBY9 CapZ-interacting protein chr1 Not Cancer Driver No 1 hippie 70 416 70 70 0
RFC1 RFC1 P35251 Replication factor C subunit 1 chr4 Not Cancer Driver No 1 hippie, biogrid 147 674 82 82 0
RSRC2 RSRC2 Q7L4I2 Arginine/serine-rich coiled-coil protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 58 401 54 54 0
S100A1 S100A1 P23297 Protein S100-A1 chr1 Not Cancer Driver No 1 hippie 13 9 0 0 0
S100A2_ENST00000368709 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie 16 6 2 2 0
S100B S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 intact, hippie 17 13 1 1 0
S100P S100P P25815 Protein S100-P chr4 Not Cancer Driver No 1 hippie 7 3 1 1 0
SAFB_ENST00000292123 SAFB Q15424 Scaffold attachment factor B1 chr19 Not Cancer Driver No 1 hippie, biogrid 111 911 110 110 0
SCAF11 SCAF11 Q99590 Protein SCAF11 chr12 Not Cancer Driver No 1 hippie, biogrid 167 1149 134 134 0
SFSWAP_ENST00000261674 SFSWAP Q12872 Splicing factor, suppressor of white-apricot homolog chr12 Not Cancer Driver No 1 hippie, biogrid 137 769 111 111 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 Not Cancer Driver No 1 hippie 84 397 58 58 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 70 435 31 31 0
SLTM SLTM Q9NWH9 SAFB-like transcription modulator chr15 Not Cancer Driver No 1 hippie, biogrid 110 962 103 103 0
SMNDC1_ENST00000369592 SMNDC1 O75940 Survival of motor neuron-related-splicing factor 30 chr10 Not Cancer Driver No 1 hippie 16 197 15 15 0
SPATS2_ENST00000552918 SPATS2 Q86XZ4 Spermatogenesis-associated serine-rich protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 62 392 52 52 0
SPHK2 SPHK2 Q9NRA0 Sphingosine kinase 2 chr19 Not Cancer Driver No 1 biogrid 82 293 39 39 0
SREK1_ENST00000380918 SREK1 Q8WXA9 Splicing regulatory glutamine/lysine-rich protein 1 chr5 Not Cancer Driver No 1 hippie, biogrid 60 438 53 53 0
SRF SRF P11831 Serum response factor chr6 Not Cancer Driver No 1 hippie 44 443 42 42 0
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
SUGP2_ENST00000452918 SUGP2 Q8IX01 SURP and G-patch domain-containing protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 124 651 74 74 0
TCF3 TCF3 P15923 Transcription factor E2-alpha chr19 Census Yes 1 hippie 52 649 52 52 0
TH TH P07101 Tyrosine 3-monooxygenase chr11 Not Cancer Driver No 1 hippie 61 149 21 21 38
THAP12 THAP12 O43422 52 kDa repressor of the inhibitor of the protein kinase chr11 Not Cancer Driver No 1 hippie 105 136 13 13 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIM29 TRIM29 Q14134 Tripartite motif-containing protein 29 chr11 Not Cancer Driver No 1 hippie 121 351 72 72 0
TSC2 TSC2 P49815 Tuberin chr16 Census, Compendium Yes 1 hippie 192 563 50 50 53
TTPAL TTPAL Q9BTX7 Alpha-tocopherol transfer protein-like chr20 Not Cancer Driver No 1 hippie, biogrid 43 51 4 4 0
UBE2J1 UBE2J1 Q9Y385 Ubiquitin-conjugating enzyme E2 J1 chr6 Not Cancer Driver No 1 hippie 33 158 20 20 0
UTP14A UTP14A Q9BVJ6 U3 small nucleolar RNA-associated protein 14 homolog A chrX Not Cancer Driver No 1 hippie, biogrid 105 629 89 89 0
WASF1_ENST00000392586 WASF1 Q92558 Wiskott-Aldrich syndrome protein family member 1 chr6 Not Cancer Driver No 1 hippie 63 445 49 49 0
WBP11 WBP11 Q9Y2W2 WW domain-binding protein 11 chr12 Not Cancer Driver No 1 hippie, biogrid 86 606 79 79 0
WDR33 WDR33 Q9C0J8 pre-mRNA 3' end processing protein WDR33 chr2 Not Cancer Driver No 1 hippie, biogrid 191 987 153 153 0
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 140 33 9 9 0
YLPM1 YLPM1 P49750 YLP motif-containing protein 1 chr14 Not Cancer Driver No 1 hippie, biogrid 251 1985 226 226 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 hippie 30 81 10 10 0
ZC3H4 ZC3H4 Q9UPT8 Zinc finger CCCH domain-containing protein 4 chr19 Not Cancer Driver No 1 hippie, biogrid 152 1235 145 145 0
ZFC3H1 ZFC3H1 O60293 Zinc finger C3H1 domain-containing protein chr12 Not Cancer Driver No 1 hippie, biogrid 210 1025 115 115 0
ZFP36 ZFP36 P26651 mRNA decay activator protein ZFP36 chr19 Not Cancer Driver No 1 hippie 43 262 34 34 0
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 Compendium Yes 1 hippie 57 212 30 30 0
ZNF638 ZNF638 Q14966 Zinc finger protein 638 chr2 Not Cancer Driver No 1 hippie, biogrid 243 1667 209 209 0