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MAP3K6 ,MAP3K6 ,O95382
  • Uniprot Accession= O95382
  • Ensembl Transcript= ENST00000493901.5
  • Uniprot Name= MAP3K6
  • Name= Mitogen-activated protein kinase kinase kinase 6
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 17
  • Number of Interaction partner in biogrid: 32
  • Number of Interaction partner in hippie: 45
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTA2 ACTA2 P62736 Actin, aortic smooth muscle chr10 Not Cancer Driver No 1 hippie, biogrid 50 39 4 4 17
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 Not Cancer Driver No 1 hippie, biogrid 112 43 5 5 5
AGL_ENST00000361915 AGL P35573 Glycogen debranching enzyme chr1 Not Cancer Driver No 1 intact, hippie, biogrid 182 143 23 23 1
ASPM ASPM Q8IZT6 Abnormal spindle-like microcephaly-associated protein chr1 Not Cancer Driver No 1 intact, hippie, biogrid 554 424 67 67 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 52 214 31 31 0
D2HGDH D2HGDH Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 61 46 1 1 0
DHFR DHFR P00374 Dihydrofolate reductase chr5 Not Cancer Driver No 1 hippie, biogrid 16 12 2 2 2
EEF1AKMT3 EEF1AKMT3 Q96AZ1 EEF1A lysine methyltransferase 3 chr12 Not Cancer Driver No 1 hippie 23 33 1 1 0
ERGIC2 ERGIC2 Q96RQ1 Endoplasmic reticulum-Golgi intermediate compartment protein 2 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 37 25 2 2 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 70 150 20 20 0
GDPD3 GDPD3 Q7L5L3 Lysophospholipase D GDPD3 chr16 Not Cancer Driver No 1 hippie, biogrid 50 12 2 2 0
HAL HAL P42357 Histidine ammonia-lyase chr12 Not Cancer Driver No 1 intact, hippie, biogrid 98 34 6 6 4
HNRNPCL2 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 hippie, biogrid 51 199 41 41 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
KRT2 KRT2 P35908 Keratin, type II cytoskeletal 2 epidermal chr12 Not Cancer Driver No 1 hippie, biogrid 122 335 59 59 15
LIMCH1_ENST00000313860 LIMCH1 Q9UPQ0 LIM and calponin homology domains-containing protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 177 880 140 140 0
LIMD1 LIMD1 Q9UGP4 LIM domain-containing protein 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 58 428 36 36 0
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 104 75 27 27 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 Not Cancer Driver No 1 hippie 197 242 29 29 0
MAP3K6 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 chr1 Not Cancer Driver No 1 hippie 108 390 31 31 0
MAPK4 MAPK4 P31152 Mitogen-activated protein kinase 4 chr18 Not Cancer Driver No 1 hippie, biogrid 111 222 42 42 0
NPRL2 NPRL2 Q8WTW4 GATOR complex protein NPRL2 chr3 Compendium Yes 1 hippie, biogrid 37 10 3 3 1
NUDCD2 NUDCD2 Q8WVJ2 NudC domain-containing protein 2 chr5 Not Cancer Driver No 1 hippie 12 39 6 6 0
PCDHA12 PCDHA12 Q9UN75 Protocadherin alpha-12 chr5 Not Cancer Driver No 1 hippie, biogrid 327 243 62 62 0
PCDHA4 PCDHA4 Q9UN74 Protocadherin alpha-4 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 313 231 73 73 0
PEX5_ENST00000420616 PEX5 P50542 Peroxisomal targeting signal 1 receptor chr12 Not Cancer Driver No 1 hippie, biogrid 73 321 36 36 2
PLEKHO2 PLEKHO2 Q8TD55 Pleckstrin homology domain-containing family O member 2 chr15 Not Cancer Driver No 3 intact, hippie, biogrid 61 402 56 56 0
PRKAA2 PRKAA2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 chr1 Not Cancer Driver No 1 intact, hippie 128 98 26 26 0
PRKAB2 PRKAB2 O43741 5'-AMP-activated protein kinase subunit beta-2 chr1 Not Cancer Driver No 1 intact, hippie 31 110 12 12 0
RNF123 RNF123 Q5XPI4 E3 ubiquitin-protein ligase RNF123 chr3 Not Cancer Driver No 2 hippie, biogrid 167 220 28 28 0
S100P S100P P25815 Protein S100-P chr4 Not Cancer Driver No 1 hippie, biogrid 7 3 1 1 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 intact, hippie, biogrid 142 47 28 28 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie, biogrid 27 75 9 9 0
SHMT2 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial chr12 Not Cancer Driver No 1 hippie 57 58 5 5 1
TGM1 TGM1 P22735 Protein-glutamine gamma-glutamyltransferase K chr14 Not Cancer Driver No 1 hippie, biogrid 118 230 37 37 65
TNFSF13B TNFSF13B Q9Y275 Tumor necrosis factor ligand superfamily member 13B chr13 Not Cancer Driver No 3 hippie, biogrid 41 91 15 15 0
UBAC1 UBAC1 Q9BSL1 Ubiquitin-associated domain-containing protein 1 chr9 Not Cancer Driver No 2 hippie, biogrid 38 241 23 23 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
USP4 USP4 Q13107 Ubiquitin carboxyl-terminal hydrolase 4 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 102 286 22 22 0
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 Not Cancer Driver No 1 intact, hippie 87 118 11 11 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 intact, hippie, biogrid 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 2 intact, hippie, biogrid 15 55 3 3 0