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MAP3K21 ,MAP3K21 ,Q5TCX8
  • Uniprot Accession= Q5TCX8
  • Ensembl Transcript= ENST00000366624.7
  • Uniprot Name= MAP3K21
  • Name= Mitogen-activated protein kinase kinase kinase 21
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 52
  • Number of Interaction partner in biogrid: 0
  • Number of Interaction partner in hippie: 104
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AGAP1 AGAP1 Q9UPQ3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 chr2 Not Cancer Driver No 1 hippie 163 403 81 81 0
ANKRD34A ANKRD34A Q69YU3 Ankyrin repeat domain-containing protein 34A chr1 Not Cancer Driver No 2 intact, hippie 90 410 78 78 0
BASP1_ENST00000616743 BASP1 P80723 Brain acid soluble protein 1 chr5 Not Cancer Driver No 1 intact, hippie 39 227 39 39 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
C11orf52 C11orf52 Q96A22 Uncharacterized protein C11orf52 chr11 Not Cancer Driver No 1 hippie 15 108 12 12 0
CAMSAP2 CAMSAP2 Q08AD1 Calmodulin-regulated spectrin-associated protein 2 chr1 Not Cancer Driver No 1 hippie 176 1025 127 127 0
CBY1_ENST00000216029 CBY1 Q9Y3M2 Protein chibby homolog 1 chr22 Not Cancer Driver No 2 intact, hippie 13 98 11 11 0
CCT8L2 CCT8L2 Q96SF2 T-complex protein 1 subunit theta-like 2 chr22 Not Cancer Driver No 1 hippie 216 104 46 46 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 hippie 80 328 43 43 0
CDC25C CDC25C P30307 M-phase inducer phosphatase 3 chr5 Not Cancer Driver No 2 intact, hippie 61 224 26 26 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 intact, hippie 52 214 31 31 0
CDK16_ENST00000357227 CDK16 Q00536 Cyclin-dependent kinase 16 chrX Not Cancer Driver No 1 hippie 55 139 30 30 0
CGN CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 2 intact, hippie 152 1179 149 149 0
CHODL CHODL Q9H9P2 Chondrolectin chr21 Not Cancer Driver No 1 hippie 50 45 7 7 0
CHUK CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 Not Cancer Driver No 1 intact, hippie 74 116 9 9 0
CLINT1_ENST00000411809 CLINT1 Q14677 Clathrin interactor 1 chr5 Not Cancer Driver No 1 intact, hippie 61 475 51 51 0
CLK1_ENST00000321356 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 64 131 21 21 0
CLTB CLTB P09497 Clathrin light chain B chr5 Not Cancer Driver No 1 intact, hippie 33 193 28 28 0
CXADR CXADR P78310 Coxsackievirus and adenovirus receptor chr21 Not Cancer Driver No 1 hippie 51 98 19 19 0
DCLK1 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 chr13 Not Cancer Driver No 1 hippie 209 252 77 77 0
DENND1A DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 Not Cancer Driver No 1 hippie 117 589 76 76 0
DENND4C_ENST00000602925 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 Not Cancer Driver No 2 intact, hippie 190 710 69 69 0
DIRAS3_ENST00000646789 DIRAS3 O95661 GTP-binding protein Di-Ras3 chr1 Not Cancer Driver No 1 hippie 38 21 3 3 0
DNAJC10 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 Not Cancer Driver No 1 intact, hippie 110 36 3 3 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 Not Cancer Driver No 1 hippie 96 514 64 64 0
EFNB1 EFNB1 P98172 Ephrin-B1 chrX Not Cancer Driver No 1 hippie 46 126 14 14 19
EIF4E2 EIF4E2 O60573 Eukaryotic translation initiation factor 4E type 2 chr2 Not Cancer Driver No 2 intact, hippie 27 80 5 5 0
EXOSC9_ENST00000243498 EXOSC9 Q06265 Exosome complex component RRP45 chr4 Not Cancer Driver No 1 intact, hippie 58 154 18 18 1
FAM110A_ENST00000246100 FAM110A Q9BQ89 Protein FAM110A chr20 Not Cancer Driver No 2 intact, hippie 20 244 12 12 0
FAM110B FAM110B Q8TC76 Protein FAM110B chr8 Not Cancer Driver No 2 intact, hippie 75 299 65 65 0
FAM53C_ENST00000434981 FAM53C Q9NYF3 Protein FAM53C chr5 Not Cancer Driver No 2 intact, hippie 51 296 45 45 0
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 intact, hippie 70 150 20 20 0
GIGYF1_ENST00000646601 GIGYF1 O75420 GRB10-interacting GYF protein 1 chr7 Not Cancer Driver No 1 hippie 138 857 115 115 0
GIGYF2_ENST00000409547 GIGYF2 Q6Y7W6 GRB10-interacting GYF protein 2 chr2 Not Cancer Driver No 1 hippie 176 1096 158 158 6
HAVCR2 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 Not Cancer Driver No 1 intact, hippie 69 17 2 2 3
HDAC4 HDAC4 P56524 Histone deacetylase 4 chr2 Not Cancer Driver No 2 intact, hippie 182 749 132 132 0
HIF1AN HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 Not Cancer Driver No 1 hippie 37 77 9 9 0
HIST1H1C H1-2 P16403 Histone H1.2 chr6 Not Cancer Driver No 1 intact 79 211 78 78 0
HOOK2 HOOK2 Q96ED9 Protein Hook homolog 2 chr19 Not Cancer Driver No 1 intact 94 487 62 62 0
HPCA HPCA P84074 Neuron-specific calcium-binding protein hippocalcin chr1 Not Cancer Driver No 1 hippie 24 42 4 4 3
HPCAL1_ENST00000381765 HPCAL1 P37235 Hippocalcin-like protein 1 chr2 Not Cancer Driver No 1 hippie 34 44 9 9 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 24 200 13 13 0
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 Census, Compendium Yes 1 intact, hippie 106 211 31 31 1
IL17RB IL17RB Q9NRM6 Interleukin-17 receptor B chr3 Not Cancer Driver No 1 hippie 50 30 3 3 0
INPP5E INPP5E Q9NRR6 Phosphatidylinositol polyphosphate 5-phosphatase type IV chr9 Not Cancer Driver No 2 intact, hippie 43 272 16 16 15
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie 28 24 2 2 0
KCTD3 KCTD3 Q9Y597 BTB/POZ domain-containing protein KCTD3 chr1 Not Cancer Driver No 2 intact, hippie 113 324 45 45 0
KIF13B KIF13B Q9NQT8 Kinesin-like protein KIF13B chr8 Not Cancer Driver No 1 hippie 187 968 82 82 0
KIF1C KIF1C O43896 Kinesin-like protein KIF1C chr17 Not Cancer Driver No 2 intact, hippie 131 695 94 94 1
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie 788 7 2 2 27
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 2 intact, hippie 114 404 58 58 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie 43 55 7 7 1
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie 13 96 7 7 0
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie 86 94 13 13 1
LIMA1_ENST00000341247 LIMA1 Q9UHB6 LIM domain and actin-binding protein 1 chr12 Not Cancer Driver No 1 hippie 88 687 81 81 0
LRFN1 LRFN1 Q9P244 Leucine-rich repeat and fibronectin type III domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 96 278 37 37 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie 95 84 12 12 0
MAGI1 MAGI1 Q96QZ7 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 chr3 Not Cancer Driver No 2 intact, hippie 260 1212 220 220 0
MAP3K10 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 Not Cancer Driver No 2 intact, hippie 112 589 62 62 0
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 Not Cancer Driver No 1 hippie 97 466 54 54 0
MAP3K9_ENST00000554752 MAP3K9 P80192 Mitogen-activated protein kinase kinase kinase 9 chr14 Not Cancer Driver No 1 intact, hippie 167 684 104 104 0
MAPKAP1 MAPKAP1 Q9BPZ7 Target of rapamycin complex 2 subunit MAPKAP1 chr9 Not Cancer Driver No 1 hippie 70 173 25 25 0
MAST3 MAST3 O60307 Microtubule-associated serine/threonine-protein kinase 3 chr19 Not Cancer Driver No 2 intact, hippie 169 783 100 100 0
NADK_ENST00000341991 NADK O95544 NAD kinase chr1 Not Cancer Driver No 1 hippie 59 91 18 18 0
NCALD NCALD P61601 Neurocalcin-delta chr8 Not Cancer Driver No 1 hippie 37 34 4 4 0
NCS1 NCS1 P62166 Neuronal calcium sensor 1 chr9 Not Cancer Driver No 1 hippie 25 26 2 2 0
NF1 NF1 P21359 Neurofibromin chr17 Census, Compendium Yes 2 intact, hippie 375 406 47 47 85
OPALIN OPALIN Q96PE5 Opalin chr10 Not Cancer Driver No 1 hippie 29 86 18 18 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 intact, hippie 30 22 3 3 1
PHLDB2 PHLDB2 Q86SQ0 Pleckstrin homology-like domain family B member 2 chr3 Not Cancer Driver No 1 hippie 235 1030 190 190 0
PLEKHA7 PLEKHA7 Q6IQ23 Pleckstrin homology domain-containing family A member 7 chr11 Not Cancer Driver No 2 intact, hippie 152 919 121 121 0
PPM1H PPM1H Q9ULR3 Protein phosphatase 1H chr12 Not Cancer Driver No 1 hippie 71 140 23 23 0
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 hippie 31 43 4 4 0
RAB35 RAB35 Q15286 Ras-related protein Rab-35 chr12 Not Cancer Driver No 1 hippie 25 25 2 2 0
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RALGPS2 RALGPS2 Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 chr1 Not Cancer Driver No 2 intact, hippie 83 183 23 23 0
RASAL2_ENST00000462775 RASAL2 Q9UJF2 Ras GTPase-activating protein nGAP chr1 Not Cancer Driver No 2 intact, hippie 164 606 86 86 0
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 52 19 2 2 0
RHOV RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 25 47 5 5 0
RTKN RTKN Q9BST9 Rhotekin chr2 Not Cancer Driver No 1 hippie 67 265 35 35 0
SH3PXD2A_ENST00000369774 SH3PXD2A Q5TCZ1 SH3 and PX domain-containing protein 2A chr10 Not Cancer Driver No 1 hippie 141 797 101 101 0
SIPA1L1 SIPA1L1 O43166 Signal-induced proliferation-associated 1-like protein 1 chr14 Not Cancer Driver No 2 intact, hippie 321 1175 226 226 0
SLC31A1 SLC31A1 O15431 High affinity copper uptake protein 1 chr9 Not Cancer Driver No 1 hippie 22 28 6 6 0
SLX1A_ENST00000345535 SLX1A Q9BQ83-2 Isoform 2 of Structure-specific endonuclease subunit SLX1 chr16 Not Cancer Driver No 1 hippie 5 27 0 0 0
SRGAP2 SRGAP2 O75044 SLIT-ROBO Rho GTPase-activating protein 2 chr1 Not Cancer Driver No 1 hippie 122 541 71 71 0
SRSF12 SRSF12 Q8WXF0 Serine/arginine-rich splicing factor 12 chr6 Not Cancer Driver No 2 intact, hippie 36 205 31 31 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
STX7 STX7 O15400 Syntaxin-7 chr6 Not Cancer Driver No 1 hippie 29 164 14 14 0
SYDE1 SYDE1 Q6ZW31 Rho GTPase-activating protein SYDE1 chr19 Not Cancer Driver No 2 intact, hippie 62 412 27 27 0
TACC3 TACC3 Q9Y6A5 Transforming acidic coiled-coil-containing protein 3 chr4 Not Cancer Driver No 1 hippie 98 707 81 81 0
TESK2 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 chr1 Not Cancer Driver No 2 intact, hippie 77 242 43 43 0
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 2 intact, hippie 370 810 194 194 0
TNIP2 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 Not Cancer Driver No 1 hippie 43 316 36 36 0
USP21_ENST00000289865 USP21 Q9UK80 Ubiquitin carboxyl-terminal hydrolase 21 chr1 Not Cancer Driver No 2 intact, hippie 95 230 47 47 0
USP9X_ENST00000378308 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 intact, hippie 339 405 51 51 1
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 4 intact, hippie 22 109 4 4 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 intact, hippie 32 41 3 3 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 intact, hippie 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 2 intact, hippie 15 55 3 3 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 2 intact, hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 2 intact, hippie 30 81 10 10 0
ZBTB21 ZBTB21 Q9ULJ3 Zinc finger and BTB domain-containing protein 21 chr21 Not Cancer Driver No 2 intact, hippie 136 645 75 75 0
ZNF638 ZNF638 Q14966 Zinc finger protein 638 chr2 Not Cancer Driver No 2 intact, hippie 243 1667 209 209 0