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KLHL12 ,KLHL12 ,Q53G59
  • Uniprot Accession= Q53G59
  • Ensembl Transcript= ENST00000367261.7
  • Uniprot Name= KLHL12
  • Name= Kelch-like protein 12
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 6
  • Number of Interaction partner in hippie: 102
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ARAF_ENST00000377045 ARAF P10398 Serine/threonine-protein kinase A-Raf chrX Census, Compendium Yes 1 hippie 84 181 32 32 0
ARHGDIB ARHGDIB P52566 Rho GDP-dissociation inhibitor 2 chr12 Not Cancer Driver No 1 hippie 33 92 13 13 0
ARIH1 ARIH1 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 chr15 Not Cancer Driver No 1 hippie 46 119 7 7 0
ARRB1 ARRB1 P49407 Beta-arrestin-1 chr11 Not Cancer Driver No 1 hippie 49 154 13 13 0
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie 46 122 22 22 0
ARRDC1 ARRDC1 Q8N5I2 Arrestin domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie 39 141 11 11 0
ATXN1 ATXN1 P54253 Ataxin-1 chr6 Not Cancer Driver No 1 hippie 193 604 168 168 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
BCL6_ENST00000232014 BCL6 P41182 B-cell lymphoma 6 protein chr3 Census, Compendium Yes 1 hippie 134 328 67 67 0
C1QTNF2 C1QTNF2 A0A499FIM1 C1q and tumor necrosis factor related protein 2 chr5 Not Cancer Driver No 1 hippie 58 169 38 38 0
CAND1 CAND1 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 chr12 Not Cancer Driver No 1 hippie 161 88 7 7 0
CARD10_ENST00000251973 CARD10 Q9BWT7 Caspase recruitment domain-containing protein 10 chr22 Not Cancer Driver No 1 hippie 94 474 40 40 0
CCBE1 CCBE1 Q6UXH8 Collagen and calcium-binding EGF domain-containing protein 1 chr18 Not Cancer Driver No 1 hippie 92 227 58 58 5
COL16A1 COL16A1 Q07092 Collagen alpha-1(XVI) chain chr1 Not Cancer Driver No 1 hippie, biogrid 192 1381 163 163 0
COL3A1 COL3A1 P02461 Collagen alpha-1(III) chain chr2 Census Yes 1 hippie 402 1182 337 337 103
COL8A1_ENST00000273342 COL8A1 P27658 Collagen alpha-1(VIII) chain chr3 Not Cancer Driver No 1 hippie 156 586 133 133 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
COPS6 COPS6 Q7L5N1 COP9 signalosome complex subunit 6 chr7 Not Cancer Driver No 1 hippie 38 30 6 6 0
CPSF6_ENST00000435070 CPSF6 Q16630 Cleavage and polyadenylation specificity factor subunit 6 chr12 Not Cancer Driver No 1 hippie 85 484 75 75 0
CRTC3 CRTC3 Q6UUV7 CREB-regulated transcription coactivator 3 chr15 Census Yes 1 hippie 70 608 68 68 0
CUL1_ENST00000602748 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 hippie 151 65 9 9 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 hippie 123 167 23 23 3
CUL4B CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 1 hippie 138 207 38 38 2
DCUN1D1 DCUN1D1 Q96GG9 DCN1-like protein 1 chr3 Not Cancer Driver No 1 hippie 34 13 0 0 0
DGCR6 DGCR6 Q14129 Protein DGCR6 chr22 Not Cancer Driver No 1 hippie 27 60 9 9 0
DRD4 DRD4 P21917 D(4) dopamine receptor chr11 Not Cancer Driver No 1 hippie 26 109 0 0 0
DROSHA_ENST00000344624 DROSHA Q9NRR4 Ribonuclease 3 chr5 Census, Compendium Yes 1 hippie 175 682 100 100 0
DVL1 DVL1 O14640 Segment polarity protein dishevelled homolog DVL-1 chr1 Not Cancer Driver No 1 hippie 73 434 38 38 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 Not Cancer Driver No 1 hippie 96 514 64 64 0
DVL3 DVL3 Q92997 Segment polarity protein dishevelled homolog DVL-3 chr3 Not Cancer Driver No 1 hippie 97 437 58 58 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FAM90A1 FAM90A1 Q86YD7 Protein FAM90A1 chr12 Not Cancer Driver No 1 hippie 123 461 121 121 0
FBXL17 FBXL17 Q9UF56 F-box/LRR-repeat protein 17 chr5 Not Cancer Driver No 1 hippie 58 194 1 1 0
FGD2 FGD2 Q7Z6J4 FYVE, RhoGEF and PH domain-containing protein 2 chr6 Not Cancer Driver No 1 hippie 113 158 26 26 0
FLNA FLNA P21333 Filamin-A chrX Census Yes 1 hippie 416 1456 214 214 28
FMR1 FMR1 Q06787 Synaptic functional regulator FMR1 chrX Not Cancer Driver No 1 hippie 124 327 70 70 3
GLYCTK GLYCTK Q8IVS8 Glycerate kinase chr3 Not Cancer Driver No 1 hippie 51 86 12 12 1
HTT HTT P42858 Huntingtin chr4 Not Cancer Driver No 1 hippie 336 666 69 69 2
INMT INMT O95050 Indolethylamine N-methyltransferase chr7 Not Cancer Driver No 1 hippie 64 5 0 0 0
KEAP1_ENST00000393623 KEAP1 Q14145 Kelch-like ECH-associated protein 1 chr19 Census, Compendium Yes 1 hippie 237 57 12 12 0
KHSRP KHSRP Q92945 Far upstream element-binding protein 2 chr19 Not Cancer Driver No 1 hippie 84 684 81 81 0
KLHL12 KLHL12 Q53G59 Kelch-like protein 12 chr1 Not Cancer Driver No 1 hippie 65 33 6 6 0
KLHL24_ENST00000242810 KLHL24 Q6TFL4 Kelch-like protein 24 chr3 Not Cancer Driver No 1 hippie 102 17 6 6 0
KLHL26 KLHL26 Q53HC5 Kelch-like protein 26 chr19 Not Cancer Driver No 2 hippie, biogrid 75 56 5 5 0
KLHL2_ENST00000226725 KLHL2 O95198 Kelch-like protein 2 chr4 Not Cancer Driver No 2 hippie, biogrid 80 42 5 5 0
KLHL3 KLHL3 Q9UH77 Kelch-like protein 3 chr5 Not Cancer Driver No 2 hippie, biogrid 67 34 9 9 32
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 hippie 114 404 58 58 0
LNPK_ENST00000272748 LNPK Q9C0E8 Endoplasmic reticulum junction formation protein lunapark chr2 Not Cancer Driver No 1 hippie 62 257 43 43 0
LNX1 LNX1 Q8TBB1 E3 ubiquitin-protein ligase LNX chr4 Not Cancer Driver No 1 hippie 117 261 40 40 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 22 24 1 1 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 hippie 10 17 1 1 0
MAPRE1 MAPRE1 Q15691 Microtubule-associated protein RP/EB family member 1 chr20 Not Cancer Driver No 1 hippie 26 109 11 11 0
MED12 MED12 Q93074 Mediator of RNA polymerase II transcription subunit 12 chrX Census, Compendium Yes 1 hippie 409 974 175 175 5
MED25 MED25 Q71SY5 Mediator of RNA polymerase II transcription subunit 25 chr19 Not Cancer Driver No 1 hippie 103 432 54 54 2
MED28 MED28 Q9H204 Mediator of RNA polymerase II transcription subunit 28 chr4 Not Cancer Driver No 1 hippie 24 101 18 18 0
MPP1 MPP1 Q00013 55 kDa erythrocyte membrane protein chrX Not Cancer Driver No 1 hippie 79 194 33 33 0
MRPL10_ENST00000351111 MRPL10 Q7Z7H8 39S ribosomal protein L10, mitochondrial chr17 Not Cancer Driver No 1 hippie 37 40 6 6 0
MTNR1A MTNR1A P48039 Melatonin receptor type 1A chr4 Not Cancer Driver No 1 hippie 72 0 0 0 0
MYO15B_ENST00000633867 MYO15B Q96JP2 Unconventional myosin-XVB chr17 Not Cancer Driver No 1 hippie 28 771 14 14 0
NDC80 NDC80 O14777 Kinetochore protein NDC80 homolog chr18 Not Cancer Driver No 1 hippie 80 313 45 45 0
NEDD8 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 10 36 5 5 0
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 hippie 75 38 4 4 0
NUDCD3 NUDCD3 Q8IVD9 NudC domain-containing protein 3 chr7 Not Cancer Driver No 1 hippie 30 199 16 16 0
PDCD6 PDCD6 O75340 Programmed cell death protein 6 chr5 Not Cancer Driver No 1 hippie 21 24 1 1 0
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 164 231 44 44 7
PEA15_ENST00000360472 PEA15 Q15121 Astrocytic phosphoprotein PEA-15 chr1 Not Cancer Driver No 1 hippie 12 35 5 5 0
PEF1 PEF1 Q9UBV8 Peflin chr1 Not Cancer Driver No 1 hippie 44 122 20 20 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PNKP PNKP Q96T60 Bifunctional polynucleotide phosphatase/kinase chr19 Not Cancer Driver No 1 hippie 53 177 23 23 4
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 Census, Compendium Yes 1 hippie 179 214 31 31 2
PRR13 PRR13 Q9NZ81 Proline-rich protein 13 chr12 Not Cancer Driver No 1 hippie 6 148 6 6 0
RGL3_ENST00000380456 RGL3 Q3MIN7 Ral guanine nucleotide dissociation stimulator-like 3 chr19 Compendium Yes 1 hippie 90 406 57 57 0
RIN1 RIN1 Q13671 Ras and Rab interactor 1 chr11 Not Cancer Driver No 1 hippie 76 376 43 43 0
RIT1_ENST00000368323 RIT1 Q92963 GTP-binding protein Rit1 chr1 Not Cancer Driver No 1 hippie 34 43 3 3 5
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RPP25L RPP25L Q8N5L8 Ribonuclease P protein subunit p25-like protein chr9 Not Cancer Driver No 1 hippie 31 113 18 18 0
SCYL1 SCYL1 Q96KG9 N-terminal kinase-like protein chr11 Not Cancer Driver No 1 hippie, biogrid 85 312 32 32 0
SDCBP_ENST00000260130 SDCBP O00560 Syntenin-1 chr8 Not Cancer Driver No 1 hippie 39 17 2 2 0
SEC13_ENST00000350697 SEC13 P55735 Protein SEC13 homolog chr3 Not Cancer Driver No 1 hippie 34 36 6 6 0
SEC16A SEC16A O15027 Protein transport protein Sec16A chr9 Not Cancer Driver No 1 hippie 285 1923 235 235 0
SEC23A SEC23A Q15436 Protein transport protein Sec23A chr14 Not Cancer Driver No 1 hippie 100 73 8 8 1
SEC23B SEC23B Q15437 Protein transport protein Sec23B chr20 Not Cancer Driver No 1 hippie 105 82 4 4 7
SEC31A_ENST00000355196 SEC31A O94979 Protein transport protein Sec31A chr4 Not Cancer Driver No 1 hippie 139 519 58 58 0
SKP1_ENST00000517625 SKP1 P63208 S-phase kinase-associated protein 1 chr5 Not Cancer Driver No 1 hippie 19 95 17 17 0
SLC16A11 SLC16A11 Q8NCK7 Monocarboxylate transporter 11 chr17 Not Cancer Driver No 1 hippie 33 72 5 5 0
SNX20 SNX20 Q7Z614 Sorting nexin-20 chr16 Not Cancer Driver No 1 hippie 56 72 12 12 0
SYNE4 SYNE4 Q8N205 Nesprin-4 chr19 Not Cancer Driver No 1 hippie 50 236 31 31 0
TACC3 TACC3 Q9Y6A5 Transforming acidic coiled-coil-containing protein 3 chr4 Not Cancer Driver No 1 hippie, biogrid 98 707 81 81 0
TAOK2 TAOK2 Q9UL54 Serine/threonine-protein kinase TAO2 chr16 Not Cancer Driver No 1 hippie 191 666 102 102 0
TBC1D10C TBC1D10C Q8IV04 Carabin chr11 Not Cancer Driver No 1 hippie 58 192 32 32 0
TCEANC_ENST00000380600 TCEANC Q8N8B7 Transcription elongation factor A N-terminal and central domain-containing protein chrX Not Cancer Driver No 1 hippie 38 138 12 12 0
TTBK2 TTBK2 Q6IQ55 Tau-tubulin kinase 2 chr15 Not Cancer Driver No 1 hippie 151 848 107 107 0
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 hippie 16 16 3 3 0
UBE2M UBE2M P61081 NEDD8-conjugating enzyme Ubc12 chr19 Not Cancer Driver No 1 hippie 30 32 6 6 0
UBXN1_ENST00000301935 UBXN1 Q04323 UBX domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 35 271 33 33 0
UBXN7 UBXN7 O94888 UBX domain-containing protein 7 chr3 Not Cancer Driver No 1 hippie 65 327 39 39 0
VEGFB VEGFB P49765 Vascular endothelial growth factor B chr11 Not Cancer Driver No 1 hippie 25 125 22 22 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 hippie 142 117 36 36 133
VTA1 VTA1 Q9NP79 Vacuolar protein sorting-associated protein VTA1 homolog chr6 Not Cancer Driver No 1 hippie 49 152 25 25 0
ZBP1 ZBP1 Q9H171 Z-DNA-binding protein 1 chr20 Not Cancer Driver No 1 hippie 97 385 80 80 0
ZBTB4_ENST00000380599 ZBTB4 Q9P1Z0 Zinc finger and BTB domain-containing protein 4 chr17 Not Cancer Driver No 1 hippie 140 788 109 109 0