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IVL ,IVL ,P07476
  • Uniprot Accession= P07476
  • Ensembl Transcript= ENST00000368764.3
  • Uniprot Name= IVL
  • Name= Involucrin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 38
  • Number of Interaction partner in biogrid: 103
  • Number of Interaction partner in hippie: 124
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD9 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 2 intact, hippie, biogrid 69 28 5 5 12
ACD_ENST00000620761 ACD Q96AP0 Adrenocortical dysplasia protein homolog chr16 Not Cancer Driver No 1 hippie 49 256 34 34 1
ACTA2 ACTA2 P62736 Actin, aortic smooth muscle chr10 Not Cancer Driver No 1 hippie, biogrid 50 39 4 4 17
AGPAT1 AGPAT1 Q99943 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha chr6 Not Cancer Driver No 1 hippie, biogrid 36 38 5 5 0
ANKRD36B ANKRD36B Q8N2N9 Ankyrin repeat domain-containing protein 36B chr2 Not Cancer Driver No 1 hippie, biogrid 63 803 39 39 0
ATP6AP2 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 56 0 0 0 2
BLMH BLMH Q13867 Bleomycin hydrolase chr17 Not Cancer Driver No 1 hippie, biogrid 54 15 1 1 0
BPHL BPHL Q86WA6 Valacyclovir hydrolase chr6 Not Cancer Driver No 1 hippie, biogrid 35 12 1 1 0
C18orf21 C18orf21 Q32NC0 UPF0711 protein C18orf21 chr18 Not Cancer Driver No 1 hippie, biogrid 21 112 12 12 0
CALML5 CALML5 Q9NZT1 Calmodulin-like protein 5 chr10 Not Cancer Driver No 1 hippie, biogrid 34 98 21 21 0
CASP14 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 50 84 13 13 0
CCNYL1 CCNYL1 Q8N7R7 Cyclin-Y-like protein 1 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 31 100 8 8 0
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 69 14 5 5 0
CDH1 CDH1 P12830 Cadherin-1 chr16 Census, Compendium Yes 1 hippie 150 400 82 82 5
CDK15 CDK15 Q96Q40 Cyclin-dependent kinase 15 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 66 35 4 4 0
CERS3 CERS3 Q8IU89 Ceramide synthase 3 chr15 Not Cancer Driver No 1 hippie, biogrid 90 21 10 10 0
CHMP3 CHMP3 Q9Y3E7 Charged multivesicular body protein 3 chr2 Not Cancer Driver No 1 hippie, biogrid 25 137 13 13 0
CORO1C_ENST00000541050 CORO1C Q9ULV4 Coronin-1C chr12 Not Cancer Driver No 1 hippie, biogrid 61 84 13 13 0
CSGALNACT1_ENST00000332246 CSGALNACT1 Q8TDX6 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 91 131 28 28 0
CSTA CSTA P01040 Cystatin-A chr3 Not Cancer Driver No 1 hippie 16 54 9 9 0
CTSD CTSD P07339 Cathepsin D chr11 Not Cancer Driver No 1 hippie, biogrid 57 6 1 1 2
DDX19B DDX19B Q9UMR2 ATP-dependent RNA helicase DDX19B chr16 Not Cancer Driver No 2 intact, hippie, biogrid 44 113 9 9 0
DHRS2_ENST00000250383 DHRS2 Q13268 Dehydrogenase/reductase SDR family member 2, mitochondrial chr14 Not Cancer Driver No 1 intact, hippie 47 0 0 0 0
DKK2 DKK2 Q9UBU2 Dickkopf-related protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 108 70 22 22 0
DPPA4 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 hippie, biogrid 94 180 46 46 0
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 hippie 483 1124 204 204 6
EEF1A2 EEF1A2 Q05639 Elongation factor 1-alpha 2 chr20 Not Cancer Driver No 1 hippie, biogrid 74 121 17 17 3
EIF2B5 EIF2B5 Q13144 Translation initiation factor eIF-2B subunit epsilon chr3 Not Cancer Driver No 1 hippie, biogrid 76 179 16 16 29
ELAC2 ELAC2 Q9BQ52 Zinc phosphodiesterase ELAC protein 2 chr17 Not Cancer Driver No 1 hippie, biogrid 86 208 30 30 10
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 Census, Compendium Yes 1 hippie, biogrid 92 208 22 22 2
EVPL_ENST00000301607 EVPL Q92817 Envoplakin chr17 Not Cancer Driver No 1 hippie 290 1222 169 169 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FCF1 FCF1 Q9Y324 rRNA-processing protein FCF1 homolog chr14 Not Cancer Driver No 2 intact, hippie, biogrid 28 46 4 4 0
FMNL2 FMNL2 Q96PY5 Formin-like protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 119 409 56 56 0
FNDC1 FNDC1 Q4ZHG4 Fibronectin type III domain-containing protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 399 1362 302 302 0
FNDC5_ENST00000640867 FNDC5 Q8NAU1 Fibronectin type III domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 17 74 8 8 0
FRMD1 FRMD1 Q8N878 FERM domain-containing protein 1 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 82 259 36 36 0
FSTL1 FSTL1 Q12841 Follistatin-related protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 41 51 7 7 0
FTH1_ENST00000620041 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 2 hippie, biogrid 20 57 7 7 0
GABPA_ENST00000400075 GABPA Q06546 GA-binding protein alpha chain chr21 Not Cancer Driver No 1 hippie, biogrid 58 103 8 8 0
GID8 GID8 Q9NWU2 Glucose-induced degradation protein 8 homolog chr20 Not Cancer Driver No 2 intact, hippie 30 60 6 6 0
GMCL1 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 33 80 2 2 0
GOT1 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 Not Cancer Driver No 1 hippie, biogrid 56 35 5 5 0
GUCY1A1_ENST00000513574 GUCY1A1 Q02108 Guanylate cyclase soluble subunit alpha-1 chr4 Not Cancer Driver No 1 hippie 181 54 8 8 0
HCN1 HCN1 O60741 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 chr5 Not Cancer Driver No 1 hippie, biogrid 432 365 187 187 16
HDAC9_ENST00000432645 HDAC9 Q9UKV0 Histone deacetylase 9 chr7 Not Cancer Driver No 1 hippie, biogrid 286 631 178 178 0
HIST1H4A H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 15 31 5 5 0
HIST1H4B H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 29 31 6 6 0
HIST1H4C H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 29 31 7 7 0
HIST1H4D H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 32 31 8 8 0
HIST1H4E H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 45 31 14 14 0
HIST1H4F H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 30 31 7 7 0
HIST1H4H H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 22 31 9 9 0
HIST1H4I H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 33 31 10 10 0
HIST1H4J H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 26 31 9 9 0
HIST1H4K H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 44 31 13 13 0
HIST1H4L H4-16 P62805 Histone H4 chr6 Not Cancer Driver No 1 intact 25 31 14 14 0
HIST4H4 H4-16 P62805 Histone H4 chr12 Not Cancer Driver No 1 intact 21 31 7 7 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 70 290 58 58 4
HSF2 HSF2 Q03933 Heat shock factor protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 64 292 37 37 0
ITGA9 ITGA9 Q13797 Integrin alpha-9 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 137 70 14 14 0
IVL IVL P07476 Involucrin chr1 Not Cancer Driver No 1 hippie 115 585 115 115 0
JADE1_ENST00000512960 JADE1 Q6IE81 Protein Jade-1 chr4 Not Cancer Driver No 1 intact, hippie, biogrid 94 409 47 47 0
KAT7 KAT7 O95251 Histone acetyltransferase KAT7 chr17 Census Yes 1 hippie, biogrid 97 327 47 47 0
KLHL11 KLHL11 Q9NVR0 Kelch-like protein 11 chr17 Not Cancer Driver No 1 hippie, biogrid 73 85 8 8 0
KRT1 KRT1 P04264 Keratin, type II cytoskeletal 1 chr12 Not Cancer Driver No 1 hippie 133 426 98 98 20
L2HGDH_ENST00000421284 L2HGDH Q9H9P8 L-2-hydroxyglutarate dehydrogenase, mitochondrial chr14 Not Cancer Driver No 3 intact, hippie, biogrid 52 0 0 0 8
LACC1 LACC1 Q8IV20 Purine nucleoside phosphorylase LACC1 chr13 Not Cancer Driver No 1 intact, hippie 50 4 0 0 1
LIAS LIAS O43766 Lipoyl synthase, mitochondrial chr4 Not Cancer Driver No 1 hippie, biogrid 46 82 10 10 1
LRRC10 LRRC10 Q5BKY1 Leucine-rich repeat-containing protein 10 chr12 Not Cancer Driver No 1 hippie, biogrid 52 38 11 11 0
LY86 LY86 O95711 Lymphocyte antigen 86 chr6 Not Cancer Driver No 1 hippie, biogrid 29 0 0 0 0
MBD4 MBD4 O95243 Methyl-CpG-binding domain protein 4 chr3 Not Cancer Driver No 1 hippie, biogrid 61 268 27 27 0
MBNL1_ENST00000463374 MBNL1 Q9NR56 Muscleblind-like protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 56 153 20 20 0
MPI MPI P34949 Mannose-6-phosphate isomerase chr15 Not Cancer Driver No 2 hippie, biogrid 35 61 10 10 13
NHLRC2 NHLRC2 Q8NBF2 NHL repeat-containing protein 2 chr10 Not Cancer Driver No 1 hippie 74 103 12 12 0
NPPA NPPA P01160 Natriuretic peptides A chr1 Not Cancer Driver No 2 intact, hippie, biogrid 32 71 14 14 1
NRSN1 NRSN1 Q8IZ57 Neurensin-1 chr6 Not Cancer Driver No 1 hippie, biogrid 46 17 9 9 0
NT5C1A NT5C1A Q9BXI3 Cytosolic 5'-nucleotidase 1A chr1 Not Cancer Driver No 1 hippie, biogrid 86 95 16 16 0
NUDT3 NUDT3 O95989 Diphosphoinositol polyphosphate phosphohydrolase 1 chr6 Not Cancer Driver No 1 hippie, biogrid 22 38 5 5 0
OR13C3 OR13C3 Q8NGS6 Olfactory receptor 13C3 chr9 Not Cancer Driver No 1 hippie, biogrid 99 0 0 0 0
OR2A4 OR2A4 O95047 Olfactory receptor 2A4 chr6 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
P2RX6 P2RX6 O15547 P2X purinoceptor 6 chr22 Not Cancer Driver No 1 hippie, biogrid 33 43 1 1 0
PCP4 PCP4 P48539 Calmodulin regulator protein PCP4 chr21 Not Cancer Driver No 1 hippie, biogrid 16 62 16 16 0
PDE4DIP_ENST00000369354 PDE4DIP Q5VU43 Myomegalin chr1 Census, Compendium Yes 2 intact, hippie, biogrid 555 1633 395 395 0
PHF11 PHF11 Q9UIL8 PHD finger protein 11 chr13 Not Cancer Driver No 1 hippie, biogrid 34 82 10 10 0
PHF8 PHF8 Q9UPP1 Histone lysine demethylase PHF8 chrX Not Cancer Driver No 1 hippie, biogrid 154 603 93 93 1
PI4KA PI4KA P42356 Phosphatidylinositol 4-kinase alpha chr22 Not Cancer Driver No 1 hippie, biogrid 267 142 11 11 1
PIGT PIGT Q969N2 GPI transamidase component PIG-T chr20 Not Cancer Driver No 1 hippie, biogrid 51 36 6 6 1
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 57 99 13 13 23
PKP1 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 106 190 26 26 0
POF1B_ENST00000262753 POF1B Q8WVV4 Protein POF1B chrX Not Cancer Driver No 1 hippie, biogrid 154 391 104 104 1
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 Census, Compendium Yes 1 hippie 113 31 6 6 9
POU3F3 POU3F3 P20264 POU domain, class 3, transcription factor 3 chr2 Not Cancer Driver No 1 hippie, biogrid 43 402 30 30 4
PPP2R2B_ENST00000394409 PPP2R2B Q00005 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform chr5 Not Cancer Driver No 1 hippie, biogrid 101 76 22 22 0
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 intact 83 72 6 6 0
PRXL2A PRXL2A Q9BRX8 Peroxiredoxin-like 2A chr10 Not Cancer Driver No 1 hippie 34 0 0 0 0
PTDSS1 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 81 44 7 7 3
RANBP3 RANBP3 Q9H6Z4 Ran-binding protein 3 chr19 Not Cancer Driver No 1 hippie, biogrid 71 468 54 54 0
RBM24 RBM24 Q9BX46 RNA-binding protein 24 chr6 Not Cancer Driver No 3 intact, hippie, biogrid 29 20 3 3 0
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 Not Cancer Driver No 1 hippie, biogrid 38 69 9 9 0
RIPPLY3 RIPPLY3 P57055 Protein ripply3 chr21 Not Cancer Driver No 1 hippie, biogrid 44 190 44 44 0
RNF115 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 hippie, biogrid 30 136 14 14 0
RNF25 RNF25 Q96BH1 E3 ubiquitin-protein ligase RNF25 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 56 285 42 42 0
SARAF SARAF Q96BY9 Store-operated calcium entry-associated regulatory factor chr8 Not Cancer Driver No 1 hippie, biogrid 32 73 8 8 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 hippie, biogrid 142 47 28 28 0
SERPINB5 SERPINB5 P36952 Serpin B5 chr18 Not Cancer Driver No 1 hippie, biogrid 57 50 7 7 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie, biogrid 27 75 9 9 0
SH2D3A SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 68 305 40 40 0
SINHCAF_ENST00000454658 SINHCAF Q9NP50 SIN3-HDAC complex-associated factor chr12 Not Cancer Driver No 1 intact, hippie 24 108 10 10 0
SLC25A6 SLC25A6 P12236 ADP/ATP translocase 3 chrX Not Cancer Driver No 1 hippie, biogrid 41 0 0 0 0
SLC35F2 SLC35F2 Q8IXU6 Solute carrier family 35 member F2 chr11 Not Cancer Driver No 1 hippie, biogrid 53 12 0 0 0
SLC37A4_ENST00000545985 SLC37A4 O43826 Glucose-6-phosphate exchanger SLC37A4 chr11 Not Cancer Driver No 1 hippie, biogrid 41 17 1 1 32
SPRR3 SPRR3 Q9UBC9 Small proline-rich protein 3 chr1 Not Cancer Driver No 1 hippie 57 169 57 57 0
SRRT SRRT Q9BXP5 Serrate RNA effector molecule homolog chr7 Not Cancer Driver No 1 hippie, biogrid 146 595 108 108 0
SSBP2_ENST00000320672 SSBP2 P81877 Single-stranded DNA-binding protein 2 chr5 Not Cancer Driver No 1 hippie, biogrid 36 296 29 29 0
SSUH2 SSUH2 Q9Y2M2 Protein SSUH2 homolog chr3 Not Cancer Driver No 1 hippie, biogrid 58 76 7 7 0
ST6GALNAC6_ENST00000373146 ST6GALNAC6 Q969X2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 chr9 Not Cancer Driver No 1 hippie, biogrid 44 86 13 13 0
ST7 ST7 Q9NRC1 Suppressor of tumorigenicity 7 protein chr7 Not Cancer Driver No 1 hippie, biogrid 62 64 5 5 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 hippie, biogrid 75 135 14 14 9
STX17_ENST00000534052 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 27 81 4 4 0
SUSD3 SUSD3 Q96L08 Sushi domain-containing protein 3 chr9 Not Cancer Driver No 3 intact, hippie, biogrid 37 124 15 15 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 Not Cancer Driver No 1 intact, hippie 42 302 26 26 0
TBC1D22B TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 2 intact, hippie, biogrid 55 205 27 27 0
TEFM TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 37 26 5 5 0
TSPAN6 TSPAN6 O43657 Tetraspanin-6 chrX Not Cancer Driver No 1 hippie, biogrid 34 0 0 0 0
UCHL5 UCHL5 Q9Y5K5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 chr1 Not Cancer Driver No 1 hippie 33 41 7 7 0
UGT1A10 UGT1A10 Q9HAW8 UDP-glucuronosyltransferase 1A10 chr2 Not Cancer Driver No 3 hippie, biogrid 114 11 2 2 0
UPK1A_ENST00000222275 UPK1A O00322 Uroplakin-1a chr19 Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 0
WDR77 WDR77 Q9BQA1 Methylosome protein 50 chr1 Not Cancer Driver No 1 intact 30 41 2 2 0
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 hippie 79 108 9 9 3
ZC3HC1 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 70 250 34 34 0
ZDHHC19 ZDHHC19 Q8WVZ1 Palmitoyltransferase ZDHHC19 chr3 Not Cancer Driver No 1 hippie, biogrid 48 35 10 10 0
ZDHHC6 ZDHHC6 Q9H6R6 Palmitoyltransferase ZDHHC6 chr10 Not Cancer Driver No 1 hippie, biogrid 43 11 3 3 0
ZFPL1 ZFPL1 O95159 Zinc finger protein-like 1 chr11 Not Cancer Driver No 1 hippie, biogrid 40 127 16 16 0
ZIC1 ZIC1 Q15915 Zinc finger protein ZIC 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 187 246 113 113 1
ZNF550_ENST00000457177 ZNF550 Q7Z398 Zinc finger protein 550 chr19 Not Cancer Driver No 1 hippie, biogrid 49 109 17 17 0
ZSCAN12_ENST00000396827 ZSCAN12 O43309-2 Isoform 2 of Zinc finger and SCAN domain-containing protein 12 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 44 237 25 25 0
ZSCAN20 ZSCAN20 P17040 Zinc finger and SCAN domain-containing protein 20 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 180 534 84 84 0