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IQGAP3 ,IQGAP3 ,Q86VI3
  • Uniprot Accession= Q86VI3
  • Ensembl Transcript= ENST00000361170.6
  • Uniprot Name= IQGAP3
  • Name= Ras GTPase-activating-like protein IQGAP3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 24
  • Number of Interaction partner in biogrid: 67
  • Number of Interaction partner in hippie: 121
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACRBP ACRBP Q8NEB7 Acrosin-binding protein chr12 Not Cancer Driver No 1 hippie, biogrid 81 200 27 27 0
ACTL6B ACTL6B O94805 Actin-like protein 6B chr7 Not Cancer Driver No 1 hippie, biogrid 77 108 19 19 3
AGR2 AGR2 O95994 Anterior gradient protein 2 homolog chr7 Not Cancer Driver No 1 hippie 23 20 2 2 0
AMZ1 AMZ1 Q400G9 Archaemetzincin-1 chr7 Not Cancer Driver No 1 hippie, biogrid 78 147 18 18 0
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie, biogrid 144 767 104 104 2
APBA3 APBA3 O96018 Amyloid-beta A4 precursor protein-binding family A member 3 chr19 Not Cancer Driver No 1 hippie, biogrid 55 306 43 43 0
ARMC5_ENST00000563544 ARMC5 Q96C12 Armadillo repeat-containing protein 5 chr16 Not Cancer Driver No 1 hippie, biogrid 135 267 41 41 17
ATG7 ATG7 O95352 Ubiquitin-like modifier-activating enzyme ATG7 chr3 Compendium Yes 1 hippie, biogrid 77 53 8 8 6
B4GALT2_ENST00000372324 B4GALT2 O60909 Beta-1,4-galactosyltransferase 2 chr1 Not Cancer Driver No 1 hippie, biogrid 53 105 14 14 0
BCL11B BCL11B Q9C0K0 B-cell lymphoma/leukemia 11B chr14 Census, Compendium Yes 1 hippie, biogrid 156 699 114 114 2
BRD7_ENST00000394688 BRD7 Q9NPI1 Bromodomain-containing protein 7 chr16 Compendium Yes 1 hippie 82 482 57 57 0
BSND BSND Q8WZ55 Barttin chr1 Not Cancer Driver No 1 hippie, biogrid 57 209 36 36 4
C12orf74_ENST00000544406 C12orf74 Q6ZR37-3 Isoform 3 of Pleckstrin homology domain-containing family G member 7 chr12 Not Cancer Driver No 1 hippie, biogrid 29 159 26 26 0
CACNG4 CACNG4 Q9UBN1 Voltage-dependent calcium channel gamma-4 subunit chr17 Not Cancer Driver No 1 hippie, biogrid 51 71 17 17 0
CALM1 CALM1 P0DP23 Calmodulin-1 chr14 Not Cancer Driver No 2 intact, hippie 19 115 15 15 7
CALM3_ENST00000596362 CALM3 P0DP25 Calmodulin-3 chr19 Not Cancer Driver No 1 intact 17 115 10 10 3
CARMIL2 CARMIL2 Q6F5E8 Capping protein, Arp2/3 and myosin-I linker protein 2 chr16 Not Cancer Driver No 1 hippie 154 669 75 75 4
CBWD1_ENST00000356521 CBWD1 Q9BRT8 COBW domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie, biogrid 27 62 8 8 0
CBX6 CBX6 O95503 Chromobox protein homolog 6 chr22 Not Cancer Driver No 1 hippie, biogrid 57 335 54 54 0
CCDC198_ENST00000216445 CCDC198 Q9NVL8 Uncharacterized protein CCDC198 chr14 Not Cancer Driver No 1 intact, hippie 46 255 40 40 0
CDC16_ENST00000356221 CDC16 Q13042 Cell division cycle protein 16 homolog chr13 Not Cancer Driver No 2 intact, hippie, biogrid 68 54 7 7 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 2 intact, hippie, biogrid 39 23 2 2 1
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CIAO2A CIAO2A Q9H5X1 Cytosolic iron-sulfur assembly component 2A chr15 Not Cancer Driver No 1 hippie 24 28 4 4 0
CLUAP1_ENST00000576634 CLUAP1 Q96AJ1 Clusterin-associated protein 1 chr16 Not Cancer Driver No 1 hippie 48 203 22 22 0
CRYAA CRYAA P02489 Alpha-crystallin A chain chr21 Not Cancer Driver No 1 hippie, biogrid 34 42 11 11 10
CRYAB_ENST00000616970 CRYAB P02511 Alpha-crystallin B chain chr11 Not Cancer Driver No 1 hippie, biogrid 22 59 11 11 4
CRYBB3 CRYBB3 P26998 Beta-crystallin B3 chr22 Not Cancer Driver No 1 hippie, biogrid 31 35 6 6 2
D2HGDH D2HGDH Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 61 46 1 1 0
DMRTB1 DMRTB1 Q96MA1 Doublesex- and mab-3-related transcription factor B1 chr1 Not Cancer Driver No 1 hippie, biogrid 61 284 48 48 0
DMWD DMWD Q09019 Dystrophia myotonica WD repeat-containing protein chr19 Not Cancer Driver No 1 intact 66 374 24 24 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
EPS15L1_ENST00000248070 EPS15L1 Q9UBC2 Epidermal growth factor receptor substrate 15-like 1 chr19 Not Cancer Driver No 1 hippie 109 603 76 76 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
FAM167A FAM167A Q96KS9 Protein FAM167A chr8 Not Cancer Driver No 1 hippie, biogrid 33 116 17 17 0
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact, hippie 173 241 26 26 37
FLRT1 FLRT1 Q9NZU1 Leucine-rich repeat transmembrane protein FLRT1 chr11 Not Cancer Driver No 1 hippie, biogrid 74 90 9 9 0
FOXD4 FOXD4 Q12950 Forkhead box protein D4 chr9 Not Cancer Driver No 1 hippie, biogrid 77 327 55 55 0
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 hippie, biogrid 19 36 7 7 2
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GALNT9 GALNT9 Q9HCQ5 Polypeptide N-acetylgalactosaminyltransferase 9 chr12 Not Cancer Driver No 1 hippie, biogrid 80 32 2 2 0
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 Not Cancer Driver No 1 hippie, biogrid 82 75 19 19 0
GRK6_ENST00000355472 GRK6 P43250 G protein-coupled receptor kinase 6 chr5 Not Cancer Driver No 1 hippie, biogrid 65 68 10 10 0
GSN GSN P06396 Gelsolin chr9 Not Cancer Driver No 1 intact, hippie 76 316 28 28 2
HECTD1 HECTD1 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 chr14 Not Cancer Driver No 1 hippie 274 991 108 108 0
HERC1 HERC1 Q15751 Probable E3 ubiquitin-protein ligase HERC1 chr15 Not Cancer Driver No 1 hippie, biogrid 487 1344 129 129 1
HES6 HES6 Q96HZ4 Transcription cofactor HES-6 chr2 Not Cancer Driver No 1 hippie, biogrid 10 130 6 6 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HR HR O43593 Lysine-specific demethylase hairless chr8 Not Cancer Driver No 1 hippie, biogrid 130 587 74 74 3
IL17RA IL17RA Q96F46 Interleukin-17 receptor A chr22 Not Cancer Driver No 1 intact, hippie, biogrid 92 301 20 20 0
INAVA_ENST00000367342 INAVA Q3KP66 Innate immunity activator protein chr1 Not Cancer Driver No 1 hippie 112 553 98 98 1
IQCB1 IQCB1 Q15051 IQ calmodulin-binding motif-containing protein 1 chr3 Not Cancer Driver No 1 hippie 72 88 8 8 0
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX Compendium Yes 1 intact, hippie, biogrid 71 337 39 39 0
IST1_ENST00000541571 IST1 P53990 IST1 homolog chr16 Not Cancer Driver No 1 hippie, biogrid 31 185 17 17 0
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KIFAP3 KIFAP3 Q92845 Kinesin-associated protein 3 chr1 Not Cancer Driver No 1 hippie 116 71 10 10 0
KLF11 KLF11 O14901 Krueppel-like factor 11 chr2 Not Cancer Driver No 1 hippie 57 308 38 38 2
KLHL14 KLHL14 Q9P2G3 Kelch-like protein 14 chr18 Not Cancer Driver No 1 hippie, biogrid 117 81 10 10 0
KRT2 KRT2 P35908 Keratin, type II cytoskeletal 2 epidermal chr12 Not Cancer Driver No 1 hippie, biogrid 122 335 59 59 15
KRT38 KRT38 O76015 Keratin, type I cuticular Ha8 chr17 Not Cancer Driver No 1 hippie, biogrid 89 52 15 15 0
LGR4 LGR4 Q9BXB1 Leucine-rich repeat-containing G-protein coupled receptor 4 chr11 Not Cancer Driver No 1 hippie 108 16 3 3 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRRC29 LRRC29 Q8WV35 Leucine-rich repeat-containing protein 29 chr16 Not Cancer Driver No 1 hippie, biogrid 20 47 2 2 0
LRRC31 LRRC31 Q6UY01 Leucine-rich repeat-containing protein 31 chr3 Not Cancer Driver No 1 hippie 109 80 10 10 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
MBIP MBIP Q9NS73 MAP3K12-binding inhibitory protein 1 chr14 Not Cancer Driver No 1 hippie, biogrid 47 190 20 20 0
MECOM_ENST00000494292 MECOM Q03112 Histone-lysine N-methyltransferase MECOM chr3 Census, Compendium Yes 1 hippie 287 749 159 159 3
MYCBPAP_ENST00000436259 MYCBPAP Q8TBZ2 MYCBP-associated protein chr17 Not Cancer Driver No 1 hippie, biogrid 144 534 81 81 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYH2_ENST00000397183 MYH2 Q9UKX2 Myosin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 572 1073 338 338 1
MYL4_ENST00000572316 MYL4 P12829 Myosin light chain 4 chr17 Not Cancer Driver No 1 hippie, biogrid 29 104 11 11 1
MYL6_ENST00000548293 MYL6 P60660 Myosin light polypeptide 6 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 13 17 1 1 0
NCAPH2_ENST00000420993 NCAPH2 Q6IBW4 Condensin-2 complex subunit H2 chr22 Not Cancer Driver No 2 hippie, biogrid 67 335 39 39 0
NFKB1_ENST00000505458 NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit chr4 Not Cancer Driver No 1 hippie 104 344 38 38 0
NINL NINL Q9Y2I6 Ninein-like protein chr20 Not Cancer Driver No 1 hippie 230 881 150 150 0
NPAS1_ENST00000449844 NPAS1 Q99742 Neuronal PAS domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 53 309 23 23 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
PASK_ENST00000234040 PASK Q96RG2 PAS domain-containing serine/threonine-protein kinase chr2 Not Cancer Driver No 1 hippie 181 412 62 62 0
PEX19 PEX19 P40855 Peroxisomal biogenesis factor 19 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 41 266 38 38 0
PKN3 PKN3 Q6P5Z2 Serine/threonine-protein kinase N3 chr9 Not Cancer Driver No 1 hippie, biogrid 99 392 49 49 0
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 Not Cancer Driver No 1 hippie, biogrid 72 69 7 7 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRDM16 PRDM16 Q9HAZ2 Histone-lysine N-methyltransferase PRDM16 chr1 Census Yes 1 hippie 254 830 152 152 1
PRKAG3_ENST00000529249 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 74 144 25 25 0
PSKH2 PSKH2 Q96QS6 Serine/threonine-protein kinase H2 chr8 Not Cancer Driver No 1 intact, hippie, biogrid 86 87 19 19 0
PTBP3_ENST00000374255 PTBP3 O95758 Polypyrimidine tract-binding protein 3 chr9 Not Cancer Driver No 1 intact, hippie 61 114 9 9 0
PUS7_ENST00000469408 PUS7 Q96PZ0 Pseudouridylate synthase 7 homolog chr7 Not Cancer Driver No 1 hippie, biogrid 73 162 17 17 1
PXN_ENST00000228307 PXN P49023 Paxillin chr12 Not Cancer Driver No 1 intact, hippie 62 341 24 24 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 3 intact, hippie 66 2 1 1 6
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 2 hippie, biogrid 24 0 0 0 4
RFXANK_ENST00000407360 RFXANK O14593 DNA-binding protein RFXANK chr19 Not Cancer Driver No 1 hippie, biogrid 22 120 6 6 1
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 52 19 2 2 0
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 30 53 7 7 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 Not Cancer Driver No 1 hippie 20 10 0 0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOV RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 25 47 5 5 0
RIPK4_ENST00000352483 RIPK4 P57078 Receptor-interacting serine/threonine-protein kinase 4 chr21 Not Cancer Driver No 1 intact, hippie 119 232 34 34 3
RPS6KL1_ENST00000557413 RPS6KL1 Q9Y6S9 Ribosomal protein S6 kinase-like 1 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 60 161 16 16 0
SF3B3 SF3B3 Q15393 Splicing factor 3B subunit 3 chr16 Not Cancer Driver No 1 hippie, biogrid 154 145 19 19 0
SIRT6 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 Not Cancer Driver No 1 hippie, biogrid 33 164 12 12 0
SOHLH1_ENST00000298466 SOHLH1 Q5JUK2 Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 chr9 Not Cancer Driver No 1 hippie, biogrid 48 252 39 39 0
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 intact, hippie 39 312 39 39 0
SPRED1 SPRED1 Q7Z699 Sprouty-related, EVH1 domain-containing protein 1 chr15 Not Cancer Driver No 1 intact, hippie 71 194 35 35 2
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
STK32C STK32C Q86UX6 Serine/threonine-protein kinase 32C chr10 Not Cancer Driver No 1 hippie, biogrid 49 172 10 10 0
SULT1C4 SULT1C4 O75897 Sulfotransferase 1C4 chr2 Not Cancer Driver No 1 hippie, biogrid 57 19 5 5 0
SWSAP1 SWSAP1 Q6NVH7 ATPase SWSAP1 chr19 Not Cancer Driver No 1 hippie, biogrid 26 104 14 14 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 Not Cancer Driver No 1 intact, hippie 42 302 26 26 0
TFPT TFPT P0C1Z6 TCF3 fusion partner chr19 Census Yes 1 hippie, biogrid 41 237 41 41 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIM52 TRIM52 Q96A61 E3 ubiquitin-protein ligase TRIM52 chr5 Not Cancer Driver No 1 hippie, biogrid 23 147 13 13 0
TRMU TRMU O75648 Mitochondrial tRNA-specific 2-thiouridylase 1 chr22 Not Cancer Driver No 1 hippie, biogrid 40 28 5 5 2
TTYH1_ENST00000376530 TTYH1 Q9H313 Protein tweety homolog 1 chr19 Not Cancer Driver No 1 hippie, biogrid 56 21 3 3 0
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 hippie, biogrid 40 63 11 11 5
TULP2 TULP2 O00295 Tubby-related protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 73 311 43 43 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16