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INTS3_ENST00000435409 ,INTS3 ,Q68E01
  • Uniprot Accession= Q68E01
  • Ensembl Transcript= ENST00000435409.6
  • Uniprot Name= INTS3
  • Name= Integrator complex subunit 3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 20
  • Number of Interaction partner in biogrid: 42
  • Number of Interaction partner in hippie: 113
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADORA3 ADORA3 P0DMS8 Adenosine receptor A3 chr1 Not Cancer Driver No 1 hippie, biogrid 45 4 1 1 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
ALDH3A2_ENST00000579855 ALDH3A2 P51648 Aldehyde dehydrogenase family 3 member A2 chr17 Not Cancer Driver No 1 hippie, biogrid 47 5 2 2 26
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 Census, Compendium Yes 1 hippie 338 106 14 14 1
ATRIP ATRIP Q8WXE1 ATR-interacting protein chr3 Not Cancer Driver No 1 hippie 76 383 32 32 0
BLM BLM P54132 Bloom syndrome protein chr15 Census Yes 1 hippie 153 667 70 70 8
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
BTNL9 BTNL9 Q6UXG8 Butyrophilin-like protein 9 chr5 Not Cancer Driver No 1 hippie, biogrid 69 87 4 4 0
CAPZA2 CAPZA2 P47755 F-actin-capping protein subunit alpha-2 chr7 Not Cancer Driver No 1 hippie 37 19 0 0 0
CD70_ENST00000245903 CD70 P32970 CD70 antigen chr19 Not Cancer Driver No 2 hippie, biogrid 33 11 2 2 0
CDC5L CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 intact, hippie 100 618 77 77 0
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
COMTD1 COMTD1 Q86VU5 Catechol O-methyltransferase domain-containing protein 1 chr10 Not Cancer Driver No 3 intact, hippie, biogrid 11 23 0 0 0
CPNE2_ENST00000535318 CPNE2 Q96FN4 Copine-2 chr16 Not Cancer Driver No 2 intact, hippie, biogrid 62 32 4 4 0
CTDP1 CTDP1 Q9Y5B0 RNA polymerase II subunit A C-terminal domain phosphatase chr18 Not Cancer Driver No 1 hippie 121 624 87 87 0
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 hippie 48 53 6 6 1
DNAI2 DNAI2 Q9GZS0 Dynein axonemal intermediate chain 2 chr17 Not Cancer Driver No 1 hippie, biogrid 136 209 47 47 0
DNAJB6 DNAJB6 O75190 DnaJ homolog subfamily B member 6 chr7 Not Cancer Driver No 1 hippie, biogrid 33 198 17 17 3
E2F3 E2F3 O00716 Transcription factor E2F3 chr6 Not Cancer Driver No 1 intact, hippie 46 253 20 20 0
EED_ENST00000263360 EED O75530 Polycomb protein EED chr11 Census Yes 1 hippie 64 79 11 11 6
EEF1AKMT3 EEF1AKMT3 Q96AZ1 EEF1A lysine methyltransferase 3 chr12 Not Cancer Driver No 1 hippie 23 33 1 1 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FAF2 FAF2 Q96CS3 FAS-associated factor 2 chr5 Not Cancer Driver No 1 hippie, biogrid 54 171 16 16 0
FOXL1 FOXL1 Q12952 Forkhead box protein L1 chr16 Not Cancer Driver No 1 intact, hippie 62 212 26 26 0
GLCE GLCE O94923 D-glucuronyl C5-epimerase chr15 Not Cancer Driver No 1 hippie, biogrid 73 46 9 9 0
GPR17 GPR17 Q13304 Uracil nucleotide/cysteinyl leukotriene receptor chr2 Not Cancer Driver No 1 hippie, biogrid 57 16 4 4 0
GPR45 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 97 0 0 0 0
GYPA_ENST00000360771 GYPA P02724 Glycophorin-A chr4 Not Cancer Driver No 1 hippie, biogrid 46 94 31 31 0
HNRNPCL2 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 hippie, biogrid 51 199 41 41 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
INIP INIP Q9NRY2 SOSS complex subunit C chr9 Not Cancer Driver No 3 intact, hippie, biogrid 25 79 16 16 0
INTS1 INTS1 Q8N201 Integrator complex subunit 1 chr7 Not Cancer Driver No 2 hippie, biogrid 234 368 43 43 1
INTS10 INTS10 Q9NVR2 Integrator complex subunit 10 chr8 Not Cancer Driver No 1 hippie 61 49 6 6 0
INTS11_ENST00000435064 INTS11 Q5TA45 Integrator complex subunit 11 chr1 Not Cancer Driver No 2 intact, hippie 64 24 2 2 0
INTS12 INTS12 Q96CB8 Integrator complex subunit 12 chr4 Not Cancer Driver No 1 hippie 45 382 40 40 0
INTS13 INTS13 Q9NVM9 Integrator complex subunit 13 chr12 Not Cancer Driver No 1 hippie 89 300 44 44 0
INTS14_ENST00000313182 INTS14 Q96SY0 Integrator complex subunit 14 chr15 Not Cancer Driver No 1 hippie 63 118 12 12 0
INTS2 INTS2 Q9H0H0 Integrator complex subunit 2 chr17 Not Cancer Driver No 1 hippie 149 97 8 8 0
INTS3_ENST00000435409 INTS3 Q68E01 Integrator complex subunit 3 chr1 Not Cancer Driver No 2 hippie, biogrid 125 213 25 25 0
INTS4 INTS4 Q96HW7 Integrator complex subunit 4 chr11 Not Cancer Driver No 1 hippie 117 82 7 7 0
INTS5 INTS5 Q6P9B9 Integrator complex subunit 5 chr11 Not Cancer Driver No 1 hippie 123 189 22 22 0
INTS6 INTS6 Q9UL03 Integrator complex subunit 6 chr13 Not Cancer Driver No 3 intact, hippie, biogrid 96 389 49 49 0
INTS6L INTS6L Q5JSJ4 Integrator complex subunit 6-like chrX Not Cancer Driver No 1 hippie 143 356 59 59 0
INTS7 INTS7 Q9NVH2 Integrator complex subunit 7 chr1 Not Cancer Driver No 1 hippie 106 88 17 17 0
INTS8 INTS8 Q75QN2 Integrator complex subunit 8 chr8 Not Cancer Driver No 1 hippie 104 102 10 10 1
INTS9 INTS9 Q9NV88 Integrator complex subunit 9 chr8 Not Cancer Driver No 1 hippie 68 50 5 5 0
KIR2DL4_ENST00000357494 KIR2DL4 Q99706-4 Isoform 4 of Killer cell immunoglobulin-like receptor 2DL4 chr19 Not Cancer Driver No 1 hippie, biogrid 43 166 16 16 0
KLK15 KLK15 Q9H2R5 Kallikrein-15 chr19 Not Cancer Driver No 1 hippie, biogrid 94 73 38 38 0
LEO1 LEO1 Q8WVC0 RNA polymerase-associated protein LEO1 chr15 Not Cancer Driver No 1 biogrid 74 611 69 69 0
LPAR6_ENST00000620633 LPAR6 P43657 Lysophosphatidic acid receptor 6 chr13 Not Cancer Driver No 1 hippie, biogrid 39 0 0 0 3
LSM3 LSM3 P62310 U6 snRNA-associated Sm-like protein LSm3 chr3 Not Cancer Driver No 1 hippie, biogrid 12 28 2 2 0
MFSD4A MFSD4A Q8N468 Major facilitator superfamily domain-containing protein 4A chr1 Not Cancer Driver No 1 hippie 56 29 3 3 0
NABP1 NABP1 Q96AH0 SOSS complex subunit B2 chr2 Not Cancer Driver No 3 intact, hippie 25 102 11 11 0
NABP2_ENST00000341463 NABP2 Q9BQ15 SOSS complex subunit B1 chr12 Not Cancer Driver No 6 intact, hippie, biogrid 25 125 17 17 0
NAIF1 NAIF1 Q69YI7 Nuclear apoptosis-inducing factor 1 chr9 Not Cancer Driver No 1 hippie 46 219 27 27 0
NBN NBN O60934 Nibrin chr8 Census Yes 1 hippie 90 417 54 54 1
NCAPD2 NCAPD2 Q15021 Condensin complex subunit 1 chr12 Not Cancer Driver No 1 biogrid 124 345 35 35 0
NFKB1_ENST00000505458 NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit chr4 Not Cancer Driver No 1 intact, hippie 104 344 38 38 0
NPAS1_ENST00000449844 NPAS1 Q99742 Neuronal PAS domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 53 309 23 23 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
NR3C1_ENST00000343796 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 92 362 37 37 12
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
OCIAD1 OCIAD1 Q9NX40 OCIA domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 37 169 25 25 0
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 30 157 13 13 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PNKD PNKD Q8N490 Probable hydrolase PNKD chr2 Not Cancer Driver No 2 intact, hippie, biogrid 52 160 25 25 2
POLR2A POLR2A P24928-2 Isoform 2 of DNA-directed RNA polymerase II subunit RPB1 chr17 Census Yes 1 hippie 56 230 20 20 0
POLR2B_ENST00000314595 POLR2B P30876 DNA-directed RNA polymerase II subunit RPB2 chr4 Not Cancer Driver No 1 hippie 166 173 25 25 0
POLR2C POLR2C P19387 DNA-directed RNA polymerase II subunit RPB3 chr16 Not Cancer Driver No 2 hippie, biogrid 34 108 11 11 0
POLR2D POLR2D O15514 DNA-directed RNA polymerase II subunit RPB4 chr2 Not Cancer Driver No 1 hippie 13 54 2 2 0
POLR2E POLR2E P19388 DNA-directed RNA polymerases I, II, and III subunit RPABC1 chr19 Not Cancer Driver No 1 hippie 31 36 3 3 0
POLR2G POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 Not Cancer Driver No 1 hippie 15 15 1 1 0
POLR2H_ENST00000456318 POLR2H P52434 DNA-directed RNA polymerases I, II, and III subunit RPABC3 chr3 Not Cancer Driver No 1 hippie 16 14 1 1 0
POLR2J POLR2J P52435 DNA-directed RNA polymerase II subunit RPB11-a chr7 Not Cancer Driver No 1 hippie, biogrid 12 0 0 0 0
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 Not Cancer Driver No 1 intact, hippie 41 12 1 1 8
PPP2CB PPP2CB P62714 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform chr8 Not Cancer Driver No 1 hippie 37 12 0 0 0
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 Census, Compendium Yes 3 intact, hippie 179 0 0 0 4
PPP2R1B_ENST00000527614 PPP2R1B P30154 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform chr11 Not Cancer Driver No 1 hippie 72 17 1 1 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RP2 RP2 O75695 Protein XRP2 chrX Not Cancer Driver No 1 hippie, biogrid 45 28 6 6 10
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 Not Cancer Driver No 1 hippie 51 98 6 6 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 Not Cancer Driver No 1 hippie 28 114 16 16 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 Not Cancer Driver No 1 hippie 13 4 1 1 0
RPAP2 RPAP2 Q8IXW5 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 chr1 Not Cancer Driver No 1 hippie, biogrid 56 293 25 25 0
S1PR4 S1PR4 O95977 Sphingosine 1-phosphate receptor 4 chr19 Not Cancer Driver No 1 hippie, biogrid 68 11 2 2 0
SIGLECL1 SIGLECL1 Q8N7X8 SIGLEC family-like protein 1 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 56 35 14 14 0
SMC1A SMC1A Q14683 Structural maintenance of chromosomes protein 1A chrX Census, Compendium Yes 1 hippie 200 717 114 114 21
SNW1_ENST00000261531 SNW1 Q13573 SNW domain-containing protein 1 chr14 Not Cancer Driver No 1 hippie 62 488 56 56 0
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 intact, hippie 39 312 39 39 0
SSB SSB P05455 Lupus La protein chr2 Not Cancer Driver No 1 biogrid 39 181 18 18 0
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie 27 0 0 0 6
SSBP2_ENST00000320672 SSBP2 P81877 Single-stranded DNA-binding protein 2 chr5 Not Cancer Driver No 1 hippie 36 296 29 29 0
ST6GAL1 ST6GAL1 P15907 Beta-galactoside alpha-2,6-sialyltransferase 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 55 34 8 8 0
STAG2_ENST00000371157 STAG2 Q8N3U4 Cohesin subunit SA-2 chrX Census, Compendium Yes 1 hippie 179 330 46 46 3
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
SUZ12 SUZ12 Q15022 Polycomb protein SUZ12 chr17 Census, Compendium Yes 1 hippie 83 483 46 46 3
TACSTD2 TACSTD2 P09758 Tumor-associated calcium signal transducer 2 chr1 Not Cancer Driver No 1 hippie, biogrid 22 27 1 1 0
TEAD2_ENST00000311227 TEAD2 Q15562 Transcriptional enhancer factor TEF-4 chr19 Not Cancer Driver No 1 intact, hippie 66 220 31 31 0
TEX13B TEX13B Q9BXU2 Testis-expressed protein 13B chrX Not Cancer Driver No 1 hippie, biogrid 59 109 20 20 0
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 Not Cancer Driver No 1 intact, hippie 227 1632 190 190 0
TPST2 TPST2 O60704 Protein-tyrosine sulfotransferase 2 chr22 Not Cancer Driver No 1 hippie, biogrid 47 48 6 6 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
UBA1 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie 117 165 22 22 6
UBE2N UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 Not Cancer Driver No 1 hippie 25 24 3 3 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie, biogrid 30 35 3 3 0
WDR76 WDR76 Q9H967 WD repeat-containing protein 76 chr15 Not Cancer Driver No 1 hippie 60 288 33 33 0
XRN2 XRN2 Q9H0D6 5'-3' exoribonuclease 2 chr20 Not Cancer Driver No 1 biogrid 129 427 63 63 0
ZBTB14_ENST00000615385 ZBTB14 O43829 Zinc finger and BTB domain-containing protein 14 chr18 Not Cancer Driver No 1 intact, hippie 72 207 28 28 0
ZMYND8_ENST00000311275 ZMYND8 Q9ULU4 Protein kinase C-binding protein 1 chr20 Not Cancer Driver No 1 hippie 176 830 124 124 0
ZNF592_ENST00000299927 ZNF592 Q92610 Zinc finger protein 592 chr15 Not Cancer Driver No 1 hippie 150 856 100 100 0
ZNF687 ZNF687 Q8N1G0 Zinc finger protein 687 chr1 Not Cancer Driver No 1 hippie 138 776 83 83 1