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INSRR ,INSRR ,P14616
  • Uniprot Accession= P14616
  • Ensembl Transcript= ENST00000368195.3
  • Uniprot Name= INSRR
  • Name= Insulin receptor-related protein
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 30
  • Number of Interaction partner in biogrid: 48
  • Number of Interaction partner in hippie: 52
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACVR1B_ENST00000257963 ACVR1B P36896 Activin receptor type-1B chr12 Census Yes 1 hippie, biogrid 114 0 0 0 0
ACVR1_ENST00000434821 ACVR1 Q04771 Activin receptor type-1 chr2 Census, Compendium Yes 1 hippie, biogrid 78 21 8 8 8
ANKLE2 ANKLE2 Q86XL3 Ankyrin repeat and LEM domain-containing protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 127 521 71 71 2
ARF4 ARF4 P18085 ADP-ribosylation factor 4 chr3 Not Cancer Driver No 1 intact 17 0 0 0 0
ARHGEF40 ARHGEF40 Q8TER5 Rho guanine nucleotide exchange factor 40 chr14 Not Cancer Driver No 1 hippie, biogrid 161 781 75 75 0
ASH2L ASH2L Q9UBL3 Set1/Ash2 histone methyltransferase complex subunit ASH2 chr8 Not Cancer Driver No 1 hippie, biogrid 95 293 39 39 0
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 Not Cancer Driver No 1 hippie, biogrid 168 341 64 64 0
BMPR1A BMPR1A P36894 Bone morphogenetic protein receptor type-1A chr10 Census, Compendium Yes 1 hippie, biogrid 66 21 0 0 8
CALM1 CALM1 P0DP23 Calmodulin-1 chr14 Not Cancer Driver No 1 intact 19 115 15 15 7
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 52 214 31 31 0
CDKAL1 CDKAL1 Q5VV42 Threonylcarbamoyladenosine tRNA methylthiotransferase chr6 Not Cancer Driver No 1 hippie, biogrid 80 120 14 14 0
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 Not Cancer Driver No 1 intact 27 70 12 12 0
CKAP4 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 intact 73 409 55 55 0
CLCC1 CLCC1 Q96S66 Chloride channel CLIC-like protein 1 chr1 Not Cancer Driver No 1 intact 37 196 19 19 1
CTDSP2 CTDSP2 O14595 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 chr12 Not Cancer Driver No 1 hippie 35 18 0 0 0
CXXC1_ENST00000285106 CXXC1 Q9P0U4 CXXC-type zinc finger protein 1 chr18 Not Cancer Driver No 1 hippie, biogrid 115 366 65 65 0
CYP51A1 CYP51A1 Q16850 Lanosterol 14-alpha demethylase chr7 Not Cancer Driver No 1 hippie, biogrid 49 7 2 2 0
DCAKD DCAKD Q8WVC6 Dephospho-CoA kinase domain-containing protein chr17 Not Cancer Driver No 1 hippie, biogrid 31 2 0 0 0
DDR1_ENST00000324771 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 chr6 Not Cancer Driver No 1 hippie, biogrid 123 253 49 49 0
DDX56 DDX56 Q9NY93 Probable ATP-dependent RNA helicase DDX56 chr7 Not Cancer Driver No 1 intact 50 107 13 13 0
DEFB116 DEFB116 Q30KQ4 Beta-defensin 116 chr20 Not Cancer Driver No 1 hippie, biogrid 40 14 7 7 0
DNAJC10 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 Not Cancer Driver No 1 intact 110 36 3 3 0
EPHA8 EPHA8 P29322 Ephrin type-A receptor 8 chr1 Not Cancer Driver No 1 intact 197 121 17 17 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 2 hippie, biogrid 275 314 41 41 1
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 hippie, biogrid 70 150 20 20 0
FKBP8_ENST00000222308 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie, biogrid 71 160 25 25 0
GNG12 GNG12 Q9UBI6 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 chr1 Not Cancer Driver No 1 intact 10 26 5 5 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact 28 10 1 1 0
GRIK5_ENST00000593562 GRIK5 Q16478 Glutamate receptor ionotropic, kainate 5 chr19 Not Cancer Driver No 1 hippie 176 135 9 9 0
GRWD1 GRWD1 Q9BQ67 Glutamate-rich WD repeat-containing protein 1 chr19 Not Cancer Driver No 1 intact 44 187 14 14 0
HAL HAL P42357 Histidine ammonia-lyase chr12 Not Cancer Driver No 1 intact 98 34 6 6 4
HMGCR_ENST00000511206 HMGCR P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase chr5 Not Cancer Driver No 1 hippie, biogrid 84 112 12 12 0
HNRNPCL2 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 intact 51 199 41 41 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 3 intact, hippie, biogrid 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 3 intact, hippie, biogrid 100 254 43 43 0
IDH2 IDH2 P48735 Isocitrate dehydrogenase [NADP], mitochondrial chr15 Census, Compendium Yes 1 hippie, biogrid 74 59 1 1 7
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 Not Cancer Driver No 1 hippie, biogrid 183 265 37 37 6
INSR INSR P06213 Insulin receptor chr19 Not Cancer Driver No 3 intact, hippie, biogrid 190 280 57 57 64
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 hippie, biogrid 147 120 7 7 2
KRT27 KRT27 Q7Z3Y8 Keratin, type I cytoskeletal 27 chr17 Not Cancer Driver No 1 hippie 80 142 28 28 0
LEMD3 LEMD3 Q9Y2U8 Inner nuclear membrane protein Man1 chr12 Not Cancer Driver No 1 hippie, biogrid 78 509 33 33 0
LRRC49_ENST00000260382 LRRC49 Q8IUZ0 Leucine-rich repeat-containing protein 49 chr15 Not Cancer Driver No 1 intact 117 124 21 21 0
MEOX2 MEOX2 P50222 Homeobox protein MOX-2 chr7 Not Cancer Driver No 1 intact, hippie 70 274 63 63 0
MMGT1 MMGT1 Q8N4V1 ER membrane protein complex subunit 5 chrX Not Cancer Driver No 1 hippie, biogrid 24 17 4 4 0
MRPS23 MRPS23 Q9Y3D9 28S ribosomal protein S23, mitochondrial chr17 Not Cancer Driver No 1 intact 21 58 6 6 1
MYADM MYADM Q96S97 Myeloid-associated differentiation marker chr19 Not Cancer Driver No 1 hippie, biogrid 73 0 0 0 0
MYO1B MYO1B O43795 Unconventional myosin-Ib chr2 Not Cancer Driver No 1 intact 144 34 4 4 0
MYO1D MYO1D O94832 Unconventional myosin-Id chr17 Not Cancer Driver No 1 intact 126 61 6 6 0
NOP53 NOP53 Q9NZM5 Ribosome biogenesis protein NOP53 chr19 Not Cancer Driver No 1 intact 59 391 41 41 0
NSA2 NSA2 O95478 Ribosome biogenesis protein NSA2 homolog chr5 Not Cancer Driver No 1 intact 29 134 17 17 0
OSBPL5 OSBPL5 Q9H0X9 Oxysterol-binding protein-related protein 5 chr11 Not Cancer Driver No 1 hippie, biogrid 100 444 43 43 0
OSBPL8 OSBPL8 Q9BZF1 Oxysterol-binding protein-related protein 8 chr12 Not Cancer Driver No 1 hippie, biogrid 105 401 37 37 0
OTULIN OTULIN Q96BN8 Ubiquitin thioesterase otulin chr5 Not Cancer Driver No 1 hippie, biogrid 47 97 5 5 2
PKMYT1 PKMYT1 Q99640 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase chr16 Not Cancer Driver No 1 hippie, biogrid 39 228 19 19 0
PLCD3 PLCD3 Q8N3E9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 chr17 Not Cancer Driver No 1 hippie, biogrid 61 229 22 22 0
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 1 hippie, biogrid 94 154 22 22 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 Compendium Yes 1 hippie, biogrid 79 43 9 9 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 Not Cancer Driver No 1 hippie, biogrid 49 140 25 25 0
RAB13 RAB13 P51153 Ras-related protein Rab-13 chr1 Not Cancer Driver No 1 hippie, biogrid 19 40 0 0 0
RBBP5 RBBP5 Q15291 Retinoblastoma-binding protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 57 218 19 19 0
RHBDF2 RHBDF2 Q6PJF5 Inactive rhomboid protein 2 chr17 Not Cancer Driver No 1 hippie, biogrid 93 284 36 36 2
SETD1A SETD1A O15047 Histone-lysine N-methyltransferase SETD1A chr16 Not Cancer Driver No 1 hippie, biogrid 223 1327 188 188 5
SLC27A4 SLC27A4 Q6P1M0 Long-chain fatty acid transport protein 4 chr9 Not Cancer Driver No 1 hippie, biogrid 83 27 3 3 5
SREBF1_ENST00000261646 SREBF1 P36956 Sterol regulatory element-binding protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 127 528 64 64 4
SRPRA SRPRA P08240 Signal recognition particle receptor subunit alpha chr11 Not Cancer Driver No 1 intact 95 232 40 40 0
SRPRB SRPRB Q9Y5M8 Signal recognition particle receptor subunit beta chr3 Not Cancer Driver No 1 intact 30 23 3 3 0
STIM1_ENST00000300737 STIM1 Q13586 Stromal interaction molecule 1 chr11 Not Cancer Driver No 1 intact 70 387 45 45 13
STYX STYX Q8WUJ0 Serine/threonine/tyrosine-interacting protein chr14 Not Cancer Driver No 1 intact 20 30 2 2 0
TAP1 TAP1 Q03518-2 Isoform 2 of Antigen peptide transporter 1 chr6 Not Cancer Driver No 1 hippie, biogrid 67 83 6 6 0
TMEM200A TMEM200A Q86VY9 Transmembrane protein 200A chr6 Not Cancer Driver No 1 hippie, biogrid 194 272 116 116 0
TXNDC5 TXNDC5 Q8NBS9 Thioredoxin domain-containing protein 5 chr6 Not Cancer Driver No 1 intact 47 104 12 12 0
TYW1 TYW1 Q9NV66 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 chr7 Not Cancer Driver No 1 hippie, biogrid 102 152 21 21 0
VAPB VAPB O95292 Vesicle-associated membrane protein-associated protein B/C chr20 Not Cancer Driver No 1 intact 16 138 8 8 3
VASN VASN Q6EMK4 Vasorin chr16 Not Cancer Driver No 1 hippie, biogrid 37 233 8 8 0
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 Not Cancer Driver No 1 hippie, biogrid 133 543 61 61 0
VRK2 VRK2 Q86Y07 Serine/threonine-protein kinase VRK2 chr2 Not Cancer Driver No 1 hippie, biogrid 63 126 15 15 0
ZMYM3 ZMYM3 Q14202 Zinc finger MYM-type protein 3 chrX Census Yes 1 hippie, biogrid 203 538 90 90 0