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HMGCL ,HMGCL ,P35914
  • Uniprot Accession= P35914
  • Ensembl Transcript= ENST00000374490.7
  • Uniprot Name= HMGCL
  • Name= Hydroxymethylglutaryl-CoA lyase, mitochondrial
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 7
  • Number of Interaction partner in biogrid: 33
  • Number of Interaction partner in hippie: 48
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACADVL_ENST00000356839 ACADVL P49748 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial chr17 Not Cancer Driver No 3 intact, hippie, biogrid 50 100 5 5 37
ADAMTS10_ENST00000597188 ADAMTS10 Q9H324 A disintegrin and metalloproteinase with thrombospondin motifs 10 chr19 Not Cancer Driver No 1 hippie 193 157 35 35 1
ALAS1_ENST00000484952 ALAS1 P13196 5-aminolevulinate synthase, non-specific, mitochondrial chr3 Not Cancer Driver No 3 intact, hippie, biogrid 68 177 16 16 0
ALDH4A1 ALDH4A1 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 63 46 9 9 1
ARL6IP1 ARL6IP1 Q15041 ADP-ribosylation factor-like protein 6-interacting protein 1 chr16 Not Cancer Driver No 1 hippie 35 9 1 1 0
ATPAF2 ATPAF2 Q8N5M1 ATP synthase mitochondrial F1 complex assembly factor 2 chr17 Not Cancer Driver No 1 hippie, biogrid 25 66 4 4 1
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
CAT CAT P04040 Catalase chr11 Not Cancer Driver No 1 hippie 70 176 18 18 0
COX17_ENST00000497116 COX17 Q14061 Cytochrome c oxidase copper chaperone chr3 Not Cancer Driver No 1 hippie, biogrid 7 15 2 2 0
CTDSP1 CTDSP1 Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 chr2 Not Cancer Driver No 1 hippie, biogrid 34 46 2 2 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CYB5R3_ENST00000352397 CYB5R3 P00387 NADH-cytochrome b5 reductase 3 chr22 Not Cancer Driver No 1 hippie, biogrid 42 24 3 3 9
DBT DBT P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 64 81 11 11 3
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 Not Cancer Driver No 1 hippie 37 153 16 16 0
FABP3 FABP3 P05413 Fatty acid-binding protein, heart chr1 Not Cancer Driver No 1 hippie, biogrid 22 3 0 0 0
FASTKD1 FASTKD1 Q53R41 FAST kinase domain-containing protein 1, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 125 0 0 0 0
FBXO21 FBXO21 O94952 F-box only protein 21 chr12 Not Cancer Driver No 2 hippie, biogrid 73 17 3 3 0
FPGS FPGS Q05932 Folylpolyglutamate synthase, mitochondrial chr9 Not Cancer Driver No 3 intact, hippie, biogrid 68 141 18 18 0
GLS GLS O94925 Glutaminase kidney isoform, mitochondrial chr2 Not Cancer Driver No 3 intact, hippie, biogrid 71 187 9 9 3
GTF2B GTF2B Q00403 Transcription initiation factor IIB chr1 Not Cancer Driver No 1 hippie 33 80 6 6 0
HES1 HES1 Q14469 Transcription factor HES-1 chr3 Not Cancer Driver No 1 hippie 37 226 32 32 0
HMGCLL1 HMGCLL1 Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic chr6 Not Cancer Driver No 2 intact, hippie, biogrid 113 2 1 1 0
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 hippie 36 25 6 6 0
HSD17B10 HSD17B10 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 chrX Not Cancer Driver No 1 hippie 27 15 3 3 11
INHBA_ENST00000442711 INHBA P08476 Inhibin beta A chain chr7 Not Cancer Driver No 1 hippie, biogrid 148 154 63 63 0
INS INS P01308 Insulin chr11 Not Cancer Driver No 1 hippie 15 5 1 1 22
IVD IVD P26440 Isovaleryl-CoA dehydrogenase, mitochondrial chr15 Not Cancer Driver No 1 hippie, biogrid 46 8 0 0 14
KCNMA1 KCNMA1 Q12791 Calcium-activated potassium channel subunit alpha-1 chr10 Not Cancer Driver No 1 intact 222 225 39 39 5
L2HGDH_ENST00000421284 L2HGDH Q9H9P8 L-2-hydroxyglutarate dehydrogenase, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 52 0 0 0 8
LSM12 LSM12 Q3MHD2 Protein LSM12 homolog chr17 Not Cancer Driver No 1 hippie, biogrid 13 66 7 7 0
LYPLAL1 LYPLAL1 Q5VWZ2 Lysophospholipase-like protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
MCCC2 MCCC2 Q9HCC0 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 60 25 2 2 52
MGME1 MGME1 Q9BQP7 Mitochondrial genome maintenance exonuclease 1 chr20 Not Cancer Driver No 3 hippie, biogrid 33 95 7 7 1
MIPEP MIPEP Q99797 Mitochondrial intermediate peptidase chr13 Not Cancer Driver No 1 hippie, biogrid 77 40 2 2 3
MRPS36 MRPS36 P82909 Alpha-ketoglutarate dehydrogenase component 4 chr5 Not Cancer Driver No 1 hippie, biogrid 12 103 12 12 0
MS4A7 MS4A7 Q9GZW8 Membrane-spanning 4-domains subfamily A member 7 chr11 Not Cancer Driver No 1 hippie, biogrid 45 24 1 1 0
MSRB2 MSRB2 Q9Y3D2 Methionine-R-sulfoxide reductase B2, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 17 65 6 6 0
PCCB_ENST00000251654 PCCB P05166 Propionyl-CoA carboxylase beta chain, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 59 64 12 12 25
PEX5_ENST00000420616 PEX5 P50542 Peroxisomal targeting signal 1 receptor chr12 Not Cancer Driver No 1 hippie 73 321 36 36 2
PIR_ENST00000380420 PIR O00625 Pirin chrX Not Cancer Driver No 1 hippie, biogrid 29 185 16 16 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PNPT1 PNPT1 Q8TCS8 Polyribonucleotide nucleotidyltransferase 1, mitochondrial chr2 Not Cancer Driver No 2 hippie, biogrid 86 115 10 10 2
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 hippie, biogrid 31 43 4 4 0
RAB1A RAB1A P62820 Ras-related protein Rab-1A chr2 Not Cancer Driver No 1 hippie, biogrid 16 38 2 2 0
RAB7A RAB7A P51149 Ras-related protein Rab-7a chr3 Not Cancer Driver No 1 hippie, biogrid 27 11 0 0 4
RNF126 RNF126 Q9BV68 E3 ubiquitin-protein ligase RNF126 chr19 Not Cancer Driver No 1 hippie 33 182 22 22 0
SIRT4 SIRT4 Q9Y6E7 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial chr12 Not Cancer Driver No 1 hippie 46 4 0 0 0
TOMM40_ENST00000405636 TOMM40 O96008 Mitochondrial import receptor subunit TOM40 homolog chr19 Not Cancer Driver No 1 hippie, biogrid 17 98 1 1 0
TXNDC12 TXNDC12 O95881 Thioredoxin domain-containing protein 12 chr1 Not Cancer Driver No 1 hippie, biogrid 21 44 6 6 0
WDYHV1 NTAQ1 Q96HA8 Protein N-terminal glutamine amidohydrolase chr8 Not Cancer Driver No 1 intact 38 26 3 3 0