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HECTD3 ,HECTD3 ,Q5T447
  • Uniprot Accession= Q5T447
  • Ensembl Transcript= ENST00000372172.4
  • Uniprot Name= HECTD3
  • Name= E3 ubiquitin-protein ligase HECTD3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 3
  • Number of Interaction partner in biogrid: 66
  • Number of Interaction partner in hippie: 108
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ANGPT2 ANGPT2 O15123 Angiopoietin-2 chr8 Not Cancer Driver No 2 hippie, biogrid 63 96 10 10 1
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
BRD1_ENST00000216267 BRD1 O95696 Bromodomain-containing protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 171 425 68 68 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 142 106 12 12 1
CASP9 CASP9 P55211 Caspase-9 chr1 Census Yes 1 hippie 49 71 7 7 0
CAVIN1 CAVIN1 Q6NZI2 Caveolae-associated protein 1 chr17 Not Cancer Driver No 1 hippie 66 280 50 50 0
CCNG1_ENST00000393929 CCNG1 P51959 Cyclin-G1 chr5 Not Cancer Driver No 1 hippie, biogrid 25 0 0 0 0
CCT2 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 1 hippie, biogrid 63 46 3 3 0
CCT4 CCT4 P50991 T-complex protein 1 subunit delta chr2 Not Cancer Driver No 1 hippie, biogrid 51 92 2 2 0
CCT6A CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 1 hippie, biogrid 66 5 1 1 0
CCT6B CCT6B Q92526 T-complex protein 1 subunit zeta-2 chr17 Not Cancer Driver No 1 hippie, biogrid 90 1 0 0 0
CCT7 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 1 hippie, biogrid 59 36 6 6 0
CEP192 CEP192 Q8TEP8 Centrosomal protein of 192 kDa chr18 Not Cancer Driver No 1 hippie, biogrid 274 1214 110 110 0
CHRDL1_ENST00000394797 CHRDL1 Q9BU40 Chordin-like protein 1 chrX Not Cancer Driver No 2 hippie, biogrid 106 67 13 13 1
CLEC3A CLEC3A O75596 C-type lectin domain family 3 member A chr16 Not Cancer Driver No 2 hippie, biogrid 65 21 3 3 0
CNR2 CNR2 P34972 Cannabinoid receptor 2 chr1 Not Cancer Driver No 1 hippie 57 21 4 4 0
COPS7B_ENST00000410024 COPS7B Q9H9Q2 COP9 signalosome complex subunit 7b chr2 Not Cancer Driver No 2 hippie, biogrid 22 74 6 6 0
COX7B2 COX7B2 Q8TF08 Cytochrome c oxidase subunit 7B2, mitochondrial chr4 Not Cancer Driver No 1 hippie, biogrid 19 6 0 0 0
CPA6 CPA6 Q8N4T0 Carboxypeptidase A6 chr8 Not Cancer Driver No 1 hippie, biogrid 106 7 0 0 2
DKK2 DKK2 Q9UBU2 Dickkopf-related protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 108 70 22 22 0
DNAJC28_ENST00000381947 DNAJC28 Q9NX36 DnaJ homolog subfamily C member 28 chr21 Not Cancer Driver No 1 hippie, biogrid 55 139 11 11 0
EBI3 EBI3 Q14213 Interleukin-27 subunit beta chr19 Not Cancer Driver No 1 hippie, biogrid 32 10 1 1 0
EGFL6_ENST00000361306 EGFL6 Q8IUX8 Epidermal growth factor-like protein 6 chrX Not Cancer Driver No 2 hippie, biogrid 80 103 22 22 0
EMILIN3 EMILIN3 Q9NT22 EMILIN-3 chr20 Not Cancer Driver No 1 hippie, biogrid 97 337 40 40 0
FAM81A FAM81A Q8TBF8 Protein FAM81A chr15 Not Cancer Driver No 1 hippie, biogrid 49 157 13 13 0
FEZF1 FEZF1 A0PJY2 Fez family zinc finger protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 77 151 27 27 1
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact, hippie 173 241 26 26 37
FOSL2 FOSL2 P15408 Fos-related antigen 2 chr2 Not Cancer Driver No 3 hippie, biogrid 54 323 54 54 0
FST FST P19883 Follistatin chr5 Not Cancer Driver No 1 hippie, biogrid 50 20 7 7 0
GADD45GIP1 GADD45GIP1 Q8TAE8 Growth arrest and DNA damage-inducible proteins-interacting protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 19 193 19 19 0
GAS2L1_ENST00000621062 GAS2L1 Q99501 GAS2-like protein 1 chr22 Not Cancer Driver No 2 hippie, biogrid 76 474 50 50 0
GAST GAST P01350 Gastrin chr17 Not Cancer Driver No 2 hippie, biogrid 19 80 15 15 0
GREM2 GREM2 Q9H772 Gremlin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 54 22 9 9 3
GRIN2C GRIN2C Q14957 Glutamate receptor ionotropic, NMDA 2C chr17 Not Cancer Driver No 1 intact, hippie 111 276 6 6 0
GSN GSN P06396 Gelsolin chr9 Not Cancer Driver No 1 intact, hippie 76 316 28 28 2
HASPIN HASPIN Q8TF76 Serine/threonine-protein kinase haspin chr17 Not Cancer Driver No 1 hippie 87 373 36 36 0
HECTD3 HECTD3 Q5T447 E3 ubiquitin-protein ligase HECTD3 chr1 Not Cancer Driver No 1 hippie 88 55 5 5 0
HLA-DPB1 HLA-DPB1 P04440 HLA class II histocompatibility antigen, DP beta 1 chain chr6 Not Cancer Driver No 1 hippie, biogrid 38 39 4 4 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 hippie 100 254 43 43 0
LAD1 LAD1 O00515 Ladinin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 98 505 98 98 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRRC17 LRRC17 Q8N6Y2 Leucine-rich repeat-containing protein 17 chr7 Not Cancer Driver No 1 hippie, biogrid 58 88 11 11 0
LYZL1 LYZL1 Q6UWQ5-2 Isoform 2 of Lysozyme-like protein 1 chr10 Not Cancer Driver No 2 hippie, biogrid 32 6 4 4 0
LYZL2 LYZL2 Q7Z4W2-2 Isoform 2 of Lysozyme-like protein 2 chr10 Not Cancer Driver No 2 hippie, biogrid 44 2 0 0 0
MALT1 MALT1 Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 chr18 Census, Compendium Yes 1 hippie 75 139 12 12 1
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 1 hippie 70 411 58 58 0
MRM2_ENST00000440306 MRM2 Q9UI43 rRNA methyltransferase 2, mitochondrial chr7 Not Cancer Driver No 1 hippie 37 15 1 1 1
MRPL30 MRPL30 Q8TCC3 39S ribosomal protein L30, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 29 75 11 11 0
MRPS24 MRPS24 Q96EL2 28S ribosomal protein S24, mitochondrial chr7 Not Cancer Driver No 2 hippie, biogrid 20 1 0 0 0
MRPS26 MRPS26 Q9BYN8 28S ribosomal protein S26, mitochondrial chr20 Not Cancer Driver No 1 hippie, biogrid 18 102 6 6 0
MRPS34_ENST00000397375 MRPS34 P82930 28S ribosomal protein S34, mitochondrial chr16 Not Cancer Driver No 2 hippie, biogrid 13 56 2 2 1
MRPS7 MRPS7 Q9Y2R9 28S ribosomal protein S7, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 31 26 0 0 1
MRPS9 MRPS9 P82933 28S ribosomal protein S9, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 49 75 9 9 0
NCAPH NCAPH Q15003 Condensin complex subunit 2 chr2 Not Cancer Driver No 1 hippie 97 465 60 60 1
NKAP NKAP Q8N5F7 NF-kappa-B-activating protein chrX Not Cancer Driver No 1 hippie, biogrid 80 409 77 77 3
NR3C1_ENST00000343796 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 92 362 37 37 12
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
OVOL2 OVOL2 Q9BRP0 Transcription factor Ovo-like 2 chr20 Not Cancer Driver No 1 hippie, biogrid 29 139 8 8 0
PARD6B PARD6B Q9BYG5 Partitioning defective 6 homolog beta chr20 Not Cancer Driver No 3 hippie, biogrid 50 166 23 23 0
PATE1 PATE1 Q8WXA2 Prostate and testis expressed protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 0
PCBP3 PCBP3 P57721 Poly(rC)-binding protein 3 chr21 Not Cancer Driver No 1 hippie, biogrid 65 230 48 48 0
PLA2G2D PLA2G2D Q9UNK4 Group IID secretory phospholipase A2 chr1 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POGLUT1 POGLUT1 Q8NBL1 Protein O-glucosyltransferase 1 chr3 Not Cancer Driver No 2 hippie, biogrid 57 0 0 0 3
PPL PPL O60437 Periplakin chr16 Not Cancer Driver No 1 hippie 219 1133 133 133 0
PRR27_ENST00000502294 PRR27 Q6MZM9 Proline-rich protein 27 chr4 Not Cancer Driver No 1 hippie, biogrid 52 115 30 30 0
RBFA RBFA Q8N0V3 Putative ribosome-binding factor A, mitochondrial chr18 Not Cancer Driver No 2 hippie, biogrid 43 159 19 19 0
RPL3 RPL3 P39023 60S ribosomal protein L3 chr22 Not Cancer Driver No 1 hippie, biogrid 34 79 3 3 0
RPS4X RPS4X P62701 40S ribosomal protein S4, X isoform chrX Not Cancer Driver No 3 hippie, biogrid 32 35 6 6 0
RPS4Y1 RPS4Y1 P22090 40S ribosomal protein S4, Y isoform 1 chrY Not Cancer Driver No 1 hippie, biogrid 10 34 0 0 0
RSPO1_ENST00000401068 RSPO1 Q2MKA7 R-spondin-1 chr1 Not Cancer Driver No 3 hippie, biogrid 59 82 16 16 0
SCCPDH SCCPDH Q8NBX0 Saccharopine dehydrogenase-like oxidoreductase chr1 Not Cancer Driver No 2 hippie, biogrid 56 26 1 1 0
SERPINA5_ENST00000554276 SERPINA5 P05154 Plasma serine protease inhibitor chr14 Not Cancer Driver No 2 hippie, biogrid 103 24 17 17 0
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 Not Cancer Driver No 1 hippie 51 13 2 2 48
SLC7A11 SLC7A11 Q9UPY5 Cystine/glutamate transporter chr4 Not Cancer Driver No 1 hippie, biogrid 70 15 2 2 0
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 79 137 12 12 0
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SPINK14 SPINK14 Q6IE38 Serine protease inhibitor Kazal-type 14 chr5 Not Cancer Driver No 1 hippie, biogrid 19 0 0 0 0
STX8 STX8 Q9UNK0 Syntaxin-8 chr17 Not Cancer Driver No 1 hippie 32 98 10 10 0
SULF2_ENST00000484875 SULF2 Q8IWU5 Extracellular sulfatase Sulf-2 chr20 Not Cancer Driver No 1 hippie, biogrid 145 142 18 18 0
TCP1 TCP1 P17987 T-complex protein 1 subunit alpha chr6 Not Cancer Driver No 1 hippie, biogrid 54 55 10 10 0
TEFM TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 37 26 5 5 0
TIFAB TIFAB Q6ZNK6 TRAF-interacting protein with FHA domain-containing protein B chr5 Not Cancer Driver No 1 hippie 32 26 7 7 0
TIMP3 TIMP3 P35625 Metalloproteinase inhibitor 3 chr22 Not Cancer Driver No 1 hippie, biogrid 43 3 1 1 5
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TRAF3_ENST00000392745 TRAF3 Q13114 TNF receptor-associated factor 3 chr14 Compendium Yes 1 hippie 61 101 9 9 1
TRIOBP_ENST00000644935 TRIOBP Q9H2D6 TRIO and F-actin-binding protein chr22 Not Cancer Driver No 1 hippie 386 2196 370 370 1
TRMT10C TRMT10C Q7L0Y3 tRNA methyltransferase 10 homolog C chr3 Not Cancer Driver No 3 hippie, biogrid 56 59 10 10 2
UBE2A UBE2A P49459 Ubiquitin-conjugating enzyme E2 A chrX Compendium Yes 1 hippie 35 67 13 13 2
UBE2C UBE2C O00762 Ubiquitin-conjugating enzyme E2 C chr20 Not Cancer Driver No 1 hippie 13 40 0 0 0
UBE2D2 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 19 13 1 1 0
UBE2D3_ENST00000394801 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 hippie 21 13 4 4 0
UBE2Q2 UBE2Q2 Q8WVN8 Ubiquitin-conjugating enzyme E2 Q2 chr15 Not Cancer Driver No 1 hippie 35 122 10 10 0
UBE2S UBE2S Q16763 Ubiquitin-conjugating enzyme E2 S chr19 Not Cancer Driver No 1 hippie 25 102 12 12 0
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 64 543 58 58 0
UBXN10 UBXN10 Q96LJ8 UBX domain-containing protein 10 chr1 Not Cancer Driver No 1 hippie 51 254 48 48 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
VWA8 VWA8 A3KMH1 von Willebrand factor A domain-containing protein 8 chr13 Not Cancer Driver No 1 hippie, biogrid 246 384 36 36 0
WFDC10A WFDC10A Q9H1F0 WAP four-disulfide core domain protein 10A chr20 Not Cancer Driver No 2 hippie, biogrid 16 0 0 0 0
WNT9B WNT9B O14905 Protein Wnt-9b chr17 Not Cancer Driver No 3 hippie, biogrid 47 11 4 4 0
ZBBX_ENST00000392766 ZBBX A8MT70 Zinc finger B-box domain-containing protein 1 chr3 Not Cancer Driver No 2 hippie, biogrid 259 462 155 155 0
ZDHHC17 ZDHHC17 Q8IUH5 Palmitoyltransferase ZDHHC17 chr12 Not Cancer Driver No 1 hippie 84 49 9 9 0
ZNF317 ZNF317 Q96PQ6 Zinc finger protein 317 chr19 Not Cancer Driver No 2 hippie, biogrid 85 202 26 26 0
ZRANB1 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 87 158 25 25 0
ZZEF1 ZZEF1 O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 chr17 Not Cancer Driver No 1 hippie 292 580 69 69 0