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GTF2B ,GTF2B ,Q00403
  • Uniprot Accession= Q00403
  • Ensembl Transcript= ENST00000370500.9
  • Uniprot Name= GTF2B
  • Name= Transcription initiation factor IIB
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 56
  • Number of Interaction partner in biogrid: 23
  • Number of Interaction partner in hippie: 149
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 Not Cancer Driver No 1 hippie 52 35 4 4 0
ALKBH2_ENST00000343075 ALKBH2 Q6NS38 DNA oxidative demethylase ALKBH2 chr12 Not Cancer Driver No 1 hippie, biogrid 34 73 14 14 0
AMY1A AMY1A P0DUB6 Alpha-amylase 1A chr1 Not Cancer Driver No 2 intact, hippie 20 29 0 0 0
AMY1C AMY1C P0DTE8 Alpha-amylase 1C chr1 Not Cancer Driver No 3 biogrid 37 29 2 2 0
ANXA8L1 ANXA8L1 Q5VT79 Annexin A8-like protein 1 chr10 Not Cancer Driver No 1 hippie 5 37 0 0 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 intact, hippie 128 418 71 71 17
ASCL4 ASCL4 Q6XD76 Achaete-scute homolog 4 chr12 Not Cancer Driver No 1 intact, hippie 25 78 15 15 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 Not Cancer Driver No 1 hippie 53 259 38 38 0
BAHD1 BAHD1 Q8TBE0 Bromo adjacent homology domain-containing 1 protein chr15 Not Cancer Driver No 1 intact, hippie 103 618 93 93 0
BCL3 BCL3 P20749 B-cell lymphoma 3 protein chr19 Census Yes 1 hippie 44 259 23 23 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
C14orf93_ENST00000397379 C14orf93 Q9H972 Uncharacterized protein C14orf93 chr14 Not Cancer Driver No 1 intact, hippie 62 375 43 43 0
CBLB CBLB Q13191 E3 ubiquitin-protein ligase CBL-B chr3 Census Yes 1 hippie 160 562 104 104 0
CBX2 CBX2 Q14781 Chromobox protein homolog 2 chr17 Not Cancer Driver No 1 intact, hippie 56 487 53 53 2
CCNH CCNH P51946 Cyclin-H chr5 Not Cancer Driver No 1 hippie 40 28 4 4 0
CIITA_ENST00000324288 CIITA P33076 MHC class II transactivator chr16 Census, Compendium Yes 1 hippie 195 318 53 53 2
CREBBP CREBBP Q92793 CREB-binding protein chr16 Census, Compendium Yes 2 intact, hippie 412 1796 247 247 33
CSNK1D CSNK1D P48730 Casein kinase I isoform delta chr17 Not Cancer Driver No 1 hippie 59 132 16 16 2
CST1 CST1 P01037 Cystatin-SN chr20 Not Cancer Driver No 3 intact, hippie, biogrid 33 0 0 0 0
CST2 CST2 P09228 Cystatin-SA chr20 Not Cancer Driver No 3 hippie, biogrid 36 0 0 0 0
CST4 CST4 P01036 Cystatin-S chr20 Not Cancer Driver No 3 hippie, biogrid 37 2 0 0 0
CTBP1 CTBP1 Q13363 C-terminal-binding protein 1 chr4 Not Cancer Driver No 1 hippie 42 123 9 9 1
CTDP1 CTDP1 Q9Y5B0 RNA polymerase II subunit A C-terminal domain phosphatase chr18 Not Cancer Driver No 1 hippie, biogrid 121 624 87 87 0
DCAF8 DCAF8 Q5TAQ9 DDB1- and CUL4-associated factor 8 chr1 Not Cancer Driver No 1 intact, hippie 85 273 55 55 1
DEPDC7 DEPDC7 Q96QD5 DEP domain-containing protein 7 chr11 Not Cancer Driver No 1 intact, hippie 67 48 5 5 0
DHX9 DHX9 Q08211 ATP-dependent RNA helicase A chr1 Compendium Yes 1 hippie 182 331 42 42 0
DRAP1 DRAP1 Q14919 Dr1-associated corepressor chr11 Not Cancer Driver No 1 hippie 28 170 22 22 0
DUSP6 DUSP6 Q16828 Dual specificity protein phosphatase 6 chr12 Not Cancer Driver No 1 hippie 43 39 3 3 4
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
ENG ENG P17813 Endoglin chr9 Not Cancer Driver No 1 intact, hippie 60 114 15 15 32
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 Census, Compendium Yes 1 intact, hippie 150 5 0 0 35
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESRRA_ENST00000000442 ESRRA P11474 Steroid hormone receptor ERR1 chr11 Compendium Yes 1 hippie 37 101 9 9 0
FAM160A2_ENST00000449352 FHIP1B Q8N612 FHF complex subunit HOOK interacting protein 1B chr11 Not Cancer Driver No 1 intact 129 415 54 54 0
FAM98C FAM98C Q17RN3 Protein FAM98C chr19 Not Cancer Driver No 1 intact, hippie 48 93 19 19 0
FAM9A_ENST00000381003 FAM9A Q8IZU1 Protein FAM9A chrX Not Cancer Driver No 1 intact, hippie 77 332 77 77 0
FBL FBL P22087 rRNA 2'-O-methyltransferase fibrillarin chr19 Not Cancer Driver No 1 hippie, biogrid 46 145 22 22 0
FBXO25 FBXO25 Q8TCJ0 F-box only protein 25 chr8 Not Cancer Driver No 1 hippie 33 20 0 0 0
FOXF2 FOXF2 Q12947 Forkhead box protein F2 chr6 Not Cancer Driver No 1 hippie 44 277 10 10 0
GTF2B GTF2B Q00403 Transcription initiation factor IIB chr1 Not Cancer Driver No 1 hippie 33 80 6 6 0
GTF2E1 GTF2E1 P29083 General transcription factor IIE subunit 1 chr3 Not Cancer Driver No 1 hippie 71 264 48 48 0
GTF2E2 GTF2E2 P29084 Transcription initiation factor IIE subunit beta chr8 Not Cancer Driver No 1 hippie 34 130 16 16 2
GTF2F1 GTF2F1 P35269 General transcription factor IIF subunit 1 chr19 Not Cancer Driver No 1 hippie 63 426 48 48 0
GTF2F2 GTF2F2 P13984 General transcription factor IIF subunit 2 chr13 Not Cancer Driver No 3 intact, hippie, biogrid 20 112 9 9 0
GTF2H4 GTF2H4 Q92759 General transcription factor IIH subunit 4 chr6 Not Cancer Driver No 1 hippie 46 30 5 5 0
HES4_ENST00000304952 HES4 Q9HCC6 Transcription factor HES-4 chr1 Not Cancer Driver No 1 hippie 5 124 3 3 0
HMGCL HMGCL P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial chr1 Not Cancer Driver No 1 hippie 17 8 2 2 19
HNF4A HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 135 127 48 48 5
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 Not Cancer Driver No 1 hippie 59 335 37 37 0
IK IK Q13123 Protein Red chr5 Not Cancer Driver No 1 hippie 61 482 50 50 0
IKZF1 IKZF1 Q13422 DNA-binding protein Ikaros chr7 Census, Compendium Yes 1 hippie 143 326 92 92 5
JADE3_ENST00000611250 JADE3 Q92613 Protein Jade-3 chrX Not Cancer Driver No 1 intact, hippie 110 421 52 52 0
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 Census, Compendium Yes 1 hippie 167 63 10 10 7
JCHAIN JCHAIN P01591 Immunoglobulin J chain chr4 Not Cancer Driver No 1 intact, hippie 37 9 3 3 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KLF15 KLF15 Q9UIH9 Krueppel-like factor 15 chr3 Not Cancer Driver No 1 hippie 66 273 48 48 0
KLF5 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 77 366 40 40 0
LPIN1_ENST00000256720 LPIN1 Q14693 Phosphatidate phosphatase LPIN1 chr2 Not Cancer Driver No 1 intact, hippie 120 447 70 70 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LSM4 LSM4 Q9Y4Z0 U6 snRNA-associated Sm-like protein LSm4 chr19 Not Cancer Driver No 1 hippie, biogrid 19 64 9 9 0
LSM5 LSM5 Q9Y4Y9 U6 snRNA-associated Sm-like protein LSm5 chr7 Not Cancer Driver No 1 hippie, biogrid 7 15 0 0 0
LTN1_ENST00000361371 LTN1 O94822 E3 ubiquitin-protein ligase listerin chr21 Not Cancer Driver No 1 hippie 192 124 23 23 0
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 104 275 38 38 1
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX Not Cancer Driver No 1 hippie 75 483 74 74 46
MED1 MED1 Q15648 Mediator of RNA polymerase II transcription subunit 1 chr17 Not Cancer Driver No 1 hippie 162 1104 117 117 0
MED21 MED21 Q13503 Mediator of RNA polymerase II transcription subunit 21 chr12 Not Cancer Driver No 1 hippie 12 46 3 3 0
MED4 MED4 Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 chr13 Not Cancer Driver No 1 hippie 29 161 17 17 0
MKX MKX Q8IYA7 Homeobox protein Mohawk chr10 Not Cancer Driver No 1 hippie 87 288 81 81 0
MLC1 MLC1 Q15049 Membrane protein MLC1 chr22 Not Cancer Driver No 1 intact, hippie 53 35 7 7 15
MUC7 MUC7 Q8TAX7 Mucin-7 chr4 Not Cancer Driver No 3 intact, hippie, biogrid 151 338 142 142 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYH11_ENST00000300036 MYH11 P35749 Myosin-11 chr16 Census, Compendium Yes 1 hippie 353 1180 201 201 2
MYL12B_ENST00000237500 MYL12B O14950 Myosin regulatory light chain 12B chr18 Not Cancer Driver No 1 intact, hippie 23 61 13 13 0
NAP1L1 NAP1L1 P55209 Nucleosome assembly protein 1-like 1 chr12 Not Cancer Driver No 1 hippie, biogrid 47 207 31 31 0
NCBP3 NCBP3 Q53F19 Nuclear cap-binding protein subunit 3 chr17 Not Cancer Driver No 1 hippie 52 507 42 42 0
NCOA1_ENST00000348332 NCOA1 Q15788 Nuclear receptor coactivator 1 chr2 Census, Compendium Yes 1 hippie 188 1217 149 149 0
NCOA3 NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 chr20 Not Cancer Driver No 1 hippie 176 1231 160 160 0
NCOR1 NCOR1 O75376 Nuclear receptor corepressor 1 chr17 Census, Compendium Yes 1 hippie 352 2347 340 340 0
NOLC1_ENST00000605788 NOLC1 Q14978 Nucleolar and coiled-body phosphoprotein 1 chr10 Not Cancer Driver No 1 hippie 74 662 69 69 0
NR1D2 NR1D2 Q14995 Nuclear receptor subfamily 1 group D member 2 chr3 Not Cancer Driver No 1 hippie 76 223 25 25 0
NR2F1_ENST00000327111 NR2F1 P10589 COUP transcription factor 1 chr5 Not Cancer Driver No 2 intact, hippie 67 110 6 6 4
NR5A1 NR5A1 Q13285 Steroidogenic factor 1 chr9 Not Cancer Driver No 1 hippie 60 133 29 29 24
NSUN2 NSUN2 Q08J23 RNA cytosine C(5)-methyltransferase NSUN2 chr5 Not Cancer Driver No 1 hippie, biogrid 112 221 21 21 1
NVL NVL O15381 Nuclear valosin-containing protein-like chr1 Not Cancer Driver No 1 intact, hippie 90 267 31 31 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OXSM OXSM Q9NWU1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial chr3 Not Cancer Driver No 2 intact, hippie, biogrid 62 44 6 6 0
PBX4 PBX4 Q9BYU1 Pre-B-cell leukemia transcription factor 4 chr19 Not Cancer Driver No 1 intact, hippie 47 262 26 26 0
PHF19_ENST00000373896 PHF19 Q5T6S3 PHD finger protein 19 chr9 Not Cancer Driver No 1 intact, hippie 66 129 19 19 0
PIGR PIGR P01833 Polymeric immunoglobulin receptor chr1 Not Cancer Driver No 1 hippie, biogrid 126 177 37 37 0
PKP2 PKP2 Q99959 Plakophilin-2 chr12 Not Cancer Driver No 1 hippie 176 434 98 98 8
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POLR2A POLR2A P24928-2 Isoform 2 of DNA-directed RNA polymerase II subunit RPB1 chr17 Census Yes 2 hippie, biogrid 56 230 20 20 0
POLR2C POLR2C P19387 DNA-directed RNA polymerase II subunit RPB3 chr16 Not Cancer Driver No 1 intact, hippie 34 108 11 11 0
POLR2E POLR2E P19388 DNA-directed RNA polymerases I, II, and III subunit RPABC1 chr19 Not Cancer Driver No 3 intact, hippie 31 36 3 3 0
POLR2F_ENST00000442738 POLR2F P61218 DNA-directed RNA polymerases I, II, and III subunit RPABC2 chr22 Not Cancer Driver No 1 hippie 22 57 13 13 0
POLR2G POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 Not Cancer Driver No 1 intact, hippie 15 15 1 1 0
POLR2H_ENST00000456318 POLR2H P52434 DNA-directed RNA polymerases I, II, and III subunit RPABC3 chr3 Not Cancer Driver No 1 hippie, biogrid 16 14 1 1 0
POLR2J POLR2J P52435 DNA-directed RNA polymerase II subunit RPB11-a chr7 Not Cancer Driver No 1 hippie, biogrid 12 0 0 0 0
POLR3A POLR3A O14802 DNA-directed RNA polymerase III subunit RPC1 chr10 Not Cancer Driver No 1 hippie 155 113 17 17 15
POU3F2 POU3F2 P20265 POU domain, class 3, transcription factor 2 chr6 Not Cancer Driver No 1 intact, hippie 52 361 36 36 0
PRB1_ENST00000545626 PRB1 G3V1R1 Basic salivary proline-rich protein 1 chr12 Not Cancer Driver No 3 hippie, biogrid 66 178 66 66 0
PRB2 PRB2 P02812 Basic salivary proline-rich protein 2 chr12 Not Cancer Driver No 1 intact, hippie 187 416 187 187 0
PRPF18 PRPF18 Q99633 Pre-mRNA-splicing factor 18 chr10 Not Cancer Driver No 1 hippie, biogrid 52 93 18 18 0
PSMA3 PSMA3 P25788 Proteasome subunit alpha type-3 chr14 Not Cancer Driver No 1 hippie 27 30 5 5 0
PSMC2_ENST00000292644 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie 63 120 13 13 0
PSMC5 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 hippie 52 64 6 6 0
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 Not Cancer Driver No 1 intact, hippie 32 65 15 15 0
REL REL Q04864 Proto-oncogene c-Rel chr2 Census Yes 1 hippie 68 363 43 43 0
RELA RELA Q04206 Transcription factor p65 chr11 Compendium Yes 1 hippie 75 400 48 48 0
REST REST Q13127 RE1-silencing transcription factor chr4 Not Cancer Driver No 1 hippie 142 868 113 113 4
RFC5 RFC5 P40937 Replication factor C subunit 5 chr12 Not Cancer Driver No 1 hippie, biogrid 38 20 1 1 0
RNF183_ENST00000297894 RNF183 Q96D59 E3 ubiquitin-protein ligase RNF183 chr9 Not Cancer Driver No 1 intact, hippie 22 29 1 1 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 intact, hippie 46 9 3 3 4
RPP25 RPP25 Q9BUL9 Ribonuclease P protein subunit p25 chr15 Not Cancer Driver No 1 intact, hippie 11 162 11 11 0
RPS4X RPS4X P62701 40S ribosomal protein S4, X isoform chrX Not Cancer Driver No 1 intact, hippie 32 35 6 6 0
RUSC1 RUSC1 Q9BVN2 AP-4 complex accessory subunit RUSC1 chr1 Not Cancer Driver No 1 intact, hippie 99 640 69 69 0
RYBP RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 37 214 37 37 0
SAP25_ENST00000538735 SAP25 Q8TEE9 Histone deacetylase complex subunit SAP25 chr7 Not Cancer Driver No 1 hippie 7 143 6 6 0
SAP30 SAP30 O75446 Histone deacetylase complex subunit SAP30 chr4 Not Cancer Driver No 1 hippie 26 123 17 17 0
SEM1_ENST00000356686 SEM1 Q6ZVN7 Putative protein SEM1, isoform 2 chr7 Not Cancer Driver No 1 hippie 2 52 1 1 0
SERPINB1 SERPINB1 P30740 Leukocyte elastase inhibitor chr6 Not Cancer Driver No 3 intact, hippie, biogrid 39 14 0 0 0
SLC22A2 SLC22A2 O15244 Solute carrier family 22 member 2 chr6 Not Cancer Driver No 1 intact, hippie 126 31 11 11 0
SMURF1 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 chr7 Not Cancer Driver No 1 hippie 89 256 31 31 0
SP1 SP1 P08047 Transcription factor Sp1 chr12 Not Cancer Driver No 1 hippie 96 599 71 71 0
SPATA22_ENST00000397168 SPATA22 Q8NHS9 Spermatogenesis-associated protein 22 chr17 Not Cancer Driver No 1 intact, hippie 71 220 40 40 0
SPPL2B SPPL2B Q8TCT7 Signal peptide peptidase-like 2B chr19 Not Cancer Driver No 1 intact, hippie 68 99 17 17 0
SYNCRIP SYNCRIP O60506 Heterogeneous nuclear ribonucleoprotein Q chr6 Not Cancer Driver No 1 intact, hippie 93 285 39 39 0
TAF11 TAF11 Q15544 Transcription initiation factor TFIID subunit 11 chr6 Not Cancer Driver No 1 hippie 22 137 16 16 0
TAF9 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 Not Cancer Driver No 1 hippie 25 203 19 19 0
TBP TBP P20226 TATA-box-binding protein chr6 Not Cancer Driver No 3 intact, hippie 40 164 14 14 0
TBPL1 TBPL1 P62380 TATA box-binding protein-like 1 chr6 Not Cancer Driver No 1 hippie 27 6 0 0 0
TCEA1 TCEA1 P23193 Transcription elongation factor A protein 1 chr8 Census Yes 1 hippie 48 223 36 36 0
TCEA2 TCEA2 Q15560 Transcription elongation factor A protein 2 chr20 Not Cancer Driver No 1 hippie 45 194 40 40 0
THRA THRA P10827 Thyroid hormone receptor alpha chr17 Not Cancer Driver No 1 hippie 69 207 30 30 2
TIMM44 TIMM44 O43615 Mitochondrial import inner membrane translocase subunit TIM44 chr19 Not Cancer Driver No 1 intact, hippie 56 175 22 22 0
TNIP1_ENST00000522226 TNIP1 Q15025 TNFAIP3-interacting protein 1 chr5 Not Cancer Driver No 3 intact, hippie 85 625 83 83 0
TRAM2 TRAM2 Q15035 Translocating chain-associated membrane protein 2 chr6 Not Cancer Driver No 1 hippie 46 20 2 2 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRMT1L TRMT1L Q7Z2T5 TRMT1-like protein chr1 Not Cancer Driver No 1 intact, hippie 71 241 19 19 0
USP2 USP2 O75604 Ubiquitin carboxyl-terminal hydrolase 2 chr11 Not Cancer Driver No 1 intact, hippie 88 213 39 39 0
VCAM1 VCAM1 P19320 Vascular cell adhesion protein 1 chr1 Not Cancer Driver No 1 intact, hippie 188 110 28 28 0
VDR_ENST00000549336 VDR P11473 Vitamin D3 receptor chr12 Not Cancer Driver No 1 hippie 64 102 16 16 14
VSX2 VSX2 P58304 Visual system homeobox 2 chr14 Not Cancer Driver No 1 intact, hippie 43 268 23 23 5
WWP2 WWP2 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 chr16 Not Cancer Driver No 1 hippie 112 422 57 57 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 intact, hippie 32 41 3 3 0
YY1 YY1 P25490 Transcriptional repressor protein YY1 chr14 Not Cancer Driver No 1 hippie 37 336 26 26 2
ZG16B ZG16B Q96DA0 Zymogen granule protein 16 homolog B chr16 Not Cancer Driver No 3 intact, hippie, biogrid 28 36 2 2 0
ZNF829_ENST00000391711 ZNF829 Q3KNS6 Zinc finger protein 829 chr19 Not Cancer Driver No 1 intact, hippie 83 57 19 19 0
ZSCAN1 ZSCAN1 Q8NBB4 Zinc finger and SCAN domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 132 298 98 98 0
ZSCAN22 ZSCAN22 P10073 Zinc finger and SCAN domain-containing protein 22 chr19 Not Cancer Driver No 1 intact, hippie 81 250 35 35 0