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GBA_ENST00000368373 ,GBA ,P04062
  • Uniprot Accession= P04062
  • Ensembl Transcript= ENST00000368373.7
  • Uniprot Name= GBA
  • Name= Lysosomal acid glucosylceramidase
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 12
  • Number of Interaction partner in hippie: 73
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
A2M A2M P01023 Alpha-2-macroglobulin chr12 Not Cancer Driver No 1 hippie 260 144 22 22 0
AGK AGK Q53H12 Acylglycerol kinase, mitochondrial chr7 Not Cancer Driver No 1 hippie 71 77 6 6 0
APOC3 APOC3 P02656 Apolipoprotein C-III chr11 Not Cancer Driver No 1 hippie, biogrid 14 12 2 2 1
ARL8B ARL8B Q9NVJ2 ADP-ribosylation factor-like protein 8B chr3 Not Cancer Driver No 1 hippie 28 0 0 0 0
ATP5PF_ENST00000400090 ATP5PF P18859 ATP synthase-coupling factor 6, mitochondrial chr21 Not Cancer Driver No 1 hippie 14 15 1 1 0
ATP6V1A ATP6V1A P38606 V-type proton ATPase catalytic subunit A chr3 Not Cancer Driver No 1 hippie 86 31 2 2 4
ATP6V1B1 ATP6V1B1 P15313 V-type proton ATPase subunit B, kidney isoform chr2 Not Cancer Driver No 1 hippie 77 66 14 14 9
ATP6V1B2 ATP6V1B2 P21281 V-type proton ATPase subunit B, brain isoform chr8 Not Cancer Driver No 1 hippie 63 49 4 4 1
B4GALT7 B4GALT7 Q9UBV7 Beta-1,4-galactosyltransferase 7 chr5 Not Cancer Driver No 1 hippie 32 44 6 6 2
BMP2K BMP2K Q9NSY1 BMP-2-inducible protein kinase chr4 Not Cancer Driver No 1 hippie 124 827 89 89 0
CANX_ENST00000504734 CANX P27824 Calnexin chr5 Not Cancer Driver No 1 hippie 65 334 38 38 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CCT3 CCT3 P49368 T-complex protein 1 subunit gamma chr1 Not Cancer Driver No 1 hippie 71 95 12 12 0
CCT8 CCT8 P50990 T-complex protein 1 subunit theta chr21 Not Cancer Driver No 1 hippie 41 36 2 2 0
CNPY2 CNPY2 Q9Y2B0 Protein canopy homolog 2 chr12 Not Cancer Driver No 1 hippie, biogrid 24 24 3 3 0
COMT COMT P21964 Catechol O-methyltransferase chr22 Not Cancer Driver No 1 hippie 21 5 0 0 0
DHCR24 DHCR24 Q15392 Delta(24)-sterol reductase chr1 Not Cancer Driver No 1 hippie 55 0 0 0 6
ERP27 ERP27 Q96DN0 Endoplasmic reticulum resident protein 27 chr12 Not Cancer Driver No 1 hippie, biogrid 43 28 10 10 0
ESYT1_ENST00000394048 ESYT1 Q9BSJ8 Extended synaptotagmin-1 chr12 Not Cancer Driver No 1 hippie 126 278 32 32 0
EYA1_ENST00000647540 EYA1 Q99502 Eyes absent homolog 1 chr8 Not Cancer Driver No 1 hippie 168 341 99 99 15
FBXO6 FBXO6 Q9NRD1 F-box only protein 6 chr1 Not Cancer Driver No 1 hippie 31 27 3 3 0
FGD6 FGD6 Q6ZV73 FYVE, RhoGEF and PH domain-containing protein 6 chr12 Not Cancer Driver No 1 hippie 198 804 117 117 0
FMR1 FMR1 Q06787 Synaptic functional regulator FMR1 chrX Not Cancer Driver No 1 hippie 124 327 70 70 3
GUCA1B GUCA1B Q9UMX6 Guanylyl cyclase-activating protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 26 2 0 0 1
HCCS HCCS P53701 Holocytochrome c-type synthase chrX Not Cancer Driver No 1 hippie 48 117 25 25 1
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSP90B1 HSP90B1 P14625 Endoplasmin chr12 Not Cancer Driver No 1 hippie 94 268 35 35 0
HSPA4 HSPA4 P34932 Heat shock 70 kDa protein 4 chr5 Not Cancer Driver No 1 hippie 80 351 24 24 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 hippie 61 82 6 6 2
HYOU1 HYOU1 Q9Y4L1 Hypoxia up-regulated protein 1 chr11 Not Cancer Driver No 1 hippie 132 373 47 47 0
IMP3_ENST00000403490 IMP3 Q9NV31 U3 small nucleolar ribonucleoprotein protein IMP3 chr15 Not Cancer Driver No 1 hippie 12 1 0 0 0
ITCH ITCH Q96J02 E3 ubiquitin-protein ligase Itchy homolog chr20 Not Cancer Driver No 1 hippie 95 335 42 42 0
JPH1 JPH1 Q9HDC5 Junctophilin-1 chr8 Not Cancer Driver No 1 hippie 131 421 89 89 0
LAIR2 LAIR2 Q6ISS4 Leukocyte-associated immunoglobulin-like receptor 2 chr19 Not Cancer Driver No 1 hippie, biogrid 46 77 26 26 0
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 1 hippie 47 93 10 10 0
MTREX MTREX P42285 Exosome RNA helicase MTR4 chr5 Not Cancer Driver No 1 hippie 117 160 15 15 0
MYDGF MYDGF Q969H8 Myeloid-derived growth factor chr19 Not Cancer Driver No 1 hippie 23 26 4 4 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 1 hippie 150 711 79 79 0
NHLRC2 NHLRC2 Q8NBF2 NHL repeat-containing protein 2 chr10 Not Cancer Driver No 1 hippie 74 103 12 12 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 hippie 75 38 4 4 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX Not Cancer Driver No 1 hippie 156 89 16 16 2
PATJ PATJ Q8NI35 InaD-like protein chr1 Not Cancer Driver No 1 hippie 261 918 142 142 0
PCBP2_ENST00000439930 PCBP2 Q15366 Poly(rC)-binding protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 40 200 24 24 0
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 Not Cancer Driver No 1 hippie 137 99 7 7 0
PI4KB_ENST00000368873 PI4KB Q9UBF8 Phosphatidylinositol 4-kinase beta chr1 Not Cancer Driver No 1 hippie 93 311 34 34 0
PLD4_ENST00000392593 PLD4 Q96BZ4 5'-3' exonuclease PLD4 chr14 Not Cancer Driver No 1 biogrid 46 76 10 10 0
POMK POMK Q9H5K3 Protein O-mannose kinase chr8 Not Cancer Driver No 1 hippie 53 30 9 9 3
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PSAP PSAP P07602 Prosaposin chr10 Not Cancer Driver No 1 hippie 59 28 2 2 8
RAB14 RAB14 P61106 Ras-related protein Rab-14 chr9 Not Cancer Driver No 1 hippie 20 41 4 4 0
RAB21 RAB21 Q9UL25 Ras-related protein Rab-21 chr12 Not Cancer Driver No 1 hippie 23 59 4 4 0
RAB27A_ENST00000336787 RAB27A P51159 Ras-related protein Rab-27A chr15 Not Cancer Driver No 1 hippie, biogrid 25 15 4 4 3
RAB27B RAB27B O00194 Ras-related protein Rab-27B chr18 Not Cancer Driver No 1 hippie, biogrid 42 43 9 9 0
RDH11 RDH11 Q8TC12 Retinol dehydrogenase 11 chr14 Not Cancer Driver No 1 hippie 25 2 0 0 0
RIN3 RIN3 Q8TB24 Ras and Rab interactor 3 chr14 Not Cancer Driver No 1 hippie 137 417 61 61 0
RIPK4_ENST00000352483 RIPK4 P57078 Receptor-interacting serine/threonine-protein kinase 4 chr21 Not Cancer Driver No 1 hippie 119 232 34 34 3
RNF20 RNF20 Q5VTR2 E3 ubiquitin-protein ligase BRE1A chr9 Not Cancer Driver No 1 hippie 126 561 64 64 0
RPS6KA3_ENST00000379565 RPS6KA3 P51812 Ribosomal protein S6 kinase alpha-3 chrX Compendium Yes 1 hippie 106 145 18 18 13
SCAMP3 SCAMP3 O14828 Secretory carrier-associated membrane protein 3 chr1 Not Cancer Driver No 1 hippie 46 130 23 23 0
SCARB2 SCARB2 Q14108 Lysosome membrane protein 2 chr4 Not Cancer Driver No 1 hippie 61 13 3 3 1
SDF2L1 SDF2L1 Q9HCN8 Stromal cell-derived factor 2-like protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 16 130 9 9 0
SEC61B SEC61B P60468 Protein transport protein Sec61 subunit beta chr9 Not Cancer Driver No 1 hippie, biogrid 11 60 7 7 0
SLC25A5 SLC25A5 P05141 ADP/ATP translocase 2 chrX Not Cancer Driver No 1 hippie 41 0 0 0 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 Not Cancer Driver No 1 hippie 21 107 13 13 5
SPDYE4 SPDYE4 A6NLX3 Speedy protein E4 chr17 Not Cancer Driver No 1 hippie 42 79 12 12 0
TCP1 TCP1 P17987 T-complex protein 1 subunit alpha chr6 Not Cancer Driver No 1 hippie 54 55 10 10 0
TMEM106B TMEM106B Q9NUM4 Transmembrane protein 106B chr7 Not Cancer Driver No 1 hippie 31 56 4 4 1
TMEM192 TMEM192 Q8IY95 Transmembrane protein 192 chr4 Not Cancer Driver No 1 hippie 31 5 1 1 0
TMPRSS4_ENST00000437212 TMPRSS4 Q9NRS4 Transmembrane protease serine 4 chr11 Not Cancer Driver No 1 hippie, biogrid 47 35 4 4 0
TOP3B_ENST00000357179 TOP3B O95985 DNA topoisomerase 3-beta-1 chr22 Not Cancer Driver No 1 hippie 102 151 17 17 0
ZCCHC8 ZCCHC8 Q6NZY4 Zinc finger CCHC domain-containing protein 8 chr12 Census Yes 1 hippie 81 503 56 56 1
ZFP91 ZFP91 Q96JP5 E3 ubiquitin-protein ligase ZFP91 chr11 Not Cancer Driver No 1 hippie 85 383 55 55 0
ZMYND11 ZMYND11 Q15326 Zinc finger MYND domain-containing protein 11 chr10 Not Cancer Driver No 1 hippie 71 184 26 26 0