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GADD45A ,GADD45A ,P24522
  • Uniprot Accession= P24522
  • Ensembl Transcript= ENST00000370986.8
  • Uniprot Name= GADD45A
  • Name= Growth arrest and DNA damage-inducible protein GADD45 alpha
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 11
  • Number of Interaction partner in hippie: 98
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADAP1_ENST00000265846 ADAP1 O75689 Arf-GAP with dual PH domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie 33 30 3 3 0
AICDA AICDA Q9GZX7 Single-stranded DNA cytosine deaminase chr12 Not Cancer Driver No 1 hippie 56 0 0 0 8
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie 34 103 14 14 0
ASCC2 ASCC2 Q9H1I8 Activating signal cointegrator 1 complex subunit 2 chr22 Not Cancer Driver No 1 hippie 87 326 34 34 0
AURKA_ENST00000395915 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 36 178 21 21 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 Not Cancer Driver No 1 hippie 42 130 17 17 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 hippie 80 45 4 4 0
CBX4 CBX4 O00257 E3 SUMO-protein ligase CBX4 chr17 Not Cancer Driver No 1 hippie, biogrid 72 477 63 63 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 Not Cancer Driver No 1 hippie 49 145 14 14 0
CDAN1 CDAN1 Q8IWY9 Codanin-1 chr15 Not Cancer Driver No 1 hippie 123 429 30 30 9
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie 40 1 0 0 0
CDK11A CDK11A Q9UQ88 Cyclin-dependent kinase 11A chr1 Not Cancer Driver No 1 hippie 66 485 44 44 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 Census, Compendium Yes 1 hippie 48 121 30 30 0
CENPB CENPB P07199 Major centromere autoantigen B chr20 Not Cancer Driver No 1 hippie 64 374 39 39 0
CHD3_ENST00000330494 CHD3 Q12873 Chromodomain-helicase-DNA-binding protein 3 chr17 Not Cancer Driver No 1 hippie 235 1015 122 122 18
CLEC3B CLEC3B P05452 Tetranectin chr3 Not Cancer Driver No 1 hippie 34 50 13 13 0
CNOT9_ENST00000273064 CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 chr2 Compendium Yes 1 hippie 42 30 0 0 0
CRELD2_ENST00000328268 CRELD2 Q6UXH1 Protein disulfide isomerase CRELD2 chr22 Not Cancer Driver No 1 hippie 39 33 6 6 0
DCTN2_ENST00000548249 DCTN2 Q13561 Dynactin subunit 2 chr12 Not Cancer Driver No 1 hippie 46 253 32 32 0
DDX19B DDX19B Q9UMR2 ATP-dependent RNA helicase DDX19B chr16 Not Cancer Driver No 1 hippie, biogrid 44 113 9 9 0
DNAJC13 DNAJC13 O75165 DnaJ homolog subfamily C member 13 chr3 Not Cancer Driver No 1 hippie 276 141 17 17 0
DNMT1_ENST00000340748 DNMT1 P26358 DNA (cytosine-5)-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie 203 702 78 78 4
DYNC1H1 DYNC1H1 Q14204 Cytoplasmic dynein 1 heavy chain 1 chr14 Not Cancer Driver No 1 hippie 505 495 62 62 21
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 hippie 109 100 14 14 0
EEF1G EEF1G P26641 Elongation factor 1-gamma chr11 Not Cancer Driver No 1 hippie 44 66 5 5 0
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 Census Yes 1 hippie 175 816 121 121 6
ERG28 ERG28 Q9UKR5 Ergosterol biosynthetic protein 28 homolog chr14 Not Cancer Driver No 1 hippie 19 3 0 0 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
FAM83D FAM83D Q9H4H8 Protein FAM83D chr20 Not Cancer Driver No 1 hippie 70 273 29 29 0
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 Census, Compendium Yes 1 hippie 55 62 18 18 22
FBN3_ENST00000601739 FBN3 Q75N90 Fibrillin-3 chr19 Not Cancer Driver No 1 hippie 454 102 25 25 0
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 hippie 19 36 7 7 2
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 Not Cancer Driver No 1 hippie 10 39 5 5 0
GADD45B GADD45B O75293 Growth arrest and DNA damage-inducible protein GADD45 beta chr19 Not Cancer Driver No 1 hippie 9 14 0 0 0
GADD45G GADD45G O95257 Growth arrest and DNA damage-inducible protein GADD45 gamma chr9 Not Cancer Driver No 1 hippie 13 20 2 2 0
GADD45GIP1 GADD45GIP1 Q8TAE8 Growth arrest and DNA damage-inducible proteins-interacting protein 1 chr19 Not Cancer Driver No 1 hippie 19 193 19 19 0
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 hippie 39 24 3 3 0
GBP2 GBP2 P32456 Guanylate-binding protein 2 chr1 Not Cancer Driver No 1 hippie 75 134 15 15 0
GNB2 GNB2 P62879 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 chr7 Not Cancer Driver No 1 hippie 50 21 0 0 7
HNRNPA0 HNRNPA0 Q13151 Heterogeneous nuclear ribonucleoprotein A0 chr5 Not Cancer Driver No 1 hippie 25 172 14 14 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 70 290 58 58 4
IGSF21 IGSF21 Q96ID5 Immunoglobulin superfamily member 21 chr1 Not Cancer Driver No 1 hippie 119 183 47 47 0
ING4 ING4 Q9UNL4 Inhibitor of growth protein 4 chr12 Not Cancer Driver No 1 hippie 31 108 15 15 0
JMJD1C JMJD1C Q15652 Probable JmjC domain-containing histone demethylation protein 2C chr10 Not Cancer Driver No 1 hippie 305 1640 200 200 0
KAT14 KAT14 Q9H8E8 Cysteine-rich protein 2-binding protein chr20 Not Cancer Driver No 1 hippie 123 343 57 57 0
KHSRP KHSRP Q92945 Far upstream element-binding protein 2 chr19 Not Cancer Driver No 1 hippie 84 684 81 81 0
KLK6 KLK6 Q92876 Kallikrein-6 chr19 Not Cancer Driver No 1 hippie 62 28 12 12 0
LMO4 LMO4 P61968 LIM domain transcription factor LMO4 chr1 Not Cancer Driver No 1 hippie 30 11 1 1 0
LNX2 LNX2 Q8N448 Ligand of Numb protein X 2 chr13 Not Cancer Driver No 1 hippie 85 277 35 35 0
LRIF1 LRIF1 Q5T3J3 Ligand-dependent nuclear receptor-interacting factor 1 chr1 Not Cancer Driver No 1 hippie, biogrid 116 520 74 74 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 Not Cancer Driver No 1 hippie 48 55 11 11 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 Not Cancer Driver No 2 hippie, biogrid 261 520 86 86 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 Not Cancer Driver No 1 hippie 39 25 1 1 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MASP1_ENST00000337774 MASP1 P48740 Mannan-binding lectin serine protease 1 chr3 Not Cancer Driver No 1 hippie 142 72 14 14 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MICAL1_ENST00000358807 MICAL1 Q8TDZ2 [F-actin]-monooxygenase MICAL1 chr6 Not Cancer Driver No 1 hippie 112 364 37 37 0
MIDN MIDN Q504T8 Midnolin chr19 Not Cancer Driver No 1 hippie 43 446 43 43 0
MPP1 MPP1 Q00013 55 kDa erythrocyte membrane protein chrX Not Cancer Driver No 1 hippie 79 194 33 33 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 Census, Compendium Yes 1 hippie 379 296 37 37 18
NKIRAS2_ENST00000393880 NKIRAS2 Q9NYR9 NF-kappa-B inhibitor-interacting Ras-like protein 2 chr17 Not Cancer Driver No 1 hippie, biogrid 23 27 3 3 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 hippie 29 249 22 22 0
NRBP1_ENST00000379852 NRBP1 Q9UHY1 Nuclear receptor-binding protein chr2 Not Cancer Driver No 1 hippie 64 189 29 29 0
NUCB2_ENST00000622082 NUCB2 P80303 Nucleobindin-2 chr11 Not Cancer Driver No 1 hippie 49 265 40 40 0
PALD1 PALD1 Q9ULE6 Paladin chr10 Not Cancer Driver No 1 hippie, biogrid 132 154 21 21 0
PARVG_ENST00000422871 PARVG Q9HBI0 Gamma-parvin chr22 Not Cancer Driver No 1 hippie 54 44 9 9 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 hippie 30 22 3 3 1
PEAK1_ENST00000312493 PEAK1 Q9H792 Inactive tyrosine-protein kinase PEAK1 chr15 Not Cancer Driver No 1 hippie, biogrid 222 1232 150 150 0
PFKFB4 PFKFB4 Q16877 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 chr3 Not Cancer Driver No 1 hippie 71 44 3 3 0
PPARA_ENST00000402126 PPARA Q07869 Peroxisome proliferator-activated receptor alpha chr22 Not Cancer Driver No 1 hippie 63 68 9 9 0
PRR14L PRR14L Q5THK1 Protein PRR14L chr22 Not Cancer Driver No 1 hippie, biogrid 103 1525 63 63 0
PSMC3_ENST00000298852 PSMC3 P17980 26S proteasome regulatory subunit 6A chr11 Not Cancer Driver No 1 hippie 55 131 10 10 0
PTN PTN P21246 Pleiotrophin chr7 Not Cancer Driver No 1 hippie 43 51 11 11 0
PTPRK_ENST00000368215 PTPRK Q15262 Receptor-type tyrosine-protein phosphatase kappa chr6 Census, Compendium Yes 1 hippie 292 302 57 57 0
PUS1 PUS1 Q9Y606 Pseudouridylate synthase 1 homolog chr12 Not Cancer Driver No 1 hippie, biogrid 48 157 18 18 1
RAI1 RAI1 Q7Z5J4 Retinoic acid-induced protein 1 chr17 Not Cancer Driver No 1 hippie 208 1690 188 188 0
RARA RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 70 167 14 14 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 Not Cancer Driver No 1 hippie 49 151 19 19 2
RPS2 RPS2 P15880 40S ribosomal protein S2 chr16 Not Cancer Driver No 1 hippie 34 85 14 14 0
RPS7_ENST00000645674 RPS7 P62081 40S ribosomal protein S7 chr2 Not Cancer Driver No 1 hippie 29 39 7 7 0
RXRA RXRA P19793 Retinoic acid receptor RXR-alpha chr9 Compendium Yes 1 hippie 90 184 26 26 0
SETX SETX Q7Z333 Probable helicase senataxin chr9 Not Cancer Driver No 1 hippie, biogrid 342 1240 156 156 20
SH3GLB1_ENST00000370558 SH3GLB1 Q9Y371 Endophilin-B1 chr1 Not Cancer Driver No 1 hippie 41 82 10 10 0
SPTBN4_ENST00000598249 SPTBN4 Q9H254 Spectrin beta chain, non-erythrocytic 4 chr19 Not Cancer Driver No 1 hippie 312 866 103 103 0
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
SYNE4 SYNE4 Q8N205 Nesprin-4 chr19 Not Cancer Driver No 1 hippie 50 236 31 31 0
TDG TDG Q13569 G/T mismatch-specific thymine DNA glycosylase chr12 Not Cancer Driver No 1 hippie 75 185 31 31 0
TIAL1_ENST00000436547 TIAL1 Q01085 Nucleolysin TIAR chr10 Not Cancer Driver No 1 hippie 45 122 12 12 0
TLE1 TLE1 Q04724 Transducin-like enhancer protein 1 chr9 Not Cancer Driver No 1 hippie 111 381 53 53 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TRMT2A_ENST00000403707 TRMT2A Q8IZ69 tRNA (uracil-5-)-methyltransferase homolog A chr22 Not Cancer Driver No 1 hippie, biogrid 64 157 20 20 0
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 13 14 0 0 0
UBR1 UBR1 Q8IWV7 E3 ubiquitin-protein ligase UBR1 chr15 Not Cancer Driver No 1 hippie 170 165 15 15 18
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 Not Cancer Driver No 1 hippie 146 329 36 36 0
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 hippie 84 316 57 57 1
ZHX1_ENST00000522655 ZHX1 Q9UKY1 Zinc fingers and homeoboxes protein 1 chr8 Not Cancer Driver No 1 hippie 109 575 68 68 0
ZNF135_ENST00000313434 ZNF135 P52742 Zinc finger protein 135 chr19 Not Cancer Driver No 1 hippie 137 207 50 50 0