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FLG2 ,FLG2 ,Q5D862
  • Uniprot Accession= Q5D862
  • Ensembl Transcript= ENST00000388718.5
  • Uniprot Name= FLG2
  • Name= Filaggrin-2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 17
  • Number of Interaction partner in biogrid: 29
  • Number of Interaction partner in hippie: 98
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AGO1 AGO1 Q9UL18 Protein argonaute-1 chr1 Not Cancer Driver No 1 intact, hippie 126 87 11 11 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie, biogrid 49 20 4 4 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 Not Cancer Driver No 1 hippie, biogrid 41 83 12 12 9
ARMC12_ENST00000373866 ARMC12 Q5T9G4 Armadillo repeat-containing protein 12 chr6 Not Cancer Driver No 1 hippie 58 8 0 0 0
ATP6AP2 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 56 0 0 0 2
BTF3 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 hippie 27 192 24 24 0
CASP14 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 50 84 13 13 0
CCNC CCNC P24863 Cyclin-C chr6 Census Yes 1 hippie, biogrid 32 33 3 3 0
CCNF CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 106 221 23 23 3
CD274 CD274 Q9NZQ7 Programmed cell death 1 ligand 1 chr9 Census Yes 1 hippie 29 54 9 9 0
CDC73 CDC73 Q6P1J9 Parafibromin chr1 Census, Compendium Yes 1 hippie 110 210 39 39 2
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie, biogrid 40 1 0 0 0
CDK2 CDK2 P24941 Cyclin-dependent kinase 2 chr12 Not Cancer Driver No 1 hippie 24 0 0 0 0
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 Not Cancer Driver No 1 hippie 48 5 1 1 0
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 2 intact, hippie 287 145 18 18 151
CHD3_ENST00000330494 CHD3 Q12873 Chromodomain-helicase-DNA-binding protein 3 chr17 Not Cancer Driver No 1 hippie 235 1015 122 122 18
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
CSNK1E CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 1 hippie 62 133 18 18 0
CUL2_ENST00000374748 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 intact, hippie 87 66 3 3 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CYLD CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 116 213 31 31 3
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 hippie 48 53 6 6 1
DCUN1D1 DCUN1D1 Q96GG9 DCN1-like protein 1 chr3 Not Cancer Driver No 1 intact, hippie 34 13 0 0 0
DDX39B_ENST00000458640 DDX39B Q13838 Spliceosome RNA helicase DDX39B chr6 Not Cancer Driver No 1 hippie 49 34 8 8 0
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 133 301 47 47 18
DHFR2_ENST00000314636 DHFR2 Q86XF0 Dihydrofolate reductase 2, mitochondrial chr3 Not Cancer Driver No 1 hippie 25 20 0 0 0
DSC1 DSC1 Q08554 Desmocollin-1 chr18 Not Cancer Driver No 1 hippie, biogrid 219 265 65 65 0
DSG1 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 1 hippie, biogrid 250 496 130 130 0
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 hippie, biogrid 483 1124 204 204 6
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 intact, hippie 90 92 11 11 1
FAM160A1_ENST00000505231 FHIP1A Q05DH4 FHF complex subunit HOOK interacting protein 1A chr4 Not Cancer Driver No 1 intact 47 341 8 8 0
FAM160A2_ENST00000449352 FHIP1B Q8N612 FHF complex subunit HOOK interacting protein 1B chr11 Not Cancer Driver No 1 intact 129 415 54 54 0
FAM160B1 FHIP2A Q5W0V3 FHF complex subunit HOOK interacting protein 2A chr10 Not Cancer Driver No 1 intact 92 130 13 13 0
FASTKD3 FASTKD3 Q14CZ7 FAST kinase domain-containing protein 3, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 106 6 1 1 0
FBP1_ENST00000375326 FBP1 P09467 Fructose-1,6-bisphosphatase 1 chr9 Not Cancer Driver No 1 hippie 33 19 0 0 4
FBXO6 FBXO6 Q9NRD1 F-box only protein 6 chr1 Not Cancer Driver No 1 hippie 31 27 3 3 0
FGFRL1_ENST00000264748 FGFRL1 Q8N441 Fibroblast growth factor receptor-like 1 chr4 Not Cancer Driver No 1 hippie, biogrid 74 278 34 34 0
FLG FLG P20930 Filaggrin chr1 Not Cancer Driver No 1 hippie, biogrid 1612 3956 1593 1593 0
FTH1_ENST00000620041 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 1 hippie, biogrid 20 57 7 7 0
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GABARAPL1_ENST00000545887 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 Not Cancer Driver No 1 hippie 19 10 1 1 0
GABARAPL2 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 11 2 1 1 0
GMCL1 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 1 hippie, biogrid 33 80 2 2 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 70 290 58 58 4
HRNR HRNR Q86YZ3 Hornerin chr1 Not Cancer Driver No 1 hippie, biogrid 612 2767 601 601 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
IQCB1 IQCB1 Q15051 IQ calmodulin-binding motif-containing protein 1 chr3 Not Cancer Driver No 1 hippie 72 88 8 8 0
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 intact, hippie 147 120 7 7 2
JUP JUP P14923 Junction plakoglobin chr17 Not Cancer Driver No 1 hippie, biogrid 112 241 37 37 0
KCNJ2_ENST00000535240 KCNJ2 P63252 Inward rectifier potassium channel 2 chr17 Not Cancer Driver No 1 hippie 103 49 11 11 12
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KLF5 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 77 366 40 40 0
KPRP KPRP Q5T749 Keratinocyte proline-rich protein chr1 Not Cancer Driver No 1 hippie, biogrid 198 193 68 68 0
KRT17 KRT17 Q04695 Keratin, type I cytoskeletal 17 chr17 Not Cancer Driver No 1 hippie 86 160 31 31 18
LARP7_ENST00000344442 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 58 350 44 44 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
MAD2L1 MAD2L1 Q13257 Mitotic spindle assembly checkpoint protein MAD2A chr4 Not Cancer Driver No 1 intact, hippie 26 12 1 1 0
MAGEA3 MAGEA3 P43357 Melanoma-associated antigen 3 chrX Not Cancer Driver No 1 hippie 79 103 18 18 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 22 24 1 1 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact, hippie 10 17 1 1 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 intact, hippie 128 750 126 126 18
METTL14 METTL14 Q9HCE5 N6-adenosine-methyltransferase non-catalytic subunit chr4 Not Cancer Driver No 1 hippie 60 224 26 26 0
METTL3 METTL3 Q86U44 N6-adenosine-methyltransferase catalytic subunit chr14 Not Cancer Driver No 1 hippie 74 274 29 29 0
NCAPD3 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie 193 304 42 42 1
NEK2 NEK2 P51955 Serine/threonine-protein kinase Nek2 chr1 Not Cancer Driver No 1 hippie 61 92 19 19 0
NLRP7_ENST00000590030 NLRP7 Q8WX94 NACHT, LRR and PYD domains-containing protein 7 chr19 Not Cancer Driver No 1 hippie 300 71 20 20 9
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
PCLAF PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 20 111 20 20 0
PHKG2 PHKG2 P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform chr16 Not Cancer Driver No 1 hippie 48 50 6 6 4
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 57 99 13 13 23
PKP1 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 106 190 26 26 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PRPF8 PRPF8 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 chr17 Not Cancer Driver No 1 hippie 255 225 26 26 8
PRSS16 PRSS16 Q9NQE7 Thymus-specific serine protease chr6 Not Cancer Driver No 1 hippie, biogrid 85 26 5 5 0
PTDSS1 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 81 44 7 7 3
RPS19BP1 RPS19BP1 Q86WX3 Active regulator of SIRT1 chr22 Not Cancer Driver No 1 hippie, biogrid 5 112 5 5 0
RYBP RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 37 214 37 37 0
SERPINB12_ENST00000269491 SERPINB12 Q96P63 Serpin B12 chr18 Not Cancer Driver No 1 hippie, biogrid 82 21 6 6 0
SH2D3A SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 68 305 40 40 0
SOAT1 SOAT1 P35610 Sterol O-acyltransferase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 73 49 4 4 0
STAG1 STAG1 Q8WVM7 Cohesin subunit SA-1 chr3 Census Yes 1 hippie 226 391 66 66 8
STK24 STK24 Q9Y6E0 Serine/threonine-protein kinase 24 chr13 Not Cancer Driver No 1 hippie 67 118 16 16 0
STK26 STK26 Q9P289 Serine/threonine-protein kinase 26 chrX Not Cancer Driver No 1 hippie 62 119 18 18 0
STK4 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 Not Cancer Driver No 1 hippie 70 231 30 30 0
STX17_ENST00000534052 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 27 81 4 4 0
SUFU SUFU Q9UMX1 Suppressor of fused homolog chr10 Census Yes 1 intact 55 199 19 19 2
TBC1D22B TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 1 hippie, biogrid 55 205 27 27 0
TCF3 TCF3 P15923 Transcription factor E2-alpha chr19 Census Yes 1 hippie 52 649 52 52 0
TGM3 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 141 85 19 19 0
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
UCHL1 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie 33 34 7 7 4
UFL1 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 109 141 24 24 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 intact 170 215 45 45 0
VDAC1_ENST00000395047 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 38 36 4 4 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WAPL_ENST00000618527 WAPL Q7Z5K2 Wings apart-like protein homolog chr10 Not Cancer Driver No 1 hippie 140 621 68 68 0
WTAP_ENST00000621533 WTAP Q15007 Pre-mRNA-splicing regulator WTAP chr6 Not Cancer Driver No 1 hippie 60 305 50 50 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 Not Cancer Driver No 1 hippie 51 489 49 49 0
ZUP1 ZUP1 Q96AP4 Zinc finger-containing ubiquitin peptidase 1 chr6 Not Cancer Driver No 1 hippie 63 204 19 19 0