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FLG ,FLG ,P20930
  • Uniprot Accession= P20930
  • Ensembl Transcript= ENST00000368799.1
  • Uniprot Name= FLG
  • Name= Filaggrin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 19
  • Number of Interaction partner in biogrid: 57
  • Number of Interaction partner in hippie: 94
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD9 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 69 28 5 5 12
ALDH3A1_ENST00000444455 ALDH3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring chr17 Not Cancer Driver No 1 hippie, biogrid 73 36 7 7 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie, biogrid 49 20 4 4 0
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 Not Cancer Driver No 1 hippie, biogrid 36 101 6 6 9
AQP12B_ENST00000621682 AQP12B A6NM10 Aquaporin-12B chr2 Not Cancer Driver No 1 hippie, biogrid 46 37 0 0 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 Not Cancer Driver No 1 hippie 40 25 6 6 1
ATP6AP2 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 56 0 0 0 2
BLMH BLMH Q13867 Bleomycin hydrolase chr17 Not Cancer Driver No 1 hippie, biogrid 54 15 1 1 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 50 150 30 30 0
C18orf21 C18orf21 Q32NC0 UPF0711 protein C18orf21 chr18 Not Cancer Driver No 1 hippie, biogrid 21 112 12 12 0
CASP14 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 50 84 13 13 0
CCNC CCNC P24863 Cyclin-C chr6 Census Yes 1 hippie, biogrid 32 33 3 3 0
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 69 14 5 5 0
CFAP298 CFAP298 P57076 Cilia- and flagella-associated protein 298 chr21 Not Cancer Driver No 2 intact, hippie 26 111 10 10 0
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 hippie 71 75 8 8 4
CUL2_ENST00000374748 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 intact, hippie 87 66 3 3 0
CYLD CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 116 213 31 31 3
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 133 301 47 47 18
DPPA4 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 hippie, biogrid 94 180 46 46 0
DSG1 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 1 hippie, biogrid 250 496 130 130 0
DTL DTL Q9NZJ0 Denticleless protein homolog chr1 Not Cancer Driver No 1 hippie, biogrid 73 331 49 49 0
E2F6 E2F6 O75461 Transcription factor E2F6 chr2 Not Cancer Driver No 1 hippie, biogrid 20 105 10 10 0
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 Census, Compendium Yes 1 hippie, biogrid 92 208 22 22 2
ERP27 ERP27 Q96DN0 Endoplasmic reticulum resident protein 27 chr12 Not Cancer Driver No 1 hippie, biogrid 43 28 10 10 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 2 intact, hippie 90 92 11 11 1
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FCF1 FCF1 Q9Y324 rRNA-processing protein FCF1 homolog chr14 Not Cancer Driver No 2 intact, hippie, biogrid 28 46 4 4 0
FIBIN FIBIN Q8TAL6 Fin bud initiation factor homolog chr11 Not Cancer Driver No 1 hippie, biogrid 42 51 12 12 0
FLG2 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 613 2252 577 577 0
FLNC FLNC Q14315 Filamin-C chr7 Not Cancer Driver No 1 hippie 546 1442 288 288 7
FNDC5_ENST00000640867 FNDC5 Q8NAU1 Fibronectin type III domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 17 74 8 8 0
FRMD1 FRMD1 Q8N878 FERM domain-containing protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 82 259 36 36 0
FTH1_ENST00000620041 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 2 hippie, biogrid 20 57 7 7 0
GALNT9 GALNT9 Q9HCQ5 Polypeptide N-acetylgalactosaminyltransferase 9 chr12 Not Cancer Driver No 1 hippie, biogrid 80 32 2 2 0
GMCL1 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 2 hippie, biogrid 33 80 2 2 0
GOT1 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 Not Cancer Driver No 1 hippie, biogrid 56 35 5 5 0
GPR18_ENST00000397470 GPR18 Q14330 N-arachidonyl glycine receptor chr13 Not Cancer Driver No 2 hippie, biogrid 36 0 0 0 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 70 290 58 58 4
HTN3_ENST00000526767 HTN3 P15516 Histatin-3 chr4 Not Cancer Driver No 1 hippie 10 13 3 3 0
INPP5A INPP5A Q14642 Inositol polyphosphate-5-phosphatase A chr10 Not Cancer Driver No 1 hippie, biogrid 59 7 4 4 0
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KLF5 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 77 366 40 40 0
KLK5_ENST00000593428 KLK5 Q9Y337 Kallikrein-5 chr19 Not Cancer Driver No 1 intact, hippie 69 75 16 16 0
LARP7_ENST00000344442 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 58 350 44 44 0
LRRC10 LRRC10 Q5BKY1 Leucine-rich repeat-containing protein 10 chr12 Not Cancer Driver No 1 hippie, biogrid 52 38 11 11 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
MAK_ENST00000474039 MAK P20794 Serine/threonine-protein kinase MAK chr6 Not Cancer Driver No 2 intact, hippie 80 323 51 51 5
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact, hippie 10 17 1 1 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 intact, hippie 128 750 126 126 18
MCL1 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 Not Cancer Driver No 2 hippie, biogrid 30 203 21 21 0
METTL14 METTL14 Q9HCE5 N6-adenosine-methyltransferase non-catalytic subunit chr4 Not Cancer Driver No 1 hippie 60 224 26 26 0
MPG MPG P29372 DNA-3-methyladenine glycosylase chr16 Not Cancer Driver No 1 hippie 35 141 21 21 0
NCAPD3 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie 193 304 42 42 1
NPHP1_ENST00000393272 NPHP1 O15259 Nephrocystin-1 chr2 Not Cancer Driver No 1 hippie, biogrid 108 259 32 32 1
OR13C3 OR13C3 Q8NGS6 Olfactory receptor 13C3 chr9 Not Cancer Driver No 1 hippie, biogrid 99 0 0 0 0
OR2A4 OR2A4 O95047 Olfactory receptor 2A4 chr6 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
P2RX6 P2RX6 O15547 P2X purinoceptor 6 chr22 Not Cancer Driver No 1 hippie, biogrid 33 43 1 1 0
PCLAF PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 20 111 20 20 0
PCSK6 PCSK6 P29122 Proprotein convertase subtilisin/kexin type 6 chr15 Not Cancer Driver No 1 hippie 138 207 45 45 0
PI4KA PI4KA P42356 Phosphatidylinositol 4-kinase alpha chr22 Not Cancer Driver No 1 hippie, biogrid 267 142 11 11 1
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 57 99 13 13 23
PKP1 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 106 190 26 26 0
PPP2R2B_ENST00000394409 PPP2R2B Q00005 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform chr5 Not Cancer Driver No 1 hippie, biogrid 101 76 22 22 0
PRSS16 PRSS16 Q9NQE7 Thymus-specific serine protease chr6 Not Cancer Driver No 1 hippie, biogrid 85 26 5 5 0
PSMD14 PSMD14 O00487 26S proteasome non-ATPase regulatory subunit 14 chr2 Not Cancer Driver No 1 hippie 23 67 6 6 0
PTDSS1 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 81 44 7 7 3
RIPPLY3 RIPPLY3 P57055 Protein ripply3 chr21 Not Cancer Driver No 1 hippie, biogrid 44 190 44 44 0
RNLS RNLS Q5VYX0 Renalase chr10 Not Cancer Driver No 1 intact 42 15 1 1 0
SAMD12 SAMD12 Q8N8I0 Sterile alpha motif domain-containing protein 12 chr8 Not Cancer Driver No 1 hippie 46 60 11 11 0
SARAF SARAF Q96BY9 Store-operated calcium entry-associated regulatory factor chr8 Not Cancer Driver No 1 hippie, biogrid 32 73 8 8 0
SCN3B_ENST00000299333 SCN3B Q9NY72 Sodium channel subunit beta-3 chr11 Not Cancer Driver No 1 hippie, biogrid 63 16 5 5 3
SH2D3A SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 68 305 40 40 0
SLC25A6 SLC25A6 P12236 ADP/ATP translocase 3 chrX Not Cancer Driver No 1 hippie, biogrid 41 0 0 0 0
SLC35F2 SLC35F2 Q8IXU6 Solute carrier family 35 member F2 chr11 Not Cancer Driver No 1 hippie, biogrid 53 12 0 0 0
SLX4 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 Not Cancer Driver No 1 intact, hippie 271 1573 232 232 0
ST6GALNAC6_ENST00000373146 ST6GALNAC6 Q969X2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 chr9 Not Cancer Driver No 1 hippie, biogrid 44 86 13 13 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 hippie, biogrid 75 135 14 14 9
STK16_ENST00000396738 STK16 O75716 Serine/threonine-protein kinase 16 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 42 48 3 3 0
STK4 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 Not Cancer Driver No 1 intact, hippie 70 231 30 30 0
STX17_ENST00000534052 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 27 81 4 4 0
TBC1D22B TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 1 hippie, biogrid 55 205 27 27 0
TGM3 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 141 85 19 19 0
TMEM79_ENST00000295694 TMEM79 Q9BSE2 Transmembrane protein 79 chr1 Not Cancer Driver No 1 hippie 56 149 20 20 0
TNFRSF19 TNFRSF19 Q9NS68 Tumor necrosis factor receptor superfamily member 19 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 72 103 19 19 0
TUBG1 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 hippie 51 44 10 10 3
TXNIP TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie 61 77 14 14 0
UCHL5 UCHL5 Q9Y5K5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 chr1 Not Cancer Driver No 1 hippie 33 41 7 7 0
UCP2 UCP2 P55851 Mitochondrial uncoupling protein 2 chr11 Not Cancer Driver No 3 intact, hippie, biogrid 31 11 3 3 0
USP1_ENST00000371146 USP1 O94782 Ubiquitin carboxyl-terminal hydrolase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 63 403 30 30 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 intact, hippie 142 117 36 36 133
ZC3HC1 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 70 250 34 34 0
ZDHHC19 ZDHHC19 Q8WVZ1 Palmitoyltransferase ZDHHC19 chr3 Not Cancer Driver No 1 hippie, biogrid 48 35 10 10 0
ZSCAN12_ENST00000396827 ZSCAN12 O43309-2 Isoform 2 of Zinc finger and SCAN domain-containing protein 12 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 44 237 25 25 0