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FAM189B ,FAM189B ,P81408
  • Uniprot Accession= P81408
  • Ensembl Transcript= ENST00000361361.6
  • Uniprot Name= FAM189B
  • Name= Protein FAM189B
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 60
  • Number of Interaction partner in biogrid: 106
  • Number of Interaction partner in hippie: 115
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCA2_ENST00000371605 ABCA2 Q9BZC7 ATP-binding cassette sub-family A member 2 chr9 Not Cancer Driver No 1 hippie, biogrid 240 497 44 44 0
ABCD4 ABCD4 O14678 Lysosomal cobalamin transporter ABCD4 chr14 Not Cancer Driver No 1 hippie, biogrid 77 6 1 1 3
ABRAXAS2 ABRAXAS2 Q15018 BRISC complex subunit Abraxas 2 chr10 Not Cancer Driver No 1 intact, hippie 47 207 26 26 0
ACP2 ACP2 P11117 Lysosomal acid phosphatase chr11 Not Cancer Driver No 2 intact, hippie, biogrid 41 77 11 11 0
ADGRL1 ADGRL1 O94910 Adhesion G protein-coupled receptor L1 chr19 Not Cancer Driver No 1 intact, hippie 163 562 57 57 0
AMFR AMFR Q9UKV5 E3 ubiquitin-protein ligase AMFR chr16 Not Cancer Driver No 1 hippie, biogrid 73 229 30 30 0
ANKRD13A ANKRD13A Q8IZ07 Ankyrin repeat domain-containing protein 13A chr12 Not Cancer Driver No 3 intact, hippie, biogrid 54 167 16 16 0
ANKRD13D ANKRD13D Q6ZTN6 Ankyrin repeat domain-containing protein 13D chr11 Not Cancer Driver No 3 intact, hippie, biogrid 67 286 24 24 0
ASGR2 ASGR2 P07307 Asialoglycoprotein receptor 2 chr17 Not Cancer Driver No 1 hippie, biogrid 49 71 8 8 0
BABAM1_ENST00000601043 BABAM1 Q9NWV8 BRISC and BRCA1-A complex member 1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 35 113 14 14 0
BABAM2_ENST00000342045 BABAM2 Q9NXR7 BRISC and BRCA1-A complex member 2 chr2 Not Cancer Driver No 1 intact, hippie 52 0 0 0 0
BAG3 BAG3 O95817 BAG family molecular chaperone regulator 3 chr10 Not Cancer Driver No 1 hippie, biogrid 57 571 57 57 7
BTN2A1 BTN2A1 Q7KYR7 Butyrophilin subfamily 2 member A1 chr6 Not Cancer Driver No 1 hippie, biogrid 86 38 9 9 0
BTN2A2 BTN2A2 Q8WVV5 Butyrophilin subfamily 2 member A2 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 92 24 2 2 0
CAPN15 CAPN15 O75808 Calpain-15 chr16 Not Cancer Driver No 1 intact, hippie, biogrid 98 385 29 29 0
CD79B_ENST00000006750 CD79B P40259 B-cell antigen receptor complex-associated protein beta chain chr17 Census, Compendium Yes 2 intact, hippie, biogrid 25 43 10 10 1
CFAP74 CFAP74 Q9C0B2 Cilia- and flagella-associated protein 74 chr1 Not Cancer Driver No 1 hippie, biogrid 112 579 66 66 0
CHRNA4 CHRNA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 chr20 Not Cancer Driver No 1 hippie, biogrid 144 186 33 33 2
CHRNA9 CHRNA9 Q9UGM1 Neuronal acetylcholine receptor subunit alpha-9 chr4 Not Cancer Driver No 1 hippie, biogrid 76 23 6 6 0
CHRND CHRND Q07001 Acetylcholine receptor subunit delta chr2 Not Cancer Driver No 2 intact, hippie, biogrid 110 71 19 19 7
CLEC12B CLEC12B Q2HXU8 C-type lectin domain family 12 member B chr12 Not Cancer Driver No 1 hippie, biogrid 34 57 8 8 0
CLEC2D_ENST00000290855 CLEC2D Q9UHP7 C-type lectin domain family 2 member D chr12 Not Cancer Driver No 2 intact, hippie, biogrid 28 14 1 1 0
CLRN2 CLRN2 A0PK11 Clarin-2 chr4 Not Cancer Driver No 1 hippie, biogrid 54 0 0 0 1
COLEC12 COLEC12 Q5KU26 Collectin-12 chr18 Not Cancer Driver No 1 intact, hippie, biogrid 147 450 90 90 0
CTDNEP1_ENST00000318988 CTDNEP1 O95476 CTD nuclear envelope phosphatase 1 chr17 Not Cancer Driver No 1 intact, hippie, biogrid 20 0 0 0 0
CUEDC1_ENST00000407144 CUEDC1 Q9NWM3 CUE domain-containing protein 1 chr17 Not Cancer Driver No 1 intact, hippie, biogrid 53 325 44 44 0
CYHR1_ENST00000438911 CYHR1 Q6ZMK1 Cysteine and histidine-rich protein 1 chr8 Not Cancer Driver No 2 intact, hippie, biogrid 24 11 0 0 0
DHRS7_ENST00000557185 DHRS7 Q9Y394 Dehydrogenase/reductase SDR family member 7 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 37 10 0 0 0
EDA EDA Q92838 Ectodysplasin-A chrX Not Cancer Driver No 1 intact, hippie, biogrid 73 243 43 43 71
EPN1_ENST00000270460 EPN1 Q9Y6I3 Epsin-1 chr19 Not Cancer Driver No 1 hippie, biogrid 87 493 71 71 0
EVA1C EVA1C P58658 Protein eva-1 homolog C chr21 Not Cancer Driver No 1 hippie, biogrid 47 60 2 2 0
FAM189A2 FAM189A2 Q15884 Protein FAM189A2 chr9 Not Cancer Driver No 3 intact, hippie, biogrid 62 231 29 29 0
FNDC3B_ENST00000416957 FNDC3B Q53EP0 Fibronectin type III domain-containing protein 3B chr3 Not Cancer Driver No 1 intact, hippie, biogrid 164 433 53 53 0
FSHR FSHR P23945 Follicle-stimulating hormone receptor chr2 Not Cancer Driver No 2 hippie, biogrid 226 28 11 11 16
GABRE GABRE P78334 Gamma-aminobutyric acid receptor subunit epsilon chrX Not Cancer Driver No 1 hippie, biogrid 133 73 19 19 0
GPM6A_ENST00000393658 GPM6A P51674 Neuronal membrane glycoprotein M6-a chr4 Not Cancer Driver No 1 hippie, biogrid 83 15 5 5 0
GPR21 GPR21 Q99679 Probable G-protein coupled receptor 21 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 39 2 0 0 0
GPR52 GPR52 Q9Y2T5 G-protein coupled receptor 52 chr1 Not Cancer Driver No 1 hippie, biogrid 48 9 2 2 0
HBB HBB P68871 Hemoglobin subunit beta chr11 Not Cancer Driver No 1 hippie, biogrid 45 7 2 2 5
HECW1 HECW1 Q76N89 E3 ubiquitin-protein ligase HECW1 chr7 Not Cancer Driver No 2 hippie, biogrid 420 748 191 191 0
HECW2_ENST00000644256 HECW2 Q9P2P5 E3 ubiquitin-protein ligase HECW2 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 348 845 195 195 4
HERC3 HERC3 Q15034 Probable E3 ubiquitin-protein ligase HERC3 chr4 Not Cancer Driver No 2 intact, hippie, biogrid 112 56 7 7 0
HERC4 HERC4 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 111 40 2 2 0
HFE HFE Q30201 Hereditary hemochromatosis protein chr6 Not Cancer Driver No 1 hippie, biogrid 55 27 2 2 11
HLA-E HLA-E P13747 HLA class I histocompatibility antigen, alpha chain E chr6 Not Cancer Driver No 1 hippie, biogrid 63 138 39 39 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie, biogrid 149 251 52 52 0
HTR3C HTR3C Q8WXA8 5-hydroxytryptamine receptor 3C chr3 Not Cancer Driver No 1 hippie, biogrid 82 35 7 7 0
IL17RA IL17RA Q96F46 Interleukin-17 receptor A chr22 Not Cancer Driver No 1 hippie, biogrid 92 301 20 20 0
ITCH ITCH Q96J02 E3 ubiquitin-protein ligase Itchy homolog chr20 Not Cancer Driver No 3 hippie, biogrid 95 335 42 42 0
KCNMB3 KCNMB3 Q9NPA1 Calcium-activated potassium channel subunit beta-3 chr3 Not Cancer Driver No 1 hippie, biogrid 27 22 2 2 0
KCNS3_ENST00000304101 KCNS3 Q9BQ31 Potassium voltage-gated channel subfamily S member 3 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 103 23 2 2 0
KCNT2 KCNT2 Q6UVM3 Potassium channel subfamily T member 2 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 353 245 89 89 1
KLRG2 KLRG2 A4D1S0 Killer cell lectin-like receptor subfamily G member 2 chr7 Not Cancer Driver No 1 hippie, biogrid 51 238 30 30 0
LMBR1 LMBR1 Q8WVP7 Limb region 1 protein homolog chr7 Not Cancer Driver No 1 intact, hippie, biogrid 56 19 1 1 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRP10 LRP10 Q7Z4F1 Low-density lipoprotein receptor-related protein 10 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 99 237 32 32 0
LRP12 LRP12 Q9Y561 Low-density lipoprotein receptor-related protein 12 chr8 Not Cancer Driver No 1 intact, hippie, biogrid 199 240 54 54 0
LRP3 LRP3 O75074 Low-density lipoprotein receptor-related protein 3 chr19 Not Cancer Driver No 1 hippie, biogrid 88 214 20 20 0
MPPE1 MPPE1 Q53F39 Metallophosphoesterase 1 chr18 Not Cancer Driver No 2 intact, hippie, biogrid 39 27 5 5 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 3 intact, hippie, biogrid 150 711 79 79 0
NEDD4L NEDD4L Q96PU5 E3 ubiquitin-protein ligase NEDD4-like chr18 Not Cancer Driver No 3 intact, hippie, biogrid 126 463 60 60 4
NKAIN1 NKAIN1 Q4KMZ8 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 0
NPLOC4 NPLOC4 Q8TAT6 Nuclear protein localization protein 4 homolog chr17 Not Cancer Driver No 1 intact, hippie, biogrid 78 47 8 8 0
OR10H2 OR10H2 O60403 Olfactory receptor 10H2 chr19 Not Cancer Driver No 1 hippie, biogrid 90 0 0 0 0
PCDHGA5 PCDHGA5 Q9Y5G8 Protocadherin gamma-A5 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 253 339 75 75 0
PCDHGC4 PCDHGC4 Q9Y5F7 Protocadherin gamma-C4 chr5 Not Cancer Driver No 1 hippie, biogrid 136 460 59 59 0
PCDHGC5 PCDHGC5 Q9Y5F6 Protocadherin gamma-C5 chr5 Not Cancer Driver No 1 hippie, biogrid 135 492 72 72 0
PCNX3 PCNX3 Q9H6A9 Pecanex-like protein 3 chr11 Not Cancer Driver No 1 intact, hippie 185 839 71 71 0
PDE3B PDE3B Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B chr11 Not Cancer Driver No 1 intact, hippie, biogrid 135 393 37 37 0
PDZD8 PDZD8 Q8NEN9 PDZ domain-containing protein 8 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 126 484 65 65 0
PIGA PIGA P37287 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A chrX Not Cancer Driver No 1 intact, hippie, biogrid 51 21 0 0 13
PTCHD3_ENST00000622555 PTCHD3 Q3KNS1-2 Isoform 2 of Patched domain-containing protein 3 chr10 Not Cancer Driver No 1 hippie, biogrid 133 130 38 38 0
PTGER3_ENST00000370931 PTGER3 P43115 Prostaglandin E2 receptor EP3 subtype chr1 Not Cancer Driver No 1 hippie, biogrid 79 17 2 2 0
RABEP2 RABEP2 Q9H5N1 Rab GTPase-binding effector protein 2 chr16 Not Cancer Driver No 1 hippie, biogrid 87 441 71 71 0
RABGEF1_ENST00000284957 RABGEF1 Q9UJ41 Rab5 GDP/GTP exchange factor chr7 Not Cancer Driver No 1 intact, hippie, biogrid 73 175 35 35 0
RBCK1 RBCK1 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 chr20 Not Cancer Driver No 1 hippie, biogrid 52 140 14 14 2
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 38 69 9 9 0
RHBDD3 RHBDD3 Q9Y3P4 Rhomboid domain-containing protein 3 chr22 Not Cancer Driver No 3 intact, hippie, biogrid 24 147 16 16 0
RNF111_ENST00000557998 RNF111 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia chr15 Not Cancer Driver No 1 intact, hippie, biogrid 111 855 96 96 0
RNF31 RNF31 Q96EP0 E3 ubiquitin-protein ligase RNF31 chr14 Not Cancer Driver No 1 hippie, biogrid 142 319 45 45 0
SCN4A SCN4A P35499 Sodium channel protein type 4 subunit alpha chr17 Not Cancer Driver No 1 hippie, biogrid 324 372 80 80 60
SCRIB_ENST00000320476 SCRIB Q14160 Protein scribble homolog chr8 Not Cancer Driver No 1 intact, hippie 196 1064 135 135 2
SETD7 SETD7 Q8WTS6 Histone-lysine N-methyltransferase SETD7 chr4 Not Cancer Driver No 1 hippie, biogrid 42 105 7 7 0
SIDT2_ENST00000620360 SIDT2 Q8NBJ9 SID1 transmembrane family member 2 chr11 Not Cancer Driver No 1 hippie, biogrid 113 23 6 6 0
SLC12A4_ENST00000316341 SLC12A4 Q9UP95 Solute carrier family 12 member 4 chr16 Not Cancer Driver No 1 hippie, biogrid 122 171 17 17 0
SLC27A3_ENST00000271857 SLC27A3 X6R3N0 Solute carrier family 27 (Fatty acid transporter), member 3, isoform CRA_d chr1 Not Cancer Driver No 1 intact, hippie, biogrid 80 171 16 16 0
SLC30A1 SLC30A1 Q9Y6M5 Zinc transporter 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 49 144 9 9 0
SLC47A1 SLC47A1 Q96FL8 Multidrug and toxin extrusion protein 1 chr17 Not Cancer Driver No 1 intact, hippie, biogrid 65 63 7 7 0
SMO SMO Q99835 Smoothened homolog chr7 Census, Compendium Yes 1 hippie, biogrid 112 241 27 27 1
SMPD2 SMPD2 O60906 Sphingomyelin phosphodiesterase 2 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 45 48 5 5 0
SNTA1 SNTA1 Q13424 Alpha-1-syntrophin chr20 Not Cancer Driver No 1 hippie 43 238 14 14 2
SPINT2 SPINT2 O43291 Kunitz-type protease inhibitor 2 chr19 Not Cancer Driver No 3 intact, hippie, biogrid 46 25 3 3 1
ST7 ST7 Q9NRC1 Suppressor of tumorigenicity 7 protein chr7 Not Cancer Driver No 1 intact, hippie, biogrid 62 64 5 5 0
ST7L ST7L Q8TDW4 Suppressor of tumorigenicity 7 protein-like chr1 Not Cancer Driver No 1 intact, hippie, biogrid 58 80 6 6 0
TAX1BP1 TAX1BP1 Q86VP1 Tax1-binding protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 78 429 50 50 0
TMEM179B TMEM179B Q7Z7N9 Transmembrane protein 179B chr11 Not Cancer Driver No 1 intact, hippie, biogrid 14 8 0 0 0
TMEM9B TMEM9B Q9NQ34 Transmembrane protein 9B chr11 Not Cancer Driver No 2 intact, hippie, biogrid 12 0 0 0 0
TPM2 TPM2 P07951 Tropomyosin beta chain chr9 Not Cancer Driver No 1 hippie, biogrid 39 232 35 35 15
TRIM32 TRIM32 Q13049 E3 ubiquitin-protein ligase TRIM32 chr9 Not Cancer Driver No 1 hippie, biogrid 82 87 10 10 3
TRIP10 TRIP10 Q15642 Cdc42-interacting protein 4 chr19 Not Cancer Driver No 1 hippie, biogrid 72 460 61 61 0
TRIP6 TRIP6 Q15654 Thyroid receptor-interacting protein 6 chr7 Not Cancer Driver No 1 hippie, biogrid 62 268 19 19 0
TSPAN17_ENST00000515708 TSPAN17 Q96FV3 Tetraspanin-17 chr5 Not Cancer Driver No 3 hippie, biogrid 23 0 0 0 0
TSPAN3 TSPAN3 O60637 Tetraspanin-3 chr15 Not Cancer Driver No 2 hippie, biogrid 23 0 0 0 0
TTYH1_ENST00000376530 TTYH1 Q9H313 Protein tweety homolog 1 chr19 Not Cancer Driver No 1 hippie, biogrid 56 21 3 3 0
UBASH3B UBASH3B Q8TF42 Ubiquitin-associated and SH3 domain-containing protein B chr11 Not Cancer Driver No 1 hippie, biogrid 86 73 6 6 0
UBXN7 UBXN7 O94888 UBX domain-containing protein 7 chr3 Not Cancer Driver No 1 hippie, biogrid 65 327 39 39 0
UFD1 UFD1 Q92890 Ubiquitin recognition factor in ER-associated degradation protein 1 chr22 Not Cancer Driver No 1 intact, hippie 26 100 7 7 0
UQCRH UQCRH P07919 Cytochrome b-c1 complex subunit 6, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 11 49 8 8 0
UTRN UTRN P46939 Utrophin chr6 Not Cancer Driver No 1 intact, hippie, biogrid 476 1283 183 183 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 intact, hippie, biogrid 88 186 16 16 16
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 4 intact, hippie, biogrid 79 108 9 9 3
WWP1 WWP1 Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 chr8 Not Cancer Driver No 3 intact, hippie, biogrid 139 431 75 75 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 51 489 49 49 0
ZDHHC12 ZDHHC12 Q96GR4 Palmitoyltransferase ZDHHC12 chr9 Not Cancer Driver No 1 hippie, biogrid 23 13 1 1 0
ZNRF4 ZNRF4 Q8WWF5 E3 ubiquitin-protein ligase ZNRF4 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 115 99 26 26 0