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EPHA2 ,EPHA2 ,P29317
  • Uniprot Accession= P29317
  • Ensembl Transcript= ENST00000358432.7
  • Uniprot Name= EPHA2
  • Name= Ephrin type-A receptor 2
  • Chromosome= chr1
  • Driver status= Compendium
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 103
  • Number of Interaction partner in hippie: 249
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCB5 ABCB5 Q2M3G0 ATP-binding cassette sub-family B member 5 chr7 Not Cancer Driver No 1 hippie 370 106 35 35 0
ACP1_ENST00000272065 ACP1 P24666 Low molecular weight phosphotyrosine protein phosphatase chr2 Not Cancer Driver No 1 hippie 28 13 2 2 0
AFDN_ENST00000447894 AFDN P55196 Afadin chr6 Census Yes 1 hippie 248 1247 180 180 0
AGPS AGPS O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal chr2 Not Cancer Driver No 1 hippie, biogrid 68 151 10 10 6
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
ALK ALK Q9UM73 ALK tyrosine kinase receptor chr2 Census, Compendium Yes 1 hippie, biogrid 303 575 114 114 16
ANKFY1_ENST00000341657 ANKFY1 Q9P2R3 Rabankyrin-5 chr17 Not Cancer Driver No 1 hippie, biogrid 109 185 29 29 0
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 Not Cancer Driver No 1 hippie 59 61 12 12 0
AP2A1 AP2A1 O95782 AP-2 complex subunit alpha-1 chr19 Not Cancer Driver No 1 hippie 95 188 12 12 0
AP2B1_ENST00000621914 AP2B1 P63010 AP-2 complex subunit beta chr17 Not Cancer Driver No 1 hippie 85 95 12 12 0
AP2M1_ENST00000292807 AP2M1 Q96CW1 AP-2 complex subunit mu chr3 Not Cancer Driver No 1 hippie 55 41 9 9 1
AP2S1_ENST00000263270 AP2S1 P53680 AP-2 complex subunit sigma chr19 Not Cancer Driver No 1 hippie 4 0 0 0 3
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARAF_ENST00000377045 ARAF P10398 Serine/threonine-protein kinase A-Raf chrX Census, Compendium Yes 1 hippie 84 181 32 32 0
ARF6 ARF6 P62330 ADP-ribosylation factor 6 chr14 Not Cancer Driver No 1 hippie, biogrid 18 5 0 0 0
ARHGEF16 ARHGEF16 Q5VV41 Rho guanine nucleotide exchange factor 16 chr1 Not Cancer Driver No 1 hippie 68 297 13 13 0
ARNT ARNT P27540 Aryl hydrocarbon receptor nuclear translocator chr1 Census Yes 1 hippie 77 511 56 56 0
ARRDC3 ARRDC3 Q96B67 Arrestin domain-containing protein 3 chr5 Not Cancer Driver No 1 hippie 52 95 12 12 0
ATG12 ATG12 O94817 Ubiquitin-like protein ATG12 chr5 Not Cancer Driver No 1 hippie, biogrid 15 60 8 8 0
ATP6V0A1_ENST00000343619 ATP6V0A1 Q93050 V-type proton ATPase 116 kDa subunit a 1 chr17 Not Cancer Driver No 1 hippie, biogrid 98 85 14 14 0
AURKA_ENST00000395915 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 36 178 21 21 0
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 Not Cancer Driver No 1 hippie 168 341 64 64 0
B3GAT1_ENST00000312527 B3GAT1 Q9P2W7 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 85 93 32 32 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BET1 BET1 O15155 BET1 homolog chr7 Not Cancer Driver No 1 hippie 14 7 2 2 0
C11orf52 C11orf52 Q96A22 Uncharacterized protein C11orf52 chr11 Not Cancer Driver No 1 hippie, biogrid 15 108 12 12 0
CAMK1G_ENST00000361322 CAMK1G Q96NX5 Calcium/calmodulin-dependent protein kinase type 1G chr1 Not Cancer Driver No 1 biogrid 62 91 16 16 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 Census Yes 1 hippie 60 128 21 21 0
CCND2 CCND2 P30279 G1/S-specific cyclin-D2 chr12 Census, Compendium Yes 1 hippie 39 29 7 7 5
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 2 hippie, biogrid 69 14 5 5 0
CD44 CD44 P16070 CD44 antigen chr11 Not Cancer Driver No 1 hippie 75 542 60 60 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 biogrid 80 328 43 43 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 hippie, biogrid 52 214 31 31 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 39 23 2 2 1
CDH1 CDH1 P12830 Cadherin-1 chr16 Census, Compendium Yes 1 hippie 150 400 82 82 5
CDH5 CDH5 P33151 Cadherin-5 chr16 Not Cancer Driver No 1 hippie 144 305 55 55 0
CDK17 CDK17 Q00537 Cyclin-dependent kinase 17 chr12 Not Cancer Driver No 1 hippie 76 198 26 26 0
CDK4 CDK4 P11802 Cyclin-dependent kinase 4 chr12 Census, Compendium Yes 1 hippie 52 52 5 5 3
CDK6 CDK6 Q00534 Cyclin-dependent kinase 6 chr7 Census Yes 1 hippie 40 24 3 3 1
CDKN2A_ENST00000304494 CDKN2A P42771 Cyclin-dependent kinase inhibitor 2A chr9 Census, Compendium Yes 1 hippie 166 83 88 88 36
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 Not Cancer Driver No 1 hippie 15 67 3 3 0
CDKN2C_ENST00000371761 CDKN2C P42773 Cyclin-dependent kinase 4 inhibitor C chr1 Census, Compendium Yes 1 hippie 23 49 6 6 0
CIR1 CIR1 Q86X95 Corepressor interacting with RBPJ 1 chr2 Not Cancer Driver No 1 hippie, biogrid 46 385 42 42 0
CKM CKM P06732 Creatine kinase M-type chr19 Not Cancer Driver No 1 biogrid 58 118 19 19 0
CLDN4 CLDN4 O14493 Claudin-4 chr7 Not Cancer Driver No 1 hippie 40 0 0 0 0
CLTC_ENST00000269122 CLTC Q00610 Clathrin heavy chain 1 chr17 Census, Compendium Yes 1 hippie 190 71 6 6 1
CSNK1G2 CSNK1G2 P78368 Casein kinase I isoform gamma-2 chr19 Not Cancer Driver No 1 hippie, biogrid 43 111 13 13 0
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 2 hippie, biogrid 415 288 301 301 14
CUL5 CUL5 Q93034 Cullin-5 chr11 Not Cancer Driver No 1 hippie 97 5 1 1 0
CXADR CXADR P78310 Coxsackievirus and adenovirus receptor chr21 Not Cancer Driver No 1 hippie, biogrid 51 98 19 19 0
CYP2S1 CYP2S1 Q96SQ9 Cytochrome P450 2S1 chr19 Not Cancer Driver No 2 hippie, biogrid 75 46 10 10 0
DDR1_ENST00000324771 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 chr6 Not Cancer Driver No 2 hippie, biogrid 123 253 49 49 0
DENND6A DENND6A Q8IWF6 Protein DENND6A chr3 Not Cancer Driver No 1 hippie, biogrid 54 69 2 2 0
DIRAS3_ENST00000646789 DIRAS3 O95661 GTP-binding protein Di-Ras3 chr1 Not Cancer Driver No 1 hippie, biogrid 38 21 3 3 0
DNAJC5 DNAJC5 Q9H3Z4 DnaJ homolog subfamily C member 5 chr20 Not Cancer Driver No 1 hippie, biogrid 23 46 6 6 1
DNAJC5B DNAJC5B Q9UF47 DnaJ homolog subfamily C member 5B chr8 Not Cancer Driver No 1 hippie, biogrid 64 31 7 7 0
DUSP18_ENST00000404885 DUSP18 Q8NEJ0 Dual specificity protein phosphatase 18 chr22 Not Cancer Driver No 1 hippie 18 0 0 0 0
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 Not Cancer Driver No 1 hippie 34 15 5 5 0
DUSP26 DUSP26 Q9BV47 Dual specificity protein phosphatase 26 chr8 Not Cancer Driver No 1 hippie 56 14 6 6 0
DYRK2 DYRK2 Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 chr12 Not Cancer Driver No 1 hippie 77 294 39 39 0
EBAG9_ENST00000620557 EBAG9 O00559 Receptor-binding cancer antigen expressed on SiSo cells chr8 Not Cancer Driver No 1 hippie, biogrid 35 173 29 29 0
EDAR EDAR Q9UNE0 Tumor necrosis factor receptor superfamily member EDAR chr2 Not Cancer Driver No 1 hippie, biogrid 81 116 20 20 18
EEF2 EEF2 P13639 Elongation factor 2 chr19 Not Cancer Driver No 1 hippie, biogrid 111 78 14 14 1
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 Not Cancer Driver No 1 hippie 29 46 5 5 0
EFNA2 EFNA2 O43921 Ephrin-A2 chr19 Not Cancer Driver No 1 hippie 16 13 2 2 0
EFNA3 EFNA3 P52797 Ephrin-A3 chr1 Not Cancer Driver No 1 hippie 24 31 11 11 0
EFNA4_ENST00000368409 EFNA4 P52798 Ephrin-A4 chr1 Not Cancer Driver No 2 hippie, biogrid 28 17 3 3 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 Not Cancer Driver No 2 hippie, biogrid 34 25 6 6 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ELOVL5_ENST00000304434 ELOVL5 Q9NYP7 Elongation of very long chain fatty acids protein 5 chr6 Not Cancer Driver No 1 hippie, biogrid 34 25 4 4 2
EPB41L4A_ENST00000621003 EPB41L4A Q9HCS5 Band 4.1-like protein 4A chr5 Not Cancer Driver No 1 hippie, biogrid 119 378 65 65 0
EPHA1 EPHA1 P21709 Ephrin type-A receptor 1 chr7 Not Cancer Driver No 1 hippie, biogrid 147 211 38 38 0
EPHA2 EPHA2 P29317 Ephrin type-A receptor 2 chr1 Compendium Yes 1 hippie 171 187 39 39 3
EPHA6_ENST00000502694 EPHA6 Q9UF33-2 Isoform 2 of Ephrin type-A receptor 6 chr3 Not Cancer Driver No 1 hippie, biogrid 123 38 16 16 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 Census, Compendium Yes 2 hippie, biogrid 280 71 15 15 0
EPHB2 EPHB2 P29323 Ephrin type-B receptor 2 chr1 Not Cancer Driver No 1 hippie, biogrid 186 119 17 17 7
EPN2 EPN2 O95208 Epsin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 73 543 61 61 0
EPS15 EPS15 P42566 Epidermal growth factor receptor substrate 15 chr1 Census, Compendium Yes 1 hippie 106 543 66 66 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 1 hippie 275 314 41 41 1
ERGIC1 ERGIC1 Q969X5 Endoplasmic reticulum-Golgi intermediate compartment protein 1 chr5 Not Cancer Driver No 1 hippie, biogrid 38 26 2 2 0
ERGIC2 ERGIC2 Q96RQ1 Endoplasmic reticulum-Golgi intermediate compartment protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 37 25 2 2 0
EZR EZR P15311 Ezrin chr6 Census Yes 2 hippie, biogrid 66 295 35 35 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FGFR4 FGFR4 P22455 Fibroblast growth factor receptor 4 chr5 Census, Compendium Yes 1 hippie 113 162 28 28 0
FLOT1 FLOT1 O75955 Flotillin-1 chr6 Not Cancer Driver No 1 hippie, biogrid 43 122 15 15 0
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GATAD1 GATAD1 Q8WUU5 GATA zinc finger domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie 14 131 4 4 1
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie, biogrid 86 110 26 26 50
GJB7 GJB7 Q6PEY0 Gap junction beta-7 protein chr6 Not Cancer Driver No 1 hippie, biogrid 30 0 0 0 0
GJD3 GJD3 Q8N144 Gap junction delta-3 protein chr17 Not Cancer Driver No 1 hippie, biogrid 5 79 0 0 0
GLIS2 GLIS2 Q9BZE0 Zinc finger protein GLIS2 chr16 Not Cancer Driver No 1 hippie 42 300 25 25 0
GOLIM4 GOLIM4 O00461 Golgi integral membrane protein 4 chr3 Not Cancer Driver No 2 hippie, biogrid 93 612 89 89 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 hippie 28 10 1 1 0
GRK2 GRK2 P25098 Beta-adrenergic receptor kinase 1 chr11 Not Cancer Driver No 1 hippie 77 87 8 8 0
GRM1_ENST00000282753 GRM1 Q13255 Metabotropic glutamate receptor 1 chr6 Not Cancer Driver No 1 hippie 346 339 91 91 3
HCK_ENST00000534862 HCK P08631 Tyrosine-protein kinase HCK chr20 Not Cancer Driver No 1 biogrid 112 124 25 25 0
HEXIM1 HEXIM1 O94992 Protein HEXIM1 chr17 Not Cancer Driver No 1 hippie 40 352 40 40 0
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 Compendium Yes 1 hippie 233 43 16 16 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie, biogrid 107 16 4 4 18
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 2 hippie, biogrid 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 hippie 100 254 43 43 0
HSPA12B HSPA12B Q96MM6 Heat shock 70 kDa protein 12B chr20 Not Cancer Driver No 1 hippie, biogrid 75 126 18 18 0
ILKAP ILKAP Q9H0C8 Integrin-linked kinase-associated serine/threonine phosphatase 2C chr2 Not Cancer Driver No 1 hippie 60 154 28 28 0
INPP1 INPP1 P49441 Inositol polyphosphate 1-phosphatase chr2 Not Cancer Driver No 1 biogrid 44 23 1 1 0
INPPL1 INPPL1 O15357 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 chr11 Not Cancer Driver No 1 hippie 174 566 76 76 4
ITGA3 ITGA3 P26006 Integrin alpha-3 chr17 Not Cancer Driver No 1 hippie 106 129 18 18 3
ITGAV ITGAV P06756 Integrin alpha-V chr2 Census Yes 1 hippie 153 92 9 9 0
ITGB1_ENST00000302278 ITGB1 P05556 Integrin beta-1 chr10 Not Cancer Driver No 1 hippie 103 84 10 10 0
ITGB3 ITGB3 P05106 Integrin beta-3 chr17 Not Cancer Driver No 1 hippie 124 66 5 5 30
ITGB5 ITGB5 P18084 Integrin beta-5 chr3 Not Cancer Driver No 1 hippie 86 27 3 3 0
KCNJ2_ENST00000535240 KCNJ2 P63252 Inward rectifier potassium channel 2 chr17 Not Cancer Driver No 1 hippie 103 49 11 11 12
KDELR2 KDELR2 P33947 ER lumen protein-retaining receptor 2 chr7 Not Cancer Driver No 1 hippie 23 0 0 0 1
KPNA3 KPNA3 O00505 Importin subunit alpha-4 chr13 Not Cancer Driver No 1 hippie 65 108 11 11 0
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 2 hippie, biogrid 788 7 2 2 27
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 2 hippie, biogrid 47 93 10 10 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie, biogrid 43 55 7 7 1
LAMP3 LAMP3 Q9UQV4 Lysosome-associated membrane glycoprotein 3 chr3 Not Cancer Driver No 1 hippie, biogrid 67 222 38 38 0
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie, biogrid 13 96 7 7 0
LATS2 LATS2 Q9NRM7 Serine/threonine-protein kinase LATS2 chr13 Census, Compendium Yes 1 hippie 178 687 116 116 0
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie, biogrid 86 94 13 13 1
LMAN1 LMAN1 P49257 Protein ERGIC-53 chr18 Not Cancer Driver No 1 hippie, biogrid 63 222 25 25 1
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRRIQ1 LRRIQ1 Q96JM4 Leucine-rich repeat and IQ domain-containing protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 389 884 205 205 0
LSM7 LSM7 Q9UK45 U6 snRNA-associated Sm-like protein LSm7 chr19 Not Cancer Driver No 1 hippie 5 21 0 0 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie, biogrid 95 84 12 12 0
MACROD1 MACROD1 Q9BQ69 ADP-ribose glycohydrolase MACROD1 chr11 Not Cancer Driver No 1 hippie, biogrid 24 45 1 1 0
MAGEB10_ENST00000614159 MAGEB10 Q96LZ2 Melanoma-associated antigen B10 chrX Not Cancer Driver No 1 hippie, biogrid 97 160 49 49 0
MALL MALL Q13021 MAL-like protein chr2 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 0
MAN1A1 MAN1A1 P33908 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA chr6 Not Cancer Driver No 1 hippie, biogrid 118 134 23 23 0
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 104 75 27 27 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 Not Cancer Driver No 1 hippie 40 85 10 10 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 Not Cancer Driver No 1 hippie 48 55 11 11 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 Not Cancer Driver No 1 hippie 39 25 1 1 0
MARCKS MARCKS P29966 Myristoylated alanine-rich C-kinase substrate chr6 Not Cancer Driver No 1 hippie, biogrid 14 328 14 14 0
MAS1 MAS1 P04201 Proto-oncogene Mas chr6 Not Cancer Driver No 1 hippie, biogrid 47 5 2 2 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 Census, Compendium Yes 1 hippie 57 202 26 26 1
METTL7A_ENST00000332160 METTL7A Q9H8H3 Putative methyltransferase-like protein 7A chr12 Not Cancer Driver No 1 hippie, biogrid 31 0 0 0 0
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 Census, Compendium Yes 1 hippie 226 62 15 15 19
MIB1 MIB1 Q86YT6 E3 ubiquitin-protein ligase MIB1 chr18 Not Cancer Driver No 1 hippie 122 282 34 34 1
MICALL1 MICALL1 Q8N3F8 MICAL-like protein 1 chr22 Not Cancer Driver No 1 hippie 90 630 72 72 0
MRAP2 MRAP2 Q96G30 Melanocortin-2 receptor accessory protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 55 75 17 17 0
MRPS35 MRPS35 P82673 28S ribosomal protein S35, mitochondrial chr12 Not Cancer Driver No 1 hippie 42 92 13 13 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 Census Yes 1 hippie 92 37 4 4 70
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NCSTN NCSTN Q92542 Nicastrin chr1 Not Cancer Driver No 1 hippie, biogrid 94 72 11 11 1
NDUFA13 NDUFA13 Q9P0J0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 chr19 Not Cancer Driver No 1 hippie 29 24 4 4 1
NF1 NF1 P21359 Neurofibromin chr17 Census, Compendium Yes 1 hippie 375 406 47 47 85
NF2 NF2 P35240 Merlin chr22 Census, Compendium Yes 1 hippie 69 252 26 26 16
NFIC NFIC P08651 Nuclear factor 1 C-type chr19 Not Cancer Driver No 1 hippie 61 327 44 44 0
NOMO1 NOMO1 Q15155 Nodal modulator 1 chr16 Not Cancer Driver No 1 hippie 130 128 23 23 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie, biogrid 284 10 0 0 14
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 2 hippie, biogrid 168 57 8 8 25
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 Census, Compendium Yes 1 hippie, biogrid 249 57 21 21 0
NUDT9 NUDT9 Q9BW91 ADP-ribose pyrophosphatase, mitochondrial chr4 Not Cancer Driver No 1 hippie 27 177 16 16 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
OCLN OCLN Q16625 Occludin chr5 Not Cancer Driver No 1 biogrid 54 244 21 21 1
OPCML OPCML Q14982 Opioid-binding protein/cell adhesion molecule chr11 Not Cancer Driver No 1 hippie 125 36 18 18 1
PANX1 PANX1 Q96RD7 Pannexin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 54 45 7 7 2
PARD3 PARD3 Q8TEW0 Partitioning defective 3 homolog chr10 Not Cancer Driver No 1 hippie, biogrid 200 1144 170 170 2
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 Not Cancer Driver No 1 hippie 137 99 7 7 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 Census, Compendium Yes 1 hippie 290 173 45 45 2
PEBP1 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 1 hippie 23 76 13 13 0
PIFO PIFO Q8TCI5 Protein pitchfork chr1 Not Cancer Driver No 2 hippie, biogrid 31 70 11 11 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 154 268 61 61 2
PIK3R2_ENST00000617130 PIK3R2 O00459 Phosphatidylinositol 3-kinase regulatory subunit beta chr19 Not Cancer Driver No 1 hippie 96 418 47 47 3
PKLR PKLR P30613 Pyruvate kinase PKLR chr1 Not Cancer Driver No 1 biogrid 112 26 5 5 101
PKM_ENST00000335181 PKM P14618 Pyruvate kinase PKM chr15 Not Cancer Driver No 1 hippie 78 58 13 13 0
PPM1L PPM1L Q5SGD2 Protein phosphatase 1L chr3 Not Cancer Driver No 1 hippie 67 25 2 2 0
PRKACA PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha chr19 Census Yes 1 hippie, biogrid 53 24 0 0 2
PSME2 PSME2 Q9UL46 Proteasome activator complex subunit 2 chr14 Not Cancer Driver No 1 hippie 32 39 3 3 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 Census, Compendium Yes 1 hippie 505 76 4 4 41
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 Not Cancer Driver No 1 hippie 134 425 55 55 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 Census, Compendium Yes 1 hippie 129 260 38 38 60
PTPN7_ENST00000367279 PTPN7 P35236-2 Isoform 2 of Tyrosine-protein phosphatase non-receptor type 7 chr1 Not Cancer Driver No 1 hippie 56 199 32 32 0
PTPRO PTPRO Q16827 Receptor-type tyrosine-protein phosphatase O chr12 Not Cancer Driver No 1 hippie 204 137 34 34 0
PTPRR PTPRR Q15256 Receptor-type tyrosine-protein phosphatase R chr12 Not Cancer Driver No 1 hippie 172 73 28 28 0
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 hippie, biogrid 31 43 4 4 0
RAB2A RAB2A P61019 Ras-related protein Rab-2A chr8 Not Cancer Driver No 1 hippie, biogrid 22 58 4 4 0
RAB35 RAB35 Q15286 Ras-related protein Rab-35 chr12 Not Cancer Driver No 1 hippie, biogrid 25 25 2 2 0
RAB3B RAB3B P20337 Ras-related protein Rab-3B chr1 Not Cancer Driver No 1 hippie, biogrid 36 25 6 6 0
RAB4A RAB4A P20338 Ras-related protein Rab-4A chr1 Not Cancer Driver No 1 hippie, biogrid 26 32 11 11 0
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 Not Cancer Driver No 1 hippie, biogrid 32 65 15 15 0
RAB5C_ENST00000393860 RAB5C P51148 Ras-related protein Rab-5C chr17 Not Cancer Driver No 1 hippie, biogrid 24 50 4 4 0
RAB7A RAB7A P51149 Ras-related protein Rab-7a chr3 Not Cancer Driver No 1 biogrid 27 11 0 0 4
RAB9A RAB9A P51151 Ras-related protein Rab-9A chrX Not Cancer Driver No 2 hippie, biogrid 18 21 1 1 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 Not Cancer Driver No 1 hippie 31 0 0 0 2
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 Not Cancer Driver No 1 hippie 59 328 43 43 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 hippie 89 169 38 38 22
RASA1 RASA1 P20936 Ras GTPase-activating protein 1 chr5 Compendium Yes 1 hippie 154 181 25 25 3
RASSF1 RASSF1 Q9NS23 Ras association domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie 36 79 3 3 0
RBL1 RBL1 P28749 Retinoblastoma-like protein 1 chr20 Not Cancer Driver No 1 hippie 140 335 41 41 0
RD3 RD3 Q7Z3Z2 Protein RD3 chr1 Not Cancer Driver No 1 hippie, biogrid 46 75 21 21 0
RELA RELA Q04206 Transcription factor p65 chr11 Compendium Yes 1 hippie 75 400 48 48 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 2 hippie, biogrid 52 19 2 2 0
RHOBTB2_ENST00000251822 RHOBTB2 Q9BYZ6 Rho-related BTB domain-containing protein 2 chr8 Not Cancer Driver No 1 hippie 99 131 18 18 6
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 30 53 7 7 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 Not Cancer Driver No 1 hippie 20 10 0 0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOH_ENST00000617441 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 41 12 3 3 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 34 63 6 6 0
RHOV RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 25 47 5 5 0
RND1 RND1 Q92730 Rho-related GTP-binding protein Rho6 chr12 Not Cancer Driver No 1 hippie 45 9 1 1 0
RND2 RND2 P52198 Rho-related GTP-binding protein RhoN chr17 Not Cancer Driver No 1 hippie 19 54 4 4 0
RND3_ENST00000263895 RND3 P61587 Rho-related GTP-binding protein RhoE chr2 Not Cancer Driver No 1 hippie 36 70 10 10 0
RNF144A RNF144A P50876 E3 ubiquitin-protein ligase RNF144A chr2 Not Cancer Driver No 1 hippie 63 0 0 0 0
RPS6KA2_ENST00000265678 RPS6KA2 Q15349 Ribosomal protein S6 kinase alpha-2 chr6 Not Cancer Driver No 1 hippie 133 91 15 15 0
RYBP RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 37 214 37 37 0
RYK_ENST00000623711 RYK P34925 Tyrosine-protein kinase RYK chr3 Not Cancer Driver No 1 hippie, biogrid 55 85 4 4 0
SCAMP3 SCAMP3 O14828 Secretory carrier-associated membrane protein 3 chr1 Not Cancer Driver No 1 hippie 46 130 23 23 0
SDC1_ENST00000254351 SDC1 P18827 Syndecan-1 chr2 Not Cancer Driver No 2 hippie, biogrid 31 259 30 30 0
SF3A3 SF3A3 Q12874 Splicing factor 3A subunit 3 chr1 Not Cancer Driver No 1 hippie 63 182 19 19 0
SHARPIN SHARPIN Q9H0F6 Sharpin chr8 Not Cancer Driver No 1 hippie, biogrid 34 237 16 16 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 Not Cancer Driver No 1 hippie 84 397 58 58 0
SIGLECL1 SIGLECL1 Q8N7X8 SIGLEC family-like protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 56 35 14 14 0
SLA_ENST00000338087 SLA Q13239 Src-like-adapter chr8 Not Cancer Driver No 1 hippie 59 51 11 11 0
SLC25A41 SLC25A41 Q8N5S1 Mitochondrial carrier protein SCaMC-3L chr19 Not Cancer Driver No 2 hippie, biogrid 54 59 7 7 0
SLC7A11 SLC7A11 Q9UPY5 Cystine/glutamate transporter chr4 Not Cancer Driver No 1 hippie, biogrid 70 15 2 2 0
SMARCAD1_ENST00000354268 SMARCAD1 Q9H4L7 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 chr4 Not Cancer Driver No 1 hippie 129 388 50 50 0
SOCS2_ENST00000536696 SOCS2 O14508 Suppressor of cytokine signaling 2 chr12 Not Cancer Driver No 1 hippie 32 61 2 2 0
SOCS6_ENST00000582322 SOCS6 O14544 Suppressor of cytokine signaling 6 chr18 Not Cancer Driver No 1 hippie 81 299 48 48 0
SP7 SP7 Q8TDD2 Transcription factor Sp7 chr12 Not Cancer Driver No 1 hippie, biogrid 63 332 44 44 0
SSR3_ENST00000265044 SSR3 Q9UNL2 Translocon-associated protein subunit gamma chr3 Not Cancer Driver No 1 hippie 30 18 5 5 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 hippie 75 135 14 14 9
STX4 STX4 Q12846 Syntaxin-4 chr16 Not Cancer Driver No 1 hippie, biogrid 50 152 20 20 0
STX6 STX6 O43752 Syntaxin-6 chr1 Not Cancer Driver No 1 hippie, biogrid 33 78 11 11 0
STX7 STX7 O15400 Syntaxin-7 chr6 Not Cancer Driver No 1 hippie, biogrid 29 164 14 14 0
TARDBP TARDBP Q13148 TAR DNA-binding protein 43 chr1 Not Cancer Driver No 1 hippie, biogrid 51 202 15 15 27
TAS2R7 TAS2R7 Q9NYW3 Taste receptor type 2 member 7 chr12 Not Cancer Driver No 2 hippie, biogrid 55 0 0 0 0
TEAD2_ENST00000311227 TEAD2 Q15562 Transcriptional enhancer factor TEF-4 chr19 Not Cancer Driver No 1 hippie 66 220 31 31 0
TES TES Q9UGI8 Testin chr7 Not Cancer Driver No 1 hippie 56 100 7 7 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 Not Cancer Driver No 1 hippie 41 41 4 4 10
TGFBR1_ENST00000374994 TGFBR1 P36897 TGF-beta receptor type-1 chr9 Not Cancer Driver No 1 hippie 86 23 3 3 15
TGOLN2_ENST00000377386 TGOLN2 O43493 Trans-Golgi network integral membrane protein 2 chr2 Not Cancer Driver No 1 hippie 51 399 46 46 0
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 1 hippie 370 810 194 194 0
TMEM17 TMEM17 Q86X19 Transmembrane protein 17 chr2 Not Cancer Driver No 1 hippie 22 14 2 2 0
TMEM185A TMEM185A Q8NFB2 Transmembrane protein 185A chrX Not Cancer Driver No 2 hippie, biogrid 29 19 0 0 0
TMEM216 TMEM216 Q9P0N5 Transmembrane protein 216 chr11 Not Cancer Driver No 1 hippie 11 0 0 0 7
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TPTE2 TPTE2 Q6XPS3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 chr13 Not Cancer Driver No 1 hippie 210 33 13 13 0
TPX2 TPX2 Q9ULW0 Targeting protein for Xklp2 chr20 Not Cancer Driver No 1 hippie, biogrid 92 695 86 86 0
TSG101 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 Not Cancer Driver No 1 hippie 46 159 23 23 0
TSPAN12_ENST00000415871 TSPAN12 O95859 Tetraspanin-12 chr7 Not Cancer Driver No 1 hippie 51 9 3 3 7
UBE4A_ENST00000252108 UBE4A Q14139 Ubiquitin conjugation factor E4 A chr11 Not Cancer Driver No 1 hippie 120 121 17 17 0
VOPP1 VOPP1 Q96AW1 Vesicular, overexpressed in cancer, prosurvival protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 28 51 9 9 0
VPS4B VPS4B O75351 Vacuolar protein sorting-associated protein 4B chr18 Not Cancer Driver No 1 hippie 52 195 22 22 0
ZBTB14_ENST00000615385 ZBTB14 O43829 Zinc finger and BTB domain-containing protein 14 chr18 Not Cancer Driver No 1 hippie 72 207 28 28 0
ZFPL1 ZFPL1 O95159 Zinc finger protein-like 1 chr11 Not Cancer Driver No 1 hippie, biogrid 40 127 16 16 0