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DVL1 ,DVL1 ,O14640
  • Uniprot Accession= O14640
  • Ensembl Transcript= ENST00000378888.9
  • Uniprot Name= DVL1
  • Name= Segment polarity protein dishevelled homolog DVL-1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 25
  • Number of Interaction partner in biogrid: 21
  • Number of Interaction partner in hippie: 108
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AGPS AGPS O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal chr2 Not Cancer Driver No 1 hippie, biogrid 68 151 10 10 6
AHI1_ENST00000457866 AHI1 Q8N157 Jouberin chr6 Not Cancer Driver No 1 hippie 120 500 56 56 6
ANKFY1_ENST00000341657 ANKFY1 Q9P2R3 Rabankyrin-5 chr17 Not Cancer Driver No 1 hippie, biogrid 109 185 29 29 0
ANXA7 ANXA7 P20073 Annexin A7 chr10 Not Cancer Driver No 1 intact, hippie 68 215 37 37 0
APC APC P25054 Adenomatous polyposis coli protein chr5 Census, Compendium Yes 2 intact, hippie 412 2406 345 345 22
ARHGEF19 ARHGEF19 Q8IW93 Rho guanine nucleotide exchange factor 19 chr1 Not Cancer Driver No 1 hippie 82 365 36 36 0
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 Not Cancer Driver No 1 hippie 146 450 70 70 0
ARRB1 ARRB1 P49407 Beta-arrestin-1 chr11 Not Cancer Driver No 1 hippie 49 154 13 13 0
ATN1_ENST00000396684 ATN1 P54259 Atrophin-1 chr12 Not Cancer Driver No 1 hippie 141 1176 139 139 6
AXIN1 AXIN1 O15169 Axin-1 chr16 Census, Compendium Yes 1 hippie 120 619 88 88 4
BAG3 BAG3 O95817 BAG family molecular chaperone regulator 3 chr10 Not Cancer Driver No 1 hippie 57 571 57 57 7
BRD7_ENST00000394688 BRD7 Q9NPI1 Bromodomain-containing protein 7 chr16 Compendium Yes 1 hippie 82 482 57 57 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 hippie 80 45 4 4 0
BUB1 BUB1 O43683 Mitotic checkpoint serine/threonine-protein kinase BUB1 chr2 Not Cancer Driver No 1 hippie 139 466 64 64 0
CCDC88C CCDC88C Q9P219 Protein Daple chr14 Not Cancer Driver No 1 hippie 270 1604 225 225 1
CEP128_ENST00000281129 CEP128 Q6ZU80 Centrosomal protein of 128 kDa chr14 Not Cancer Driver No 1 hippie 195 897 167 167 0
CEP135 CEP135 Q66GS9 Centrosomal protein of 135 kDa chr4 Not Cancer Driver No 1 hippie 127 690 72 72 0
CEP19 CEP19 Q96LK0 Centrosomal protein of 19 kDa chr3 Not Cancer Driver No 1 intact, hippie 30 71 11 11 0
CEP44_ENST00000296519 CEP44 Q9C0F1 Centrosomal protein of 44 kDa chr4 Not Cancer Driver No 1 hippie 55 142 17 17 0
CEP83_ENST00000339839 CEP83 Q9Y592 Centrosomal protein of 83 kDa chr12 Not Cancer Driver No 1 intact, hippie 90 488 59 59 2
CETN2 CETN2 P41208 Centrin-2 chrX Not Cancer Driver No 1 intact, hippie 33 97 11 11 0
CNTRL_ENST00000238341 CNTRL Q7Z7A1 Centriolin chr9 Census Yes 1 hippie 234 1556 159 159 0
CSNK1D CSNK1D P48730 Casein kinase I isoform delta chr17 Not Cancer Driver No 1 hippie 59 132 16 16 2
CSNK1E CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 2 intact, hippie 62 133 18 18 0
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 2 intact, hippie 71 75 8 8 4
CTNNA1 CTNNA1 P35221 Catenin alpha-1 chr5 Census Yes 1 hippie, biogrid 126 268 35 35 4
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 415 288 301 301 14
CXXC4 CXXC4 J9JIF5 CXXC-type zinc finger protein 4 chr4 Not Cancer Driver No 1 hippie 24 200 9 9 0
CYLD CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 116 213 31 31 3
DAAM1 DAAM1 Q9Y4D1 Disheveled-associated activator of morphogenesis 1 chr14 Not Cancer Driver No 2 intact, hippie 152 391 47 47 0
DAB2 DAB2 P98082 Disabled homolog 2 chr5 Not Cancer Driver No 1 hippie 144 680 125 125 0
DCAF4 DCAF4 Q8WV16 DDB1- and CUL4-associated factor 4 chr14 Not Cancer Driver No 1 intact, hippie 59 114 11 11 0
DCTN1 DCTN1 Q14203 Dynactin subunit 1 chr2 Census Yes 1 intact, hippie 172 817 111 111 11
DVL1 DVL1 O14640 Segment polarity protein dishevelled homolog DVL-1 chr1 Not Cancer Driver No 1 intact, hippie 73 434 38 38 0
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 Not Cancer Driver No 4 hippie, biogrid 96 514 64 64 0
DVL3 DVL3 Q92997 Segment polarity protein dishevelled homolog DVL-3 chr3 Not Cancer Driver No 2 intact, hippie 97 437 58 58 0
DYNLT1 DYNLT1 P63172 Dynein light chain Tctex-type 1 chr6 Not Cancer Driver No 1 hippie 7 1 0 0 0
EPB41L4A_ENST00000621003 EPB41L4A Q9HCS5 Band 4.1-like protein 4A chr5 Not Cancer Driver No 1 hippie, biogrid 119 378 65 65 0
EPS8_ENST00000645775 EPS8 Q12929 Epidermal growth factor receptor kinase substrate 8 chr12 Not Cancer Driver No 1 hippie 106 459 54 54 0
FAM160B1 FHIP2A Q5W0V3 FHF complex subunit HOOK interacting protein 2A chr10 Not Cancer Driver No 1 intact 92 130 13 13 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 intact, hippie 322 230 38 38 0
FLNC FLNC Q14315 Filamin-C chr7 Not Cancer Driver No 1 hippie, biogrid 546 1442 288 288 7
FRAT1 FRAT1 Q92837 Proto-oncogene FRAT1 chr10 Not Cancer Driver No 1 hippie 6 266 6 6 0
FZD7 FZD7 O75084 Frizzled-7 chr2 Not Cancer Driver No 1 hippie 90 22 2 2 0
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie, biogrid 86 110 26 26 50
GNAI3 GNAI3 P08754 Guanine nucleotide-binding protein G(i) subunit alpha-3 chr1 Not Cancer Driver No 1 hippie 42 11 0 0 1
GPHN_ENST00000315266 GPHN Q9NQX3 Gephyrin chr14 Census Yes 1 hippie, biogrid 126 305 41 41 2
HDHD2 HDHD2 Q9H0R4 Haloacid dehalogenase-like hydrolase domain-containing protein 2 chr18 Not Cancer Driver No 1 hippie 23 21 0 0 0
HECW1 HECW1 Q76N89 E3 ubiquitin-protein ligase HECW1 chr7 Not Cancer Driver No 1 hippie 420 748 191 191 0
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
HUWE1_ENST00000262854 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX Not Cancer Driver No 1 hippie 669 2091 329 329 21
IFITM1_ENST00000528780 IFITM1 P13164 Interferon-induced transmembrane protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 19 0 0 0 0
ITCH ITCH Q96J02 E3 ubiquitin-protein ligase Itchy homolog chr20 Not Cancer Driver No 1 hippie 95 335 42 42 0
KIAA0753 KIAA0753 Q2KHM9 Protein moonraker chr17 Not Cancer Driver No 1 intact, hippie 109 647 82 82 0
KLHL12 KLHL12 Q53G59 Kelch-like protein 12 chr1 Not Cancer Driver No 1 hippie 65 33 6 6 0
KRT8_ENST00000546897 KRT8 P05787 Keratin, type II cytoskeletal 8 chr12 Not Cancer Driver No 1 hippie, biogrid 65 221 37 37 3
LATS1 LATS1 O95835 Serine/threonine-protein kinase LATS1 chr6 Census, Compendium Yes 1 hippie, biogrid 161 788 100 100 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LTN1_ENST00000361371 LTN1 O94822 E3 ubiquitin-protein ligase listerin chr21 Not Cancer Driver No 1 hippie 192 124 23 23 0
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 104 75 27 27 0
MAPRE3 MAPRE3 Q9UPY8 Microtubule-associated protein RP/EB family member 3 chr2 Not Cancer Driver No 1 hippie, biogrid 37 120 16 16 0
MLH3_ENST00000556740 MLH3 Q9UHC1 DNA mismatch repair protein Mlh3 chr14 Not Cancer Driver No 1 intact, hippie 154 593 60 60 9
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 Census Yes 1 intact, hippie 92 37 4 4 70
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 Not Cancer Driver No 1 hippie 89 88 19 19 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 1 hippie 150 711 79 79 0
NKD2 NKD2 Q969F2 Protein naked cuticle homolog 2 chr5 Not Cancer Driver No 1 intact, hippie 64 451 64 64 0
NUMA1 NUMA1 Q14980 Nuclear mitotic apparatus protein 1 chr11 Census, Compendium Yes 1 hippie 234 1864 203 203 0
NXN NXN Q6DKJ4 Nucleoredoxin chr17 Not Cancer Driver No 1 hippie, biogrid 58 37 2 2 0
OCLN OCLN Q16625 Occludin chr5 Not Cancer Driver No 1 biogrid 54 244 21 21 1
PARD3 PARD3 Q8TEW0 Partitioning defective 3 homolog chr10 Not Cancer Driver No 1 hippie, biogrid 200 1144 170 170 2
PLGRKT PLGRKT Q9HBL7 Plasminogen receptor (KT) chr9 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 Not Cancer Driver No 1 hippie, biogrid 87 119 13 13 0
PPM1A_ENST00000395076 PPM1A P35813 Protein phosphatase 1A chr14 Not Cancer Driver No 1 hippie 60 134 24 24 0
PSMA3 PSMA3 P25788 Proteasome subunit alpha type-3 chr14 Not Cancer Driver No 1 intact, hippie 27 30 5 5 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 Not Cancer Driver No 1 intact, hippie 134 425 55 55 0
PTRH2_ENST00000470557 PTRH2 Q9Y3E5 Peptidyl-tRNA hydrolase 2, mitochondrial chr17 Not Cancer Driver No 1 hippie 14 19 2 2 1
PXN_ENST00000228307 PXN P49023 Paxillin chr12 Not Cancer Driver No 1 hippie, biogrid 62 341 24 24 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RASSF10 RASSF10 A6NK89 Ras association domain-containing protein 10 chr11 Not Cancer Driver No 1 intact, hippie 11 372 8 8 0
RASSF9 RASSF9 O75901 Ras association domain-containing protein 9 chr12 Not Cancer Driver No 1 hippie 88 131 24 24 0
RB1 RB1 P06400 Retinoblastoma-associated protein chr13 Census, Compendium Yes 1 hippie 140 282 32 32 22
RMDN3 RMDN3 Q96TC7 Regulator of microtubule dynamics protein 3 chr15 Not Cancer Driver No 1 hippie, biogrid 45 196 17 17 0
RNF43_ENST00000577716 RNF43 Q68DV7 E3 ubiquitin-protein ligase RNF43 chr17 Census, Compendium Yes 1 hippie 121 437 54 54 0
RPS6KA2_ENST00000265678 RPS6KA2 Q15349 Ribosomal protein S6 kinase alpha-2 chr6 Not Cancer Driver No 1 hippie 133 91 15 15 0
SCYL2_ENST00000360820 SCYL2 Q6P3W7 SCY1-like protein 2 chr12 Not Cancer Driver No 1 hippie 103 328 29 29 0
SDC4 SDC4 P31431 Syndecan-4 chr20 Census, Compendium Yes 1 hippie 34 110 25 25 0
SIPA1_ENST00000534313 SIPA1 Q96FS4 Signal-induced proliferation-associated protein 1 chr11 Not Cancer Driver No 1 hippie 67 666 43 43 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 70 435 31 31 0
SMAD1 SMAD1 Q15797 Mothers against decapentaplegic homolog 1 chr4 Not Cancer Driver No 1 hippie 54 161 22 22 0
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 79 137 12 12 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 Census, Compendium Yes 1 hippie 97 111 19 19 5
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SMAD7 SMAD7 O15105 Mothers against decapentaplegic homolog 7 chr18 Not Cancer Driver No 1 hippie 40 139 0 0 0
SMYD1 SMYD1 Q8NB12 Histone-lysine N-methyltransferase SMYD1 chr2 Not Cancer Driver No 1 hippie 116 31 9 9 0
SSX2IP SSX2IP Q9Y2D8 Afadin- and alpha-actinin-binding protein chr1 Not Cancer Driver No 1 intact, hippie 82 265 31 31 0
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
TMEM17 TMEM17 Q86X19 Transmembrane protein 17 chr2 Not Cancer Driver No 1 intact, hippie 22 14 2 2 0
TOMM20 TOMM20 Q15388 Mitochondrial import receptor subunit TOM20 homolog chr1 Not Cancer Driver No 1 hippie 8 25 1 1 0
TOP3B_ENST00000357179 TOP3B O95985 DNA topoisomerase 3-beta-1 chr22 Not Cancer Driver No 1 hippie, biogrid 102 151 17 17 0
TRIM69_ENST00000329464 TRIM69 Q86WT6 E3 ubiquitin-protein ligase TRIM69 chr15 Not Cancer Driver No 1 hippie 78 62 15 15 0
USP13 USP13 Q92995 Ubiquitin carboxyl-terminal hydrolase 13 chr3 Not Cancer Driver No 1 hippie, biogrid 121 224 42 42 0
VANGL1 VANGL1 Q8TAA9 Vang-like protein 1 chr1 Not Cancer Driver No 1 hippie 72 140 15 15 3
VANGL2 VANGL2 Q9ULK5 Vang-like protein 2 chr1 Not Cancer Driver No 1 hippie 122 150 37 37 3
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 hippie 79 108 9 9 3
WWP1 WWP1 Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 chr8 Not Cancer Driver No 1 hippie 139 431 75 75 0
WWP2 WWP2 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 chr16 Not Cancer Driver No 1 hippie 112 422 57 57 0
WWTR1_ENST00000360632 WWTR1 Q9GZV5 WW domain-containing transcription regulator protein 1 chr3 Census Yes 1 hippie 41 387 41 41 0
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 140 33 9 9 0
ZNF74 ZNF74 Q16587 Zinc finger protein 74 chr22 Not Cancer Driver No 1 hippie, biogrid 101 230 36 36 0
ZNRF3 ZNRF3 Q9ULT6 E3 ubiquitin-protein ligase ZNRF3 chr22 Census, Compendium Yes 1 hippie 94 510 51 51 0