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DTL ,DTL ,Q9NZJ0
  • Uniprot Accession= Q9NZJ0
  • Ensembl Transcript= ENST00000366991.4
  • Uniprot Name= DTL
  • Name= Denticleless protein homolog
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 2
  • Number of Interaction partner in biogrid: 34
  • Number of Interaction partner in hippie: 98
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ATR ATR Q13535 Serine/threonine-protein kinase ATR chr3 Census, Compendium Yes 1 hippie 338 106 14 14 1
AURKB_ENST00000585124 AURKB Q96GD4 Aurora kinase B chr17 Not Cancer Driver No 1 hippie 51 63 8 8 0
BUB3 BUB3 O43684 Mitotic checkpoint protein BUB3 chr10 Not Cancer Driver No 1 hippie 46 60 6 6 0
CAMK2A_ENST00000348628 CAMK2A Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha chr5 Not Cancer Driver No 1 hippie, biogrid 83 62 10 10 7
CAMK2D_ENST00000342666 CAMK2D Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta chr4 Not Cancer Driver No 1 hippie, biogrid 57 84 10 10 0
CARNMT1 CARNMT1 Q8N4J0 Carnosine N-methyltransferase chr9 Not Cancer Driver No 1 hippie 42 75 1 1 0
CCNA2_ENST00000618014 CCNA2 P20248 Cyclin-A2 chr4 Not Cancer Driver No 1 hippie 45 186 19 19 0
CCNF CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 106 221 23 23 3
CCT2 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 1 hippie, biogrid 63 46 3 3 0
CCT3 CCT3 P49368 T-complex protein 1 subunit gamma chr1 Not Cancer Driver No 2 hippie, biogrid 71 95 12 12 0
CCT5 CCT5 P48643 T-complex protein 1 subunit epsilon chr5 Not Cancer Driver No 1 hippie, biogrid 83 72 10 10 1
CCT6B CCT6B Q92526 T-complex protein 1 subunit zeta-2 chr17 Not Cancer Driver No 1 hippie, biogrid 90 1 0 0 0
CCT7 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 2 hippie, biogrid 59 36 6 6 0
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie 40 1 0 0 0
CDK2 CDK2 P24941 Cyclin-dependent kinase 2 chr12 Not Cancer Driver No 1 hippie 24 0 0 0 0
CDKN1A_ENST00000373711 CDKN1A P38936 Cyclin-dependent kinase inhibitor 1 chr6 Census, Compendium Yes 1 hippie 48 121 30 30 0
CDT1 CDT1 Q9H211 DNA replication factor Cdt1 chr16 Not Cancer Driver No 1 hippie 60 377 35 35 5
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 Not Cancer Driver No 1 hippie 58 86 16 16 0
COPS2_ENST00000388901 COPS2 P61201 COP9 signalosome complex subunit 2 chr15 Not Cancer Driver No 1 hippie 59 59 9 9 0
COPS3 COPS3 Q9UNS2 COP9 signalosome complex subunit 3 chr17 Not Cancer Driver No 1 hippie 55 67 10 10 0
COPS4_ENST00000264389 COPS4 Q9BT78 COP9 signalosome complex subunit 4 chr4 Not Cancer Driver No 1 hippie 50 13 0 0 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
COPS6 COPS6 Q7L5N1 COP9 signalosome complex subunit 6 chr7 Not Cancer Driver No 1 hippie, biogrid 38 30 6 6 0
COPS7A_ENST00000534947 COPS7A Q9UBW8 COP9 signalosome complex subunit 7a chr12 Not Cancer Driver No 1 hippie 32 74 10 10 0
COPS8 COPS8 Q99627 COP9 signalosome complex subunit 8 chr2 Not Cancer Driver No 2 hippie, biogrid 25 14 2 2 0
CTSV CTSV O60911 Cathepsin L2 chr9 Not Cancer Driver No 1 hippie, biogrid 55 7 1 1 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 2 hippie, biogrid 64 102 2 2 0
CUL4B CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 3 intact, hippie, biogrid 138 207 38 38 2
DCAF15 DCAF15 Q66K64 DDB1- and CUL4-associated factor 15 chr19 Not Cancer Driver No 1 hippie 50 173 18 18 0
DDA1 DDA1 Q9BW61 DET1- and DDB1-associated protein 1 chr19 Not Cancer Driver No 2 hippie, biogrid 10 70 9 9 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 1 biogrid 126 50 8 8 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 Census, Compendium Yes 1 hippie 45 70 5 5 2
DEF8 DEF8 Q6ZN54 Differentially expressed in FDCP 8 homolog chr16 Not Cancer Driver No 1 hippie, biogrid 58 123 23 23 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 hippie, biogrid 50 174 27 27 0
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 Census Yes 1 hippie 175 816 121 121 6
FBH1_ENST00000362091 FBH1 Q8NFZ0 F-box DNA helicase 1 chr10 Not Cancer Driver No 1 hippie 139 192 32 32 0
FBXO11 FBXO11 Q86XK2 F-box only protein 11 chr2 Census, Compendium Yes 1 hippie 113 242 22 22 8
FBXO38_ENST00000340253 FBXO38 Q6PIJ6 F-box only protein 38 chr5 Not Cancer Driver No 1 hippie 133 440 48 48 1
FLG FLG P20930 Filaggrin chr1 Not Cancer Driver No 1 hippie, biogrid 1612 3956 1593 1593 0
GATD1 GATD1 Q8NB37 Glutamine amidotransferase-like class 1 domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 24 2 0 0 0
GLMN GLMN Q92990 Glomulin chr1 Not Cancer Driver No 2 hippie, biogrid 49 37 6 6 0
GPS1_ENST00000306823 GPS1 Q13098 COP9 signalosome complex subunit 1 chr17 Not Cancer Driver No 2 hippie, biogrid 62 106 14 14 0
GRWD1 GRWD1 Q9BQ67 Glutamate-rich WD repeat-containing protein 1 chr19 Not Cancer Driver No 1 hippie 44 187 14 14 0
HAL HAL P42357 Histidine ammonia-lyase chr12 Not Cancer Driver No 1 hippie, biogrid 98 34 6 6 4
HLTF_ENST00000494055 HLTF Q14527 Helicase-like transcription factor chr3 Not Cancer Driver No 1 hippie 121 353 40 40 0
HSPA4 HSPA4 P34932 Heat shock 70 kDa protein 4 chr5 Not Cancer Driver No 1 hippie 80 351 24 24 0
KAT2A KAT2A Q92830 Histone acetyltransferase KAT2A chr17 Not Cancer Driver No 1 hippie 88 251 17 17 0
KLK7 KLK7 P49862 Kallikrein-7 chr19 Not Cancer Driver No 1 hippie, biogrid 43 38 8 8 0
KMT5A KMT5A Q9NQR1-2 Isoform 2 of N-lysine methyltransferase KMT5A chr12 Not Cancer Driver No 1 hippie 41 225 22 22 0
KPRP KPRP Q5T749 Keratinocyte proline-rich protein chr1 Not Cancer Driver No 1 hippie, biogrid 198 193 68 68 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie 95 84 12 12 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MGMT MGMT B4DEE8 Methylated-DNA--protein-cysteine methyltransferase chr10 Census Yes 1 hippie 43 40 15 15 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 Census Yes 1 hippie 92 37 4 4 70
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 Census Yes 1 hippie 154 386 41 41 6
NSD2_ENST00000382892 NSD2 O96028 Histone-lysine N-methyltransferase NSD2 chr4 Census, Compendium Yes 1 hippie 191 552 76 76 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 hippie 30 22 3 3 1
PDCD4 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 Not Cancer Driver No 1 hippie 57 187 32 32 0
PDCL3 PDCL3 Q9H2J4 Phosducin-like protein 3 chr2 Not Cancer Driver No 1 hippie, biogrid 48 73 13 13 0
PFDN1 PFDN1 O60925 Prefoldin subunit 1 chr5 Not Cancer Driver No 1 hippie, biogrid 8 42 4 4 0
PFDN2 PFDN2 Q9UHV9 Prefoldin subunit 2 chr1 Not Cancer Driver No 2 hippie, biogrid 18 111 11 11 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POF1B_ENST00000262753 POF1B Q8WVV4 Protein POF1B chrX Not Cancer Driver No 1 hippie, biogrid 154 391 104 104 1
POLD4 POLD4 Q9HCU8 DNA polymerase delta subunit 4 chr11 Not Cancer Driver No 1 hippie 8 50 3 3 0
PTPN3 PTPN3 P26045 Tyrosine-protein phosphatase non-receptor type 3 chr9 Not Cancer Driver No 1 hippie 139 214 28 28 0
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 Not Cancer Driver No 1 hippie 59 328 43 43 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 hippie 10 18 1 1 0
RNASE7 RNASE7 Q9H1E1 Ribonuclease 7 chr14 Not Cancer Driver No 1 hippie, biogrid 27 42 4 4 0
SAMM50 SAMM50 Q9Y512 Sorting and assembly machinery component 50 homolog chr22 Not Cancer Driver No 1 hippie, biogrid 51 34 1 1 0
SBSN SBSN Q6UWP8 Suprabasin chr19 Not Cancer Driver No 1 hippie, biogrid 82 552 74 74 0
SDE2 SDE2 Q6IQ49 Replication stress response regulator SDE2 chr1 Not Cancer Driver No 1 hippie 56 290 35 35 0
SERPINA12 SERPINA12 Q8IW75 Serpin A12 chr14 Not Cancer Driver No 1 hippie, biogrid 90 22 3 3 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie 27 75 9 9 0
SHPRH SHPRH Q149N8 E3 ubiquitin-protein ligase SHPRH chr6 Not Cancer Driver No 1 hippie 227 359 51 51 0
SLC31A1 SLC31A1 O15431 High affinity copper uptake protein 1 chr9 Not Cancer Driver No 1 hippie, biogrid 22 28 6 6 0
SLC9A3R2 SLC9A3R2 Q15599 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 chr16 Not Cancer Driver No 1 hippie, biogrid 26 328 26 26 0
TCEAL1_ENST00000372626 TCEAL1 Q15170 Transcription elongation factor A protein-like 1 chrX Not Cancer Driver No 3 hippie, biogrid 18 147 18 18 0
TDG TDG Q13569 G/T mismatch-specific thymine DNA glycosylase chr12 Not Cancer Driver No 1 hippie 75 185 31 31 0
TOB1 TOB1 P50616 Protein Tob1 chr17 Not Cancer Driver No 1 hippie 35 214 18 18 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TUBG1 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 hippie 51 44 10 10 3
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 13 14 0 0 0
UBE2D3_ENST00000394801 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 hippie 21 13 4 4 0
UBE2E1 UBE2E1 P51965 Ubiquitin-conjugating enzyme E2 E1 chr3 Not Cancer Driver No 1 hippie 21 78 10 10 0
UBE2E2_ENST00000425792 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 Not Cancer Driver No 1 hippie 28 90 15 15 0
UBE2E3_ENST00000602710 UBE2E3 Q969T4 Ubiquitin-conjugating enzyme E2 E3 chr2 Not Cancer Driver No 1 hippie 34 97 14 14 0
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 intact, hippie 16 16 3 3 0
UBE2M UBE2M P61081 NEDD8-conjugating enzyme Ubc12 chr19 Not Cancer Driver No 1 hippie 30 32 6 6 0
UBE2N UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 Not Cancer Driver No 1 hippie 25 24 3 3 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 hippie 142 117 36 36 133
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie 30 35 3 3 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 hippie 22 109 4 4 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 32 41 3 3 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 1 hippie 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 1 hippie 15 55 3 3 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 hippie 30 81 10 10 0