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DCAF8 ,DCAF8 ,Q5TAQ9
  • Uniprot Accession= Q5TAQ9
  • Ensembl Transcript= ENST00000368073.7
  • Uniprot Name= DCAF8
  • Name= DDB1- and CUL4-associated factor 8
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 44
  • Number of Interaction partner in biogrid: 47
  • Number of Interaction partner in hippie: 131
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD11 ACAD11 Q709F0 Acyl-CoA dehydrogenase family member 11 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 108 33 4 4 0
ACTN1_ENST00000193403 ACTN1 P12814 Alpha-actinin-1 chr14 Not Cancer Driver No 1 hippie 108 195 30 30 6
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 Not Cancer Driver No 1 hippie 173 788 103 103 0
AMPD2_ENST00000528667 AMPD2 Q01433 AMP deaminase 2 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 93 275 27 27 3
ARHGEF26 ARHGEF26 Q96DR7 Rho guanine nucleotide exchange factor 26 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 164 475 86 86 0
BACH1_ENST00000286800 BACH1 O14867 Transcription regulator protein BACH1 chr21 Not Cancer Driver No 1 hippie 105 328 39 39 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie 17 112 9 9 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
BRD1_ENST00000216267 BRD1 O95696 Bromodomain-containing protein 1 chr22 Not Cancer Driver No 1 hippie 171 425 68 68 0
BUB1B-PAK6 PAK6 A0A024R9Q4 Non-specific serine/threonine protein kinase chr15 Not Cancer Driver No 1 hippie, biogrid 82 398 52 52 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 Census, Compendium Yes 1 hippie 55 31 25 25 0
CCT2 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 2 intact, hippie, biogrid 63 46 3 3 0
CCT3 CCT3 P49368 T-complex protein 1 subunit gamma chr1 Not Cancer Driver No 2 intact, hippie, biogrid 71 95 12 12 0
CCT4 CCT4 P50991 T-complex protein 1 subunit delta chr2 Not Cancer Driver No 2 intact, hippie, biogrid 51 92 2 2 0
CCT5 CCT5 P48643 T-complex protein 1 subunit epsilon chr5 Not Cancer Driver No 1 intact, hippie, biogrid 83 72 10 10 1
CCT6A CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 1 hippie, biogrid 66 5 1 1 0
CCT6B CCT6B Q92526 T-complex protein 1 subunit zeta-2 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 90 1 0 0 0
CCT7 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 2 intact, hippie, biogrid 59 36 6 6 0
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 Not Cancer Driver No 1 hippie 63 313 35 35 0
COPS2_ENST00000388901 COPS2 P61201 COP9 signalosome complex subunit 2 chr15 Not Cancer Driver No 1 hippie 59 59 9 9 0
COPS3 COPS3 Q9UNS2 COP9 signalosome complex subunit 3 chr17 Not Cancer Driver No 1 hippie 55 67 10 10 0
COPS4_ENST00000264389 COPS4 Q9BT78 COP9 signalosome complex subunit 4 chr4 Not Cancer Driver No 1 hippie 50 13 0 0 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
COPS6 COPS6 Q7L5N1 COP9 signalosome complex subunit 6 chr7 Not Cancer Driver No 2 intact, hippie 38 30 6 6 0
COPS7A_ENST00000534947 COPS7A Q9UBW8 COP9 signalosome complex subunit 7a chr12 Not Cancer Driver No 1 hippie 32 74 10 10 0
CPA6 CPA6 Q8N4T0 Carboxypeptidase A6 chr8 Not Cancer Driver No 1 hippie, biogrid 106 7 0 0 2
CSN1S1 CSN1S1 P47710 Alpha-S1-casein chr4 Not Cancer Driver No 1 hippie, biogrid 31 109 16 16 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 4 intact, hippie, biogrid 64 102 2 2 0
CUL4B CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 4 intact, hippie, biogrid 138 207 38 38 2
DCAF11 DCAF11 Q8TEB1 DDB1- and CUL4-associated factor 11 chr14 Not Cancer Driver No 1 hippie 89 149 25 25 0
DCAF8L1 DCAF8L1 A6NGE4 DDB1- and CUL4-associated factor 8-like protein 1 chrX Not Cancer Driver No 2 hippie, biogrid 179 240 78 78 0
DDA1 DDA1 Q9BW61 DET1- and DDB1-associated protein 1 chr19 Not Cancer Driver No 2 hippie, biogrid 10 70 9 9 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 5 intact, biogrid 126 50 8 8 4
DMWD DMWD Q09019 Dystrophia myotonica WD repeat-containing protein chr19 Not Cancer Driver No 1 intact 66 374 24 24 0
DNAJC1 DNAJC1 Q96KC8 DnaJ homolog subfamily C member 1 chr10 Not Cancer Driver No 1 hippie, biogrid 60 315 44 44 0
DNAJC15 DNAJC15 Q9Y5T4 DnaJ homolog subfamily C member 15 chr13 Not Cancer Driver No 1 hippie, biogrid 19 25 4 4 0
DNAJC28_ENST00000381947 DNAJC28 Q9NX36 DnaJ homolog subfamily C member 28 chr21 Not Cancer Driver No 1 hippie, biogrid 55 139 11 11 0
DNAJC9 DNAJC9 Q8WXX5 DnaJ homolog subfamily C member 9 chr10 Not Cancer Driver No 1 hippie, biogrid 28 126 15 15 0
DNMT3A DNMT3A Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A chr2 Census, Compendium Yes 1 hippie 194 371 59 59 16
DR1_ENST00000370267 DR1 Q01658 Protein Dr1 chr1 Not Cancer Driver No 1 hippie 21 84 12 12 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EPB41L2_ENST00000368128 EPB41L2 O43491 Band 4.1-like protein 2 chr6 Not Cancer Driver No 1 hippie 157 708 113 113 0
EPB41L5 EPB41L5 Q9HCM4 Band 4.1-like protein 5 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 97 312 45 45 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
FARP1_ENST00000319562 FARP1 Q9Y4F1 FERM, ARHGEF and pleckstrin domain-containing protein 1 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 147 315 60 60 0
FASTKD2_ENST00000402774 FASTKD2 Q9NYY8 FAST kinase domain-containing protein 2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 74 30 2 2 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
GGH GGH Q92820 Gamma-glutamyl hydrolase chr8 Not Cancer Driver No 2 hippie, biogrid 46 5 0 0 0
GRK6_ENST00000355472 GRK6 P43250 G protein-coupled receptor kinase 6 chr5 Not Cancer Driver No 1 hippie, biogrid 65 68 10 10 0
GRN GRN P28799 Progranulin chr17 Not Cancer Driver No 1 hippie 76 29 6 6 1
GSK3A GSK3A P49840 Glycogen synthase kinase-3 alpha chr19 Not Cancer Driver No 1 intact, hippie 55 180 8 8 0
GSTK1_ENST00000358406 GSTK1 Q9Y2Q3 Glutathione S-transferase kappa 1 chr7 Not Cancer Driver No 1 intact, hippie, biogrid 33 30 3 3 0
GTF2B GTF2B Q00403 Transcription initiation factor IIB chr1 Not Cancer Driver No 1 intact, hippie 33 80 6 6 0
GTF3C3 GTF3C3 Q9Y5Q9 General transcription factor 3C polypeptide 3 chr2 Not Cancer Driver No 1 intact, hippie 109 195 22 22 0
GTPBP3_ENST00000324894 GTPBP3 Q969Y2 tRNA modification GTPase GTPBP3, mitochondrial chr19 Not Cancer Driver No 1 hippie 58 155 20 20 7
HELLS_ENST00000348459 HELLS Q9NRZ9 Lymphoid-specific helicase chr10 Not Cancer Driver No 1 hippie 78 227 25 25 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 intact, hippie 10 118 8 8 20
HTRA2 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 Compendium Yes 1 hippie 44 127 9 9 2
INAVA_ENST00000367342 INAVA Q3KP66 Innate immunity activator protein chr1 Not Cancer Driver No 1 intact, hippie 112 553 98 98 1
JPH3 JPH3 Q8WXH2 Junctophilin-3 chr16 Not Cancer Driver No 1 hippie 130 534 92 92 0
KIF1B_ENST00000377086 KIF1B O60333 Kinesin-like protein KIF1B chr1 Not Cancer Driver No 1 intact, hippie 253 633 106 106 1
KPNA1 KPNA1 P52294 Importin subunit alpha-5 chr3 Not Cancer Driver No 1 intact, hippie 65 121 18 18 0
KPNB1 KPNB1 Q14974 Importin subunit beta-1 chr17 Not Cancer Driver No 1 hippie 92 94 11 11 0
KSR2_ENST00000339824 KSR2 Q6VAB6 Kinase suppressor of Ras 2 chr12 Not Cancer Driver No 1 intact, hippie 231 434 120 120 0
LIPK LIPK Q5VXJ0 Lipase member K chr10 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
LYZL2 LYZL2 Q7Z4W2-2 Isoform 2 of Lysozyme-like protein 2 chr10 Not Cancer Driver No 1 hippie, biogrid 44 2 0 0 0
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 104 75 27 27 0
MDFI MDFI Q99750 MyoD family inhibitor chr6 Not Cancer Driver No 1 hippie 25 152 15 15 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
METTL8_ENST00000638989 METTL8 Q9H825 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial chr2 Not Cancer Driver No 2 intact, hippie, biogrid 32 95 11 11 0
MLF2_ENST00000542154 MLF2 Q15773 Myeloid leukemia factor 2 chr12 Not Cancer Driver No 1 hippie 37 187 32 32 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NDUFAF7 NDUFAF7 Q7L592 Protein arginine methyltransferase NDUFAF7, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 53 19 3 3 0
NEDD8 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 10 36 5 5 0
NEFL NEFL P07196 Neurofilament light polypeptide chr8 Not Cancer Driver No 1 hippie 92 285 39 39 12
NEK4 NEK4 P51957 Serine/threonine-protein kinase Nek4 chr3 Not Cancer Driver No 1 hippie, biogrid 78 492 49 49 0
NF2 NF2 P35240 Merlin chr22 Census, Compendium Yes 1 hippie 69 252 26 26 16
P2RY6_ENST00000540342 P2RY6 Q15077 P2Y purinoceptor 6 chr11 Not Cancer Driver No 1 intact, hippie 50 10 5 5 0
PAK6_ENST00000260404 PAK6 Q9NQU5 Serine/threonine-protein kinase PAK 6 chr15 Not Cancer Driver No 1 hippie, biogrid 82 398 52 52 0
PARP14 PARP14 Q460N5 Protein mono-ADP-ribosyltransferase PARP14 chr3 Not Cancer Driver No 1 hippie, biogrid 221 301 57 57 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 hippie 30 22 3 3 1
PDE7A PDE7A Q13946 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A chr8 Not Cancer Driver No 1 intact, hippie, biogrid 49 30 7 7 0
PEX1 PEX1 O43933 Peroxisome biogenesis factor 1 chr7 Not Cancer Driver No 1 hippie 143 304 36 36 14
PIK3R3_ENST00000372006 PIK3R3 Q92569 Phosphatidylinositol 3-kinase regulatory subunit gamma chr1 Not Cancer Driver No 1 hippie 51 149 20 20 0
PLA2G2D PLA2G2D Q9UNK4 Group IID secretory phospholipase A2 chr1 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 0
PNMA2 PNMA2 Q9UL42 Paraneoplastic antigen Ma2 chr8 Not Cancer Driver No 1 hippie 52 45 5 5 0
PODN_ENST00000618387 PODN Q7Z5L7 Podocan chr1 Not Cancer Driver No 1 hippie, biogrid 126 107 13 13 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PRMT1 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 intact, hippie 50 18 1 1 0
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie 83 72 6 6 0
PRMT8 PRMT8 Q9NR22 Protein arginine N-methyltransferase 8 chr12 Not Cancer Driver No 1 hippie 94 61 16 16 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 Not Cancer Driver No 1 intact, hippie, biogrid 134 425 55 55 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 Not Cancer Driver No 1 hippie 49 140 25 25 0
PTPN21_ENST00000328736 PTPN21 Q16825 Tyrosine-protein phosphatase non-receptor type 21 chr14 Not Cancer Driver No 1 hippie 153 593 91 91 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 hippie 89 169 38 38 22
RAN_ENST00000392369 RAN P62826 GTP-binding nuclear protein Ran chr12 Not Cancer Driver No 1 hippie 20 14 1 1 0
RBPMS_ENST00000320203 RBPMS Q93062 RNA-binding protein with multiple splicing chr8 Not Cancer Driver No 1 intact, hippie 23 87 11 11 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 hippie 10 18 1 1 0
REXO5 REXO5 Q96IC2 RNA exonuclease 5 chr16 Not Cancer Driver No 1 intact, hippie 89 101 12 12 0
RNF11 RNF11 Q9Y3C5 RING finger protein 11 chr1 Not Cancer Driver No 1 hippie 17 76 7 7 0
SFRP4 SFRP4 Q6FHJ7 Secreted frizzled-related protein 4 chr7 Census Yes 1 hippie, biogrid 81 68 22 22 0
SLC15A3 SLC15A3 Q8IY34 Solute carrier family 15 member 3 chr11 Not Cancer Driver No 1 intact, hippie 63 43 1 1 0
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SPRED1 SPRED1 Q7Z699 Sprouty-related, EVH1 domain-containing protein 1 chr15 Not Cancer Driver No 1 intact, hippie 71 194 35 35 2
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 intact, hippie 54 267 32 32 30
STAM2 STAM2 O75886 Signal transducing adapter molecule 2 chr2 Not Cancer Driver No 1 hippie 69 291 30 30 0
STOX2 STOX2 Q9P2F5 Storkhead-box protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 132 805 115 115 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUV39H1_ENST00000376687 SUV39H1 O43463 Histone-lysine N-methyltransferase SUV39H1 chrX Not Cancer Driver No 1 intact, hippie 59 15 1 1 0
TARDBP TARDBP Q13148 TAR DNA-binding protein 43 chr1 Not Cancer Driver No 1 intact, hippie 51 202 15 15 27
TCP1 TCP1 P17987 T-complex protein 1 subunit alpha chr6 Not Cancer Driver No 2 hippie, biogrid 54 55 10 10 0
TFB1M TFB1M Q8WVM0 Dimethyladenosine transferase 1, mitochondrial chr6 Not Cancer Driver No 2 hippie, biogrid 50 26 3 3 0
THAP1 THAP1 Q9NVV9 THAP domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 19 76 8 8 45
TIMM50_ENST00000607714 TIMM50 Q3ZCQ8 Mitochondrial import inner membrane translocase subunit TIM50 chr19 Not Cancer Driver No 1 hippie 39 75 7 7 0
TMCO3 TMCO3 Q6UWJ1 Transmembrane and coiled-coil domain-containing protein 3 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 97 71 4 4 0
TNS2_ENST00000314250 TNS2 Q63HR2 Tensin-2 chr12 Not Cancer Driver No 1 intact, hippie 132 799 63 63 0
TRIM54_ENST00000380075 TRIM54 Q9BYV2 Tripartite motif-containing protein 54 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 63 98 17 17 0
TRIM63 TRIM63 Q969Q1 E3 ubiquitin-protein ligase TRIM63 chr1 Not Cancer Driver No 1 hippie 47 71 13 13 0
TSC1 TSC1 Q92574 Hamartin chr9 Census, Compendium Yes 1 intact 135 732 78 78 11
TUBGCP3 TUBGCP3 Q96CW5 Gamma-tubulin complex component 3 chr13 Not Cancer Driver No 1 hippie 109 156 16 16 0
TWNK TWNK Q96RR1 Twinkle mtDNA helicase chr10 Not Cancer Driver No 1 hippie 95 135 11 11 38
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
UBE2M UBE2M P61081 NEDD8-conjugating enzyme Ubc12 chr19 Not Cancer Driver No 1 hippie 30 32 6 6 0
UNC93B1 UNC93B1 Q9H1C4 Protein unc-93 homolog B1 chr11 Not Cancer Driver No 1 intact, hippie 57 127 5 5 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 hippie 142 117 36 36 133
WDR76 WDR76 Q9H967 WD repeat-containing protein 76 chr15 Not Cancer Driver No 1 hippie 60 288 33 33 0
WDR77 WDR77 Q9BQA1 Methylosome protein 50 chr1 Not Cancer Driver No 1 hippie 30 41 2 2 0
WFS1_ENST00000503569 WFS1 O76024 Wolframin chr4 Not Cancer Driver No 1 intact, hippie 105 203 10 10 39
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 140 33 9 9 0
ZNF460 ZNF460 Q14592 Zinc finger protein 460 chr19 Not Cancer Driver No 1 hippie, biogrid 83 131 16 16 0
ZNHIT2 ZNHIT2 Q9UHR6 Zinc finger HIT domain-containing protein 2 chr11 Not Cancer Driver No 1 hippie, biogrid 29 157 15 15 0
ZRANB1 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 87 158 25 25 0