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CTSS ,CTSS ,P25774
  • Number of Interaction partner in intact: 3
  • Number of Interaction partner in biogrid: 117
  • Number of Interaction partner in hippie: 135
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTN1_ENST00000193403 ACTN1 P12814 Alpha-actinin-1 chr14 Not Cancer Driver No 1 hippie, biogrid 108 195 30 30 6
ACTN4 ACTN4 O43707 Alpha-actinin-4 chr19 Not Cancer Driver No 1 hippie, biogrid 131 244 42 42 8
AIF1L_ENST00000247291 AIF1L Q9BQI0 Allograft inflammatory factor 1-like chr9 Not Cancer Driver No 1 hippie, biogrid 9 44 1 1 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
ARL1 ARL1 P40616 ADP-ribosylation factor-like protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 17 4 0 0 0
ARPC3 ARPC3 O15145 Actin-related protein 2/3 complex subunit 3 chr12 Not Cancer Driver No 1 hippie, biogrid 17 26 6 6 0
B4GAT1 B4GAT1 O43505 Beta-1,4-glucuronyltransferase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 52 4 0 0 2
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie, biogrid 17 112 9 9 0
BAG5_ENST00000299204 BAG5 Q9UL15 BAG family molecular chaperone regulator 5 chr14 Not Cancer Driver No 1 hippie, biogrid 37 63 7 7 0
BGLAP BGLAP P02818 Osteocalcin chr1 Not Cancer Driver No 1 hippie 13 21 2 2 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
C19orf70_ENST00000309324 MICOS13 Q5XKP0 MICOS complex subunit MIC13 chr19 Not Cancer Driver No 1 hippie 12 3 0 0 0
CALM1 CALM1 P0DP23 Calmodulin-1 chr14 Not Cancer Driver No 1 hippie 19 115 15 15 7
CALM2 CALM2 P0DP24 Calmodulin-2 chr2 Not Cancer Driver No 1 biogrid 18 115 13 13 8
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie, biogrid 45 245 31 31 0
CALU_ENST00000249364 CALU O43852 Calumenin chr7 Not Cancer Driver No 1 hippie, biogrid 34 130 12 12 0
CHID1_ENST00000436108 CHID1 Q9BWS9 Chitinase domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 53 4 0 0 0
CKAP4 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 hippie, biogrid 73 409 55 55 0
CLDN3 CLDN3 O15551 Claudin-3 chr7 Not Cancer Driver No 1 intact, hippie 12 0 0 0 0
CLGN_ENST00000414773 CLGN O14967 Calmegin chr4 Not Cancer Driver No 1 hippie, biogrid 86 255 36 36 0
CNPY2 CNPY2 Q9Y2B0 Protein canopy homolog 2 chr12 Not Cancer Driver No 1 hippie, biogrid 24 24 3 3 0
CNPY3 CNPY3 Q9BT09 Protein canopy homolog 3 chr6 Not Cancer Driver No 1 hippie, biogrid 28 87 12 12 0
COL14A1 COL14A1 Q05707 Collagen alpha-1(XIV) chain chr8 Not Cancer Driver No 1 hippie, biogrid 402 711 188 188 0
COLGALT1 COLGALT1 Q8NBJ5 Procollagen galactosyltransferase 1 chr19 Not Cancer Driver No 1 hippie, biogrid 89 114 11 11 3
COQ8A COQ8A Q8NI60 Atypical kinase COQ8A, mitochondrial chr1 Not Cancer Driver No 1 hippie 95 166 29 29 12
CPD CPD O75976 Carboxypeptidase D chr17 Not Cancer Driver No 1 hippie, biogrid 131 476 45 45 0
CRELD2_ENST00000328268 CRELD2 Q6UXH1 Protein disulfide isomerase CRELD2 chr22 Not Cancer Driver No 1 hippie, biogrid 39 33 6 6 0
CST3_ENST00000376925 CST3 P01034 Cystatin-C chr20 Not Cancer Driver No 1 hippie 17 31 1 1 2
CST5 CST5 P28325 Cystatin-D chr20 Not Cancer Driver No 1 hippie 36 6 2 2 0
CTSB CTSB P07858 Cathepsin B chr8 Not Cancer Driver No 1 hippie, biogrid 41 7 2 2 0
CTSS CTSS P25774 Cathepsin S chr1 Not Cancer Driver No 1 hippie, biogrid 54 0 0 0 0
CTSZ CTSZ Q9UBR2 Cathepsin Z chr20 Not Cancer Driver No 1 hippie, biogrid 30 10 0 0 0
DDOST_ENST00000375048 DDOST P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit chr1 Not Cancer Driver No 1 hippie, biogrid 34 13 3 3 1
DNAJB11_ENST00000265028 DNAJB11 Q9UBS4 DnaJ homolog subfamily B member 11 chr3 Not Cancer Driver No 1 hippie, biogrid 52 141 21 21 2
DNAJB12_ENST00000444643 DNAJB12 Q9NXW2 DnaJ homolog subfamily B member 12 chr10 Not Cancer Driver No 1 hippie, biogrid 43 227 20 20 0
DNAJC10 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 Not Cancer Driver No 1 hippie, biogrid 110 36 3 3 0
DNAJC3 DNAJC3 Q13217 DnaJ homolog subfamily C member 3 chr13 Not Cancer Driver No 1 hippie, biogrid 60 131 17 17 0
DPM1_ENST00000371588 DPM1 O60762 Dolichol-phosphate mannosyltransferase subunit 1 chr20 Not Cancer Driver No 1 hippie, biogrid 38 29 6 6 3
EMC1 EMC1 Q8N766 ER membrane protein complex subunit 1 chr1 Not Cancer Driver No 1 hippie, biogrid 107 59 6 6 2
ERLIN2_ENST00000519638 ERLIN2 O94905 Erlin-2 chr8 Not Cancer Driver No 1 hippie, biogrid 38 22 3 3 0
ERO1A ERO1A Q96HE7 ERO1-like protein alpha chr14 Not Cancer Driver No 1 hippie 48 32 5 5 0
ERP29 ERP29 P30040 Endoplasmic reticulum resident protein 29 chr12 Not Cancer Driver No 1 hippie, biogrid 29 34 5 5 0
ERP44 ERP44 Q9BS26 Endoplasmic reticulum resident protein 44 chr9 Not Cancer Driver No 1 hippie, biogrid 43 43 3 3 0
FKBP10 FKBP10 Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 chr17 Not Cancer Driver No 1 hippie, biogrid 60 134 8 8 3
GANAB_ENST00000356638 GANAB Q14697 Neutral alpha-glucosidase AB chr11 Not Cancer Driver No 1 hippie, biogrid 129 132 20 20 3
GXYLT1 GXYLT1 Q4G148 Glucoside xylosyltransferase 1 chr12 Not Cancer Driver No 1 hippie, biogrid 58 7 0 0 0
HAGH HAGH Q16775 Hydroxyacylglutathione hydrolase, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 26 41 1 1 0
HLA-A_ENST00000376809 HLA-A P04439 HLA class I histocompatibility antigen, A alpha chain chr6 Census, Compendium Yes 1 hippie, biogrid 128 125 60 60 0
HSD17B12 HSD17B12 Q53GQ0 Very-long-chain 3-oxoacyl-CoA reductase chr11 Not Cancer Driver No 1 hippie, biogrid 32 9 0 0 0
HSP90B1 HSP90B1 P14625 Endoplasmin chr12 Not Cancer Driver No 1 hippie, biogrid 94 268 35 35 0
HYOU1 HYOU1 Q9Y4L1 Hypoxia up-regulated protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 132 373 47 47 0
IKBIP_ENST00000342502 IKBIP Q70UQ0 Inhibitor of nuclear factor kappa-B kinase-interacting protein chr12 Not Cancer Driver No 1 hippie, biogrid 53 69 8 8 0
IPO4 IPO4 Q8TEX9 Importin-4 chr14 Not Cancer Driver No 1 hippie, biogrid 106 87 5 5 0
IRF2 IRF2 P14316 Interferon regulatory factor 2 chr4 Not Cancer Driver No 2 intact, hippie, biogrid 85 288 73 73 0
KNG1 KNG1 P01042 Kininogen-1 chr3 Not Cancer Driver No 1 hippie 130 294 66 66 1
KRI1 KRI1 Q8N9T8 Protein KRI1 homolog chr19 Not Cancer Driver No 1 hippie, biogrid 91 607 84 84 0
LMAN1 LMAN1 P49257 Protein ERGIC-53 chr18 Not Cancer Driver No 1 hippie, biogrid 63 222 25 25 1
LRPAP1 LRPAP1 P30533 Alpha-2-macroglobulin receptor-associated protein chr4 Not Cancer Driver No 1 hippie, biogrid 41 188 20 20 0
MANF MANF P55145 Mesencephalic astrocyte-derived neurotrophic factor chr3 Not Cancer Driver No 1 hippie, biogrid 14 1 0 0 0
MESD_ENST00000561312 MESD Q14696 LRP chaperone MESD chr15 Not Cancer Driver No 1 hippie 21 150 14 14 0
MIA3 MIA3 Q5JRA6 Transport and Golgi organization protein 1 homolog chr1 Not Cancer Driver No 1 hippie, biogrid 222 1490 178 178 0
MINPP1 MINPP1 Q9UNW1 Multiple inositol polyphosphate phosphatase 1 chr10 Not Cancer Driver No 1 hippie, biogrid 52 46 2 2 2
MLF2_ENST00000542154 MLF2 Q15773 Myeloid leukemia factor 2 chr12 Not Cancer Driver No 1 hippie, biogrid 37 187 32 32 0
MMS19 MMS19 Q96T76 MMS19 nucleotide excision repair protein homolog chr10 Not Cancer Driver No 1 hippie, biogrid 73 11 0 0 0
MOGS MOGS Q13724 Mannosyl-oligosaccharide glucosidase chr2 Not Cancer Driver No 1 hippie, biogrid 105 200 29 29 2
MRTO4 MRTO4 Q9UKD2 mRNA turnover protein 4 homolog chr1 Not Cancer Driver No 1 hippie, biogrid 23 73 5 5 0
MYDGF MYDGF Q969H8 Myeloid-derived growth factor chr19 Not Cancer Driver No 1 hippie 23 26 4 4 0
MYO18A MYO18A Q92614 Unconventional myosin-XVIIIa chr17 Not Cancer Driver No 1 hippie, biogrid 268 1237 176 176 0
MYO1B MYO1B O43795 Unconventional myosin-Ib chr2 Not Cancer Driver No 1 hippie, biogrid 144 34 4 4 0
MYO1C MYO1C O00159 Unconventional myosin-Ic chr17 Not Cancer Driver No 1 hippie, biogrid 110 66 11 11 0
MYO1D MYO1D O94832 Unconventional myosin-Id chr17 Not Cancer Driver No 1 hippie, biogrid 126 61 6 6 0
MYO6 MYO6 Q9UM54 Unconventional myosin-VI chr6 Not Cancer Driver No 1 hippie, biogrid 176 342 41 41 3
NAMPT NAMPT P43490 Nicotinamide phosphoribosyltransferase chr7 Not Cancer Driver No 1 hippie, biogrid 50 27 5 5 0
NOC2L NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 Not Cancer Driver No 1 hippie, biogrid 77 281 31 31 0
NOMO3 NOMO3 P69849 Nodal modulator 3 chr16 Not Cancer Driver No 1 hippie, biogrid 44 129 3 3 0
NUCB2_ENST00000622082 NUCB2 P80303 Nucleobindin-2 chr11 Not Cancer Driver No 1 hippie, biogrid 49 265 40 40 0
NUP188 NUP188 Q5SRE5 Nucleoporin NUP188 chr9 Not Cancer Driver No 1 hippie, biogrid 190 152 20 20 0
NUP210 NUP210 Q8TEM1 Nuclear pore membrane glycoprotein 210 chr3 Not Cancer Driver No 1 hippie, biogrid 262 156 19 19 0
OCLN OCLN Q16625 Occludin chr5 Not Cancer Driver No 1 intact, hippie 54 244 21 21 1
OS9 OS9 Q13438 Protein OS-9 chr12 Not Cancer Driver No 1 hippie, biogrid 72 451 49 49 0
P4HA1_ENST00000394890 P4HA1 P13674 Prolyl 4-hydroxylase subunit alpha-1 chr10 Not Cancer Driver No 1 hippie, biogrid 65 54 8 8 0
PDIA3 PDIA3 P30101 Protein disulfide-isomerase A3 chr15 Not Cancer Driver No 1 hippie, biogrid 57 98 11 11 0
PDIA4 PDIA4 P13667 Protein disulfide-isomerase A4 chr7 Not Cancer Driver No 1 hippie, biogrid 81 147 22 22 0
PFKL PFKL P17858 ATP-dependent 6-phosphofructokinase, liver type chr21 Not Cancer Driver No 1 hippie, biogrid 91 29 4 4 0
PFKP PFKP Q01813 ATP-dependent 6-phosphofructokinase, platelet type chr10 Not Cancer Driver No 1 hippie, biogrid 133 43 10 10 0
PIGS PIGS Q96S52 GPI transamidase component PIG-S chr17 Not Cancer Driver No 1 hippie, biogrid 59 32 4 4 2
PLCG1_ENST00000373271 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 158 186 21 21 0
PLD3_ENST00000409735 PLD3 Q8IV08 5'-3' exonuclease PLD3 chr19 Not Cancer Driver No 1 hippie, biogrid 70 62 7 7 0
PLOD1 PLOD1 Q02809 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 86 12 0 0 5
PLOD3 PLOD3 O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 chr7 Not Cancer Driver No 1 hippie, biogrid 108 65 8 8 1
POFUT1 POFUT1 Q9H488 GDP-fucose protein O-fucosyltransferase 1 chr20 Not Cancer Driver No 1 hippie, biogrid 56 17 2 2 0
PON2 PON2 Q15165 Serum paraoxonase/arylesterase 2 chr7 Not Cancer Driver No 1 hippie, biogrid 46 13 3 3 0
PRDX4 PRDX4 Q13162 Peroxiredoxin-4 chrX Not Cancer Driver No 1 hippie, biogrid 36 29 2 2 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 Not Cancer Driver No 1 hippie, biogrid 538 421 61 61 2
RALY RALY Q9UKM9 RNA-binding protein Raly chr20 Not Cancer Driver No 1 hippie, biogrid 58 187 32 32 0
RBM11 RBM11 P57052 Splicing regulator RBM11 chr21 Not Cancer Driver No 1 hippie, biogrid 67 124 38 38 0
RCN1 RCN1 Q15293 Reticulocalbin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 35 158 19 19 0
RNF5 RNF5 Q99942 E3 ubiquitin-protein ligase RNF5 chr6 Not Cancer Driver No 1 hippie, biogrid 17 69 3 3 0
RPF2 RPF2 Q9H7B2 Ribosome production factor 2 homolog chr6 Not Cancer Driver No 1 hippie, biogrid 37 92 9 9 0
RPN1 RPN1 P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 chr3 Census Yes 1 hippie, biogrid 50 69 3 3 0
RPN2 RPN2 P04844 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 chr20 Not Cancer Driver No 1 hippie, biogrid 53 26 4 4 0
SDF2 SDF2 Q99470 Stromal cell-derived factor 2 chr17 Not Cancer Driver No 1 hippie, biogrid 22 93 10 10 0
SDF2L1 SDF2L1 Q9HCN8 Stromal cell-derived factor 2-like protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 16 130 9 9 0
SEC16A SEC16A O15027 Protein transport protein Sec16A chr9 Not Cancer Driver No 1 hippie, biogrid 285 1923 235 235 0
SEC61A1 SEC61A1 P61619 Protein transport protein Sec61 subunit alpha isoform 1 chr3 Not Cancer Driver No 1 hippie, biogrid 57 0 0 0 2
SEL1L SEL1L Q9UBV2 Protein sel-1 homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 95 187 18 18 0
SELENOF_ENST00000616787 SELENOF O60613 Selenoprotein F chr1 Not Cancer Driver No 1 hippie 7 0 0 0 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 hippie 142 47 28 28 0
SERPINB4 SERPINB4 P48594 Serpin B4 chr18 Not Cancer Driver No 1 hippie 120 48 18 18 0
SERPINH1_ENST00000358171 SERPINH1 P50454 Serpin H1 chr11 Not Cancer Driver No 1 hippie, biogrid 51 52 6 6 1
SLC25A11 SLC25A11 Q02978 Mitochondrial 2-oxoglutarate/malate carrier protein chr17 Not Cancer Driver No 1 hippie, biogrid 37 16 1 1 3
SLC25A13_ENST00000265631 SLC25A13 Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 chr7 Not Cancer Driver No 1 hippie, biogrid 111 23 2 2 1
SLPI SLPI P03973 Antileukoproteinase chr20 Not Cancer Driver No 1 hippie 20 0 0 0 0
SPTAN1_ENST00000372731 SPTAN1 Q13813 Spectrin alpha chain, non-erythrocytic 1 chr9 Not Cancer Driver No 1 hippie, biogrid 315 980 114 114 0
SRPRB SRPRB Q9Y5M8 Signal recognition particle receptor subunit beta chr3 Not Cancer Driver No 1 hippie, biogrid 30 23 3 3 0
STT3A_ENST00000529196 STT3A P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A chr11 Not Cancer Driver No 1 hippie, biogrid 82 27 2 2 1
STT3B STT3B Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B chr3 Not Cancer Driver No 1 hippie, biogrid 60 136 9 9 0
SUN1 SUN1 O94901 SUN domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 109 246 26 26 0
TIAF1 MYO18A O95411 Putative TGFB1-induced anti-apoptotic factor 1 chr17 Not Cancer Driver No 1 hippie, biogrid 16 30 5 5 0
TMED10 TMED10 P49755 Transmembrane emp24 domain-containing protein 10 chr14 Not Cancer Driver No 1 hippie, biogrid 24 15 3 3 0
TMTC3 TMTC3 Q6ZXV5 Protein O-mannosyl-transferase TMTC3 chr12 Not Cancer Driver No 1 hippie, biogrid 122 84 7 7 2
TOMM22 TOMM22 Q9NS69 Mitochondrial import receptor subunit TOM22 homolog chr22 Not Cancer Driver No 1 hippie, biogrid 18 83 9 9 0
TOR1AIP1_ENST00000606911 TOR1AIP1 Q5JTV8 Torsin-1A-interacting protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 71 401 44 44 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie, biogrid 2891 282 1466 1466 83
TPM4_ENST00000300933 TPM4 P67936 Tropomyosin alpha-4 chain chr19 Census Yes 1 hippie, biogrid 28 216 28 28 0
TTC17 TTC17 Q96AE7 Tetratricopeptide repeat protein 17 chr11 Not Cancer Driver No 1 hippie, biogrid 161 276 46 46 0
TUBG1 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 hippie, biogrid 51 44 10 10 3
TWF1_ENST00000395510 TWF1 Q12792 Twinfilin-1 chr12 Not Cancer Driver No 1 hippie, biogrid 50 52 3 3 0
TXNDC12 TXNDC12 O95881 Thioredoxin domain-containing protein 12 chr1 Not Cancer Driver No 1 hippie, biogrid 21 44 6 6 0
UBR4 UBR4 Q5T4S7 E3 ubiquitin-protein ligase UBR4 chr1 Not Cancer Driver No 1 hippie, biogrid 565 1066 119 119 0
UGGT1 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 Not Cancer Driver No 1 hippie, biogrid 169 161 20 20 0
UGGT2 UGGT2 Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 chr13 Not Cancer Driver No 1 hippie, biogrid 190 64 6 6 0
WDR1 WDR1 O75083 WD repeat-containing protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 66 30 7 7 2
XPO5 XPO5 Q9HAV4 Exportin-5 chr6 Not Cancer Driver No 1 hippie, biogrid 112 64 7 7 0
XPOT XPOT O43592 Exportin-T chr12 Not Cancer Driver No 1 hippie, biogrid 114 0 0 0 0
YTHDF3_ENST00000539294 YTHDF3 Q7Z739 YTH domain-containing family protein 3 chr8 Not Cancer Driver No 1 hippie, biogrid 74 409 51 51 0