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COP1 ,COP1 ,Q8NHY2
  • Uniprot Accession= Q8NHY2
  • Ensembl Transcript= ENST00000367669.7
  • Uniprot Name= COP1
  • Name= E3 ubiquitin-protein ligase COP1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 53
  • Number of Interaction partner in biogrid: 0
  • Number of Interaction partner in hippie: 128
Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
Cancer Database
Cancer Driver
Number of independent pubication
Interaction Database
Number of missense mutations
Number of disordered residues
Number of mutations in disordered residues
Number of mutations in disordered residues
Number of omim mutations
ACACB_ENST00000377848 ACACB O00763 Acetyl-CoA carboxylase 2 chr12 Not Cancer Driver No 1 hippie 388 342 62 62 0
AGGF1 AGGF1 Q8N302 Angiogenic factor with G patch and FHA domains 1 chr5 Not Cancer Driver No 1 hippie 100 582 80 80 1
APBA3 APBA3 O96018 Amyloid-beta A4 precursor protein-binding family A member 3 chr19 Not Cancer Driver No 1 hippie 55 306 43 43 0
ARHGEF10L ARHGEF10L Q9HCE6 Rho guanine nucleotide exchange factor 10-like protein chr1 Census, Compendium Yes 1 hippie 155 431 47 47 0
ATF6 ATF6 P18850 Cyclic AMP-dependent transcription factor ATF-6 alpha chr1 Not Cancer Driver No 1 hippie 88 468 59 59 2
ATP23 ATP23 Q9Y6H3 Mitochondrial inner membrane protease ATP23 homolog chr12 Not Cancer Driver No 1 hippie 26 25 3 3 0
ATP5PO ATP5PO P48047 ATP synthase subunit O, mitochondrial chr21 Not Cancer Driver No 1 intact, hippie 19 9 2 2 0
ATXN7L1 ATXN7L1 Q9ULK2 Ataxin-7-like protein 1 chr7 Not Cancer Driver No 1 hippie 60 710 48 48 0
BTBD2 BTBD2 Q9BX70 BTB/POZ domain-containing protein 2 chr19 Not Cancer Driver No 1 hippie 46 118 2 2 0
CCT2 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 2 intact, hippie 63 46 3 3 0
CCT3 CCT3 P49368 T-complex protein 1 subunit gamma chr1 Not Cancer Driver No 2 intact, hippie 71 95 12 12 0
CCT4 CCT4 P50991 T-complex protein 1 subunit delta chr2 Not Cancer Driver No 1 hippie 51 92 2 2 0
CCT5 CCT5 P48643 T-complex protein 1 subunit epsilon chr5 Not Cancer Driver No 1 hippie 83 72 10 10 1
CCT6A CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 2 intact, hippie 66 5 1 1 0
CCT6B CCT6B Q92526 T-complex protein 1 subunit zeta-2 chr17 Not Cancer Driver No 1 intact, hippie 90 1 0 0 0
CCT7 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 2 intact, hippie 59 36 6 6 0
CCT8 CCT8 P50990 T-complex protein 1 subunit theta chr21 Not Cancer Driver No 1 hippie 41 36 2 2 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 Census, Compendium Yes 1 hippie 19 198 19 19 0
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 Census, Compendium Yes 1 hippie 12 342 12 12 1
CEP164 CEP164 Q9UPV0 Centrosomal protein of 164 kDa chr11 Not Cancer Driver No 1 intact, hippie 161 1198 124 124 2
CHGA CHGA P10645 Chromogranin-A chr14 Not Cancer Driver No 1 hippie 46 421 44 44 0
CMTM5 CMTM5 Q96DZ9 CKLF-like MARVEL transmembrane domain-containing protein 5 chr14 Not Cancer Driver No 1 hippie 56 12 2 2 0
COP1 COP1 Q8NHY2 E3 ubiquitin-protein ligase COP1 chr1 Not Cancer Driver No 4 intact, hippie 106 147 11 11 0
COPS2_ENST00000388901 COPS2 P61201 COP9 signalosome complex subunit 2 chr15 Not Cancer Driver No 1 hippie 59 59 9 9 0
COPS3 COPS3 Q9UNS2 COP9 signalosome complex subunit 3 chr17 Not Cancer Driver No 1 hippie 55 67 10 10 0
COPS4_ENST00000264389 COPS4 Q9BT78 COP9 signalosome complex subunit 4 chr4 Not Cancer Driver No 1 hippie 50 13 0 0 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
COPS6 COPS6 Q7L5N1 COP9 signalosome complex subunit 6 chr7 Not Cancer Driver No 1 intact, hippie 38 30 6 6 0
COPS7A_ENST00000534947 COPS7A Q9UBW8 COP9 signalosome complex subunit 7a chr12 Not Cancer Driver No 1 hippie 32 74 10 10 0
COPS7B_ENST00000410024 COPS7B Q9H9Q2 COP9 signalosome complex subunit 7b chr2 Not Cancer Driver No 1 hippie 22 74 6 6 0
COPS8 COPS8 Q99627 COP9 signalosome complex subunit 8 chr2 Not Cancer Driver No 1 hippie 25 14 2 2 0
CRTC2 CRTC2 Q53ET0 CREB-regulated transcription coactivator 2 chr1 Not Cancer Driver No 1 hippie 92 674 88 88 0
CRY1 CRY1 Q16526 Cryptochrome-1 chr12 Not Cancer Driver No 2 intact 76 91 5 5 0
CUL1_ENST00000602748 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 hippie 151 65 9 9 0
CUL2_ENST00000374748 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 hippie 87 66 3 3 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 hippie 123 167 23 23 3
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 4 intact, hippie 64 102 2 2 0
CUL4B CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 1 hippie 138 207 38 38 2
DCAF1 DCAF1 Q9Y4B6 DDB1- and CUL4-associated factor 1 chr3 Not Cancer Driver No 1 hippie 128 495 44 44 0
DCAF11 DCAF11 Q8TEB1 DDB1- and CUL4-associated factor 11 chr14 Not Cancer Driver No 1 hippie 89 149 25 25 0
DDA1 DDA1 Q9BW61 DET1- and DDB1-associated protein 1 chr19 Not Cancer Driver No 2 intact, hippie 10 70 9 9 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 2 intact 126 50 8 8 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 Census, Compendium Yes 1 hippie 45 70 5 5 2
DDOST_ENST00000375048 DDOST P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit chr1 Not Cancer Driver No 1 intact 34 13 3 3 1
DET1_ENST00000268148 DET1 Q7L5Y6 DET1 homolog chr15 Not Cancer Driver No 3 intact, hippie 97 42 12 12 0
DMC1 DMC1 Q14565 Meiotic recombination protein DMC1/LIM15 homolog chr22 Not Cancer Driver No 1 hippie 39 49 5 5 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ELOB_ENST00000409906 ELOB Q15370 Elongin-B chr16 Not Cancer Driver No 1 hippie 13 69 10 10 0
ENO1 ENO1 P06733 Alpha-enolase chr1 Not Cancer Driver No 1 intact 51 21 2 2 0
ERCC8 ERCC8 Q13216 DNA excision repair protein ERCC-8 chr5 Not Cancer Driver No 1 hippie 25 53 8 8 7
ETS1_ENST00000319397 ETS1 P14921 Protein C-ets-1 chr11 Not Cancer Driver No 1 intact, hippie 68 78 9 9 0
ETS2 ETS2 P15036 Protein C-ets-2 chr21 Not Cancer Driver No 2 intact, hippie 73 127 25 25 0
ETV1 ETV1 P50549 ETS translocation variant 1 chr7 Census Yes 3 intact, hippie 100 282 66 66 0
ETV4_ENST00000591713 ETV4 P43268 ETS translocation variant 4 chr17 Census, Compendium Yes 1 hippie 44 319 26 26 0
ETV5_ENST00000434744 ETV5 P41161 ETS translocation variant 5 chr3 Census, Compendium Yes 4 intact, hippie 92 299 52 52 0
FAM120B_ENST00000476287 FAM120B Q96EK7 Constitutive coactivator of peroxisome proliferator-activated receptor gamma chr6 Not Cancer Driver No 1 intact, hippie 127 296 48 48 0
FAR1 FAR1 Q8WVX9 Fatty acyl-CoA reductase 1 chr11 Not Cancer Driver No 1 intact 66 0 0 0 4
FOS FOS P01100 Protein c-Fos chr14 Not Cancer Driver No 1 hippie 45 245 33 33 0
FOSB FOSB P53539 Protein FosB chr19 Not Cancer Driver No 1 hippie 50 313 44 44 0
FOSL1 FOSL1 P15407 Fos-related antigen 1 chr11 Not Cancer Driver No 1 hippie 24 271 24 24 0
FOSL2 FOSL2 P15408 Fos-related antigen 2 chr2 Not Cancer Driver No 3 intact, hippie 54 323 54 54 0
FOXO1 FOXO1 Q12778 Forkhead box protein O1 chr13 Census, Compendium Yes 1 hippie 81 584 75 75 0
FOXO4 FOXO4 P98177 Forkhead box protein O4 chrX Census Yes 1 hippie 75 441 61 61 0
GRWD1 GRWD1 Q9BQ67 Glutamate-rich WD repeat-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 44 187 14 14 0
HSPA2_ENST00000247207 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 Not Cancer Driver No 1 hippie 93 286 38 38 0
HSPA6 HSPA6 P17066 Heat shock 70 kDa protein 6 chr1 Not Cancer Driver No 1 hippie 112 235 27 27 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
IGFL1 IGFL1 Q6UW32 Insulin growth factor-like family member 1 chr19 Not Cancer Driver No 1 hippie 21 0 0 0 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 Not Cancer Driver No 1 hippie 30 35 6 6 0
INSIG1 INSIG1 O15503 Insulin-induced gene 1 protein chr7 Not Cancer Driver No 1 intact 37 43 1 1 0
INSIG2 INSIG2 Q9Y5U4 Insulin-induced gene 2 protein chr2 Not Cancer Driver No 1 intact 47 11 3 3 0
JPH1 JPH1 Q9HDC5 Junctophilin-1 chr8 Not Cancer Driver No 1 intact, hippie 131 421 89 89 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
JUNB JUNB P17275 Transcription factor JunB chr19 Not Cancer Driver No 2 intact, hippie 20 305 16 16 0
JUND JUND P17535 Transcription factor JunD chr19 Not Cancer Driver No 1 intact, hippie 21 313 19 19 0
KAT6A_ENST00000406337 KAT6A Q92794 Histone acetyltransferase KAT6A chr8 Census, Compendium Yes 1 hippie 273 1420 193 193 0
KHDRBS2 KHDRBS2 Q5VWX1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 chr6 Not Cancer Driver No 1 hippie 168 268 140 140 0
KLHL42 KLHL42 Q9P2K6 Kelch-like protein 42 chr12 Not Cancer Driver No 1 hippie 48 57 4 4 0
LRR1 LRR1 Q96L50 Leucine-rich repeat protein 1 chr14 Not Cancer Driver No 1 hippie 45 3 1 1 0
LSM4 LSM4 Q9Y4Z0 U6 snRNA-associated Sm-like protein LSm4 chr19 Not Cancer Driver No 1 intact 19 64 9 9 0
MAP7_ENST00000354570 MAP7 Q14244 Ensconsin chr6 Not Cancer Driver No 1 hippie 122 745 122 122 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 intact, hippie 62 2 0 0 7
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 Census, Compendium Yes 1 hippie 57 202 26 26 1
MLF1_ENST00000355893 MLF1 P58340 Myeloid leukemia factor 1 chr3 Census Yes 1 hippie 40 243 37 37 0
MRPL10_ENST00000351111 MRPL10 Q7Z7H8 39S ribosomal protein L10, mitochondrial chr17 Not Cancer Driver No 1 intact 37 40 6 6 0
MRPL17 MRPL17 Q9NRX2 39S ribosomal protein L17, mitochondrial chr11 Not Cancer Driver No 1 intact 13 39 2 2 0
MRPL24_ENST00000368211 MRPL24 Q96A35 39S ribosomal protein L24, mitochondrial chr1 Not Cancer Driver No 1 intact 22 71 7 7 0
MRPL27 MRPL27 Q9P0M9 39S ribosomal protein L27, mitochondrial chr17 Not Cancer Driver No 1 intact 16 35 2 2 0
MRPL3 MRPL3 P09001 39S ribosomal protein L3, mitochondrial chr3 Not Cancer Driver No 1 intact 42 61 5 5 1
MRPL36 MRPL36 Q9P0J6 39S ribosomal protein L36, mitochondrial chr5 Not Cancer Driver No 1 intact 12 4 0 0 0
MRPL39_ENST00000352957 MRPL39 Q9NYK5 39S ribosomal protein L39, mitochondrial chr21 Not Cancer Driver No 1 intact 41 38 6 6 0
MVP MVP Q14764 Major vault protein chr16 Not Cancer Driver No 2 intact, hippie 141 285 31 31 0
NFIL3 NFIL3 Q16649 Nuclear factor interleukin-3-regulated protein chr9 Not Cancer Driver No 1 intact, hippie 57 333 41 41 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 Compendium Yes 1 hippie 37 102 9 9 1
PARP4 PARP4 Q9UKK3 Protein mono-ADP-ribosyltransferase PARP4 chr13 Compendium Yes 1 hippie 218 325 40 40 0
PGK1 PGK1 P00558 Phosphoglycerate kinase 1 chrX Not Cancer Driver No 1 intact 61 40 5 5 9
PNPLA2 PNPLA2 Q96AD5 Patatin-like phospholipase domain-containing protein 2 chr11 Not Cancer Driver No 1 hippie 35 101 4 4 1
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 Not Cancer Driver No 1 intact, hippie 41 12 1 1 8
PPP2R1B_ENST00000527614 PPP2R1B P30154 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform chr11 Not Cancer Driver No 1 hippie 72 17 1 1 0
PPP2R2A_ENST00000380737 PPP2R2A P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform chr8 Not Cancer Driver No 1 hippie 60 68 10 10 0
PPP2R2D PPP2R2D Q66LE6 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform chr10 Not Cancer Driver No 1 hippie 50 65 9 9 0
PTCD2 PTCD2 Q8WV60 Pentatricopeptide repeat-containing protein 2, mitochondrial chr5 Not Cancer Driver No 1 hippie 46 9 0 0 0
PTPDC1_ENST00000375360 PTPDC1 A2A3K4 Protein tyrosine phosphatase domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie 85 301 26 26 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 Not Cancer Driver No 1 hippie 49 140 25 25 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 Census, Compendium Yes 1 hippie 129 260 38 38 60
RAX2_ENST00000555978 RAX2 Q96IS3 Retina and anterior neural fold homeobox protein 2 chr19 Not Cancer Driver No 1 intact 10 121 4 4 2
RB1CC1 RB1CC1 Q8TDY2 RB1-inducible coiled-coil protein 1 chr8 Not Cancer Driver No 1 hippie 202 578 75 75 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 hippie 10 18 1 1 0
RCHY1 RCHY1 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie 33 23 0 0 0
REG1A REG1A P05451 Lithostathine-1-alpha chr2 Not Cancer Driver No 1 hippie 97 9 5 5 0
RRP15 RRP15 Q9Y3B9 RRP15-like protein chr1 Not Cancer Driver No 1 intact 50 278 48 48 0
SENP1 SENP1 Q9P0U3 Sentrin-specific protease 1 chr12 Not Cancer Driver No 1 hippie 64 355 44 44 0
SEPSECS SEPSECS Q9HD40 O-phosphoseryl-tRNA(Sec) selenium transferase chr4 Not Cancer Driver No 1 intact, hippie 47 22 7 7 3
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie 27 75 9 9 0
SIPA1_ENST00000534313 SIPA1 Q96FS4 Signal-induced proliferation-associated protein 1 chr11 Not Cancer Driver No 1 hippie 67 666 43 43 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 70 435 31 31 0
SIX5_ENST00000643139 SIX5 Q8N196 Homeobox protein SIX5 chr19 Not Cancer Driver No 1 hippie 53 499 41 41 4
SKP1_ENST00000517625 SKP1 P63208 S-phase kinase-associated protein 1 chr5 Not Cancer Driver No 1 hippie 19 95 17 17 0
SNAP29 SNAP29 O95721 Synaptosomal-associated protein 29 chr22 Not Cancer Driver No 1 hippie 21 246 20 20 0
SOGA1 SOGA1 O94964-2 Isoform 2 of Protein SOGA1 chr20 Not Cancer Driver No 1 hippie 188 1118 100 100 0
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 hippie 39 312 39 39 0
SPOP SPOP O43791 Speckle-type POZ protein chr17 Census, Compendium Yes 1 hippie 147 25 5 5 6
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
STK40_ENST00000373132 STK40 Q8N2I9 Serine/threonine-protein kinase 40 chr1 Not Cancer Driver No 1 hippie 50 103 9 9 0
TAF5 TAF5 Q15542 Transcription initiation factor TFIID subunit 5 chr10 Not Cancer Driver No 1 intact 61 294 12 12 0
TAF9 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 Not Cancer Driver No 1 intact 25 203 19 19 0
TAX1BP1 TAX1BP1 Q86VP1 Tax1-binding protein 1 chr7 Not Cancer Driver No 1 hippie 78 429 50 50 0
TCP1 TCP1 P17987 T-complex protein 1 subunit alpha chr6 Not Cancer Driver No 1 hippie 54 55 10 10 0
TEP1 TEP1 Q99973 Telomerase protein component 1 chr14 Not Cancer Driver No 1 hippie 332 396 67 67 0
TINAG TINAG Q9UJW2 Tubulointerstitial nephritis antigen chr6 Not Cancer Driver No 1 intact, hippie 141 62 22 22 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 2 intact, hippie 2891 282 1466 1466 83
TPR TPR P12270 Nucleoprotein TPR chr1 Census Yes 1 hippie 311 1990 266 266 0
TRIB1 TRIB1 Q96RU8 Tribbles homolog 1 chr8 Not Cancer Driver No 1 hippie 47 91 5 5 0
TRIB2 TRIB2 Q92519 Tribbles homolog 2 chr2 Not Cancer Driver No 3 intact, hippie 64 43 5 5 0
TRIB3_ENST00000217233 TRIB3 Q96RU7 Tribbles homolog 3 chr20 Not Cancer Driver No 1 hippie 65 114 24 24 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TSKS TSKS Q9UJT2 Testis-specific serine kinase substrate chr19 Not Cancer Driver No 1 hippie 123 479 100 100 0
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 13 14 0 0 0
UBE2D2 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 19 13 1 1 0
UBE2E1 UBE2E1 P51965 Ubiquitin-conjugating enzyme E2 E1 chr3 Not Cancer Driver No 1 hippie 21 78 10 10 0
UBE2E2_ENST00000425792 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 Not Cancer Driver No 1 hippie 28 90 15 15 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 intact 170 215 45 45 0
WASHC1 WASHC1 A8K0Z3 WASH complex subunit 1 chr9 Not Cancer Driver No 1 hippie 6 336 6 6 0
WBP1 WBP1 Q96G27 WW domain-binding protein 1 chr2 Not Cancer Driver No 3 intact 22 121 11 11 0
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie 30 35 3 3 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 hippie 22 109 4 4 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 hippie 30 81 10 10 0
ZNF263 ZNF263 O14978 Zinc finger protein 263 chr16 Not Cancer Driver No 1 hippie 90 403 58 58 0
ZNF397 ZNF397 Q8NF99 Zinc finger protein 397 chr18 Not Cancer Driver No 2 intact, hippie 49 164 21 21 0