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CDK11B ,CDK11B ,P21127
  • Uniprot Accession= P21127
  • Ensembl Transcript= ENST00000407249.7
  • Uniprot Name= CDK11B
  • Name= Cyclin-dependent kinase 11B
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 8
  • Number of Interaction partner in biogrid: 47
  • Number of Interaction partner in hippie: 109
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AL662899.2_ENST00000375880 CSNK2B Q5SRQ3 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie, biogrid 21 30 1 1 0
ANAPC15_ENST00000538393 ANAPC15 P60006 Anaphase-promoting complex subunit 15 chr11 Not Cancer Driver No 1 hippie, biogrid 15 117 14 14 0
ANKRD50 ANKRD50 Q9ULJ7 Ankyrin repeat domain-containing protein 50 chr4 Not Cancer Driver No 1 hippie, biogrid 205 432 71 71 0
AP2M1_ENST00000292807 AP2M1 Q96CW1 AP-2 complex subunit mu chr3 Not Cancer Driver No 1 hippie 55 41 9 9 1
AP3D1_ENST00000345016 AP3D1 O14617 AP-3 complex subunit delta-1 chr19 Not Cancer Driver No 1 hippie, biogrid 138 404 59 59 0
AP4M1_ENST00000421755 AP4M1 O00189 AP-4 complex subunit mu-1 chr7 Not Cancer Driver No 1 intact, hippie 63 64 7 7 0
ATXN1 ATXN1 P54253 Ataxin-1 chr6 Not Cancer Driver No 1 hippie 193 604 168 168 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
BTNL9 BTNL9 Q6UXG8 Butyrophilin-like protein 9 chr5 Not Cancer Driver No 1 hippie, biogrid 69 87 4 4 0
C12orf74_ENST00000544406 C12orf74 Q6ZR37-3 Isoform 3 of Pleckstrin homology domain-containing family G member 7 chr12 Not Cancer Driver No 1 hippie, biogrid 29 159 26 26 0
CCND3 CCND3 P30281 G1/S-specific cyclin-D3 chr6 Census, Compendium Yes 1 hippie 29 46 8 8 0
CCNL1 CCNL1 Q9UK58 Cyclin-L1 chr3 Not Cancer Driver No 1 hippie, biogrid 58 281 38 38 0
CCNT1 CCNT1 O60563 Cyclin-T1 chr12 Not Cancer Driver No 1 hippie, biogrid 85 495 61 61 0
CCNT2 CCNT2 O60583 Cyclin-T2 chr2 Not Cancer Driver No 1 hippie, biogrid 76 471 52 52 0
CCT8L2 CCT8L2 Q96SF2 T-complex protein 1 subunit theta-like 2 chr22 Not Cancer Driver No 1 hippie, biogrid 216 104 46 46 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 2 hippie, biogrid 52 214 31 31 0
CDK11A CDK11A Q9UQ88 Cyclin-dependent kinase 11A chr1 Not Cancer Driver No 1 hippie, biogrid 66 485 44 44 0
CDK11B CDK11B P21127 Cyclin-dependent kinase 11B chr1 Not Cancer Driver No 1 hippie 74 501 35 35 0
CDK7 CDK7 P50613 Cyclin-dependent kinase 7 chr5 Not Cancer Driver No 1 hippie 41 38 5 5 0
CDK8 CDK8 P49336 Cyclin-dependent kinase 8 chr13 Not Cancer Driver No 1 hippie 76 152 18 18 7
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 Census, Compendium Yes 1 hippie 335 157 130 130 13
CIAO2A CIAO2A Q9H5X1 Cytosolic iron-sulfur assembly component 2A chr15 Not Cancer Driver No 1 hippie 24 28 4 4 0
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 2 hippie, biogrid 71 75 8 8 4
CSNK2A2 CSNK2A2 P19784 Casein kinase II subunit alpha' chr16 Not Cancer Driver No 6 intact, hippie, biogrid 43 13 1 1 0
CSNK2B_ENST00000375866 CSNK2B P67870 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie, biogrid 20 19 0 0 4
CYCS_ENST00000409409 CYCS P99999 Cytochrome c chr7 Not Cancer Driver No 1 hippie, biogrid 12 19 3 3 1
DDRGK1 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 34 181 23 23 0
DDX41 DDX41 Q9UJV9 Probable ATP-dependent RNA helicase DDX41 chr5 Not Cancer Driver No 1 hippie 82 180 26 26 1
DNAI2 DNAI2 Q9GZS0 Dynein axonemal intermediate chain 2 chr17 Not Cancer Driver No 1 hippie, biogrid 136 209 47 47 0
EEF1AKMT3 EEF1AKMT3 Q96AZ1 EEF1A lysine methyltransferase 3 chr12 Not Cancer Driver No 1 hippie 23 33 1 1 0
EHHADH EHHADH Q08426 Peroxisomal bifunctional enzyme chr3 Not Cancer Driver No 1 hippie, biogrid 116 74 14 14 1
EIF3F_ENST00000309828 EIF3F O00303 Eukaryotic translation initiation factor 3 subunit F chr11 Not Cancer Driver No 1 hippie 29 125 8 8 1
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EZH1 EZH1 Q92800 Histone-lysine N-methyltransferase EZH1 chr17 Not Cancer Driver No 1 hippie, biogrid 82 213 21 21 0
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FBXO32 FBXO32 Q969P5 F-box only protein 32 chr8 Not Cancer Driver No 1 hippie 54 0 0 0 0
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 Not Cancer Driver No 1 hippie, biogrid 30 79 9 9 6
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 hippie, biogrid 70 150 20 20 0
GNL2 GNL2 Q13823 Nucleolar GTP-binding protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 87 446 51 51 0
HIST1H1E H1-4 P10412 Histone H1.4 chr6 Not Cancer Driver No 1 intact 66 213 63 63 0
HNRNPCL2 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 hippie, biogrid 51 199 41 41 0
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSPA4 HSPA4 P34932 Heat shock 70 kDa protein 4 chr5 Not Cancer Driver No 1 hippie 80 351 24 24 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie 155 419 90 90 0
IRF2BP2 IRF2BP2 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 chr1 Not Cancer Driver No 1 hippie 42 451 26 26 1
JMJD6_ENST00000397625 JMJD6 Q6NYC1 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 51 133 21 21 0
KAT7 KAT7 O95251 Histone acetyltransferase KAT7 chr17 Census Yes 1 hippie 97 327 47 47 0
KMT2E KMT2E Q8IZD2 Inactive histone-lysine N-methyltransferase 2E chr7 Not Cancer Driver No 1 hippie 233 1613 198 198 4
LARP7_ENST00000344442 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 58 350 44 44 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 hippie 519 90 17 17 23
LRRTM4_ENST00000409884 LRRTM4 Q86VH4 Leucine-rich repeat transmembrane neuronal protein 4 chr2 Not Cancer Driver No 1 hippie, biogrid 233 112 51 51 0
MAGEB2 MAGEB2 O15479 Melanoma-associated antigen B2 chrX Not Cancer Driver No 1 hippie, biogrid 98 126 35 35 0
MALL MALL Q13021 MAL-like protein chr2 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 Not Cancer Driver No 1 hippie, biogrid 43 92 5 5 0
MEPCE MEPCE Q7L2J0 7SK snRNA methylphosphate capping enzyme chr7 Not Cancer Driver No 1 hippie, biogrid 76 446 42 42 0
MFAP1 MFAP1 P55081 Microfibrillar-associated protein 1 chr15 Not Cancer Driver No 1 hippie, biogrid 58 377 53 53 0
MMGT1 MMGT1 Q8N4V1 ER membrane protein complex subunit 5 chrX Not Cancer Driver No 1 hippie 24 17 4 4 0
MSN MSN P26038 Moesin chrX Census, Compendium Yes 1 hippie 108 286 56 56 1
NOP56 NOP56 O00567 Nucleolar protein 56 chr20 Not Cancer Driver No 1 hippie, biogrid 83 191 34 34 0
NPAS1_ENST00000449844 NPAS1 Q99742 Neuronal PAS domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 53 309 23 23 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
NSRP1 NSRP1 Q9H0G5 Nuclear speckle splicing regulatory protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 61 521 56 56 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 Not Cancer Driver No 1 hippie 57 299 30 30 2
PDE4B PDE4B Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B chr1 Not Cancer Driver No 1 hippie 119 363 42 42 0
PIN1 PIN1 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 chr19 Not Cancer Driver No 1 hippie 17 115 12 12 0
PNKP PNKP Q96T60 Bifunctional polynucleotide phosphatase/kinase chr19 Not Cancer Driver No 1 hippie 53 177 23 23 4
POU2F1_ENST00000541643 POU2F1 P14859 POU domain, class 2, transcription factor 1 chr1 Not Cancer Driver No 1 hippie 95 433 50 50 0
PSENEN_ENST00000222266 PSENEN Q9NZ42 Gamma-secretase subunit PEN-2 chr19 Not Cancer Driver No 1 hippie, biogrid 17 0 0 0 0
PYHIN1 PYHIN1 Q6K0P9 Pyrin and HIN domain-containing protein 1 chr1 Not Cancer Driver No 1 hippie 174 291 99 99 0
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 Not Cancer Driver No 1 hippie 59 328 43 43 0
RANBP9 RANBP9 Q96S59 Ran-binding protein 9 chr6 Not Cancer Driver No 1 hippie 73 413 30 30 0
RAP1A_ENST00000356415 RAP1A P62834 Ras-related protein Rap-1A chr1 Not Cancer Driver No 1 hippie, biogrid 27 5 0 0 0
RARA RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 70 167 14 14 0
RBM25 RBM25 P49756 RNA-binding protein 25 chr14 Not Cancer Driver No 1 hippie, biogrid 124 549 88 88 0
RFXANK_ENST00000407360 RFXANK O14593 DNA-binding protein RFXANK chr19 Not Cancer Driver No 1 hippie, biogrid 22 120 6 6 1
RNPS1_ENST00000301730 RNPS1 Q15287 RNA-binding protein with serine-rich domain 1 chr16 Not Cancer Driver No 1 hippie, biogrid 30 305 30 30 0
RPS27A_ENST00000404735 RPS27A P62979 Ubiquitin-40S ribosomal protein S27a chr2 Not Cancer Driver No 1 hippie 18 47 2 2 0
RRP1B RRP1B Q14684 Ribosomal RNA processing protein 1 homolog B chr21 Not Cancer Driver No 1 hippie 74 513 48 48 0
RSBN1 RSBN1 Q5VWQ0 Lysine-specific demethylase 9 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 111 411 52 52 0
SAP30BP SAP30BP Q9UHR5 SAP30-binding protein chr17 Not Cancer Driver No 1 hippie, biogrid 25 233 19 19 0
SERBP1 SERBP1 Q8NC51 Plasminogen activator inhibitor 1 RNA-binding protein chr1 Not Cancer Driver No 1 hippie 53 408 53 53 0
SF1_ENST00000377390 SF1 Q15637 Splicing factor 1 chr11 Not Cancer Driver No 1 hippie 110 627 106 106 0
SIRT6 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 Not Cancer Driver No 1 hippie 33 164 12 12 0
SNRNP70 SNRNP70 P08621 U1 small nuclear ribonucleoprotein 70 kDa chr19 Not Cancer Driver No 1 hippie 38 416 37 37 0
SPDEF SPDEF O95238 SAM pointed domain-containing Ets transcription factor chr6 Not Cancer Driver No 1 hippie 47 110 24 24 0
SRSF6 SRSF6 Q13247 Serine/arginine-rich splicing factor 6 chr20 Not Cancer Driver No 1 hippie, biogrid 69 259 49 49 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
TGM2 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 chr20 Not Cancer Driver No 1 intact, hippie 123 107 26 26 0
TMEM14B_ENST00000379542 TMEM14B Q9NUH8 Transmembrane protein 14B chr6 Not Cancer Driver No 1 hippie, biogrid 13 0 0 0 0
TPPP TPPP O94811 Tubulin polymerization-promoting protein chr5 Not Cancer Driver No 1 hippie 33 149 21 21 0
TPX2 TPX2 Q9ULW0 Targeting protein for Xklp2 chr20 Not Cancer Driver No 1 hippie, biogrid 92 695 86 86 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
UHRF2 UHRF2 Q96PU4 E3 ubiquitin-protein ligase UHRF2 chr9 Not Cancer Driver No 1 hippie 88 253 22 22 0
UQCR11 UQCR11 O14957 Cytochrome b-c1 complex subunit 10 chr19 Not Cancer Driver No 1 hippie, biogrid 7 0 0 0 0
URM1_ENST00000372853 URM1 Q9BTM9 Ubiquitin-related modifier 1 chr9 Not Cancer Driver No 1 hippie 7 0 0 0 0
VDR_ENST00000549336 VDR P11473 Vitamin D3 receptor chr12 Not Cancer Driver No 1 hippie 64 102 16 16 14
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 66 140 12 12 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 hippie 22 109 4 4 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 32 41 3 3 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 1 hippie 26 77 9 9 2
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 hippie 30 81 10 10 0
ZBTB2 ZBTB2 Q8N680 Zinc finger and BTB domain-containing protein 2 chr6 Not Cancer Driver No 1 hippie 75 216 30 30 0
ZNF221 ZNF221 Q9UK13 Zinc finger protein 221 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 94 75 18 18 0
ZRSR2 ZRSR2 Q15696 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 chrX Census, Compendium Yes 2 intact, hippie, biogrid 37 324 28 28 0