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CAPN2 ,CAPN2 ,P17655
  • Uniprot Accession= P17655
  • Ensembl Transcript= ENST00000295006.5
  • Uniprot Name= CAPN2
  • Name= Calpain-2 catalytic subunit
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 24
  • Number of Interaction partner in biogrid: 43
  • Number of Interaction partner in hippie: 136
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ALDH7A1 ALDH7A1 P49419 Alpha-aminoadipic semialdehyde dehydrogenase chr5 Not Cancer Driver No 1 hippie 52 26 1 1 8
ASNS_ENST00000394308 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] chr7 Not Cancer Driver No 1 hippie 81 11 0 0 3
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 Not Cancer Driver No 1 hippie 40 25 6 6 1
ATIC ATIC P31939 Bifunctional purine biosynthesis protein ATIC chr2 Census Yes 1 hippie 74 25 1 1 1
ATXN3 ATXN3 P54252 Ataxin-3 chr14 Not Cancer Driver No 1 hippie 46 181 24 24 0
B3GNT2 B3GNT2 Q9NY97 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 51 22 6 6 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie 24 72 5 5 0
BID_ENST00000551952 BID P55957 BH3-interacting domain death agonist chr22 Not Cancer Driver No 1 hippie 23 74 9 9 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
CAPN1_ENST00000533129 CAPN1 P07384 Calpain-1 catalytic subunit chr11 Not Cancer Driver No 2 intact, hippie, biogrid 68 32 2 2 1
CAPNS1 CAPNS1 P04632 Calpain small subunit 1 chr19 Not Cancer Driver No 2 hippie, biogrid 30 58 5 5 0
CAPNS2 CAPNS2 Q96L46 Calpain small subunit 2 chr16 Not Cancer Driver No 1 hippie 21 56 5 5 0
CASP6 CASP6 P55212 Caspase-6 chr4 Not Cancer Driver No 1 hippie 28 24 4 4 0
CASP9 CASP9 P55211 Caspase-9 chr1 Census Yes 1 hippie 49 71 7 7 0
CAST_ENST00000395813 CAST P20810 Calpastatin chr5 Not Cancer Driver No 3 intact, hippie, biogrid 73 708 73 73 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 intact, hippie 30 2 0 0 0
CCZ1 CCZ1 P86791 Vacuolar fusion protein CCZ1 homolog chr7 Not Cancer Driver No 1 hippie, biogrid 40 43 3 3 0
CD109 CD109 Q6YHK3 CD109 antigen chr6 Not Cancer Driver No 1 hippie, biogrid 204 54 11 11 0
CDK5R1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 chr17 Not Cancer Driver No 1 hippie 35 103 16 16 0
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 Census, Compendium Yes 1 hippie 12 342 12 12 1
CFAP410_ENST00000339818 CFAP410 O43822 Cilia- and flagella-associated protein 410 chr21 Not Cancer Driver No 1 hippie 17 134 10 10 7
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 3 intact, hippie 287 145 18 18 151
CHORDC1 CHORDC1 Q9UHD1 Cysteine and histidine-rich domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 47 119 17 17 0
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 Not Cancer Driver No 1 intact 27 70 12 12 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
CSTF2T CSTF2T Q9H0L4 Cleavage stimulation factor subunit 2 tau variant chr10 Not Cancer Driver No 1 hippie, biogrid 87 507 75 75 0
CTH CTH P32929 Cystathionine gamma-lyase chr1 Not Cancer Driver No 1 hippie 45 49 6 6 2
DCP2 DCP2 Q8IU60 m7GpppN-mRNA hydrolase chr5 Not Cancer Driver No 1 hippie 57 167 24 24 0
DIAPH3 DIAPH3 Q9NSV4 Protein diaphanous homolog 3 chr13 Not Cancer Driver No 1 hippie, biogrid 189 492 78 78 0
DMWD DMWD Q09019 Dystrophia myotonica WD repeat-containing protein chr19 Not Cancer Driver No 1 hippie, biogrid 66 374 24 24 0
DNASE2B DNASE2B Q8WZ79 Deoxyribonuclease-2-beta chr1 Not Cancer Driver No 1 hippie, biogrid 53 14 1 1 0
DOCK7_ENST00000635253 DOCK7 Q96N67 Dedicator of cytokinesis protein 7 chr1 Not Cancer Driver No 1 hippie, biogrid 262 454 53 53 0
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 Not Cancer Driver No 1 hippie 34 15 5 5 0
DUSP28_ENST00000343217 DUSP28 Q4G0W2 Dual specificity phosphatase 28 chr2 Not Cancer Driver No 1 hippie 11 55 4 4 0
DYRK1A_ENST00000644942 DYRK1A Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A chr21 Not Cancer Driver No 1 hippie 135 447 73 73 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EIF2AK4 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 chr15 Not Cancer Driver No 1 hippie, biogrid 156 494 44 44 2
ENG ENG P17813 Endoglin chr9 Not Cancer Driver No 1 intact, hippie 60 114 15 15 32
ERCC6L ERCC6L Q2NKX8 DNA excision repair protein ERCC-6-like chrX Not Cancer Driver No 1 hippie, biogrid 137 532 72 72 0
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 Not Cancer Driver No 1 hippie 55 7 2 2 0
FAM208A_ENST00000355628 TASOR Q9UK61 Protein TASOR chr3 Not Cancer Driver No 1 hippie 150 776 68 68 0
FAM9C_ENST00000380625 FAM9C Q8IZT9 Protein FAM9C chrX Not Cancer Driver No 1 hippie, biogrid 26 157 23 23 0
FBXL12 FBXL12 Q9NXK8 F-box/LRR-repeat protein 12 chr19 Not Cancer Driver No 1 hippie 41 0 0 0 0
FMN2 FMN2 Q9NZ56 Formin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 614 1322 475 475 0
FNTA FNTA P49354 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha chr8 Not Cancer Driver No 1 hippie, biogrid 43 92 12 12 0
FNTB FNTB P49356 Protein farnesyltransferase subunit beta chr14 Not Cancer Driver No 1 hippie, biogrid 36 31 1 1 0
GAS2 GAS2 O43903 Growth arrest-specific protein 2 chr11 Not Cancer Driver No 1 hippie 73 92 16 16 0
GMDS GMDS O60547 GDP-mannose 4,6 dehydratase chr6 Not Cancer Driver No 1 hippie 51 53 6 6 0
GNS GNS P15586 N-acetylglucosamine-6-sulfatase chr12 Not Cancer Driver No 1 intact, hippie, biogrid 48 22 0 0 3
GRK2 GRK2 P25098 Beta-adrenergic receptor kinase 1 chr11 Not Cancer Driver No 1 hippie 77 87 8 8 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 hippie 56 146 13 13 0
HK1_ENST00000359426 HK1 P19367 Hexokinase-1 chr10 Not Cancer Driver No 1 hippie 127 75 16 16 6
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie, biogrid 70 290 58 58 4
HTRA4 HTRA4 P83105 Serine protease HTRA4 chr8 Not Cancer Driver No 1 hippie 57 15 0 0 0
IMMP2L_ENST00000452895 IMMP2L Q96T52 Mitochondrial inner membrane protease subunit 2 chr7 Not Cancer Driver No 1 hippie 36 29 7 7 0
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 Census, Compendium Yes 1 hippie 167 63 10 10 7
KNG1 KNG1 P01042 Kininogen-1 chr3 Not Cancer Driver No 1 hippie 130 294 66 66 1
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 114 404 58 58 0
LACTB LACTB P83111 Serine beta-lactamase-like protein LACTB, mitochondrial chr15 Not Cancer Driver No 1 intact, hippie 44 121 3 3 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 intact, hippie 43 55 7 7 1
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LSP1_ENST00000311604 LSP1 P33241 Lymphocyte-specific protein 1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 44 337 43 43 0
LZTR1_ENST00000646124 LZTR1 Q8N653 Leucine-zipper-like transcriptional regulator 1 chr22 Census, Compendium Yes 1 hippie, biogrid 160 106 18 18 26
MAN2A2 MAN2A2 P49641 Alpha-mannosidase 2x chr15 Not Cancer Driver No 1 hippie, biogrid 122 53 6 6 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 hippie 128 750 126 126 18
MCM8_ENST00000378896 MCM8 Q9UJA3 DNA helicase MCM8 chr20 Not Cancer Driver No 1 hippie, biogrid 94 188 19 19 1
MKS1 MKS1 Q9NXB0 Meckel syndrome type 1 protein chr17 Not Cancer Driver No 1 hippie, biogrid 82 152 23 23 2
MSN MSN P26038 Moesin chrX Census, Compendium Yes 1 hippie 108 286 56 56 1
MTDH MTDH Q86UE4 Protein LYRIC chr8 Not Cancer Driver No 1 hippie 83 516 81 81 0
MTO1_ENST00000370300 MTO1 Q9Y2Z2 Protein MTO1 homolog, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 70 61 2 2 1
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYO9A MYO9A B2RTY4 Unconventional myosin-IXa chr15 Not Cancer Driver No 1 hippie, biogrid 323 970 131 131 0
NAE1_ENST00000290810 NAE1 Q13564 NEDD8-activating enzyme E1 regulatory subunit chr16 Not Cancer Driver No 1 hippie 39 69 3 3 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 Compendium Yes 1 hippie 37 102 9 9 1
NMT1_ENST00000258960 NMT1 P30419 Glycylpeptide N-tetradecanoyltransferase 1 chr17 Not Cancer Driver No 1 intact, hippie 62 169 22 22 0
NPRL3_ENST00000611875 NPRL3 Q12980 GATOR complex protein NPRL3 chr16 Not Cancer Driver No 1 hippie, biogrid 45 158 22 22 0
NSFL1C_ENST00000216879 NSFL1C Q9UNZ2 NSFL1 cofactor p47 chr20 Not Cancer Driver No 1 hippie 56 266 39 39 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 75 38 4 4 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 intact, hippie 10 82 10 10 0
OFD1 OFD1 O75665 Oral-facial-digital syndrome 1 protein chrX Not Cancer Driver No 1 hippie, biogrid 129 476 58 58 5
P4HB P4HB P07237 Protein disulfide-isomerase chr17 Not Cancer Driver No 1 intact, hippie 61 79 15 15 1
PAFAH1B1 PAFAH1B1 P43034 Platelet-activating factor acetylhydrolase IB subunit beta chr17 Not Cancer Driver No 1 hippie 42 82 11 11 7
PAPSS1 PAPSS1 O43252 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 chr4 Not Cancer Driver No 1 hippie 94 82 14 14 0
PBXIP1 PBXIP1 Q96AQ6 Pre-B-cell leukemia transcription factor-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 100 605 86 86 0
PCYT2_ENST00000538936 PCYT2 Q99447 Ethanolamine-phosphate cytidylyltransferase chr17 Not Cancer Driver No 1 hippie 45 101 12 12 0
PDIA4 PDIA4 P13667 Protein disulfide-isomerase A4 chr7 Not Cancer Driver No 1 hippie 81 147 22 22 0
PIK3C2A PIK3C2A O00443 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha chr11 Not Cancer Driver No 1 hippie, biogrid 187 350 43 43 0
PIP5K1A PIP5K1A Q99755 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha chr1 Not Cancer Driver No 1 hippie, biogrid 74 216 29 29 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 Not Cancer Driver No 1 hippie 87 119 13 13 0
PLP1 PLP1 P60201 Myelin proteolipid protein chrX Not Cancer Driver No 1 intact, hippie 49 5 1 1 72
PLPBP PLPBP O94903 Pyridoxal phosphate homeostasis protein chr8 Not Cancer Driver No 1 hippie 30 96 12 12 3
PMS1 PMS1 P54277 PMS1 protein homolog 1 chr2 Census Yes 1 hippie, biogrid 114 283 38 38 0
POLR3A POLR3A O14802 DNA-directed RNA polymerase III subunit RPC1 chr10 Not Cancer Driver No 1 hippie, biogrid 155 113 17 17 15
PPIP5K2_ENST00000358359 PPIP5K2 O43314 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 chr5 Not Cancer Driver No 1 hippie, biogrid 146 419 54 54 1
PRPF40A PRPF40A O75400 Pre-mRNA-processing factor 40 homolog A chr2 Not Cancer Driver No 1 intact, hippie 83 694 57 57 0
PSG8 PSG8 Q9UQ74 Pregnancy-specific beta-1-glycoprotein 8 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 165 47 19 19 0
PTMA PTMA P06454 Prothymosin alpha chr2 Compendium Yes 1 hippie 10 111 10 10 0
PTP4A2 PTP4A2 Q12974 Protein tyrosine phosphatase type IVA 2 chr1 Not Cancer Driver No 1 hippie 14 3 1 1 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 Not Cancer Driver No 2 intact, hippie 49 140 25 25 0
PTPRN PTPRN Q16849 Receptor-type tyrosine-protein phosphatase-like N chr2 Not Cancer Driver No 1 hippie 142 498 73 73 0
RAN_ENST00000392369 RAN P62826 GTP-binding nuclear protein Ran chr12 Not Cancer Driver No 1 hippie 20 14 1 1 0
RPL23_ENST00000394332 RPL23 P62829 60S ribosomal protein L23 chr17 Not Cancer Driver No 1 hippie, biogrid 14 29 4 4 0
SMG8_ENST00000300917 SMG8 Q8ND04 Nonsense-mediated mRNA decay factor SMG8 chr17 Not Cancer Driver No 1 hippie, biogrid 145 412 57 57 1
SNRPE SNRPE P62304 Small nuclear ribonucleoprotein E chr1 Not Cancer Driver No 1 hippie 16 0 0 0 1
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 intact, hippie 39 312 39 39 0
SPANXN4 SPANXN4 Q5MJ08 Sperm protein associated with the nucleus on the X chromosome N4 chrX Not Cancer Driver No 1 hippie, biogrid 15 99 15 15 0
SPATA5L1 SPATA5L1 Q9BVQ7 Spermatogenesis-associated protein 5-like protein 1 chr15 Not Cancer Driver No 1 hippie, biogrid 62 166 13 13 0
ST13 ST13 P50502 Hsc70-interacting protein chr22 Not Cancer Driver No 1 intact 38 297 29 29 0
STAT2 STAT2 P52630 Signal transducer and activator of transcription 2 chr12 Not Cancer Driver No 1 hippie, biogrid 90 178 22 22 2
STK26 STK26 Q9P289 Serine/threonine-protein kinase 26 chrX Not Cancer Driver No 1 hippie 62 119 18 18 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 intact, hippie 10 76 7 7 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
SUMO3_ENST00000332859 SUMO3 P55854 Small ubiquitin-related modifier 3 chr21 Not Cancer Driver No 1 hippie 7 87 5 5 0
TATDN1 TATDN1 Q6P1N9 Deoxyribonuclease TATDN1 chr8 Not Cancer Driver No 1 hippie 25 0 0 0 0
TEDC1_ENST00000392523 TEDC1 Q86SX3 Tubulin epsilon and delta complex protein 1 chr14 Not Cancer Driver No 1 hippie 25 160 6 6 0
TNS1 TNS1 Q9HBL0 Tensin-1 chr2 Not Cancer Driver No 1 intact, hippie 273 1241 197 197 0
TOP2A TOP2A P11388 DNA topoisomerase 2-alpha chr17 Compendium Yes 1 hippie, biogrid 150 508 59 59 0
TUBB2A TUBB2A Q13885 Tubulin beta-2A chain chr6 Not Cancer Driver No 1 hippie 44 70 13 13 2
TUFM TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 hippie 51 50 3 3 1
TUT4_ENST00000371544 TUT4 Q5TAX3 Terminal uridylyltransferase 4 chr1 Not Cancer Driver No 1 hippie 187 771 102 102 0
TWF2 TWF2 Q6IBS0 Twinfilin-2 chr3 Not Cancer Driver No 1 hippie 34 59 8 8 0
UBA3 UBA3 Q8TBC4 NEDD8-activating enzyme E1 catalytic subunit chr3 Not Cancer Driver No 1 hippie 48 44 4 4 0
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 hippie 16 16 3 3 0
UBXN1_ENST00000301935 UBXN1 Q04323 UBX domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 35 271 33 33 0
USP54 USP54 Q70EL1 Inactive ubiquitin carboxyl-terminal hydrolase 54 chr10 Not Cancer Driver No 1 hippie, biogrid 186 1268 143 143 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WDR36 WDR36 Q8NI36 WD repeat-containing protein 36 chr5 Not Cancer Driver No 1 hippie, biogrid 140 89 11 11 2
WDR37_ENST00000263150 WDR37 Q9Y2I8 WD repeat-containing protein 37 chr10 Not Cancer Driver No 1 hippie, biogrid 63 154 16 16 4
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 140 33 9 9 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 32 41 3 3 0
ZDHHC17 ZDHHC17 Q8IUH5 Palmitoyltransferase ZDHHC17 chr12 Not Cancer Driver No 1 hippie 84 49 9 9 0
ZFYVE21_ENST00000311141 ZFYVE21 Q9BQ24 Zinc finger FYVE domain-containing protein 21 chr14 Not Cancer Driver No 1 hippie 28 19 0 0 0
ZRANB1 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 87 158 25 25 0