Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACAA2 | ACAA2 | P42765 | 3-ketoacyl-CoA thiolase, mitochondrial | chr18 | Not Cancer Driver | No | 1 | hippie, biogrid | 42 | 51 | 2 | 2 | 0 |
| ACLY_ENST00000590151 | ACLY | P53396 | ATP-citrate synthase | chr17 | Not Cancer Driver | No | 1 | hippie | 120 | 114 | 12 | 12 | 0 |
| APOD | APOD | P05090 | Apolipoprotein D | chr3 | Not Cancer Driver | No | 1 | hippie | 34 | 13 | 2 | 2 | 0 |
| APP | APP | P05067 | Amyloid-beta precursor protein | chr21 | Not Cancer Driver | No | 1 | hippie | 128 | 418 | 71 | 71 | 17 |
| ATF6 | ATF6 | P18850 | Cyclic AMP-dependent transcription factor ATF-6 alpha | chr1 | Not Cancer Driver | No | 1 | hippie | 88 | 468 | 59 | 59 | 2 |
| ATF6B | ATF6B | Q99941 | Cyclic AMP-dependent transcription factor ATF-6 beta | chr6 | Not Cancer Driver | No | 1 | hippie | 70 | 557 | 59 | 59 | 0 |
| BIN1 | BIN1 | O00499 | Myc box-dependent-interacting protein 1 | chr2 | Not Cancer Driver | No | 1 | hippie | 65 | 456 | 42 | 42 | 5 |
| BPGM_ENST00000344924 | BPGM | P07738 | Bisphosphoglycerate mutase | chr7 | Not Cancer Driver | No | 1 | hippie | 34 | 15 | 0 | 0 | 2 |
| BTNL2_ENST00000374993 | BTNL2 | Q9UIR0 | Butyrophilin-like protein 2 | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 66 | 82 | 16 | 16 | 0 |
| BTNL3 | BTNL3 | Q6UXE8 | Butyrophilin-like protein 3 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 79 | 50 | 13 | 13 | 0 |
| CCDC107 | CCDC107 | Q8WV48 | Coiled-coil domain-containing protein 107 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 14 | 215 | 12 | 12 | 0 |
| CD160_ENST00000369288 | CD160 | O95971 | CD160 antigen | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 20 | 2 | 0 | 0 | 0 |
| CD300E | CD300E | Q496F6 | CMRF35-like molecule 2 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 55 | 38 | 11 | 11 | 0 |
| CDC42_ENST00000344548 | CDC42 | P60953 | Cell division control protein 42 homolog | chr1 | Not Cancer Driver | No | 1 | hippie | 39 | 23 | 2 | 2 | 1 |
| CDH5 | CDH5 | P33151 | Cadherin-5 | chr16 | Not Cancer Driver | No | 2 | hippie, biogrid | 144 | 305 | 55 | 55 | 0 |
| CEBPD | CEBPD | P49716 | CCAAT/enhancer-binding protein delta | chr8 | Not Cancer Driver | No | 1 | hippie | 5 | 234 | 4 | 4 | 0 |
| CHRNB1 | CHRNB1 | P11230 | Acetylcholine receptor subunit beta | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 62 | 45 | 9 | 9 | 3 |
| CLEC2D_ENST00000290855 | CLEC2D | Q9UHP7 | C-type lectin domain family 2 member D | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 28 | 14 | 1 | 1 | 0 |
| CLEC3A | CLEC3A | O75596 | C-type lectin domain family 3 member A | chr16 | Not Cancer Driver | No | 2 | hippie, biogrid | 65 | 21 | 3 | 3 | 0 |
| COP1 | COP1 | Q8NHY2 | E3 ubiquitin-protein ligase COP1 | chr1 | Not Cancer Driver | No | 1 | hippie | 106 | 147 | 11 | 11 | 0 |
| CREB1_ENST00000430624 | CREB1 | P16220 | Cyclic AMP-responsive element-binding protein 1 | chr2 | Census | Yes | 1 | hippie | 25 | 277 | 23 | 23 | 0 |
| CREB3L3 | CREB3L3 | Q68CJ9 | Cyclic AMP-responsive element-binding protein 3-like protein 3 | chr19 | Not Cancer Driver | No | 1 | hippie | 96 | 338 | 67 | 67 | 1 |
| CRTC2 | CRTC2 | Q53ET0 | CREB-regulated transcription coactivator 2 | chr1 | Not Cancer Driver | No | 1 | hippie | 92 | 674 | 88 | 88 | 0 |
| CYP26B1 | CYP26B1 | Q9NR63 | Cytochrome P450 26B1 | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 113 | 10 | 3 | 3 | 2 |
| DAPK1_ENST00000622514 | DAPK1 | P53355 | Death-associated protein kinase 1 | chr9 | Not Cancer Driver | No | 1 | hippie | 193 | 114 | 11 | 11 | 0 |
| DDC | DDC | P20711 | Aromatic-L-amino-acid decarboxylase | chr7 | Not Cancer Driver | No | 1 | hippie | 98 | 5 | 0 | 0 | 9 |
| DERL1 | DERL1 | Q9BUN8 | Derlin-1 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 28 | 11 | 1 | 1 | 0 |
| DET1_ENST00000268148 | DET1 | Q7L5Y6 | DET1 homolog | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 97 | 42 | 12 | 12 | 0 |
| DNAJC1 | DNAJC1 | Q96KC8 | DnaJ homolog subfamily C member 1 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 60 | 315 | 44 | 44 | 0 |
| DNAJC16 | DNAJC16 | Q9Y2G8 | DnaJ homolog subfamily C member 16 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 84 | 63 | 2 | 2 | 0 |
| DNAJC25 | DNAJC25 | Q9H1X3 | DnaJ homolog subfamily C member 25 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 37 | 39 | 3 | 3 | 0 |
| EDDM3B | EDDM3B | P56851 | Epididymal secretory protein E3-beta | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 24 | 0 | 0 | 0 | 0 |
| EIF2AK3 | EIF2AK3 | Q9NZJ5 | Eukaryotic translation initiation factor 2-alpha kinase 3 | chr2 | Not Cancer Driver | No | 1 | hippie | 149 | 410 | 51 | 51 | 1 |
| ELOVL5_ENST00000304434 | ELOVL5 | Q9NYP7 | Elongation of very long chain fatty acids protein 5 | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 34 | 25 | 4 | 4 | 2 |
| EMD | EMD | P50402 | Emerin | chrX | Not Cancer Driver | No | 1 | hippie, biogrid | 42 | 160 | 28 | 28 | 4 |
| EPHX2 | EPHX2 | P34913 | Bifunctional epoxide hydrolase 2 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 78 | 26 | 3 | 3 | 0 |
| ERLEC1 | ERLEC1 | Q96DZ1 | Endoplasmic reticulum lectin 1 | chr2 | Not Cancer Driver | No | 3 | hippie, biogrid | 54 | 134 | 17 | 17 | 0 |
| ERN1 | ERN1 | O75460 | Serine/threonine-protein kinase/endoribonuclease IRE1 | chr17 | Not Cancer Driver | No | 1 | hippie | 125 | 250 | 28 | 28 | 0 |
| FBXO2 | FBXO2 | Q9UK22 | F-box only protein 2 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 21 | 75 | 1 | 1 | 0 |
| FBXO6 | FBXO6 | Q9NRD1 | F-box only protein 6 | chr1 | Not Cancer Driver | No | 1 | hippie | 31 | 27 | 3 | 3 | 0 |
| FHL3 | FHL3 | Q13643 | Four and a half LIM domains protein 3 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 33 | 0 | 0 | 0 | 0 |
| FKBP8_ENST00000222308 | FKBP8 | Q14318 | Peptidyl-prolyl cis-trans isomerase FKBP8 | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 71 | 160 | 25 | 25 | 0 |
| GABRD | GABRD | O14764 | Gamma-aminobutyric acid receptor subunit delta | chr1 | Not Cancer Driver | No | 2 | hippie, biogrid | 71 | 19 | 5 | 5 | 1 |
| GPIHBP1 | GPIHBP1 | Q8IV16 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 26 | 82 | 15 | 15 | 10 |
| GTF2I | GTF2I | P78347 | General transcription factor II-I | chr7 | Compendium | Yes | 1 | hippie | 74 | 365 | 27 | 27 | 0 |
| HIBADH | HIBADH | P31937 | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 28 | 7 | 2 | 2 | 0 |
| HLA-DQA1 | HLA-DQA1 | A0A173ADG5 | HLA class II histocompatibility antigen DQ alpha chain | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 29 | 5 | 0 | 0 | 0 |
| HLA-E | HLA-E | P13747 | HLA class I histocompatibility antigen, alpha chain E | chr6 | Not Cancer Driver | No | 2 | hippie, biogrid | 63 | 138 | 39 | 39 | 0 |
| HNRNPL | HNRNPL | P14866 | Heterogeneous nuclear ribonucleoprotein L | chr19 | Not Cancer Driver | No | 1 | hippie | 89 | 283 | 29 | 29 | 0 |
| HSD17B11 | HSD17B11 | Q8NBQ5 | Estradiol 17-beta-dehydrogenase 11 | chr4 | Not Cancer Driver | No | 1 | hippie, biogrid | 28 | 3 | 0 | 0 | 0 |
| HSPA5 | HSPA5 | P11021 | Endoplasmic reticulum chaperone BiP | chr9 | Not Cancer Driver | No | 1 | hippie | 73 | 282 | 35 | 35 | 0 |
| IL7 | IL7 | P13232 | Interleukin-7 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 29 | 19 | 4 | 4 | 0 |
| KCNC3 | KCNC3 | Q14003 | Potassium voltage-gated channel subfamily C member 3 | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 76 | 405 | 29 | 29 | 4 |
| KCNG4 | KCNG4 | Q8TDN1 | Potassium voltage-gated channel subfamily G member 4 | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 117 | 47 | 10 | 10 | 0 |
| LDHA_ENST00000422447 | LDHA | P00338 | L-lactate dehydrogenase A chain | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 40 | 9 | 0 | 0 | 0 |
| LMAN2 | LMAN2 | Q12907 | Vesicular integral-membrane protein VIP36 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 53 | 36 | 8 | 8 | 0 |
| LMBR1L | LMBR1L | Q6UX01 | Protein LMBR1L | chr12 | Not Cancer Driver | No | 1 | hippie | 57 | 4 | 0 | 0 | 0 |
| LRRC59 | LRRC59 | Q96AG4 | Leucine-rich repeat-containing protein 59 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 33 | 122 | 15 | 15 | 0 |
| LRRN2_ENST00000367177 | LRRN2 | O75325 | Leucine-rich repeat neuronal protein 2 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 132 | 84 | 18 | 18 | 0 |
| MAGI1 | MAGI1 | Q96QZ7 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | chr3 | Not Cancer Driver | No | 1 | hippie | 260 | 1212 | 220 | 220 | 0 |
| MAPK14_ENST00000229794 | MAPK14 | Q16539 | Mitogen-activated protein kinase 14 | chr6 | Not Cancer Driver | No | 1 | hippie | 39 | 25 | 1 | 1 | 0 |
| METTL7A_ENST00000332160 | METTL7A | Q9H8H3 | Putative methyltransferase-like protein 7A | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 31 | 0 | 0 | 0 | 0 |
| MGAT4C_ENST00000620241 | MGAT4C | Q9UBM8 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 179 | 29 | 19 | 19 | 0 |
| NEDD8-MDP1 | NEDD8-MDP1 | E9PL57 | NEDD8-MDP1 readthrough (Fragment) | chr14 | Not Cancer Driver | No | 1 | biogrid | 28 | 55 | 13 | 13 | 0 |
| NFYA | NFYA | P23511 | Nuclear transcription factor Y subunit alpha | chr6 | Not Cancer Driver | No | 1 | hippie | 43 | 187 | 29 | 29 | 0 |
| NFYC | NFYC | Q13952 | Nuclear transcription factor Y subunit gamma | chr1 | Not Cancer Driver | No | 1 | hippie | 46 | 320 | 32 | 32 | 0 |
| NNMT | NNMT | P40261 | Nicotinamide N-methyltransferase | chr11 | Not Cancer Driver | No | 1 | hippie | 51 | 5 | 1 | 1 | 0 |
| OS9 | OS9 | Q13438 | Protein OS-9 | chr12 | Not Cancer Driver | No | 2 | hippie, biogrid | 72 | 451 | 49 | 49 | 0 |
| PARG_ENST00000616448 | PARG | Q86W56 | Poly(ADP-ribose) glycohydrolase | chr10 | Not Cancer Driver | No | 1 | hippie | 60 | 519 | 1 | 1 | 0 |
| PCDH20 | PCDH20 | Q8N6Y1 | Protocadherin-20 | chr13 | Not Cancer Driver | No | 2 | hippie, biogrid | 228 | 159 | 30 | 30 | 0 |
| PCDHAC1 | PCDHAC1 | Q9H158 | Protocadherin alpha-C1 | chr5 | Not Cancer Driver | No | 2 | hippie, biogrid | 255 | 386 | 92 | 92 | 0 |
| PCDHB11 | PCDHB11 | Q9Y5F2 | Protocadherin beta-11 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 230 | 91 | 19 | 19 | 0 |
| PCDHB16 | PCDHB16 | Q9NRJ7 | Protocadherin beta-16 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 214 | 247 | 70 | 70 | 0 |
| PCDHGA7 | PCDHGA7 | Q9Y5G6 | Protocadherin gamma-A7 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 216 | 354 | 60 | 60 | 0 |
| PCDHGC5 | PCDHGC5 | Q9Y5F6 | Protocadherin gamma-C5 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 135 | 492 | 72 | 72 | 0 |
| PDE3A | PDE3A | Q14432 | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 274 | 527 | 114 | 114 | 6 |
| PEX14 | PEX14 | O75381 | Peroxisomal membrane protein PEX14 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 38 | 266 | 28 | 28 | 0 |
| PIGH | PIGH | Q14442 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 12 | 1 | 0 | 0 | 1 |
| PLGRKT | PLGRKT | Q9HBL7 | Plasminogen receptor (KT) | chr9 | Not Cancer Driver | No | 1 | hippie | 17 | 0 | 0 | 0 | 0 |
| POU5F1 | POU5F1 | Q01860 | POU domain, class 5, transcription factor 1 | chr6 | Census | Yes | 1 | hippie | 36 | 186 | 12 | 12 | 0 |
| PTRH2_ENST00000470557 | PTRH2 | Q9Y3E5 | Peptidyl-tRNA hydrolase 2, mitochondrial | chr17 | Not Cancer Driver | No | 1 | hippie | 14 | 19 | 2 | 2 | 1 |
| RAB7A | RAB7A | P51149 | Ras-related protein Rab-7a | chr3 | Not Cancer Driver | No | 1 | biogrid | 27 | 11 | 0 | 0 | 4 |
| RARRES1 | RARRES1 | P49788 | Retinoic acid receptor responder protein 1 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 24 | 79 | 3 | 3 | 0 |
| RIPK2 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | Not Cancer Driver | No | 1 | hippie | 63 | 143 | 20 | 20 | 0 |
| RNF139 | RNF139 | Q8WU17 | E3 ubiquitin-protein ligase RNF139 | chr8 | Not Cancer Driver | No | 1 | hippie | 76 | 68 | 4 | 4 | 0 |
| RNF168 | RNF168 | Q8IYW5 | E3 ubiquitin-protein ligase RNF168 | chr3 | Not Cancer Driver | No | 1 | hippie | 77 | 471 | 66 | 66 | 0 |
| RNF4 | RNF4 | P78317 | E3 ubiquitin-protein ligase RNF4 | chr4 | Not Cancer Driver | No | 1 | hippie | 14 | 117 | 7 | 7 | 0 |
| RPN1 | RPN1 | P04843 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | chr3 | Census | Yes | 1 | hippie, biogrid | 50 | 69 | 3 | 3 | 0 |
| SAR1A_ENST00000373238 | SAR1A | Q9NR31 | GTP-binding protein SAR1a | chr10 | Not Cancer Driver | No | 1 | hippie | 23 | 4 | 0 | 0 | 0 |
| SEC62 | SEC62 | Q99442 | Translocation protein SEC62 | chr3 | Not Cancer Driver | No | 2 | hippie, biogrid | 41 | 211 | 23 | 23 | 0 |
| SEC63 | SEC63 | Q9UGP8 | Translocation protein SEC63 homolog | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 98 | 266 | 37 | 37 | 0 |
| SH3TC1 | SH3TC1 | Q8TE82 | SH3 domain and tetratricopeptide repeat-containing protein 1 | chr4 | Not Cancer Driver | No | 1 | hippie | 160 | 233 | 32 | 32 | 0 |
| SOX2 | SOX2 | P48431 | Transcription factor SOX-2 | chr3 | Census | Yes | 1 | hippie | 39 | 312 | 39 | 39 | 0 |
| SPARC | SPARC | P09486 | SPARC | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 60 | 69 | 5 | 5 | 2 |
| SPPL2B | SPPL2B | Q8TCT7 | Signal peptide peptidase-like 2B | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 68 | 99 | 17 | 17 | 0 |
| SREBF2 | SREBF2 | Q12772 | Sterol regulatory element-binding protein 2 | chr22 | Not Cancer Driver | No | 1 | hippie | 124 | 357 | 43 | 43 | 0 |
| SRF | SRF | P11831 | Serum response factor | chr6 | Not Cancer Driver | No | 1 | hippie | 44 | 443 | 42 | 42 | 0 |
| SSR1 | SSR1 | P43307 | Translocon-associated protein subunit alpha | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 26 | 114 | 10 | 10 | 0 |
| ST7 | ST7 | Q9NRC1 | Suppressor of tumorigenicity 7 protein | chr7 | Not Cancer Driver | No | 1 | hippie | 62 | 64 | 5 | 5 | 0 |
| STIM1_ENST00000300737 | STIM1 | Q13586 | Stromal interaction molecule 1 | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 70 | 387 | 45 | 45 | 13 |
| STK40_ENST00000373132 | STK40 | Q8N2I9 | Serine/threonine-protein kinase 40 | chr1 | Not Cancer Driver | No | 2 | hippie, biogrid | 50 | 103 | 9 | 9 | 0 |
| STX4 | STX4 | Q12846 | Syntaxin-4 | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 50 | 152 | 20 | 20 | 0 |
| SUMO2 | SUMO2 | P61956 | Small ubiquitin-related modifier 2 | chr17 | Not Cancer Driver | No | 1 | hippie | 9 | 69 | 6 | 6 | 0 |
| SYVN1 | SYVN1 | Q86TM6 | E3 ubiquitin-protein ligase synoviolin | chr11 | Not Cancer Driver | No | 1 | hippie | 63 | 284 | 32 | 32 | 0 |
| TMEM106B | TMEM106B | Q9NUM4 | Transmembrane protein 106B | chr7 | Not Cancer Driver | No | 1 | hippie | 31 | 56 | 4 | 4 | 1 |
| TNFRSF1A | TNFRSF1A | P19438 | Tumor necrosis factor receptor superfamily member 1A | chr12 | Not Cancer Driver | No | 1 | hippie | 58 | 111 | 15 | 15 | 12 |
| TRIB1 | TRIB1 | Q96RU8 | Tribbles homolog 1 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 47 | 91 | 5 | 5 | 0 |
| TRIM25 | TRIM25 | Q14258 | E3 ubiquitin/ISG15 ligase TRIM25 | chr17 | Not Cancer Driver | No | 1 | hippie | 59 | 225 | 20 | 20 | 0 |
| WFS1_ENST00000503569 | WFS1 | O76024 | Wolframin | chr4 | Not Cancer Driver | No | 1 | hippie | 105 | 203 | 10 | 10 | 39 |
| XBP1 | XBP1 | P17861 | X-box-binding protein 1 | chr22 | Not Cancer Driver | No | 1 | hippie | 19 | 169 | 9 | 9 | 0 |
| YY1 | YY1 | P25490 | Transcriptional repressor protein YY1 | chr14 | Not Cancer Driver | No | 1 | hippie | 37 | 336 | 26 | 26 | 2 |
| ZYG11A | ZYG11A | Q6WRX3 | Protein zyg-11 homolog A | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 52 | 7 | 0 | 0 | 0 |
Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|