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ASPM ,ASPM ,Q8IZT6
  • Uniprot Accession= Q8IZT6
  • Ensembl Transcript= ENST00000367409.8
  • Uniprot Name= ASPM
  • Name= Abnormal spindle-like microcephaly-associated protein
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 55
  • Number of Interaction partner in biogrid: 60
  • Number of Interaction partner in hippie: 133
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTC1 ACTC1 P68032 Actin, alpha cardiac muscle 1 chr15 Not Cancer Driver No 1 hippie 114 48 19 19 11
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie 144 767 104 104 2
ANO3 ANO3 Q9BYT9 Anoctamin-3 chr11 Not Cancer Driver No 1 intact, hippie 197 102 20 20 4
AURKA_ENST00000395915 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 36 178 21 21 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 50 150 30 30 0
CALM1 CALM1 P0DP23 Calmodulin-1 chr14 Not Cancer Driver No 2 intact, hippie, biogrid 19 115 15 15 7
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie 45 245 31 31 0
CALU_ENST00000249364 CALU O43852 Calumenin chr7 Not Cancer Driver No 1 intact, hippie 34 130 12 12 0
CCDC83_ENST00000342404 CCDC83 Q8IWF9 Coiled-coil domain-containing protein 83 chr11 Not Cancer Driver No 1 intact, hippie, biogrid 70 168 25 25 0
CDC16_ENST00000356221 CDC16 Q13042 Cell division cycle protein 16 homolog chr13 Not Cancer Driver No 2 intact, hippie, biogrid 68 54 7 7 0
CDH5 CDH5 P33151 Cadherin-5 chr16 Not Cancer Driver No 2 intact, hippie, biogrid 144 305 55 55 0
CDK4 CDK4 P11802 Cyclin-dependent kinase 4 chr12 Census, Compendium Yes 2 intact, hippie 52 52 5 5 3
CENPB CENPB P07199 Major centromere autoantigen B chr20 Not Cancer Driver No 1 hippie 64 374 39 39 0
CEP78_ENST00000424347 CEP78 Q5JTW2 Centrosomal protein of 78 kDa chr9 Not Cancer Driver No 1 hippie 79 295 32 32 0
CLUAP1_ENST00000576634 CLUAP1 Q96AJ1 Clusterin-associated protein 1 chr16 Not Cancer Driver No 1 hippie 48 203 22 22 0
CNKSR1 CNKSR1 Q969H4 Connector enhancer of kinase suppressor of ras 1 chr1 Not Cancer Driver No 2 hippie, biogrid 118 405 68 68 0
COPS7B_ENST00000410024 COPS7B Q9H9Q2 COP9 signalosome complex subunit 7b chr2 Not Cancer Driver No 2 intact, hippie, biogrid 22 74 6 6 0
CREB3 CREB3 O43889 Cyclic AMP-responsive element-binding protein 3 chr9 Not Cancer Driver No 1 hippie, biogrid 33 168 11 11 0
CRTAC1 CRTAC1 Q9NQ79 Cartilage acidic protein 1 chr10 Not Cancer Driver No 2 intact, hippie, biogrid 113 167 19 19 0
CRYZ_ENST00000340866 CRYZ Q08257 Quinone oxidoreductase chr1 Not Cancer Driver No 1 hippie 49 0 0 0 0
CSRNP1 CSRNP1 Q96S65 Cysteine/serine-rich nuclear protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 71 312 33 33 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 123 167 23 23 3
DCTN3 DCTN3 O75935 Dynactin subunit 3 chr9 Not Cancer Driver No 1 hippie 18 3 0 0 0
DKK3_ENST00000326932 DKK3 Q9UBP4 Dickkopf-related protein 3 chr11 Not Cancer Driver No 2 hippie, biogrid 44 161 22 22 0
DNAJB5_ENST00000312316 DNAJB5 O75953 DnaJ homolog subfamily B member 5 chr9 Not Cancer Driver No 1 hippie, biogrid 49 147 18 18 0
DNAJB6 DNAJB6 O75190 DnaJ homolog subfamily B member 6 chr7 Not Cancer Driver No 1 hippie, biogrid 33 198 17 17 3
DNAJB7 DNAJB7 Q7Z6W7 DnaJ homolog subfamily B member 7 chr22 Not Cancer Driver No 2 hippie, biogrid 43 138 21 21 0
DNAJB8_ENST00000319153 DNAJB8 Q8NHS0 DnaJ homolog subfamily B member 8 chr3 Not Cancer Driver No 1 hippie, biogrid 64 92 30 30 0
DTNBP1 DTNBP1 Q96EV8 Dysbindin chr6 Not Cancer Driver No 3 intact, hippie, biogrid 49 210 25 25 0
EAF1 EAF1 Q96JC9 ELL-associated factor 1 chr3 Not Cancer Driver No 1 hippie, biogrid 17 257 17 17 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EID1 EID1 Q9Y6B2 EP300-interacting inhibitor of differentiation 1 chr15 Not Cancer Driver No 2 intact, hippie, biogrid 22 159 17 17 0
EIF2B5 EIF2B5 Q13144 Translation initiation factor eIF-2B subunit epsilon chr3 Not Cancer Driver No 1 hippie, biogrid 76 179 16 16 29
EIF6_ENST00000374436 EIF6 P56537 Eukaryotic translation initiation factor 6 chr20 Not Cancer Driver No 1 intact, hippie 30 17 3 3 0
ELL ELL P55199 RNA polymerase II elongation factor ELL chr19 Census, Compendium Yes 1 intact, hippie 67 446 53 53 0
ENTR1 ENTR1 Q96C92 Endosome-associated-trafficking regulator 1 chr9 Not Cancer Driver No 1 intact, hippie 64 267 38 38 0
FAM160A2_ENST00000449352 FHIP1B Q8N612 FHF complex subunit HOOK interacting protein 1B chr11 Not Cancer Driver No 1 intact 129 415 54 54 0
FEZ1 FEZ1 Q99689 Fasciculation and elongation protein zeta-1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 66 277 49 49 0
FOXJ1 FOXJ1 Q92949 Forkhead box protein J1 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 25 279 18 18 0
FSD2 FSD2 A1L4K1 Fibronectin type III and SPRY domain-containing protein 2 chr15 Not Cancer Driver No 1 hippie, biogrid 116 300 60 60 0
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 hippie, biogrid 19 36 7 7 2
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GPN3_ENST00000228827 GPN3 Q9UHW5 GPN-loop GTPase 3 chr12 Not Cancer Driver No 2 hippie, biogrid 28 19 0 0 0
GPRASP2 GPRASP2 Q96D09 G-protein coupled receptor-associated sorting protein 2 chrX Not Cancer Driver No 1 hippie 133 506 81 81 1
HAUS7 HAUS7 Q99871 HAUS augmin-like complex subunit 7 chrX Not Cancer Driver No 2 hippie, biogrid 51 78 7 7 0
HERC2 HERC2 O95714 E3 ubiquitin-protein ligase HERC2 chr15 Compendium Yes 1 hippie 718 971 150 150 1
HIST1H2BJ_ENST00000339812 H2BC11 P06899 Histone H2B type 1-J chr6 Not Cancer Driver No 1 intact 22 75 13 13 0
HLA-DPA1 HLA-DPA1 P20036 HLA class II histocompatibility antigen, DP alpha 1 chain chr6 Not Cancer Driver No 1 hippie, biogrid 37 30 4 4 0
HSP90B1 HSP90B1 P14625 Endoplasmin chr12 Not Cancer Driver No 1 intact, hippie 94 268 35 35 0
IARS2 IARS2 Q9NSE4 Isoleucine--tRNA ligase, mitochondrial chr1 Not Cancer Driver No 2 intact, hippie, biogrid 149 145 22 22 0
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie 155 419 90 90 0
INTU INTU Q9ULD6 Protein inturned chr4 Not Cancer Driver No 1 intact, hippie, biogrid 146 282 52 52 0
IPO7 IPO7 O95373 Importin-7 chr11 Not Cancer Driver No 1 hippie 138 202 30 30 0
IPO9 IPO9 Q96P70 Importin-9 chr1 Not Cancer Driver No 1 hippie 145 102 22 22 0
KATNA1 KATNA1 O75449 Katanin p60 ATPase-containing subunit A1 chr6 Not Cancer Driver No 1 hippie 66 199 30 30 0
KATNAL2_ENST00000356157 KATNAL2 Q8IYT4 Katanin p60 ATPase-containing subunit A-like 2 chr18 Not Cancer Driver No 1 hippie 84 142 30 30 0
KATNB1 KATNB1 Q9BVA0 Katanin p80 WD40 repeat-containing subunit B1 chr16 Not Cancer Driver No 2 intact, hippie 70 179 24 24 3
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KIF2A_ENST00000401507 KIF2A O00139 Kinesin-like protein KIF2A chr5 Not Cancer Driver No 1 hippie 74 336 37 37 2
KIFC1 KIFC1 Q9BW19 Kinesin-like protein KIFC1 chr6 Compendium Yes 1 intact, hippie 99 450 67 67 0
KRT38 KRT38 O76015 Keratin, type I cuticular Ha8 chr17 Not Cancer Driver No 1 hippie, biogrid 89 52 15 15 0
LIG4 LIG4 P49917 DNA ligase 4 chr13 Not Cancer Driver No 1 hippie 134 63 10 10 2
LIMS1_ENST00000393310 LIMS1 P48059 LIM and senescent cell antigen-like-containing domain protein 1 chr2 Not Cancer Driver No 1 intact, hippie 34 0 0 0 0
LURAP1 LURAP1 Q96LR2 Leucine rich adaptor protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 30 169 18 18 0
LZTS2 LZTS2 Q9BRK4 Leucine zipper putative tumor suppressor 2 chr10 Not Cancer Driver No 2 hippie, biogrid 78 508 66 66 0
MAP3K6 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 108 390 31 31 0
MAPK6 MAPK6 Q16659 Mitogen-activated protein kinase 6 chr15 Not Cancer Driver No 1 hippie 79 165 20 20 0
MAPK8IP2 MAPK8IP2 Q13387 C-Jun-amino-terminal kinase-interacting protein 2 chr22 Not Cancer Driver No 1 hippie, biogrid 49 568 27 27 0
MID2 MID2 Q9UJV3 Probable E3 ubiquitin-protein ligase MID2 chrX Not Cancer Driver No 1 hippie 112 95 24 24 1
MOAP1_ENST00000298894 MOAP1 Q96BY2 Modulator of apoptosis 1 chr14 Not Cancer Driver No 2 intact, hippie, biogrid 48 47 8 8 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 Census, Compendium Yes 1 intact, hippie 379 296 37 37 18
MXD3_ENST00000513063 MXD3 Q9BW11 Max dimerization protein 3 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 17 156 13 13 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYL2 MYL2 P10916 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform chr12 Not Cancer Driver No 2 intact, hippie, biogrid 44 34 8 8 6
MZT2B_ENST00000281871 MZT2B Q6NZ67 Mitotic-spindle organizing protein 2B chr2 Not Cancer Driver No 1 intact, hippie 14 113 14 14 0
NAP1L1 NAP1L1 P55209 Nucleosome assembly protein 1-like 1 chr12 Not Cancer Driver No 2 intact, hippie 47 207 31 31 0
NAP1L4 NAP1L4 Q99733 Nucleosome assembly protein 1-like 4 chr11 Not Cancer Driver No 2 intact, hippie 38 194 19 19 0
NCAPH2_ENST00000420993 NCAPH2 Q6IBW4 Condensin-2 complex subunit H2 chr22 Not Cancer Driver No 2 hippie, biogrid 67 335 39 39 0
NDC80 NDC80 O14777 Kinetochore protein NDC80 homolog chr18 Not Cancer Driver No 1 hippie, biogrid 80 313 45 45 0
NEUROG3 NEUROG3 Q9Y4Z2 Neurogenin-3 chr10 Not Cancer Driver No 2 intact, hippie, biogrid 53 156 34 34 2
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 intact, hippie 29 249 22 22 0
NUMA1 NUMA1 Q14980 Nuclear mitotic apparatus protein 1 chr11 Census, Compendium Yes 1 hippie 234 1864 203 203 0
OS9 OS9 Q13438 Protein OS-9 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 72 451 49 49 0
PACS2_ENST00000325438 PACS2 Q86VP3 Phosphofurin acidic cluster sorting protein 2 chr14 Not Cancer Driver No 1 hippie 122 460 59 59 1
PER2 PER2 O15055 Period circadian protein homolog 2 chr2 Not Cancer Driver No 1 hippie, biogrid 166 782 101 101 1
PEX19 PEX19 P40855 Peroxisomal biogenesis factor 19 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 41 266 38 38 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 Not Cancer Driver No 1 hippie 87 119 13 13 0
PNMA2 PNMA2 Q9UL42 Paraneoplastic antigen Ma2 chr8 Not Cancer Driver No 1 hippie, biogrid 52 45 5 5 0
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 Census, Compendium Yes 1 intact, hippie 179 0 0 0 4
PPP6R2_ENST00000216061 PPP6R2 O75170 Serine/threonine-protein phosphatase 6 regulatory subunit 2 chr22 Not Cancer Driver No 2 intact, hippie, biogrid 103 491 63 63 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 Not Cancer Driver No 1 intact, hippie 72 124 17 17 0
PSMD8 PSMD8 P48556 26S proteasome non-ATPase regulatory subunit 8 chr19 Not Cancer Driver No 1 hippie, biogrid 20 78 2 2 0
RCN1 RCN1 Q15293 Reticulocalbin-1 chr11 Not Cancer Driver No 1 intact, hippie 35 158 19 19 0
RCN2_ENST00000394885 RCN2 Q14257 Reticulocalbin-2 chr15 Not Cancer Driver No 2 intact, hippie 35 125 11 11 0
RPP38_ENST00000378202 RPP38 P78345 Ribonuclease P protein subunit p38 chr10 Not Cancer Driver No 1 intact, hippie 36 118 19 19 0
RPS6KA1_ENST00000374168 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 Not Cancer Driver No 1 hippie 94 178 32 32 0
RSPH6A RSPH6A Q9H0K4 Radial spoke head protein 6 homolog A chr19 Not Cancer Driver No 1 hippie, biogrid 129 483 94 94 0
SKAP1_ENST00000584924 SKAP1 Q86WV1 Src kinase-associated phosphoprotein 1 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 67 130 27 27 0
SLC25A10_ENST00000350690 SLC25A10 Q9UBX3 Mitochondrial dicarboxylate carrier chr17 Not Cancer Driver No 1 hippie 33 0 0 0 0
SMYD2 SMYD2 Q9NRG4 N-lysine methyltransferase SMYD2 chr1 Not Cancer Driver No 1 hippie 42 12 0 0 0
SNX7 SNX7 Q9UNH6-3 Isoform 3 of Sorting nexin-7 chr1 Not Cancer Driver No 1 hippie, biogrid 65 117 17 17 0
SPC24 SPC24 Q8NBT2 Kinetochore protein Spc24 chr19 Not Cancer Driver No 3 hippie, biogrid 9 88 5 5 0
SSR3_ENST00000265044 SSR3 Q9UNL2 Translocon-associated protein subunit gamma chr3 Not Cancer Driver No 1 intact, hippie 30 18 5 5 0
STIL_ENST00000360380 STIL Q15468 SCL-interrupting locus protein chr1 Census, Compendium Yes 1 hippie, biogrid 147 735 85 85 1
STK32C STK32C Q86UX6 Serine/threonine-protein kinase 32C chr10 Not Cancer Driver No 1 hippie, biogrid 49 172 10 10 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
TENT5A TENT5A Q96IP4 Terminal nucleotidyltransferase 5A chr6 Not Cancer Driver No 1 hippie 43 0 0 0 0
TEX13A_ENST00000609007 TEX13A Q9BXU3 Testis-expressed protein 13A chrX Not Cancer Driver No 2 intact, hippie, biogrid 105 259 63 63 0
THAP7_ENST00000399133 THAP7 Q9BT49 THAP domain-containing protein 7 chr22 Not Cancer Driver No 1 hippie, biogrid 34 214 24 24 0
TP53INP1 TP53INP1 Q96A56 Tumor protein p53-inducible nuclear protein 1 chr8 Not Cancer Driver No 2 intact, hippie, biogrid 32 134 20 20 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TP63 TP63 Q9H3D4 Tumor protein 63 chr3 Census, Compendium Yes 1 hippie 229 398 143 143 28
TP73 TP73 O15350 Tumor protein p73 chr1 Not Cancer Driver No 1 hippie 82 443 55 55 0
TRAFD1_ENST00000412615 TRAFD1 O14545 TRAF-type zinc finger domain-containing protein 1 chr12 Not Cancer Driver No 3 intact, hippie, biogrid 55 374 32 32 0
TRIM36 TRIM36 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 chr5 Not Cancer Driver No 1 hippie, biogrid 106 89 21 21 1
TRIM52 TRIM52 Q96A61 E3 ubiquitin-protein ligase TRIM52 chr5 Not Cancer Driver No 1 hippie, biogrid 23 147 13 13 0
TRIM66_ENST00000299550 TRIM66 O15016 Tripartite motif-containing protein 66 chr11 Not Cancer Driver No 1 hippie 58 723 32 32 0
TSGA10IP TSGA10IP Q3SY00 Testis-specific protein 10-interacting protein chr11 Not Cancer Driver No 1 hippie, biogrid 79 552 79 79 0
TUBA1B TUBA1B P68363 Tubulin alpha-1B chain chr12 Not Cancer Driver No 1 hippie 41 52 9 9 0
TUBA1C_ENST00000301072 TUBA1C Q9BQE3 Tubulin alpha-1C chain chr12 Not Cancer Driver No 1 intact, hippie 39 50 5 5 0
TUBG1 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 intact, hippie 51 44 10 10 3
TUBGCP2_ENST00000368563 TUBGCP2 Q9BSJ2 Gamma-tubulin complex component 2 chr10 Not Cancer Driver No 1 intact, hippie 124 93 16 16 0
TUBGCP3 TUBGCP3 Q96CW5 Gamma-tubulin complex component 3 chr13 Not Cancer Driver No 1 hippie 109 156 16 16 0
TUBGCP4 TUBGCP4 Q9UGJ1 Gamma-tubulin complex component 4 chr15 Not Cancer Driver No 1 hippie 79 62 5 5 0
TUBGCP6 TUBGCP6 Q96RT7 Gamma-tubulin complex component 6 chr22 Not Cancer Driver No 1 hippie 221 815 105 105 0
UBE3A UBE3A Q05086 Ubiquitin-protein ligase E3A chr15 Not Cancer Driver No 1 hippie 141 136 22 22 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 intact, hippie 88 186 16 16 16
WDR62_ENST00000270301 WDR62 O43379 WD repeat-containing protein 62 chr19 Not Cancer Driver No 1 intact, hippie 181 792 100 100 5
ZCCHC10 ZCCHC10 Q8TBK6 Zinc finger CCHC domain-containing protein 10 chr5 Not Cancer Driver No 1 hippie, biogrid 12 144 11 11 0
ZNF333 ZNF333 Q96JL9 Zinc finger protein 333 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 79 271 32 32 0
ZNF460 ZNF460 Q14592 Zinc finger protein 460 chr19 Not Cancer Driver No 1 hippie, biogrid 83 131 16 16 0
ZUP1 ZUP1 Q96AP4 Zinc finger-containing ubiquitin peptidase 1 chr6 Not Cancer Driver No 1 hippie 63 204 19 19 0