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ARHGEF11_ENST00000361409 ,ARHGEF11 ,O15085
  • Uniprot Accession= O15085
  • Ensembl Transcript= ENST00000361409.2
  • Uniprot Name= ARHGEF11
  • Name= Rho guanine nucleotide exchange factor 11
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 18
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 81
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCA1 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 Not Cancer Driver No 1 hippie 284 245 40 40 31
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
ARAP2 ARAP2 Q8WZ64 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 289 449 86 86 0
ARHGEF11_ENST00000361409 ARHGEF11 O15085 Rho guanine nucleotide exchange factor 11 chr1 Not Cancer Driver No 1 hippie 213 1036 138 138 0
ARHGEF12 ARHGEF12 Q9NZN5 Rho guanine nucleotide exchange factor 12 chr11 Census, Compendium Yes 1 hippie, biogrid 212 972 150 150 0
ARHGEF40 ARHGEF40 Q8TER5 Rho guanine nucleotide exchange factor 40 chr14 Not Cancer Driver No 1 hippie, biogrid 161 781 75 75 0
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie 46 122 22 22 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 2 intact, hippie 39 23 2 2 1
CGN CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 1 hippie, biogrid 152 1179 149 149 0
COMMD9 COMMD9 Q9P000 COMM domain-containing protein 9 chr11 Not Cancer Driver No 1 hippie, biogrid 25 0 0 0 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
CRK CRK P46108 Adapter molecule crk chr17 Not Cancer Driver No 1 hippie 30 197 23 23 0
DAAM1 DAAM1 Q9Y4D1 Disheveled-associated activator of morphogenesis 1 chr14 Not Cancer Driver No 1 intact, hippie 152 391 47 47 0
DISC1_ENST00000439617 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 132 514 82 82 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
FAM124B FAM124B Q9H5Z6 Protein FAM124B chr2 Not Cancer Driver No 1 hippie, biogrid 68 194 10 10 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 92 70 13 13 0
GNA12 GNA12 Q03113 Guanine nucleotide-binding protein subunit alpha-12 chr7 Not Cancer Driver No 1 hippie 41 20 0 0 0
GNA13 GNA13 Q14344 Guanine nucleotide-binding protein subunit alpha-13 chr17 Compendium Yes 1 hippie 52 32 4 4 0
GNAQ GNAQ P50148 Guanine nucleotide-binding protein G(q) subunit alpha chr9 Census, Compendium Yes 1 hippie 57 14 1 1 1
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact, hippie 28 10 1 1 0
GSK3A GSK3A P49840 Glycogen synthase kinase-3 alpha chr19 Not Cancer Driver No 1 intact, hippie 55 180 8 8 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 intact, hippie 56 146 13 13 0
HNRNPCL2 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 intact, hippie 51 199 41 41 0
HOOK3 HOOK3 Q86VS8 Protein Hook homolog 3 chr8 Census Yes 1 hippie 79 493 55 55 0
IFT57 IFT57 Q9NWB7 Intraflagellar transport protein 57 homolog chr3 Not Cancer Driver No 1 hippie 46 219 18 18 0
INA INA Q16352 Alpha-internexin chr10 Not Cancer Driver No 1 hippie, biogrid 62 256 43 43 0
ISCA2 ISCA2 Q86U28 Iron-sulfur cluster assembly 2 homolog, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 13 38 3 3 1
KRT19 KRT19 P08727 Keratin, type I cytoskeletal 19 chr17 Not Cancer Driver No 1 hippie, biogrid 57 165 19 19 0
LARP1 LARP1 Q6PKG0-3 Isoform 2 of La-related protein 1 chr5 Not Cancer Driver No 1 hippie 136 726 100 100 0
LONP2 LONP2 Q86WA8 Lon protease homolog 2, peroxisomal chr16 Not Cancer Driver No 1 hippie, biogrid 116 163 26 26 0
LPAR1_ENST00000358883 LPAR1 Q92633 Lysophosphatidic acid receptor 1 chr9 Not Cancer Driver No 1 hippie 79 21 6 6 0
LPAR2_ENST00000586703 LPAR2 Q9HBW0 Lysophosphatidic acid receptor 2 chr19 Not Cancer Driver No 1 hippie 47 2 0 0 0
LRCH3_ENST00000425562 LRCH3 Q96II8 DISP complex protein LRCH3 chr3 Not Cancer Driver No 1 hippie, biogrid 101 415 55 55 0
MAP1A MAP1A P78559 Microtubule-associated protein 1A chr15 Not Cancer Driver No 1 hippie 369 2443 311 311 0
MAP1B MAP1B P46821 Microtubule-associated protein 1B chr5 Not Cancer Driver No 1 hippie 332 1947 278 278 0
MPRIP_ENST00000341712 MPRIP Q6WCQ1 Myosin phosphatase Rho-interacting protein chr17 Not Cancer Driver No 1 hippie, biogrid 118 735 95 95 0
MTX2 MTX2 O75431 Metaxin-2 chr2 Not Cancer Driver No 1 hippie, biogrid 33 0 0 0 0
MYO5A MYO5A Q9Y4I1 Unconventional myosin-Va chr15 Census, Compendium Yes 1 hippie, biogrid 224 497 58 58 0
MZT2B_ENST00000281871 MZT2B Q6NZ67 Mitotic-spindle organizing protein 2B chr2 Not Cancer Driver No 1 hippie, biogrid 14 113 14 14 0
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 Not Cancer Driver No 1 intact, hippie 48 111 17 17 0
NOA1 NOA1 Q8NC60 Nitric oxide-associated protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 74 225 25 25 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUP98_ENST00000359171 NUP98 P52948 Nuclear pore complex protein Nup98-Nup96 chr11 Census Yes 1 hippie 227 1008 107 107 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
PAK4 PAK4 O96013 Serine/threonine-protein kinase PAK 4 chr19 Not Cancer Driver No 4 intact, hippie, biogrid 58 340 33 33 0
PAK5 PAK5 Q9P286 Serine/threonine-protein kinase PAK 5 chr20 Not Cancer Driver No 1 intact, hippie 226 407 123 123 0
PDF PDF Q9HBH1 Peptide deformylase, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 7 8 0 0 0
PFN1 PFN1 P07737 Profilin-1 chr17 Not Cancer Driver No 1 hippie, biogrid 16 7 1 1 3
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 intact, hippie 154 268 61 61 2
PLCG1_ENST00000373271 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 158 186 21 21 0
PLEKHG4B PLEKHG4B Q96PX9 Pleckstrin homology domain-containing family G member 4B chr5 Not Cancer Driver No 1 intact, hippie, biogrid 234 704 107 107 0
PLXNB1_ENST00000296440 PLXNB1 O43157 Plexin-B1 chr3 Not Cancer Driver No 2 intact, hippie 228 684 67 67 0
PLXNB2_ENST00000359337 PLXNB2 O15031 Plexin-B2 chr22 Not Cancer Driver No 1 hippie 273 304 35 35 0
PLXNB3_ENST00000361971 PLXNB3 Q9ULL4 Plexin-B3 chrX Not Cancer Driver No 2 intact, hippie 217 358 37 37 0
POTEE POTEE Q6S8J3 POTE ankyrin domain family member E chr2 Not Cancer Driver No 1 hippie, biogrid 305 462 92 92 0
PPIE_ENST00000324379 PPIE Q9UNP9 Peptidyl-prolyl cis-trans isomerase E chr1 Not Cancer Driver No 1 hippie, biogrid 51 102 17 17 0
PPP1R9B PPP1R9B Q96SB3 Neurabin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 47 695 35 35 0
PTPRF PTPRF P10586 Receptor-type tyrosine-protein phosphatase F chr1 Not Cancer Driver No 1 hippie 268 696 96 96 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RFXANK_ENST00000407360 RFXANK O14593 DNA-binding protein RFXANK chr19 Not Cancer Driver No 1 intact, hippie 22 120 6 6 1
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 3 hippie, biogrid 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 2 hippie, biogrid 52 19 2 2 0
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 2 hippie, biogrid 30 53 7 7 0
RPRD1A RPRD1A Q96P16 Regulation of nuclear pre-mRNA domain-containing protein 1A chr18 Not Cancer Driver No 1 hippie, biogrid 49 86 16 16 0
RPS6KA1_ENST00000374168 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 Not Cancer Driver No 1 hippie 94 178 32 32 0
S100A13_ENST00000392622 S100A13 Q99584 Protein S100-A13 chr1 Not Cancer Driver No 1 hippie, biogrid 12 6 0 0 0
S100A2_ENST00000368709 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie, biogrid 16 6 2 2 0
SLC1A6 SLC1A6 P48664 Excitatory amino acid transporter 4 chr19 Not Cancer Driver No 1 hippie 168 50 20 20 0
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 6
TFB1M TFB1M Q8WVM0 Dimethyladenosine transferase 1, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 50 26 3 3 0
TIGD3 TIGD3 Q6B0B8 Tigger transposable element-derived protein 3 chr11 Not Cancer Driver No 1 hippie, biogrid 77 99 21 21 0
TMOD1_ENST00000395211 TMOD1 P28289 Tropomodulin-1 chr9 Not Cancer Driver No 1 hippie, biogrid 41 195 29 29 0
TMOD2 TMOD2 Q9NZR1 Tropomodulin-2 chr15 Not Cancer Driver No 1 hippie, biogrid 33 216 22 22 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRMT61A TRMT61A Q96FX7 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A chr14 Not Cancer Driver No 3 intact, hippie, biogrid 16 74 9 9 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 intact 170 215 45 45 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WDR59 WDR59 Q6PJI9 GATOR complex protein WDR59 chr16 Not Cancer Driver No 1 hippie, biogrid 119 199 33 33 0