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APH1A ,APH1A ,Q96BI3
  • Uniprot Accession= Q96BI3
  • Ensembl Transcript= ENST00000369109.7
  • Uniprot Name= APH1A
  • Name= Gamma-secretase subunit APH-1A
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 27
  • Number of Interaction partner in biogrid: 3
  • Number of Interaction partner in hippie: 52
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTR3 ACTR3 P61158 Actin-related protein 3 chr2 Not Cancer Driver No 1 intact, hippie 32 16 2 2 0
ADAM10 ADAM10 O14672 Disintegrin and metalloproteinase domain-containing protein 10 chr15 Not Cancer Driver No 1 intact, hippie 88 156 20 20 4
ANKRD46_ENST00000519597 ANKRD46 Q86W74 Ankyrin repeat domain-containing protein 46 chr8 Not Cancer Driver No 1 intact, hippie 28 30 1 1 0
APH1A APH1A Q96BI3 Gamma-secretase subunit APH-1A chr1 Not Cancer Driver No 1 hippie 32 0 0 0 0
APOD APOD P05090 Apolipoprotein D chr3 Not Cancer Driver No 1 intact, hippie 34 13 2 2 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 intact, hippie 128 418 71 71 17
ASGR1 ASGR1 P07306 Asialoglycoprotein receptor 1 chr17 Not Cancer Driver No 1 intact, hippie 23 95 5 5 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 Not Cancer Driver No 1 hippie 53 259 38 38 0
BHLHE40 BHLHE40 O14503 Class E basic helix-loop-helix protein 40 chr3 Not Cancer Driver No 1 intact, hippie 52 242 31 31 0
CREB3 CREB3 O43889 Cyclic AMP-responsive element-binding protein 3 chr9 Not Cancer Driver No 1 hippie 33 168 11 11 0
CYTH1_ENST00000446868 CYTH1 Q15438 Cytohesin-1 chr17 Not Cancer Driver No 1 hippie 59 93 15 15 0
DDX58 DDX58 O95786 Antiviral innate immune response receptor RIG-I chr9 Not Cancer Driver No 1 hippie 118 61 10 10 2
DRD2_ENST00000542968 DRD2 P14416 D(2) dopamine receptor chr11 Not Cancer Driver No 1 intact, hippie 127 124 45 45 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ERLIN2_ENST00000519638 ERLIN2 O94905 Erlin-2 chr8 Not Cancer Driver No 1 hippie 38 22 3 3 0
FIS1 FIS1 Q9Y3D6 Mitochondrial fission 1 protein chr7 Not Cancer Driver No 1 intact, hippie 25 6 0 0 0
FXYD6_ENST00000260282 FXYD6 Q9H0Q3 FXYD domain-containing ion transport regulator 6 chr11 Not Cancer Driver No 1 intact, hippie 14 27 4 4 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 92 70 13 13 0
GLP1R GLP1R P43220 Glucagon-like peptide 1 receptor chr6 Not Cancer Driver No 1 hippie 75 18 2 2 0
GPATCH8 GPATCH8 Q9UKJ3 G patch domain-containing protein 8 chr17 Not Cancer Driver No 1 intact, hippie 210 1325 188 188 0
GPR35_ENST00000403859 GPR35 Q9HC97 G-protein coupled receptor 35 chr2 Not Cancer Driver No 1 intact, hippie 57 0 0 0 0
HES1 HES1 Q14469 Transcription factor HES-1 chr3 Not Cancer Driver No 1 intact, hippie 37 226 32 32 0
HIVEP1 HIVEP1 P15822 Zinc finger protein 40 chr6 Not Cancer Driver No 1 hippie 344 2238 292 292 0
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
IGFBP5 IGFBP5 P24593 Insulin-like growth factor-binding protein 5 chr2 Not Cancer Driver No 1 intact, hippie 27 112 17 17 0
KLF11 KLF11 O14901 Krueppel-like factor 11 chr2 Not Cancer Driver No 1 hippie 57 308 38 38 2
LAT_ENST00000360872 LAT O43561 Linker for activation of T-cells family member 1 chr16 Not Cancer Driver No 1 hippie 37 213 29 29 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
MFSD6_ENST00000281416 MFSD6 Q6ZSS7 Major facilitator superfamily domain-containing protein 6 chr2 Not Cancer Driver No 1 intact, hippie 82 252 26 26 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MPP1 MPP1 Q00013 55 kDa erythrocyte membrane protein chrX Not Cancer Driver No 1 hippie 79 194 33 33 0
MRAP2 MRAP2 Q96G30 Melanocortin-2 receptor accessory protein 2 chr6 Not Cancer Driver No 1 intact, hippie 55 75 17 17 0
NCSTN NCSTN Q92542 Nicastrin chr1 Not Cancer Driver No 4 intact, hippie 94 72 11 11 1
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 Not Cancer Driver No 3 intact, hippie 61 134 21 21 96
PSEN2 PSEN2 P49810 Presenilin-2 chr1 Not Cancer Driver No 1 hippie 68 89 16 16 7
PSENEN_ENST00000222266 PSENEN Q9NZ42 Gamma-secretase subunit PEN-2 chr19 Not Cancer Driver No 1 hippie 17 0 0 0 0
RBFOX2_ENST00000449924 RBFOX2 O43251 RNA binding protein fox-1 homolog 2 chr22 Compendium Yes 1 hippie 44 173 22 22 0
SCAND1_ENST00000305978 SCAND1 P57086 SCAN domain-containing protein 1 chr20 Not Cancer Driver No 1 intact, hippie 11 152 9 9 0
SERP1_ENST00000239944 SERP1 Q9Y6X1 Stress-associated endoplasmic reticulum protein 1 chr3 Not Cancer Driver No 1 intact, hippie 6 30 2 2 0
SLC38A7 SLC38A7 Q9NVC3 Putative sodium-coupled neutral amino acid transporter 7 chr16 Not Cancer Driver No 1 intact, hippie 50 10 0 0 0
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 Not Cancer Driver No 1 hippie, biogrid 77 116 11 11 9
SLC39A9 SLC39A9 Q9NUM3 Zinc transporter ZIP9 chr14 Not Cancer Driver No 1 intact, hippie 34 44 4 4 0
SMAGP_ENST00000398453 SMAGP Q0VAQ4 Small cell adhesion glycoprotein chr12 Not Cancer Driver No 1 intact, hippie 9 37 5 5 0
SNX19 SNX19 Q92543 Sorting nexin-19 chr11 Not Cancer Driver No 1 hippie, biogrid 131 440 57 57 0
SNX25 SNX25 Q9H3E2 Sorting nexin-25 chr4 Not Cancer Driver No 1 hippie, biogrid 101 114 10 10 0
THPO THPO P40225 Thrombopoietin chr3 Not Cancer Driver No 1 intact, hippie 63 163 25 25 0
TLE1 TLE1 Q04724 Transducin-like enhancer protein 1 chr9 Not Cancer Driver No 1 intact, hippie 111 381 53 53 0
TMED10 TMED10 P49755 Transmembrane emp24 domain-containing protein 10 chr14 Not Cancer Driver No 1 hippie 24 15 3 3 0
TMEM140 TMEM140 Q9NV12 Transmembrane protein 140 chr7 Not Cancer Driver No 1 intact, hippie 24 1 0 0 0
TMEM218 TMEM218 A2RU14 Transmembrane protein 218 chr11 Not Cancer Driver No 1 intact, hippie 14 0 0 0 0
TRARG1 TRARG1 Q8IXB3 Trafficking regulator of GLUT4 1 chr17 Not Cancer Driver No 1 hippie 33 83 11 11 0