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ALDH4A1 ,ALDH4A1 ,P30038
  • Uniprot Accession= P30038
  • Ensembl Transcript= ENST00000375341.7
  • Uniprot Name= ALDH4A1
  • Name= Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 8
  • Number of Interaction partner in biogrid: 71
  • Number of Interaction partner in hippie: 84
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACO2 ACO2 Q99798 Aconitate hydratase, mitochondrial chr22 Not Cancer Driver No 1 hippie, biogrid 94 172 19 19 5
ACSM5 ACSM5 Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 152 84 27 27 0
ADH5 ADH5 P11766 Alcohol dehydrogenase class-3 chr4 Not Cancer Driver No 1 hippie, biogrid 36 2 1 1 0
AHCY AHCY P23526 Adenosylhomocysteinase chr20 Not Cancer Driver No 1 hippie, biogrid 58 0 0 0 4
AK4 AK4 P27144 Adenylate kinase 4, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 26 24 3 3 0
ALDH4A1 ALDH4A1 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 63 46 9 9 1
ALDH6A1 ALDH6A1 Q02252 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 54 83 11 11 1
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 Not Cancer Driver No 1 intact, hippie 41 83 12 12 9
ARRB1 ARRB1 P49407 Beta-arrestin-1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 49 154 13 13 0
AUH AUH Q13825 Methylglutaconyl-CoA hydratase, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 34 29 0 0 1
C1QBP C1QBP Q07021 Complement component 1 Q subcomponent-binding protein, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 14 103 6 6 2
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 69 14 5 5 0
CFL1_ENST00000308162 CFL1 P23528 Cofilin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 21 4 0 0 0
CFL2_ENST00000341223 CFL2 Q9Y281 Cofilin-2 chr14 Not Cancer Driver No 1 hippie, biogrid 25 0 0 0 1
CLIC1_ENST00000375779 CLIC1 O00299 Chloride intracellular channel protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 32 27 5 5 0
CLIC4 CLIC4 Q9Y696 Chloride intracellular channel protein 4 chr1 Not Cancer Driver No 1 hippie, biogrid 24 49 4 4 0
CLPP CLPP Q16740 ATP-dependent Clp protease proteolytic subunit, mitochondrial chr19 Not Cancer Driver No 1 intact, hippie 22 83 9 9 3
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 17 5 1 1 1
CRYZ_ENST00000340866 CRYZ Q08257 Quinone oxidoreductase chr1 Not Cancer Driver No 1 hippie, biogrid 49 0 0 0 0
CS CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 50 13 2 2 0
DSTN DSTN P60981 Destrin chr20 Not Cancer Driver No 2 hippie, biogrid 18 0 0 0 0
ENO1 ENO1 P06733 Alpha-enolase chr1 Not Cancer Driver No 1 hippie, biogrid 51 21 2 2 0
ENO3 ENO3 P13929 Beta-enolase chr17 Not Cancer Driver No 1 hippie, biogrid 46 26 1 1 2
ESD ESD P10768 S-formylglutathione hydrolase chr13 Not Cancer Driver No 1 hippie, biogrid 33 4 0 0 0
FABP3 FABP3 P05413 Fatty acid-binding protein, heart chr1 Not Cancer Driver No 1 hippie, biogrid 22 3 0 0 0
FAHD1_ENST00000427358 FAHD1 Q6P587 Acylpyruvase FAHD1, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 15 12 0 0 0
FFAR1 FFAR1 O14842 Free fatty acid receptor 1 chr19 Not Cancer Driver No 1 hippie, biogrid 45 2 0 0 0
FXN FXN Q16595 Frataxin, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 16 73 0 0 8
GLRX5 GLRX5 Q86SX6 Glutaredoxin-related protein 5, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 7 23 0 0 2
GOT1 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 Not Cancer Driver No 1 hippie, biogrid 56 35 5 5 0
GPI_ENST00000644934 GPI P06744 Glucose-6-phosphate isomerase chr19 Not Cancer Driver No 1 hippie, biogrid 77 73 11 11 24
GPR45 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 97 0 0 0 0
GSTP1_ENST00000642444 GSTP1 P09211 Glutathione S-transferase P chr11 Not Cancer Driver No 1 hippie, biogrid 32 0 0 0 0
HINT2 HINT2 Q9BX68 Adenosine 5'-monophosphoramidase HINT2 chr9 Not Cancer Driver No 1 hippie, biogrid 10 29 2 2 0
HMGCL HMGCL P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 17 8 2 2 19
IDH2 IDH2 P48735 Isocitrate dehydrogenase [NADP], mitochondrial chr15 Census, Compendium Yes 1 hippie, biogrid 74 59 1 1 7
INHBA_ENST00000442711 INHBA P08476 Inhibin beta A chain chr7 Not Cancer Driver No 1 hippie, biogrid 148 154 63 63 0
LAP3 LAP3 P28838 Cytosol aminopeptidase chr4 Not Cancer Driver No 1 hippie, biogrid 59 99 14 14 0
LDHAL6A LDHAL6A Q6ZMR3 L-lactate dehydrogenase A-like 6A chr11 Not Cancer Driver No 1 hippie, biogrid 47 16 4 4 0
LDHAL6B LDHAL6B Q9BYZ2 L-lactate dehydrogenase A-like 6B chr15 Not Cancer Driver No 1 hippie, biogrid 54 17 2 2 0
LDHA_ENST00000422447 LDHA P00338 L-lactate dehydrogenase A chain chr11 Not Cancer Driver No 1 hippie, biogrid 40 9 0 0 0
LDHB_ENST00000350669 LDHB P07195 L-lactate dehydrogenase B chain chr12 Not Cancer Driver No 1 hippie, biogrid 47 15 2 2 11
LRRC46 LRRC46 Q96FV0 Leucine-rich repeat-containing protein 46 chr17 Not Cancer Driver No 1 hippie, biogrid 40 159 20 20 0
LYPLAL1 LYPLAL1 Q5VWZ2 Lysophospholipase-like protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
MALSU1 MALSU1 Q96EH3 Mitochondrial assembly of ribosomal large subunit protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 17 34 0 0 0
MDH2 MDH2 P40926 Malate dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 39 8 1 1 3
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
METTL17_ENST00000339374 METTL17 Q9H7H0 Methyltransferase-like protein 17, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 62 95 16 16 0
MGST3 MGST3 O14880 Microsomal glutathione S-transferase 3 chr1 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
MPST_ENST00000341116 MPST P25325 3-mercaptopyruvate sulfurtransferase chr22 Not Cancer Driver No 1 hippie, biogrid 20 72 8 8 0
MRM2_ENST00000440306 MRM2 Q9UI43 rRNA methyltransferase 2, mitochondrial chr7 Not Cancer Driver No 1 hippie 37 15 1 1 1
MSRB2 MSRB2 Q9Y3D2 Methionine-R-sulfoxide reductase B2, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 17 65 6 6 0
MTPN MTPN P58546 Myotrophin chr7 Not Cancer Driver No 1 hippie, biogrid 11 11 3 3 0
MTRF1L MTRF1L Q9UGC7 Peptide chain release factor 1-like, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 31 183 12 12 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX Not Cancer Driver No 1 hippie 156 89 16 16 2
OIT3 OIT3 Q8WWZ8 Oncoprotein-induced transcript 3 protein chr10 Not Cancer Driver No 1 hippie, biogrid 87 31 8 8 0
OR2A4 OR2A4 O95047 Olfactory receptor 2A4 chr6 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 52 50 10 10 0
PGM2 PGM2 Q96G03 Phosphopentomutase chr4 Not Cancer Driver No 1 hippie, biogrid 79 108 13 13 0
PMPCA PMPCA Q10713 Mitochondrial-processing peptidase subunit alpha chr9 Not Cancer Driver No 2 hippie, biogrid 67 23 3 3 4
PMPCB PMPCB O75439 Mitochondrial-processing peptidase subunit beta chr7 Not Cancer Driver No 1 hippie, biogrid 55 22 3 3 5
PTRHD1 PTRHD1 Q6GMV3 Putative peptidyl-tRNA hydrolase PTRHD1 chr2 Not Cancer Driver No 1 hippie, biogrid 12 22 2 2 0
PYCR1_ENST00000329875 PYCR1 P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 31 67 10 10 9
QRSL1 QRSL1 Q9H0R6 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 63 63 4 4 2
RAB33A RAB33A Q14088 Ras-related protein Rab-33A chrX Not Cancer Driver No 1 hippie, biogrid 26 12 2 2 0
RBBP4 RBBP4 Q09028 Histone-binding protein RBBP4 chr1 Not Cancer Driver No 1 hippie 53 169 23 23 0
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 32 25 5 5 0
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 6
STK16_ENST00000396738 STK16 O75716 Serine/threonine-protein kinase 16 chr2 Not Cancer Driver No 1 hippie, biogrid 42 48 3 3 0
TACO1 TACO1 Q9BSH4 Translational activator of cytochrome c oxidase 1 chr17 Not Cancer Driver No 1 hippie, biogrid 21 111 2 2 0
TBCA_ENST00000380377 TBCA O75347 Tubulin-specific chaperone A chr5 Not Cancer Driver No 1 hippie, biogrid 8 30 1 1 0
TBRG4_ENST00000494076 TBRG4 Q969Z0 FAST kinase domain-containing protein 4 chr7 Not Cancer Driver No 1 hippie, biogrid 74 60 2 2 0
TKT_ENST00000462138 TKT P29401 Transketolase chr3 Not Cancer Driver No 1 hippie, biogrid 66 86 7 7 1
TMEM184A TMEM184A Q6ZMB5 Transmembrane protein 184A chr7 Not Cancer Driver No 2 intact, hippie, biogrid 59 76 17 17 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRMT61B TRMT61B Q9BVS5 tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 48 123 10 10 0
TRUB2 TRUB2 O95900 Pseudouridylate synthase TRUB2, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 37 73 7 7 0
TSFM_ENST00000454289 TSFM P43897 Elongation factor Ts, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 37 74 7 7 2
TST_ENST00000249042 TST Q16762 Thiosulfate sulfurtransferase chr22 Not Cancer Driver No 1 hippie, biogrid 32 56 6 6 0
TUFM TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 51 50 3 3 1
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie, biogrid 30 35 3 3 0
YARS2 YARS2 Q9Y2Z4 Tyrosine--tRNA ligase, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 59 62 11 11 2