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AKT3_ENST00000366539 ,AKT3 ,Q9Y243
  • Uniprot Accession= Q9Y243
  • Ensembl Transcript= ENST00000366539.5
  • Uniprot Name= AKT3
  • Name= RAC-gamma serine/threonine-protein kinase
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of Interaction partner in intact: 33
  • Number of Interaction partner in biogrid: 22
  • Number of Interaction partner in hippie: 79
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABHD15 ABHD15 Q6UXT9 Protein ABHD15 chr17 Not Cancer Driver No 1 hippie, biogrid 50 41 3 3 0
AFAP1_ENST00000358461 AFAP1 Q8N556 Actin filament-associated protein 1 chr4 Not Cancer Driver No 1 intact, hippie 104 487 60 60 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 2 intact, hippie, biogrid 108 158 24 24 4
AKT2 AKT2 P31751 RAC-beta serine/threonine-protein kinase chr19 Census Yes 1 intact 77 84 9 9 2
AP2B1_ENST00000621914 AP2B1 P63010 AP-2 complex subunit beta chr17 Not Cancer Driver No 1 intact, hippie 85 95 12 12 0
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie 46 122 22 22 0
BASP1_ENST00000616743 BASP1 P80723 Brain acid soluble protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 39 227 39 39 0
CALD1 CALD1 Q05682 Caldesmon chr7 Not Cancer Driver No 1 intact, hippie 133 793 133 133 0
CAPZB_ENST00000375142 CAPZB P47756 F-actin-capping protein subunit beta chr1 Not Cancer Driver No 1 intact, hippie 33 66 3 3 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CCNA2_ENST00000618014 CCNA2 P20248 Cyclin-A2 chr4 Not Cancer Driver No 1 hippie 45 186 19 19 0
CD44 CD44 P16070 CD44 antigen chr11 Not Cancer Driver No 1 hippie 75 542 60 60 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 4 intact, hippie, biogrid 52 214 31 31 0
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 Not Cancer Driver No 1 intact 27 70 12 12 0
CLIP3_ENST00000593074 CLIP3 Q96DZ5 CAP-Gly domain-containing linker protein 3 chr19 Not Cancer Driver No 1 hippie 78 218 22 22 0
COBL_ENST00000265136 COBL O75128 Protein cordon-bleu chr7 Not Cancer Driver No 1 intact, hippie 233 1149 216 216 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 Census, Compendium Yes 1 hippie, biogrid 247 1212 214 214 148
COPA_ENST00000241704 COPA P53621 Coatomer subunit alpha chr1 Not Cancer Driver No 1 intact, hippie 163 157 18 18 4
CSDE1_ENST00000358528 CSDE1 O75534 Cold shock domain-containing protein E1 chr1 Not Cancer Driver No 1 hippie 118 204 29 29 0
CUL1_ENST00000602748 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 hippie 151 65 9 9 0
DAB2 DAB2 P98082 Disabled homolog 2 chr5 Not Cancer Driver No 1 intact, hippie 144 680 125 125 0
DOCK7_ENST00000635253 DOCK7 Q96N67 Dedicator of cytokinesis protein 7 chr1 Not Cancer Driver No 1 intact, hippie 262 454 53 53 0
EIF4EBP1 EIF4EBP1 Q13541 Eukaryotic translation initiation factor 4E-binding protein 1 chr8 Not Cancer Driver No 1 hippie, biogrid 8 118 8 8 0
FBXO7 FBXO7 Q9Y3I1 F-box only protein 7 chr22 Not Cancer Driver No 1 hippie 75 243 38 38 1
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 70 150 20 20 0
FLNA FLNA P21333 Filamin-A chrX Census Yes 1 intact, hippie 416 1456 214 214 28
FLOT2 FLOT2 Q14254 Flotillin-2 chr17 Not Cancer Driver No 1 intact, hippie 56 20 3 3 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 hippie 56 146 13 13 0
GSN GSN P06396 Gelsolin chr9 Not Cancer Driver No 1 intact, hippie 76 316 28 28 2
GTF3C1 GTF3C1 Q12789 General transcription factor 3C polypeptide 1 chr16 Not Cancer Driver No 1 hippie 323 735 114 114 0
HCLS1 HCLS1 P14317 Hematopoietic lineage cell-specific protein chr3 Not Cancer Driver No 1 hippie 103 446 94 94 0
HDGF_ENST00000357325 HDGF P51858 Hepatoma-derived growth factor chr1 Not Cancer Driver No 1 intact, hippie, biogrid 35 203 29 29 0
HERC1 HERC1 Q15751 Probable E3 ubiquitin-protein ligase HERC1 chr15 Not Cancer Driver No 1 hippie, biogrid 487 1344 129 129 1
HMGN1 HMGN1 P05114 Non-histone chromosomal protein HMG-14 chr21 Not Cancer Driver No 1 intact, hippie, biogrid 12 100 12 12 0
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 Census, Compendium Yes 1 hippie 68 255 41 41 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 3 intact, hippie, biogrid 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 3 intact, hippie, biogrid 100 254 43 43 0
IWS1 IWS1 Q96ST2 Protein IWS1 homolog chr2 Not Cancer Driver No 1 hippie 80 737 72 72 0
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 28 24 2 2 0
KCTD12 KCTD12 Q96CX2 BTB/POZ domain-containing protein KCTD12 chr13 Not Cancer Driver No 1 hippie 15 147 4 4 0
KRT32 KRT32 Q14532 Keratin, type I cuticular Ha2 chr17 Not Cancer Driver No 1 intact 88 74 20 20 0
LAMC1 LAMC1 P11047 Laminin subunit gamma-1 chr1 Not Cancer Driver No 1 hippie 232 562 94 94 0
MAL2 MAL2 Q969L2 Protein MAL2 chr8 Not Cancer Driver No 1 hippie 20 4 0 0 0
MARCKS MARCKS P29966 Myristoylated alanine-rich C-kinase substrate chr6 Not Cancer Driver No 1 hippie, biogrid 14 328 14 14 0
MICAL3 MICAL3 Q7RTP6 [F-actin]-monooxygenase MICAL3 chr22 Not Cancer Driver No 1 hippie 248 1264 159 159 0
MXRA5 MXRA5 Q9NR99 Matrix-remodeling-associated protein 5 chrX Not Cancer Driver No 1 hippie 753 1392 397 397 1
MYL9 MYL9 P24844 Myosin regulatory light polypeptide 9 chr20 Not Cancer Driver No 1 hippie 34 82 19 19 0
MYO1B MYO1B O43795 Unconventional myosin-Ib chr2 Not Cancer Driver No 1 intact, hippie 144 34 4 4 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 1 hippie 150 711 79 79 0
NEDD4L NEDD4L Q96PU5 E3 ubiquitin-protein ligase NEDD4-like chr18 Not Cancer Driver No 1 hippie 126 463 60 60 4
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 75 38 4 4 0
PDE3B PDE3B Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B chr11 Not Cancer Driver No 1 hippie, biogrid 135 393 37 37 0
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 Not Cancer Driver No 1 hippie 33 121 12 12 0
PFKP PFKP Q01813 ATP-dependent 6-phosphofructokinase, platelet type chr10 Not Cancer Driver No 1 hippie 133 43 10 10 0
PIANP PIANP Q8IYJ0 PILR alpha-associated neural protein chr12 Not Cancer Driver No 2 intact, hippie, biogrid 45 217 38 38 0
PKM_ENST00000335181 PKM P14618 Pyruvate kinase PKM chr15 Not Cancer Driver No 1 hippie 78 58 13 13 0
PLEKHG3 PLEKHG3 A1L390 Pleckstrin homology domain-containing family G member 3 chr14 Not Cancer Driver No 1 intact, hippie 137 885 104 104 0
PLEKHO1 PLEKHO1 Q53GL0 Pleckstrin homology domain-containing family O member 1 chr1 Not Cancer Driver No 1 hippie 55 341 46 46 0
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 Not Cancer Driver No 1 hippie 41 12 1 1 8
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 Compendium Yes 1 hippie 79 43 9 9 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 Not Cancer Driver No 2 intact, hippie 70 116 11 11 0
PRMT6 PRMT6 Q96LA8 Protein arginine N-methyltransferase 6 chr1 Not Cancer Driver No 2 hippie, biogrid 43 71 7 7 0
PRPF40A PRPF40A O75400 Pre-mRNA-processing factor 40 homolog A chr2 Not Cancer Driver No 1 hippie 83 694 57 57 0
PTMS_ENST00000309083 PTMS P20962 Parathymosin chr12 Not Cancer Driver No 1 intact, hippie, biogrid 10 102 10 10 0
RPE RPE Q96AT9 Ribulose-phosphate 3-epimerase chr2 Not Cancer Driver No 1 hippie, biogrid 31 28 6 6 0
RPL37A RPL37A P61513 60S ribosomal protein L37a chr2 Not Cancer Driver No 1 intact, hippie 4 0 0 0 0
RPS27 RPS27 P42677 40S ribosomal protein S27 chr1 Not Cancer Driver No 1 hippie 10 29 7 7 0
SNX8 SNX8 Q9Y5X2 Sorting nexin-8 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 64 114 15 15 0
SPOCK3_ENST00000511531 SPOCK3 Q9BQ16 Testican-3 chr4 Not Cancer Driver No 1 hippie 132 68 38 38 0
TCL1A TCL1A P56279 T-cell leukemia/lymphoma protein 1A chr14 Census Yes 1 hippie 30 5 1 1 0
TOX2_ENST00000358131 TOX2 Q96NM4 TOX high mobility group box family member 2 chr20 Not Cancer Driver No 2 hippie, biogrid 131 392 108 108 0
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 Not Cancer Driver No 1 intact, hippie 33 234 29 29 8
TPM4_ENST00000300933 TPM4 P67936 Tropomyosin alpha-4 chain chr19 Census Yes 1 intact, hippie 28 216 28 28 0
TSC2 TSC2 P49815 Tuberin chr16 Census, Compendium Yes 1 hippie 192 563 50 50 53
TSEN2 TSEN2 Q8NCE0 tRNA-splicing endonuclease subunit Sen2 chr3 Not Cancer Driver No 1 hippie, biogrid 54 153 17 17 1
TTC3_ENST00000355666 TTC3 P53804 E3 ubiquitin-protein ligase TTC3 chr21 Not Cancer Driver No 1 hippie 255 723 83 83 0
UBE2E1 UBE2E1 P51965 Ubiquitin-conjugating enzyme E2 E1 chr3 Not Cancer Driver No 1 hippie 21 78 10 10 0
UNC13C UNC13C Q8NB66 Protein unc-13 homolog C chr15 Not Cancer Driver No 1 hippie 681 886 268 268 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WDR1 WDR1 O75083 WD repeat-containing protein 1 chr4 Not Cancer Driver No 1 intact, hippie 66 30 7 7 2
ZNF354C ZNF354C Q86Y25 Zinc finger protein 354C chr5 Not Cancer Driver No 1 hippie 109 77 30 30 0
ZNF527 ZNF527 Q8NB42 Zinc finger protein 527 chr19 Not Cancer Driver No 1 hippie 115 66 11 11 0