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AIM2 ,AIM2 ,O14862
  • Uniprot Accession= O14862
  • Ensembl Transcript= ENST00000368130.8
  • Uniprot Name= AIM2
  • Name= Interferon-inducible protein AIM2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 74
  • Number of Interaction partner in biogrid: 98
  • Number of Interaction partner in hippie: 112
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADAR ADAR P55265 Double-stranded RNA-specific adenosine deaminase chr1 Not Cancer Driver No 1 intact, hippie, biogrid 149 675 83 83 12
ADNP ADNP Q9H2P0 Activity-dependent neuroprotector homeobox protein chr20 Not Cancer Driver No 1 intact, hippie, biogrid 130 615 66 66 0
AIM2 AIM2 O14862 Interferon-inducible protein AIM2 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 73 78 22 22 0
ALDH3A2_ENST00000579855 ALDH3A2 P51648 Aldehyde dehydrogenase family 3 member A2 chr17 Not Cancer Driver No 1 hippie, biogrid 47 5 2 2 26
ANP32B ANP32B Q92688 Acidic leucine-rich nuclear phosphoprotein 32 family member B chr9 Not Cancer Driver No 1 hippie 22 117 12 12 0
APPBP2 APPBP2 Q92624 Amyloid protein-binding protein 2 chr17 Not Cancer Driver No 1 hippie 61 10 0 0 0
BANF1_ENST00000445560 BANF1 O75531 Barrier-to-autointegration factor chr11 Not Cancer Driver No 1 intact, hippie, biogrid 10 11 2 2 1
BCL11A BCL11A Q9H165 B-cell lymphoma/leukemia 11A chr2 Census, Compendium Yes 1 hippie, biogrid 210 677 171 171 3
BCL11B BCL11B Q9C0K0 B-cell lymphoma/leukemia 11B chr14 Census, Compendium Yes 1 intact, hippie, biogrid 156 699 114 114 2
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BEND3_ENST00000369042 BEND3 Q5T5X7 BEN domain-containing protein 3 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 104 311 44 44 0
C5orf24_ENST00000435259 C5orf24 Q7Z6I8 UPF0461 protein C5orf24 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 22 182 22 22 0
CACYBP CACYBP Q9HB71 Calcyclin-binding protein chr1 Not Cancer Driver No 1 hippie, biogrid 27 92 10 10 0
CAMK2D_ENST00000342666 CAMK2D Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta chr4 Not Cancer Driver No 1 intact, hippie, biogrid 57 84 10 10 0
CASP1 CASP1 P29466 Caspase-1 chr11 Not Cancer Driver No 1 hippie 79 87 18 18 0
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 intact, hippie, biogrid 419 974 177 177 6
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie, biogrid 25 201 22 22 2
COPA_ENST00000241704 COPA P53621 Coatomer subunit alpha chr1 Not Cancer Driver No 1 intact, hippie, biogrid 163 157 18 18 4
CSNK2A2 CSNK2A2 P19784 Casein kinase II subunit alpha' chr16 Not Cancer Driver No 1 intact, hippie, biogrid 43 13 1 1 0
CTCF CTCF P49711 Transcriptional repressor CTCF chr16 Census, Compendium Yes 1 hippie, biogrid 151 481 83 83 1
DDX39A DDX39A O00148 ATP-dependent RNA helicase DDX39A chr19 Not Cancer Driver No 1 hippie, biogrid 44 37 2 2 0
DDX50 DDX50 Q9BQ39 ATP-dependent RNA helicase DDX50 chr10 Not Cancer Driver No 1 hippie, biogrid 86 274 30 30 0
DNAJC9 DNAJC9 Q8WXX5 DnaJ homolog subfamily C member 9 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 28 126 15 15 0
EEF1B2_ENST00000236957 EEF1B2 P24534 Elongation factor 1-beta chr2 Not Cancer Driver No 1 hippie, biogrid 63 71 11 11 0
EIF2AK2_ENST00000395127 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase chr2 Not Cancer Driver No 1 hippie 59 188 22 22 0
EIF3A EIF3A Q14152 Eukaryotic translation initiation factor 3 subunit A chr10 Not Cancer Driver No 1 intact, hippie, biogrid 181 835 130 130 0
EMD EMD P50402 Emerin chrX Not Cancer Driver No 1 hippie, biogrid 42 160 28 28 4
FOXC1_ENST00000645831 FOXC1 Q12948 Forkhead box protein C1 chr6 Not Cancer Driver No 1 hippie, biogrid 33 411 24 24 32
FSCN1 FSCN1 Q16658 Fascin chr7 Not Cancer Driver No 1 intact, hippie, biogrid 58 81 5 5 0
GATAD2B_ENST00000634544 GATAD2B Q8WXI9 Transcriptional repressor p66-beta chr1 Not Cancer Driver No 1 intact, hippie, biogrid 76 510 67 67 0
GTF2I GTF2I P78347 General transcription factor II-I chr7 Compendium Yes 1 intact, hippie, biogrid 74 365 27 27 0
H1FX H1-10 Q92522 Histone H1.10 chr3 Not Cancer Driver No 1 intact 12 198 12 12 0
HAT1 HAT1 O14929 Histone acetyltransferase type B catalytic subunit chr2 Not Cancer Driver No 1 intact, hippie, biogrid 51 14 2 2 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 47 135 10 10 0
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 46 145 14 14 0
HIRA HIRA P54198 Protein HIRA chr22 Not Cancer Driver No 1 intact, hippie, biogrid 138 288 37 37 0
HMBOX1_ENST00000397358 HMBOX1 Q6NT76 Homeobox-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie, biogrid 55 319 41 41 0
HOXA13 HOXA13 P31271 Homeobox protein Hox-A13 chr7 Census Yes 1 intact, hippie, biogrid 37 171 22 22 4
IKZF5 IKZF5 Q9H5V7 Zinc finger protein Pegasus chr10 Not Cancer Driver No 1 hippie, biogrid 46 282 36 36 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie, biogrid 35 281 25 25 0
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 1 hippie 47 93 10 10 0
LAS1L LAS1L Q9Y4W2 Ribosomal biogenesis protein LAS1L chrX Not Cancer Driver No 1 intact, hippie, biogrid 100 279 49 49 0
LEMD2_ENST00000614475 LEMD2 Q8NC56 LEM domain-containing protein 2 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 44 211 4 4 2
LIG3 LIG3 P49916 DNA ligase 3 chr17 Not Cancer Driver No 1 intact, hippie, biogrid 125 280 36 36 0
MAZ_ENST00000322945 MAZ P56270 Myc-associated zinc finger protein chr16 Not Cancer Driver No 1 hippie, biogrid 46 249 22 22 0
MBD1_ENST00000591416 MBD1 Q9UIS9 Methyl-CpG-binding domain protein 1 chr18 Not Cancer Driver No 1 hippie, biogrid 115 322 49 49 0
MDC1 MDC1 Q14676 Mediator of DNA damage checkpoint protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 249 1829 223 223 0
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX Not Cancer Driver No 1 intact, hippie, biogrid 75 483 74 74 46
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie, biogrid 110 101 8 8 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 Not Cancer Driver No 1 intact, hippie 84 292 35 35 1
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 Census Yes 1 intact, hippie, biogrid 154 386 41 41 6
MTA1 MTA1 Q13330 Metastasis-associated protein MTA1 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 92 327 42 42 0
MTA2 MTA2 O94776 Metastasis-associated protein MTA2 chr11 Not Cancer Driver No 1 intact, hippie, biogrid 78 283 32 32 0
MTREX MTREX P42285 Exosome RNA helicase MTR4 chr5 Not Cancer Driver No 1 intact, hippie 117 160 15 15 0
NBN NBN O60934 Nibrin chr8 Census Yes 1 hippie, biogrid 90 417 54 54 1
NCOA5 NCOA5 Q9HCD5 Nuclear receptor coactivator 5 chr20 Not Cancer Driver No 1 intact, hippie, biogrid 84 478 70 70 0
NKX2-4 NKX2-4 Q9H2Z4 Homeobox protein Nkx-2.4 chr20 Not Cancer Driver No 1 intact, hippie, biogrid 22 242 21 21 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 intact, hippie 29 249 22 22 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 intact, hippie, biogrid 62 186 24 24 0
NR2F2 NR2F2 P24468 COUP transcription factor 2 chr15 Not Cancer Driver No 1 intact, hippie, biogrid 66 101 1 1 5
NUP153_ENST00000262077 NUP153 P49790 Nuclear pore complex protein Nup153 chr6 Not Cancer Driver No 1 hippie, biogrid 180 1152 147 147 0
PARP2 PARP2 Q9UGN5 Poly [ADP-ribose] polymerase 2 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 74 172 23 23 0
PES1 PES1 O00541 Pescadillo homolog chr22 Not Cancer Driver No 1 intact, hippie, biogrid 78 248 33 33 0
PHF14 PHF14 O94880 PHD finger protein 14 chr7 Not Cancer Driver No 1 hippie, biogrid 102 565 56 56 0
PML PML P29590 Protein PML chr15 Census, Compendium Yes 1 intact, hippie, biogrid 112 312 34 34 0
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 Census, Compendium Yes 1 hippie, biogrid 113 31 6 6 9
PSMC1 PSMC1 P62191 26S proteasome regulatory subunit 4 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 36 165 10 10 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 Not Cancer Driver No 1 hippie 16 39 4 4 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 157 730 84 84 0
RBBP7_ENST00000380087 RBBP7 Q16576 Histone-binding protein RBBP7 chrX Not Cancer Driver No 1 intact, hippie, biogrid 67 138 19 19 0
RBM12B RBM12B Q8IXT5 RNA-binding protein 12B chr8 Not Cancer Driver No 1 intact, hippie, biogrid 133 524 79 79 0
RCC2 RCC2 Q9P258 Protein RCC2 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 63 194 27 27 0
RCN2_ENST00000394885 RCN2 Q14257 Reticulocalbin-2 chr15 Not Cancer Driver No 1 intact, hippie, biogrid 35 125 11 11 0
RING1 RING1 Q06587 E3 ubiquitin-protein ligase RING1 chr6 Not Cancer Driver No 1 hippie, biogrid 60 302 44 44 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RNH1_ENST00000397604 RNH1 P13489 Ribonuclease inhibitor chr11 Not Cancer Driver No 1 intact, hippie, biogrid 40 0 0 0 0
RREB1_ENST00000349384 RREB1 Q92766 Ras-responsive element-binding protein 1 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 213 1152 144 144 0
SAFB2 SAFB2 Q14151 Scaffold attachment factor B2 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 97 931 88 88 0
SAFB_ENST00000292123 SAFB Q15424 Scaffold attachment factor B1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 111 911 110 110 0
SAMD1 SAMD1 E9PIW9 Sterile alpha motif domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 25 397 18 18 0
SATB2 SATB2 Q9UPW6 DNA-binding protein SATB2 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 164 412 100 100 0
SDCBP_ENST00000260130 SDCBP O00560 Syntenin-1 chr8 Not Cancer Driver No 1 hippie, biogrid 39 17 2 2 0
SLTM SLTM Q9NWH9 SAFB-like transcription modulator chr15 Not Cancer Driver No 1 intact, hippie, biogrid 110 962 103 103 0
SMARCA5 SMARCA5 O60264 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 chr4 Not Cancer Driver No 1 intact, hippie, biogrid 116 363 48 48 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 intact, hippie 54 267 32 32 30
STRBP_ENST00000348403 STRBP Q96SI9 Spermatid perinuclear RNA-binding protein chr9 Not Cancer Driver No 1 intact, hippie, biogrid 74 306 31 31 0
SUGP2_ENST00000452918 SUGP2 Q8IX01 SURP and G-patch domain-containing protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 124 651 74 74 0
TCF20 TCF20 Q9UGU0 Transcription factor 20 chr22 Not Cancer Driver No 1 intact, hippie, biogrid 234 1811 214 214 1
TFAP2A TFAP2A P05549 Transcription factor AP-2-alpha chr6 Not Cancer Driver No 1 hippie, biogrid 77 275 44 44 4
TFAP2C TFAP2C Q92754 Transcription factor AP-2 gamma chr20 Not Cancer Driver No 1 intact, hippie, biogrid 76 282 41 41 0
TFAP4 TFAP4 Q01664 Transcription factor AP-4 chr16 Compendium Yes 1 intact, hippie, biogrid 61 285 52 52 0
TFCP2 TFCP2 Q12800 Alpha-globin transcription factor CP2 chr12 Not Cancer Driver No 1 hippie, biogrid 68 169 23 23 0
TFE3 TFE3 P19532 Transcription factor E3 chrX Census Yes 1 intact, hippie, biogrid 92 524 84 84 0
THEM6 THEM6 Q8WUY1 Protein THEM6 chr8 Not Cancer Driver No 1 intact, hippie, biogrid 3 7 0 0 0
TMPO TMPO P42166 Lamina-associated polypeptide 2, isoform alpha chr12 Not Cancer Driver No 1 hippie 78 412 52 52 0
TRIM11 TRIM11 Q96F44 E3 ubiquitin-protein ligase TRIM11 chr1 Not Cancer Driver No 1 hippie 58 132 14 14 0
TRIM27 TRIM27 P14373 Zinc finger protein RFP chr6 Census Yes 1 intact, hippie, biogrid 59 87 11 11 0
UCHL1 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie, biogrid 33 34 7 7 4
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 146 329 36 36 0
VRK3_ENST00000594948 VRK3 Q8IV63 Inactive serine/threonine-protein kinase VRK3 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 65 180 18 18 0
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 85 426 53 53 1
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 87 118 11 11 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 intact, hippie, biogrid 66 140 12 12 0
ZBTB33 ZBTB33 Q86T24 Transcriptional regulator Kaiso chrX Not Cancer Driver No 1 intact, hippie, biogrid 110 352 58 58 0
ZBTB39 ZBTB39 O15060 Zinc finger and BTB domain-containing protein 39 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 86 222 21 21 0
ZBTB44_ENST00000357899 ZBTB44 Q8NCP5 Zinc finger and BTB domain-containing protein 44 chr11 Not Cancer Driver No 1 hippie, biogrid 68 266 35 35 0
ZNF148_ENST00000485866 ZNF148 Q9UQR1 Zinc finger protein 148 chr3 Compendium Yes 1 hippie, biogrid 125 600 88 88 0
ZNF384 ZNF384 Q8TF68 Zinc finger protein 384 chr12 Census Yes 1 intact, hippie, biogrid 63 403 44 44 0
ZNF444 ZNF444 Q8N0Y2 Zinc finger protein 444 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 17 221 13 13 0
ZNF646 ZNF646 O15015 Zinc finger protein 646 chr16 Not Cancer Driver No 1 hippie, biogrid 228 1410 173 173 0
ZNF711_ENST00000373165 ZNF711 Q9Y462 Zinc finger protein 711 chrX Not Cancer Driver No 1 intact, hippie, biogrid 192 357 75 75 1
ZNF740 ZNF740 Q8NDX6 Zinc finger protein 740 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 18 67 5 5 0
ZSCAN25 ZSCAN25 Q6NSZ9 Zinc finger and SCAN domain-containing protein 25 chr7 Not Cancer Driver No 1 intact, hippie, biogrid 66 325 43 43 0