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AGO4 ,AGO4 ,Q9HCK5
  • Uniprot Accession= Q9HCK5
  • Ensembl Transcript= ENST00000373210.3
  • Uniprot Name= AGO4
  • Name= Protein argonaute-4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 67
  • Number of Interaction partner in biogrid: 38
  • Number of Interaction partner in hippie: 117
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 Not Cancer Driver No 1 intact, hippie 112 43 5 5 5
AGK AGK Q53H12 Acylglycerol kinase, mitochondrial chr7 Not Cancer Driver No 1 intact, hippie 71 77 6 6 0
AGO2 AGO2 Q9UKV8 Protein argonaute-2 chr8 Not Cancer Driver No 1 intact, hippie 126 141 15 15 11
AGO3 AGO3 Q9H9G7 Protein argonaute-3 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 110 143 19 19 0
AGO4 AGO4 Q9HCK5 Protein argonaute-4 chr1 Not Cancer Driver No 1 hippie 100 183 24 24 0
ANKMY2 ANKMY2 Q8IV38 Ankyrin repeat and MYND domain-containing protein 2 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 57 99 15 15 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARF4 ARF4 P18085 ADP-ribosylation factor 4 chr3 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
ATP5F1C ATP5F1C P36542 ATP synthase subunit gamma, mitochondrial chr10 Not Cancer Driver No 1 intact, hippie 39 11 0 0 0
ATP5ME ATP5ME P56385 ATP synthase subunit e, mitochondrial chr4 Not Cancer Driver No 1 intact, hippie 6 18 2 2 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
BCR BCR P11274 Breakpoint cluster region protein chr22 Census, Compendium Yes 1 hippie, biogrid 146 603 69 69 0
CCT5 CCT5 P48643 T-complex protein 1 subunit epsilon chr5 Not Cancer Driver No 1 intact, hippie 83 72 10 10 1
CDIPT_ENST00000569956 CDIPT O14735 CDP-diacylglycerol--inositol 3-phosphatidyltransferase chr16 Not Cancer Driver No 1 intact, hippie 21 0 0 0 0
CTNNA3 CTNNA3 Q9UI47 Catenin alpha-3 chr10 Not Cancer Driver No 1 hippie, biogrid 269 186 50 50 1
CTR9 CTR9 Q6PD62 RNA polymerase-associated protein CTR9 homolog chr11 Not Cancer Driver No 1 hippie, biogrid 164 385 48 48 0
CUL7_ENST00000265348 CUL7 Q14999 Cullin-7 chr6 Not Cancer Driver No 1 hippie, biogrid 188 372 41 41 3
CUL9 CUL9 Q8IWT3 Cullin-9 chr6 Not Cancer Driver No 1 hippie, biogrid 321 633 73 73 0
DBT DBT P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 64 81 11 11 3
DDX6 DDX6 P26196 Probable ATP-dependent RNA helicase DDX6 chr11 Census, Compendium Yes 1 hippie, biogrid 44 129 7 7 5
DICER1 DICER1 Q9UPY3 Endoribonuclease Dicer chr14 Census, Compendium Yes 2 hippie, biogrid 264 362 45 45 4
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 Not Cancer Driver No 1 intact, hippie 37 153 16 16 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 intact, hippie 50 174 27 27 0
DNAJB11_ENST00000265028 DNAJB11 Q9UBS4 DnaJ homolog subfamily B member 11 chr3 Not Cancer Driver No 1 hippie 52 141 21 21 2
ECD_ENST00000372979 ECD O95905 Protein ecdysoneless homolog chr10 Not Cancer Driver No 1 hippie, biogrid 68 254 26 26 0
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 intact, hippie 109 100 14 14 0
EEF1G EEF1G P26641 Elongation factor 1-gamma chr11 Not Cancer Driver No 1 hippie 44 66 5 5 0
EIF4B_ENST00000262056 EIF4B P23588 Eukaryotic translation initiation factor 4B chr12 Not Cancer Driver No 1 intact, hippie 94 589 90 90 0
EMD EMD P50402 Emerin chrX Not Cancer Driver No 1 hippie 42 160 28 28 4
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 hippie, biogrid 70 150 20 20 0
GALK1 GALK1 P51570 Galactokinase chr17 Not Cancer Driver No 1 intact, hippie 31 43 5 5 11
HNRNPC_ENST00000420743 HNRNPC P07910 Heterogeneous nuclear ribonucleoproteins C1/C2 chr14 Not Cancer Driver No 1 intact, hippie 42 227 35 35 0
HSD17B14 HSD17B14 Q9BPX1 17-beta-hydroxysteroid dehydrogenase 14 chr19 Not Cancer Driver No 1 hippie, biogrid 33 42 10 10 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 intact, hippie 24 200 13 13 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 Not Cancer Driver No 1 intact, hippie 73 282 35 35 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 intact, hippie 149 251 52 52 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 61 82 6 6 2
HTATSF1_ENST00000218364 HTATSF1 O43719 HIV Tat-specific factor 1 chrX Not Cancer Driver No 1 hippie, biogrid 131 573 100 100 0
IGF2BP1 IGF2BP1 Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 chr17 Not Cancer Driver No 1 hippie 141 298 80 80 0
IGFBP6 IGFBP6 P24592 Insulin-like growth factor-binding protein 6 chr12 Not Cancer Driver No 1 hippie, biogrid 22 166 18 18 0
IPO8 IPO8 O15397 Importin-8 chr12 Not Cancer Driver No 1 intact, hippie 130 111 13 13 0
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 intact, hippie 147 120 7 7 2
KBTBD8 KBTBD8 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 chr3 Not Cancer Driver No 1 hippie, biogrid 96 31 3 3 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KIF20A KIF20A O95235 Kinesin-like protein KIF20A chr5 Not Cancer Driver No 1 hippie 79 340 40 40 1
LEO1 LEO1 Q8WVC0 RNA polymerase-associated protein LEO1 chr15 Not Cancer Driver No 1 hippie, biogrid 74 611 69 69 0
LEPR LEPR P48357 Leptin receptor chr1 Not Cancer Driver No 1 hippie, biogrid 243 57 11 11 0
LIMD1 LIMD1 Q9UGP4 LIM domain-containing protein 1 chr3 Not Cancer Driver No 1 intact, hippie 58 428 36 36 0
MEX3B MEX3B Q6ZN04 RNA-binding protein MEX3B chr15 Not Cancer Driver No 1 hippie 85 437 64 64 0
MYCBP MYCBP Q99417 c-Myc-binding protein chr1 Not Cancer Driver No 1 hippie 8 54 4 4 0
NUDCD1 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 75 38 4 4 0
PABPC1 PABPC1 P11940 Polyadenylate-binding protein 1 chr8 Census, Compendium Yes 1 intact, hippie 100 317 55 55 0
PABPC4_ENST00000372857 PABPC4 Q13310 Polyadenylate-binding protein 4 chr1 Not Cancer Driver No 1 intact, hippie 89 253 49 49 0
PAF1 PAF1 Q8N7H5 RNA polymerase II-associated factor 1 homolog chr19 Not Cancer Driver No 1 hippie, biogrid 77 378 56 56 0
PCSK1N PCSK1N Q9UHG2 ProSAAS chrX Not Cancer Driver No 1 hippie, biogrid 7 187 7 7 0
PGAM5 PGAM5 Q96HS1 Serine/threonine-protein phosphatase PGAM5, mitochondrial chr12 Not Cancer Driver No 1 hippie 32 102 12 12 0
PITRM1_ENST00000224949 PITRM1 Q5JRX3 Presequence protease, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 122 220 26 26 2
PPME1_ENST00000328257 PPME1 Q9Y570 Protein phosphatase methylesterase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 35 146 9 9 0
PRDX1_ENST00000319248 PRDX1 Q06830 Peroxiredoxin-1 chr1 Not Cancer Driver No 1 intact, hippie 22 40 5 5 0
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 intact, hippie 83 72 6 6 0
PRPF40B_ENST00000380281 PRPF40B Q6NWY9 Pre-mRNA-processing factor 40 homolog B chr12 Census Yes 1 hippie, biogrid 116 629 92 92 0
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 Not Cancer Driver No 2 hippie, biogrid 11 52 3 3 0
PTS PTS Q03393 6-pyruvoyl tetrahydrobiopterin synthase chr11 Not Cancer Driver No 1 intact, hippie 9 22 1 1 24
QPCTL QPCTL Q9NXS2 Glutaminyl-peptide cyclotransferase-like protein chr19 Not Cancer Driver No 1 hippie 42 22 1 1 0
RASSF8_ENST00000541490 RASSF8 Q8NHQ8 Ras association domain-containing protein 8 chr12 Not Cancer Driver No 1 hippie, biogrid 47 206 19 19 0
RBM10_ENST00000377604 RBM10 P98175 RNA-binding protein 10 chrX Census, Compendium Yes 1 hippie 112 777 99 99 0
RPL11 RPL11 P62913 60S ribosomal protein L11 chr1 Not Cancer Driver No 1 intact, hippie 27 12 1 1 1
RPL12 RPL12 P30050 60S ribosomal protein L12 chr9 Not Cancer Driver No 1 intact, hippie 13 75 6 6 0
RPL23_ENST00000394332 RPL23 P62829 60S ribosomal protein L23 chr17 Not Cancer Driver No 1 intact, hippie 14 29 4 4 0
RPL24 RPL24 P83731 60S ribosomal protein L24 chr3 Not Cancer Driver No 1 intact, hippie 19 105 14 14 0
RPL27A RPL27A P46776 60S ribosomal protein L27a chr11 Not Cancer Driver No 1 intact, hippie 7 56 2 2 0
RPL27_ENST00000253788 RPL27 P61353 60S ribosomal protein L27 chr17 Not Cancer Driver No 1 intact, hippie 21 13 3 3 0
RPL35 RPL35 P42766 60S ribosomal protein L35 chr9 Not Cancer Driver No 1 intact, hippie 12 65 9 9 0
RPL38_ENST00000439590 RPL38 P63173 60S ribosomal protein L38 chr17 Not Cancer Driver No 1 intact, hippie 2 9 0 0 0
RPL8_ENST00000528957 RPL8 P62917 60S ribosomal protein L8 chr8 Not Cancer Driver No 1 intact, hippie 32 115 17 17 0
RPS12 RPS12 P25398 40S ribosomal protein S12 chr6 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
RPS18 RPS18 P62269 40S ribosomal protein S18 chr6 Not Cancer Driver No 1 intact, hippie 28 27 8 8 0
RPS25 RPS25 P62851 40S ribosomal protein S25 chr11 Not Cancer Driver No 1 intact, hippie 16 60 8 8 0
RPS26_ENST00000646449 RPS26 P62854 40S ribosomal protein S26 chr12 Not Cancer Driver No 1 intact, hippie 9 52 5 5 2
RPS3A RPS3A P61247 40S ribosomal protein S3a chr4 Compendium Yes 1 intact, hippie 21 85 5 5 0
RPS5_ENST00000601521 RPS5 P46782 40S ribosomal protein S5 chr19 Not Cancer Driver No 1 intact, hippie 38 40 8 8 0
RPS9_ENST00000391752 RPS9 P46781 40S ribosomal protein S9 chr19 Not Cancer Driver No 1 intact, hippie 23 34 5 5 0
SART3 SART3 Q15020 Squamous cell carcinoma antigen recognized by T-cells 3 chr12 Not Cancer Driver No 1 hippie, biogrid 101 404 45 45 0
SF3B2 SF3B2 Q13435 Splicing factor 3B subunit 2 chr11 Not Cancer Driver No 1 hippie, biogrid 110 804 105 105 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 70 435 31 31 0
SLC25A1 SLC25A1 P53007 Tricarboxylate transport protein, mitochondrial chr22 Not Cancer Driver No 1 intact, hippie 22 34 2 2 17
SLC25A10_ENST00000350690 SLC25A10 Q9UBX3 Mitochondrial dicarboxylate carrier chr17 Not Cancer Driver No 1 hippie 33 0 0 0 0
SLC25A13_ENST00000265631 SLC25A13 Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 chr7 Not Cancer Driver No 1 intact, hippie 111 23 2 2 1
SLC25A22_ENST00000628067 SLC25A22 Q9H936 Mitochondrial glutamate carrier 1 chr11 Not Cancer Driver No 1 hippie 34 22 2 2 1
SLC25A3 SLC25A3 Q00325 Phosphate carrier protein, mitochondrial chr12 Not Cancer Driver No 1 intact, hippie 49 32 4 4 1
SLC25A5 SLC25A5 P05141 ADP/ATP translocase 2 chrX Not Cancer Driver No 1 intact, hippie 41 0 0 0 0
SNRPD2_ENST00000588301 SNRPD2 P62316 Small nuclear ribonucleoprotein Sm D2 chr19 Not Cancer Driver No 1 intact, hippie 19 67 12 12 0
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 intact, hippie 27 0 0 0 6
STAMBP_ENST00000339566 STAMBP O95630 STAM-binding protein chr2 Not Cancer Driver No 1 hippie, biogrid 51 139 16 16 6
SUCLA2 SUCLA2 Q9P2R7 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial chr13 Not Cancer Driver No 1 intact, hippie 51 46 6 6 3
TARBP2 TARBP2 Q15633 RISC-loading complex subunit TARBP2 chr12 Not Cancer Driver No 1 hippie, biogrid 45 203 22 22 0
TBX20 TBX20 Q9UMR3 T-box transcription factor TBX20 chr7 Not Cancer Driver No 1 hippie, biogrid 117 201 54 54 2
TNRC6A TNRC6A Q8NDV7 Trinucleotide repeat-containing gene 6A protein chr16 Not Cancer Driver No 4 intact, hippie, biogrid 284 1830 265 265 0
TNRC6B TNRC6B Q9UPQ9 Trinucleotide repeat-containing gene 6B protein chr22 Not Cancer Driver No 2 intact, hippie 205 1735 195 195 0
TNRC6C_ENST00000301624 TNRC6C Q9HCJ0 Trinucleotide repeat-containing gene 6C protein chr17 Not Cancer Driver No 2 intact, hippie, biogrid 170 1564 162 162 0
TRIM21 TRIM21 P19474 E3 ubiquitin-protein ligase TRIM21 chr11 Not Cancer Driver No 1 intact, hippie 85 49 7 7 0
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 Not Cancer Driver No 1 hippie, biogrid 69 385 38 38 0
TUBA1A TUBA1A Q71U36 Tubulin alpha-1A chain chr12 Not Cancer Driver No 1 intact, hippie 59 52 11 11 8
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 intact, hippie 40 63 11 11 5
TUBB4B TUBB4B P68371 Tubulin beta-4B chain chr9 Not Cancer Driver No 1 intact, hippie 52 65 11 11 2
TUFM TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie 51 50 3 3 1
TUT1_ENST00000476907 TUT1 Q9H6E5 Speckle targeted PIP5K1A-regulated poly(A) polymerase chr11 Not Cancer Driver No 1 hippie, biogrid 97 410 50 50 0
TYW3 TYW3 Q6IPR3 tRNA wybutosine-synthesizing protein 3 homolog chr1 Not Cancer Driver No 1 hippie, biogrid 35 57 12 12 0
USP34 USP34 Q70CQ2 Ubiquitin carboxyl-terminal hydrolase 34 chr2 Not Cancer Driver No 1 hippie, biogrid 436 725 90 90 0
UTP25 UTP25 Q68CQ4 U3 small nucleolar RNA-associated protein 25 homolog chr1 Not Cancer Driver No 1 hippie 116 277 28 28 0
WDR77 WDR77 Q9BQA1 Methylosome protein 50 chr1 Not Cancer Driver No 1 intact, hippie 30 41 2 2 0
WTIP WTIP A6NIX2 Wilms tumor protein 1-interacting protein chr19 Not Cancer Driver No 1 intact, hippie 32 217 2 2 0
YBX1 YBX1 P67809 Y-box-binding protein 1 chr1 Not Cancer Driver No 1 intact, hippie 41 312 41 41 0
ZBP1 ZBP1 Q9H171 Z-DNA-binding protein 1 chr20 Not Cancer Driver No 1 intact 97 385 80 80 0
ZFP42_ENST00000509524 ZFP42 Q96MM3 Zinc finger protein 42 homolog chr4 Not Cancer Driver No 1 hippie, biogrid 135 76 27 27 0
ZSWIM8_ENST00000605216 ZSWIM8 A7E2V4 Zinc finger SWIM domain-containing protein 8 chr10 Not Cancer Driver No 1 hippie, biogrid 204 877 103 103 0