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ADAMTS4 ,ADAMTS4 ,O75173
  • Uniprot Accession= O75173
  • Ensembl Transcript= ENST00000367996.5
  • Uniprot Name= ADAMTS4
  • Name= A disintegrin and metalloproteinase with thrombospondin motifs 4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 17
  • Number of Interaction partner in biogrid: 55
  • Number of Interaction partner in hippie: 70
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AC244197.3 IDS B3KWA1 Iduronate 2-sulfatase (Hunter syndrome), isoform CRA_e chrX Not Cancer Driver No 1 hippie, biogrid 57 21 3 3 0
ACAN ACAN P16112 Aggrecan core protein chr15 Not Cancer Driver No 1 hippie 477 1868 323 323 2
ADAM21 ADAM21 Q9UKJ8 Disintegrin and metalloproteinase domain-containing protein 21 chr14 Not Cancer Driver No 1 hippie, biogrid 167 4 1 1 0
ADAMTS2 ADAMTS2 O95450 A disintegrin and metalloproteinase with thrombospondin motifs 2 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 298 304 79 79 0
ADAMTS4 ADAMTS4 O75173 A disintegrin and metalloproteinase with thrombospondin motifs 4 chr1 Not Cancer Driver No 1 hippie 134 159 27 27 0
ATP2B2 ATP2B2 Q01814 Plasma membrane calcium-transporting ATPase 2 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 248 360 82 82 0
BCAN BCAN Q96GW7 Brevican core protein chr1 Not Cancer Driver No 1 hippie 198 341 75 75 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 Not Cancer Driver No 2 hippie, biogrid 69 83 9 9 0
BIRC6 BIRC6 Q9NR09 Baculoviral IAP repeat-containing protein 6 chr2 Census, Compendium Yes 2 intact, hippie, biogrid 640 1312 170 170 0
BMP8B BMP8B P34820 Bone morphogenetic protein 8B chr1 Not Cancer Driver No 1 hippie, biogrid 21 90 3 3 0
CBWD2 CBWD2 Q8IUF1 COBW domain-containing protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 20 54 6 6 0
CBWD3 CBWD3 Q5JTY5 COBW domain-containing protein 3 chr9 Not Cancer Driver No 1 hippie, biogrid 16 62 1 1 0
CCDC33_ENST00000558821 CCDC33 Q8N5R6-4 Isoform 4 of Coiled-coil domain-containing protein 33 chr15 Not Cancer Driver No 2 hippie, biogrid 60 288 51 51 0
CERCAM CERCAM Q5T4B2 Inactive glycosyltransferase 25 family member 3 chr9 Not Cancer Driver No 1 hippie, biogrid 107 68 17 17 0
CHRNA5 CHRNA5 P30532 Neuronal acetylcholine receptor subunit alpha-5 chr15 Not Cancer Driver No 1 hippie, biogrid 63 24 3 3 0
DICER1 DICER1 Q9UPY3 Endoribonuclease Dicer chr14 Census, Compendium Yes 2 intact, hippie, biogrid 264 362 45 45 4
DPH6 DPH6 Q7L8W6 Diphthine--ammonia ligase chr15 Not Cancer Driver No 2 intact, hippie, biogrid 29 0 0 0 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
FEZ2_ENST00000405912 FEZ2 Q9UHY8 Fasciculation and elongation protein zeta-2 chr2 Not Cancer Driver No 1 hippie, biogrid 37 245 29 29 0
FN1 FN1 P02751 Fibronectin chr2 Compendium Yes 1 hippie 394 1243 185 185 8
FRAS1 FRAS1 Q86XX4 Extracellular matrix organizing protein FRAS1 chr4 Not Cancer Driver No 2 hippie, biogrid 628 806 116 116 0
FURIN_ENST00000610579 FURIN P09958 Furin chr15 Not Cancer Driver No 1 hippie 93 283 35 35 0
FUT11 FUT11 Q495W5 Alpha-(1,3)-fucosyltransferase 11 chr10 Not Cancer Driver No 1 hippie, biogrid 37 100 15 15 0
GANAB_ENST00000356638 GANAB Q14697 Neutral alpha-glucosidase AB chr11 Not Cancer Driver No 1 hippie, biogrid 129 132 20 20 3
GUSB GUSB P08236 Beta-glucuronidase chr7 Not Cancer Driver No 1 hippie, biogrid 93 11 0 0 36
HMGCLL1 HMGCLL1 Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic chr6 Not Cancer Driver No 1 hippie, biogrid 113 2 1 1 0
HP HP P00738 Haptoglobin chr16 Not Cancer Driver No 1 hippie 39 57 2 2 1
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 Not Cancer Driver No 1 hippie, biogrid 73 282 35 35 0
IDS IDS P22304 Iduronate 2-sulfatase chrX Not Cancer Driver No 1 hippie, biogrid 91 85 13 13 126
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 Not Cancer Driver No 1 hippie, biogrid 183 265 37 37 6
INSR INSR P06213 Insulin receptor chr19 Not Cancer Driver No 1 hippie, biogrid 190 280 57 57 64
ITPA ITPA Q9BY32 Inosine triphosphate pyrophosphatase chr20 Not Cancer Driver No 2 intact, hippie, biogrid 21 10 1 1 1
KIAA0232_ENST00000425103 KIAA0232 Q92628 Uncharacterized protein KIAA0232 chr4 Not Cancer Driver No 2 intact, hippie, biogrid 161 654 82 82 0
LGMN_ENST00000334869 LGMN Q99538 Legumain chr14 Not Cancer Driver No 1 hippie, biogrid 57 112 19 19 0
LOXL2 LOXL2 Q9Y4K0 Lysyl oxidase homolog 2 chr8 Not Cancer Driver No 2 intact, hippie, biogrid 134 39 4 4 0
LRP5 LRP5 O75197 Low-density lipoprotein receptor-related protein 5 chr11 Not Cancer Driver No 1 hippie, biogrid 253 188 28 28 55
LRP6 LRP6 O75581 Low-density lipoprotein receptor-related protein 6 chr12 Not Cancer Driver No 1 hippie, biogrid 206 255 30 30 5
MANBA MANBA O00462 Beta-mannosidase chr4 Not Cancer Driver No 2 hippie, biogrid 108 10 0 0 3
MKS1 MKS1 Q9NXB0 Meckel syndrome type 1 protein chr17 Not Cancer Driver No 2 intact, hippie, biogrid 82 152 23 23 2
MT2A MT2A P02795 Metallothionein-2 chr16 Not Cancer Driver No 1 hippie 8 0 0 0 0
NSUN3 NSUN3 Q9H649 tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 34 0 0 0 0
OLFM2 OLFM2 O95897 Noelin-2 chr19 Not Cancer Driver No 1 hippie, biogrid 74 16 2 2 0
OS9 OS9 Q13438 Protein OS-9 chr12 Not Cancer Driver No 1 hippie, biogrid 72 451 49 49 0
P3H3 P3H3 Q8IVL6 Prolyl 3-hydroxylase 3 chr12 Not Cancer Driver No 1 hippie 84 307 40 40 0
P3H4_ENST00000393928 P3H4 Q92791 Endoplasmic reticulum protein SC65 chr17 Not Cancer Driver No 1 hippie, biogrid 46 82 9 9 0
PCSK9 PCSK9 Q8NBP7 Proprotein convertase subtilisin/kexin type 9 chr1 Not Cancer Driver No 1 hippie, biogrid 86 148 27 27 9
PDIA4 PDIA4 P13667 Protein disulfide-isomerase A4 chr7 Not Cancer Driver No 1 hippie, biogrid 81 147 22 22 0
PRKAG3_ENST00000529249 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 chr2 Not Cancer Driver No 1 hippie 74 144 25 25 0
RAD51B_ENST00000487270 RAD51B O15315 DNA repair protein RAD51 homolog 2 chr14 Census Yes 2 hippie, biogrid 45 13 0 0 0
RAD51C RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 Not Cancer Driver No 1 hippie, biogrid 47 18 2 2 6
RCN2_ENST00000394885 RCN2 Q14257 Reticulocalbin-2 chr15 Not Cancer Driver No 1 hippie, biogrid 35 125 11 11 0
SCPEP1 SCPEP1 Q9HB40 Retinoid-inducible serine carboxypeptidase chr17 Not Cancer Driver No 1 hippie, biogrid 46 1 0 0 0
SERPINA1 SERPINA1 P01009 Alpha-1-antitrypsin chr14 Not Cancer Driver No 1 hippie 66 38 7 7 0
SERPINA3_ENST00000393080 SERPINA3 P01011 Alpha-1-antichymotrypsin chr14 Not Cancer Driver No 1 hippie 117 18 10 10 0
SIL1_ENST00000265195 SIL1 Q9H173 Nucleotide exchange factor SIL1 chr5 Not Cancer Driver No 1 hippie, biogrid 39 125 12 12 0
SRPX2 SRPX2 O60687 Sushi repeat-containing protein SRPX2 chrX Not Cancer Driver No 1 hippie 86 64 13 13 0
TARBP2 TARBP2 Q15633 RISC-loading complex subunit TARBP2 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 45 203 22 22 0
TFAP4 TFAP4 Q01664 Transcription factor AP-4 chr16 Compendium Yes 2 intact, hippie, biogrid 61 285 52 52 0
TOR3A TOR3A Q9H497 Torsin-3A chr1 Not Cancer Driver No 1 hippie, biogrid 50 15 0 0 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 63 4 1 1 0
TUBA1A TUBA1A Q71U36 Tubulin alpha-1A chain chr12 Not Cancer Driver No 1 intact, hippie, biogrid 59 52 11 11 8
TUBA1C_ENST00000301072 TUBA1C Q9BQE3 Tubulin alpha-1C chain chr12 Not Cancer Driver No 1 hippie, biogrid 39 50 5 5 0
TUBA4A TUBA4A P68366 Tubulin alpha-4A chain chr2 Not Cancer Driver No 1 intact, hippie, biogrid 73 39 4 4 5
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 hippie, biogrid 40 63 11 11 5
TUBB1 TUBB1 Q9H4B7 Tubulin beta-1 chain chr20 Not Cancer Driver No 2 intact, hippie, biogrid 71 38 4 4 1
TUBB3 TUBB3 Q13509 Tubulin beta-3 chain chr16 Not Cancer Driver No 2 intact, hippie, biogrid 67 53 10 10 12
UGGT2 UGGT2 Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 chr13 Not Cancer Driver No 1 hippie, biogrid 190 64 6 6 0
XIAP_ENST00000434753 XIAP P98170 E3 ubiquitin-protein ligase XIAP chrX Not Cancer Driver No 2 hippie, biogrid 89 55 6 6 0
YTHDC1_ENST00000344157 YTHDC1 Q96MU7 YTH domain-containing protein 1 chr4 Not Cancer Driver No 1 intact, hippie 137 597 117 117 0
ZBTB16_ENST00000392996 ZBTB16 Q05516 Zinc finger and BTB domain-containing protein 16 chr11 Census, Compendium Yes 1 hippie 131 268 50 50 1