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RGS21 ,RGS21 ,Q2M5E4
  • Uniprot Accession= Q2M5E4
  • Ensembl Transcript= ENST00000417209.2
  • Uniprot Name= RGS21
  • Name= Regulator of G-protein signaling 21
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 4
GO term GO name GO namespace GO def
GO:0007186 G protein-coupled receptor signaling pathway biological_process A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
GO:0009968 negative regulation of signal transduction biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. [GOC:sm]
GO:0003924 GTPase activity molecular_function Catalysis of the reaction
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]