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Total number of protein in "GO:2001233" GO term:  243

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACAA2 ACAA2 P42765 3-ketoacyl-CoA thiolase, mitochondrial chr18 GO:2001233 Not Cancer Driver No 42 0.106 51 2 0.039 0
ACKR3 ACKR3 P25106 Atypical chemokine receptor 3 chr2 GO:2001233 Census, Compendium Yes 78 0.215 0 0 0.0 1
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:2001233 Census, Compendium Yes 108 0.225 158 24 0.152 4
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:2001233 Not Cancer Driver No 146 0.148 450 70 0.156 0
ARMC10 ARMC10 Q8N2F6 Armadillo repeat-containing protein 10 chr7 GO:2001233 Not Cancer Driver No 39 0.114 58 4 0.069 0
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 GO:2001233 Not Cancer Driver No 46 0.112 122 22 0.18 0
ATAD5 ATAD5 Q96QE3 ATPase family AAA domain-containing protein 5 chr17 GO:2001233 Not Cancer Driver No 200 0.108 1075 112 0.104 0
ATF3_ENST00000366987 ATF3 P18847 Cyclic AMP-dependent transcription factor ATF-3 chr1 GO:2001233 Not Cancer Driver No 23 0.127 118 14 0.119 0
AVP AVP P01185 Vasopressin-neurophysin 2-copeptin chr20 GO:2001233 Not Cancer Driver No 14 0.085 26 0 0.0 39
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:2001233 Not Cancer Driver No 14 0.083 163 14 0.086 0
BAG5_ENST00000299204 BAG5 Q9UL15 BAG family molecular chaperone regulator 5 chr14 GO:2001233 Not Cancer Driver No 37 0.083 63 7 0.111 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:2001233 Census Yes 30 0.156 39 2 0.051 0
BBC3 BBC3 Q96PG8 Bcl-2-binding component 3, isoforms 3/4 chr19 GO:2001233 Not Cancer Driver No 20 0.077 253 20 0.079 0
BCAP31_ENST00000345046 BCAP31 P51572 B-cell receptor-associated protein 31 chrX GO:2001233 Not Cancer Driver No 37 0.15 104 14 0.135 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 GO:2001233 Not Cancer Driver No 29 0.124 55 3 0.055 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 GO:2001233 Not Cancer Driver No 42 0.212 130 17 0.131 0
BCL2L2 BCL2L2 Q92843 Bcl-2-like protein 2 chr14 GO:2001233 Not Cancer Driver No 22 0.114 34 6 0.176 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 GO:2001233 Census, Compendium Yes 24 0.1 72 5 0.069 0
BCLAF1 BCLAF1 Q9NYF8 Bcl-2-associated transcription factor 1 chr6 GO:2001233 Census, Compendium Yes 421 0.458 899 408 0.454 0
BDKRB2 BDKRB2 P30411 B2 bradykinin receptor chr14 GO:2001233 Not Cancer Driver No 81 0.207 0 0 0.0 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:2001233 Not Cancer Driver No 45 0.1 190 19 0.1 0
BID_ENST00000551952 BID P55957 BH3-interacting domain death agonist chr22 GO:2001233 Not Cancer Driver No 23 0.118 74 9 0.122 0
BMP5 BMP5 P22003 Bone morphogenetic protein 5 chr6 GO:2001233 Census Yes 163 0.359 112 62 0.554 0
BMPR1B_ENST00000394931 BMPR1B O00238 Bone morphogenetic protein receptor type-1B chr4 GO:2001233 Not Cancer Driver No 84 0.167 64 12 0.188 5
BOK BOK Q9UMX3 Bcl-2-related ovarian killer protein chr2 GO:2001233 Not Cancer Driver No 7 0.033 0 0 0.0 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:2001233 Census, Compendium Yes 224 0.12 1458 174 0.119 35
CAAP1 CAAP1 Q9H8G2 Caspase activity and apoptosis inhibitor 1 chr9 GO:2001233 Not Cancer Driver No 28 0.078 234 18 0.077 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:2001233 Not Cancer Driver No 30 0.169 2 0 0.0 0
CCAR2 CCAR2 Q8N163 Cell cycle and apoptosis regulator protein 2 chr8 GO:2001233 Not Cancer Driver No 102 0.111 528 62 0.117 0
CD44 CD44 P16070 CD44 antigen chr11 GO:2001233 Not Cancer Driver No 75 0.101 542 60 0.111 0
CD74 CD74 P04233 HLA class II histocompatibility antigen gamma chain chr5 GO:2001233 Census Yes 31 0.105 185 20 0.108 0
CDKN2D_ENST00000335766 CDKN2D P55273 Cyclin-dependent kinase 4 inhibitor D chr19 GO:2001233 Not Cancer Driver No 17 0.102 44 3 0.068 0
CFLAR CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 GO:2001233 Not Cancer Driver No 40 0.083 44 2 0.045 0
CLU_ENST00000523500 CLU P10909 Clusterin chr8 GO:2001233 Not Cancer Driver No 69 0.154 156 27 0.173 0
COL2A1 COL2A1 P02458 Collagen alpha-1(II) chain chr12 GO:2001233 Census Yes 258 0.174 1215 207 0.17 64
CREB3 CREB3 O43889 Cyclic AMP-responsive element-binding protein 3 chr9 GO:2001233 Not Cancer Driver No 33 0.089 168 11 0.065 0
CREB3L1 CREB3L1 Q96BA8 Cyclic AMP-responsive element-binding protein 3-like protein 1 chr11 GO:2001233 Census Yes 68 0.131 372 50 0.134 0
CSF2 CSF2 P04141 Granulocyte-macrophage colony-stimulating factor chr5 GO:2001233 Not Cancer Driver No 11 0.076 34 3 0.088 0
CTNNA1 CTNNA1 P35221 Catenin alpha-1 chr5 GO:2001233 Census Yes 126 0.139 268 35 0.131 4
CX3CL1 CX3CL1 P78423 Fractalkine chr16 GO:2001233 Not Cancer Driver No 66 0.166 259 44 0.17 0
CXCL12_ENST00000374429 CXCL12 P48061 Stromal cell-derived factor 1 chr10 GO:2001233 Not Cancer Driver No 16 0.172 0 0 0.0 0
DDIAS DDIAS Q8IXT1 DNA damage-induced apoptosis suppressor protein chr11 GO:2001233 Not Cancer Driver No 125 0.125 370 59 0.159 0
DDIT3_ENST00000623876 DDIT3 P35638 DNA damage-inducible transcript 3 protein chr12 GO:2001233 Census Yes 29 0.172 160 27 0.169 0
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX GO:2001233 Census, Compendium Yes 133 0.201 301 47 0.156 18
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 GO:2001233 Not Cancer Driver No 37 0.093 153 16 0.105 0
DNM1L_ENST00000549701 DNM1L O00429 Dynamin-1-like protein chr12 GO:2001233 Not Cancer Driver No 67 0.091 212 23 0.108 7
EIF2AK3 EIF2AK3 Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 chr2 GO:2001233 Not Cancer Driver No 149 0.134 410 51 0.124 1
EIF5A_ENST00000419711 EIF5A P63241 Eukaryotic translation initiation factor 5A-1 chr17 GO:2001233 Not Cancer Driver No 37 0.24 21 5 0.238 5
ELL3 ELL3 Q9HB65 RNA polymerase II elongation factor ELL3 chr15 GO:2001233 Not Cancer Driver No 50 0.126 186 13 0.07 0
ENO1 ENO1 P06733 Alpha-enolase chr1 GO:2001233 Not Cancer Driver No 51 0.118 21 2 0.095 0
EPO EPO P01588 Erythropoietin chr7 GO:2001233 Not Cancer Driver No 27 0.14 9 1 0.111 1
ERP29 ERP29 P30040 Endoplasmic reticulum resident protein 29 chr12 GO:2001233 Not Cancer Driver No 29 0.111 34 5 0.147 0
EYA1_ENST00000647540 EYA1 Q99502 Eyes absent homolog 1 chr8 GO:2001233 Not Cancer Driver No 168 0.284 341 99 0.29 15
EYA2 EYA2 O00167 Eyes absent homolog 2 chr20 GO:2001233 Not Cancer Driver No 107 0.199 204 50 0.245 0
EYA3 EYA3 Q99504 Eyes absent homolog 3 chr1 GO:2001233 Not Cancer Driver No 58 0.101 310 40 0.129 0
EYA4_ENST00000367895 EYA4 O95677 Eyes absent homolog 4 chr6 GO:2001233 Not Cancer Driver No 183 0.286 337 108 0.32 2
FAF1 FAF1 Q9UNN5 FAS-associated factor 1 chr1 GO:2001233 Not Cancer Driver No 83 0.128 241 34 0.141 0
FAIM2 FAIM2 Q9BWQ8 Protein lifeguard 2 chr12 GO:2001233 Not Cancer Driver No 37 0.117 54 11 0.204 0
FAIM_ENST00000393035 FAIM Q9NVQ4 Fas apoptotic inhibitory molecule 1 chr3 GO:2001233 Not Cancer Driver No 20 0.112 1 0 0.0 0
FBH1_ENST00000362091 FBH1 Q8NFZ0 F-box DNA helicase 1 chr10 GO:2001233 Not Cancer Driver No 139 0.133 192 32 0.167 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:2001233 Census, Compendium Yes 322 0.455 230 38 0.165 0
FEM1B FEM1B Q9UK73 Protein fem-1 homolog B chr15 GO:2001233 Not Cancer Driver No 69 0.11 33 3 0.091 0
FGA FGA P02671 Fibrinogen alpha chain chr4 GO:2001233 Not Cancer Driver No 245 0.283 522 149 0.285 7
FGB FGB P02675 Fibrinogen beta chain chr4 GO:2001233 Not Cancer Driver No 89 0.181 143 29 0.203 7
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:2001233 Not Cancer Driver No 56 0.269 34 11 0.324 2
FGFR1_ENST00000447712 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 GO:2001233 Census, Compendium Yes 152 0.185 230 43 0.187 74
FGG FGG P02679 Fibrinogen gamma chain chr4 GO:2001233 Not Cancer Driver No 81 0.179 53 8 0.151 8
FIS1 FIS1 Q9Y3D6 Mitochondrial fission 1 protein chr7 GO:2001233 Not Cancer Driver No 25 0.164 6 0 0.0 0
FLCN FLCN Q8NFG4 Folliculin chr17 GO:2001233 Census, Compendium Yes 59 0.102 157 19 0.121 5
FXN FXN Q16595 Frataxin, mitochondrial chr9 GO:2001233 Not Cancer Driver No 16 0.076 73 0 0.0 8
FZD9 FZD9 O00144 Frizzled-9 chr7 GO:2001233 Not Cancer Driver No 55 0.093 61 0 0.0 0
GATA1 GATA1 P15976 Erythroid transcription factor chrX GO:2001233 Census, Compendium Yes 68 0.165 242 41 0.169 5
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:2001233 Not Cancer Driver No 73 0.115 167 18 0.108 3
GDNF_ENST00000326524 GDNF P39905 Glial cell line-derived neurotrophic factor chr5 GO:2001233 Not Cancer Driver No 47 0.223 83 18 0.217 2
GFRAL GFRAL Q6UXV0 GDNF family receptor alpha-like chr6 GO:2001233 Not Cancer Driver No 176 0.447 5 2 0.4 0
GHITM GHITM Q9H3K2 Growth hormone-inducible transmembrane protein chr10 GO:2001233 Not Cancer Driver No 50 0.145 8 0 0.0 0
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:2001233 Not Cancer Driver No 38 0.187 12 1 0.083 0
GRINA_ENST00000395068 GRINA Q7Z429 Protein lifeguard 1 chr8 GO:2001233 Not Cancer Driver No 39 0.105 150 15 0.1 0
GSDME_ENST00000409775 GSDME O60443 Gasdermin-E chr7 GO:2001233 Not Cancer Driver No 81 0.163 14 3 0.214 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 GO:2001233 Not Cancer Driver No 56 0.133 146 13 0.089 0
HERPUD1 HERPUD1 Q15011 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein chr16 GO:2001233 Census Yes 38 0.097 248 17 0.069 0
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 GO:2001233 Compendium Yes 233 0.32 43 16 0.372 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 GO:2001233 Census Yes 118 0.143 435 51 0.117 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 GO:2001233 Not Cancer Driver No 38 0.182 207 38 0.184 0
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:2001233 Not Cancer Driver No 46 0.16 81 13 0.16 0
HNRNPK_ENST00000351839 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K chr9 GO:2001233 Not Cancer Driver No 75 0.162 302 59 0.195 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 GO:2001233 Not Cancer Driver No 24 0.037 200 13 0.065 0
HSPA1B HSPA1B P0DMV9 Heat shock 70 kDa protein 1B chr6 GO:2001233 Not Cancer Driver No 15 0.023 200 5 0.025 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 GO:2001233 Not Cancer Driver No 10 0.049 118 8 0.068 20
HTRA2 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 GO:2001233 Compendium Yes 44 0.096 127 9 0.071 2
HYOU1 HYOU1 Q9Y4L1 Hypoxia up-regulated protein 1 chr11 GO:2001233 Not Cancer Driver No 132 0.132 373 47 0.126 0
ICAM1 ICAM1 P05362 Intercellular adhesion molecule 1 chr19 GO:2001233 Not Cancer Driver No 61 0.115 251 28 0.112 0
IFI6_ENST00000361157 IFI6 P09912 Interferon alpha-inducible protein 6 chr1 GO:2001233 Not Cancer Driver No 12 0.092 7 0 0.0 0
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:2001233 Not Cancer Driver No 45 0.231 87 23 0.264 0
IL19_ENST00000270218 IL19 Q9UHD0 Interleukin-19 chr1 GO:2001233 Not Cancer Driver No 16 0.09 0 0 0.0 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:2001233 Not Cancer Driver No 30 0.111 35 6 0.171 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:2001233 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL20RA IL20RA Q9UHF4 Interleukin-20 receptor subunit alpha chr6 GO:2001233 Not Cancer Driver No 72 0.13 231 29 0.126 0
IL7 IL7 P13232 Interleukin-7 chr8 GO:2001233 Not Cancer Driver No 29 0.164 19 4 0.211 0
IL9 IL9 P15248 Interleukin-9 chr5 GO:2001233 Not Cancer Driver No 12 0.083 4 0 0.0 0
ING2 ING2 Q9H160 Inhibitor of growth protein 2 chr4 GO:2001233 Not Cancer Driver No 33 0.118 169 26 0.154 0
INHBA_ENST00000442711 INHBA P08476 Inhibin beta A chain chr7 GO:2001233 Not Cancer Driver No 148 0.347 154 63 0.409 0
INS INS P01308 Insulin chr11 GO:2001233 Not Cancer Driver No 15 0.136 5 1 0.2 22
ITPRIP_ENST00000358187 ITPRIP Q8IWB1 Inositol 1,4,5-trisphosphate receptor-interacting protein chr10 GO:2001233 Not Cancer Driver No 62 0.113 66 10 0.152 0
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:2001233 Not Cancer Driver No 67 0.079 291 28 0.096 3
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 GO:2001233 Census Yes 86 0.169 94 13 0.138 1
LGALS3 LGALS3 P17931 Galectin-3 chr14 GO:2001233 Not Cancer Driver No 15 0.06 133 6 0.045 0
LMNA LMNA P02545 Prelamin-A/C chr1 GO:2001233 Census Yes 68 0.102 544 49 0.09 131
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:2001233 Not Cancer Driver No 519 0.205 90 17 0.189 23
MADD MADD Q8WXG6 MAP kinase-activating death domain protein chr11 GO:2001233 Not Cancer Driver No 207 0.126 723 81 0.112 4
MAGEA3 MAGEA3 P43357 Melanoma-associated antigen 3 chrX GO:2001233 Not Cancer Driver No 79 0.252 103 18 0.175 0
MAL MAL P21145 Myelin and lymphocyte protein chr2 GO:2001233 Not Cancer Driver No 21 0.137 0 0 0.0 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:2001233 Not Cancer Driver No 40 0.089 85 10 0.118 0
MAPK7 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 GO:2001233 Not Cancer Driver No 92 0.113 490 50 0.102 0
MARCH7 MARCHF7 Q9H992 E3 ubiquitin-protein ligase MARCHF7 chr2 GO:2001233 Not Cancer Driver No 85 0.121 550 68 0.124 0
MCL1 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 GO:2001233 Not Cancer Driver No 30 0.086 203 21 0.103 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:2001233 Census, Compendium Yes 56 0.114 297 37 0.125 0
MIF MIF P14174 Macrophage migration inhibitory factor chr22 GO:2001233 Not Cancer Driver No 4 0.035 0 0 0.0 0
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:2001233 Not Cancer Driver No 129 0.182 124 26 0.21 0
MPV17L MPV17L Q2QL34 Mpv17-like protein chr16 GO:2001233 Not Cancer Driver No 16 0.082 3 0 0.0 0
MSX1 MSX1 P28360 Homeobox protein MSX-1 chr4 GO:2001233 Not Cancer Driver No 39 0.129 197 16 0.081 7
MUC1_ENST00000611571 MUC1 P15941 Mucin-1 chr1 GO:2001233 Census Yes 40 0.032 1050 19 0.018 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:2001233 Census, Compendium Yes 80 0.182 299 46 0.154 0
NACC2_ENST00000371753 NACC2 Q96BF6 Nucleus accumbens-associated protein 2 chr9 GO:2001233 Not Cancer Driver No 24 0.041 238 10 0.042 0
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 GO:2001233 Not Cancer Driver No 48 0.127 111 17 0.153 0
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 GO:2001233 Not Cancer Driver No 89 0.234 88 19 0.216 0
NF1 NF1 P21359 Neurofibromin chr17 GO:2001233 Census, Compendium Yes 375 0.132 406 47 0.116 85
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:2001233 Census, Compendium Yes 228 0.377 402 62 0.154 4
NKX3-1 NKX3-1 Q99801 Homeobox protein Nkx-3.1 chr8 GO:2001233 Not Cancer Driver No 35 0.15 171 16 0.094 0
NLE1 NLE1 Q9NVX2 Notchless protein homolog 1 chr17 GO:2001233 Not Cancer Driver No 60 0.124 21 3 0.143 0
NME5 NME5 P56597 Nucleoside diphosphate kinase homolog 5 chr5 GO:2001233 Not Cancer Driver No 17 0.08 6 0 0.0 0
NOL3_ENST00000268605 NOL3 O60936 Nucleolar protein 3 chr16 GO:2001233 Not Cancer Driver No 20 0.096 179 17 0.095 2
NONO NONO Q15233 Non-POU domain-containing octamer-binding protein chrX GO:2001233 Census, Compendium Yes 101 0.214 349 64 0.183 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 GO:2001233 Not Cancer Driver No 168 0.14 347 38 0.11 0
NOX1 NOX1 Q9Y5S8 NADPH oxidase 1 chrX GO:2001233 Not Cancer Driver No 101 0.179 18 8 0.444 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 GO:2001233 Not Cancer Driver No 10 0.122 82 10 0.122 0
OPA1_ENST00000392438 OPA1 O60313 Dynamin-like 120 kDa protein, mitochondrial chr3 GO:2001233 Not Cancer Driver No 114 0.119 131 17 0.13 60
P4HB P4HB P07237 Protein disulfide-isomerase chr17 GO:2001233 Not Cancer Driver No 61 0.12 79 15 0.19 1
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:2001233 Not Cancer Driver No 11 0.058 30 0 0.0 5
PARL PARL Q9H300 Presenilins-associated rhomboid-like protein, mitochondrial chr3 GO:2001233 Not Cancer Driver No 49 0.129 28 5 0.179 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:2001233 Not Cancer Driver No 119 0.117 320 34 0.106 0
PDX1 PDX1 P52945 Pancreas/duodenum homeobox protein 1 chr13 GO:2001233 Not Cancer Driver No 32 0.113 238 23 0.097 0
PEA15_ENST00000360472 PEA15 Q15121 Astrocytic phosphoprotein PEA-15 chr1 GO:2001233 Not Cancer Driver No 12 0.092 35 5 0.143 0
PF4 PF4 P02776 Platelet factor 4 chr4 GO:2001233 Not Cancer Driver No 13 0.129 0 0 0.0 0
PIAS4 PIAS4 Q8N2W9 E3 SUMO-protein ligase PIAS4 chr19 GO:2001233 Not Cancer Driver No 58 0.114 142 23 0.162 0
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 GO:2001233 Not Cancer Driver No 30 0.103 157 13 0.083 0
PIK3CB_ENST00000477593 PIK3CB P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform chr3 GO:2001233 Census, Compendium Yes 150 0.14 42 4 0.095 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 GO:2001233 Not Cancer Driver No 57 0.098 99 13 0.131 23
PLAGL2 PLAGL2 Q9UPG8 Zinc finger protein PLAGL2 chr20 GO:2001233 Not Cancer Driver No 62 0.125 204 29 0.142 0
PLAUR PLAUR Q03405 Urokinase plasminogen activator surface receptor chr19 GO:2001233 Not Cancer Driver No 49 0.146 18 5 0.278 0
PLEKHF1 PLEKHF1 Q96S99 Pleckstrin homology domain-containing family F member 1 chr19 GO:2001233 Not Cancer Driver No 30 0.108 65 10 0.154 0
PMAIP1 PMAIP1 Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 chr18 GO:2001233 Not Cancer Driver No 2 0.037 23 1 0.043 0
PPIA PPIA P62937 Peptidyl-prolyl cis-trans isomerase A chr7 GO:2001233 Not Cancer Driver No 11 0.067 24 3 0.125 0
PPIF PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial chr10 GO:2001233 Not Cancer Driver No 19 0.092 43 4 0.093 0
PPP1CA_ENST00000376745 PPP1CA P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit chr11 GO:2001233 Not Cancer Driver No 38 0.115 27 6 0.222 0
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 GO:2001233 Census, Compendium Yes 179 0.304 0 0 0.0 4
PPP2R1B_ENST00000527614 PPP2R1B P30154 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform chr11 GO:2001233 Not Cancer Driver No 72 0.12 17 1 0.059 0
PRDX2 PRDX2 P32119 Peroxiredoxin-2 chr19 GO:2001233 Not Cancer Driver No 24 0.121 30 4 0.133 0
PRELID1 PRELID1 Q9Y255 PRELI domain-containing protein 1, mitochondrial chr5 GO:2001233 Not Cancer Driver No 21 0.096 44 2 0.045 0
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:2001233 Not Cancer Driver No 110 0.237 78 15 0.192 31
PRKRA PRKRA O75569 Interferon-inducible double-stranded RNA-dependent protein kinase activator A chr2 GO:2001233 Not Cancer Driver No 41 0.131 104 12 0.115 1
PSMD10 PSMD10 O75832 26S proteasome non-ATPase regulatory subunit 10 chrX GO:2001233 Not Cancer Driver No 20 0.088 53 5 0.094 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 GO:2001233 Census, Compendium Yes 505 1.253 76 4 0.053 41
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:2001233 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:2001233 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPN2 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 GO:2001233 Not Cancer Driver No 57 0.137 120 14 0.117 0
PTTG1IP PTTG1IP P53801 Pituitary tumor-transforming gene 1 protein-interacting protein chr21 GO:2001233 Not Cancer Driver No 23 0.128 30 9 0.3 0
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 GO:2001233 Not Cancer Driver No 34 0.107 13 0 0.0 0
RAD9A RAD9A Q99638 Cell cycle checkpoint control protein RAD9A chr11 GO:2001233 Not Cancer Driver No 34 0.087 135 7 0.052 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 GO:2001233 Census, Compendium Yes 89 0.137 169 38 0.225 22
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:2001233 Census, Compendium Yes 208 0.187 105 12 0.114 139
RFFL_ENST00000394597 RFFL Q8WZ73 E3 ubiquitin-protein ligase rififylin chr17 GO:2001233 Not Cancer Driver No 50 0.138 150 21 0.14 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:2001233 Compendium Yes 82 0.122 277 39 0.141 4
RIPK3 RIPK3 Q9Y572 Receptor-interacting serine/threonine-protein kinase 3 chr14 GO:2001233 Not Cancer Driver No 66 0.127 295 39 0.132 0
RNF183_ENST00000297894 RNF183 Q96D59 E3 ubiquitin-protein ligase RNF183 chr9 GO:2001233 Not Cancer Driver No 22 0.115 29 1 0.034 0
RNF34_ENST00000361234 RNF34 Q969K3 E3 ubiquitin-protein ligase RNF34 chr12 GO:2001233 Not Cancer Driver No 30 0.081 112 7 0.062 0
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 GO:2001233 Not Cancer Driver No 16 0.11 114 13 0.114 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:2001233 Not Cancer Driver No 22 0.091 48 4 0.083 0
RPS7_ENST00000645674 RPS7 P62081 40S ribosomal protein S7 chr2 GO:2001233 Not Cancer Driver No 29 0.149 39 7 0.179 0
RRM2B RRM2B Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B chr8 GO:2001233 Not Cancer Driver No 46 0.131 32 5 0.156 9
RRN3 RRN3 Q9NYV6 RNA polymerase I-specific transcription initiation factor RRN3 chr16 GO:2001233 Not Cancer Driver No 66 0.101 115 15 0.13 0
S100A8 S100A8 P05109 Protein S100-A8 chr1 GO:2001233 Not Cancer Driver No 22 0.237 8 4 0.5 0
S100A9 S100A9 P06702 Protein S100-A9 chr1 GO:2001233 Not Cancer Driver No 18 0.158 76 7 0.092 0
SCRT2 SCRT2 Q9NQ03 Transcriptional repressor scratch 2 chr20 GO:2001233 Not Cancer Driver No 19 0.062 168 4 0.024 0
SELENOS SELENOS Q9BQE4 Selenoprotein S chr15 GO:2001233 Not Cancer Driver No 7 0.037 122 6 0.049 0
SEPT4_ENST00000317268 SEPTIN4 O43236 Septin-4 chr17 GO:2001233 Not Cancer Driver No 61 0.128 220 31 0.141 0
SERINC3_ENST00000255175 SERINC3 Q13530 Serine incorporator 3 chr20 GO:2001233 Not Cancer Driver No 73 0.154 38 9 0.237 0
SERPINE1 SERPINE1 P05121 Plasminogen activator inhibitor 1 chr7 GO:2001233 Not Cancer Driver No 78 0.194 7 2 0.286 0
SFPQ SFPQ P23246 Splicing factor, proline- and glutamine-rich chr1 GO:2001233 Census Yes 59 0.083 595 48 0.081 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:2001233 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:2001233 Not Cancer Driver No 47 0.159 1 0 0.0 0
SIAH1_ENST00000394725 SIAH1 Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 chr16 GO:2001233 Not Cancer Driver No 35 0.124 28 2 0.071 5
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:2001233 Not Cancer Driver No 70 0.094 435 31 0.071 0
SKIL_ENST00000259119 SKIL P12757 Ski-like protein chr3 GO:2001233 Not Cancer Driver No 77 0.113 356 32 0.09 0
SLC25A31 SLC25A31 Q9H0C2 ADP/ATP translocase 4 chr4 GO:2001233 Not Cancer Driver No 68 0.216 8 0 0.0 0
SLC25A4 SLC25A4 P12235 ADP/ATP translocase 1 chr4 GO:2001233 Not Cancer Driver No 24 0.081 0 0 0.0 9
SLC25A5 SLC25A5 P05141 ADP/ATP translocase 2 chrX GO:2001233 Not Cancer Driver No 41 0.138 0 0 0.0 0
SLC25A6 SLC25A6 P12236 ADP/ATP translocase 3 chrX GO:2001233 Not Cancer Driver No 41 0.138 0 0 0.0 0
SLC35F6 SLC35F6 Q8N357 Solute carrier family 35 member F6 chr2 GO:2001233 Not Cancer Driver No 33 0.089 13 0 0.0 0
SLC9A3R1 SLC9A3R1 O14745 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 chr17 GO:2001233 Not Cancer Driver No 19 0.053 318 16 0.05 4
SNAI1 SNAI1 O95863 Zinc finger protein SNAI1 chr20 GO:2001233 Not Cancer Driver No 52 0.197 97 11 0.113 0
SNAI2_ENST00000020945 SNAI2 O43623 Zinc finger protein SNAI2 chr8 GO:2001233 Not Cancer Driver No 52 0.194 52 9 0.173 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 GO:2001233 Not Cancer Driver No 16 0.104 93 9 0.097 79
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:2001233 Not Cancer Driver No 32 0.144 25 5 0.2 0
SP100_ENST00000264052 SP100 P23497 Nuclear autoantigen Sp-100 chr2 GO:2001233 Not Cancer Driver No 136 0.155 680 101 0.149 0
SRPX SRPX P78539 Sushi repeat-containing protein SRPX chrX GO:2001233 Not Cancer Driver No 71 0.153 60 10 0.167 0
STK3_ENST00000419617 STK3 Q13188 Serine/threonine-protein kinase 3 chr8 GO:2001233 Not Cancer Driver No 70 0.143 241 32 0.133 0
STK4 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 GO:2001233 Not Cancer Driver No 70 0.144 231 30 0.13 0
STRADB STRADB Q9C0K7 STE20-related kinase adapter protein beta chr2 GO:2001233 Not Cancer Driver No 53 0.127 84 7 0.083 0
STX4 STX4 Q12846 Syntaxin-4 chr16 GO:2001233 Not Cancer Driver No 50 0.168 152 20 0.132 0
STYXL1_ENST00000359697 STYXL1 Q9Y6J8 Serine/threonine/tyrosine-interacting-like protein 1 chr7 GO:2001233 Not Cancer Driver No 55 0.176 18 3 0.167 0
SYVN1 SYVN1 Q86TM6 E3 ubiquitin-protein ligase synoviolin chr11 GO:2001233 Not Cancer Driver No 63 0.102 284 32 0.113 0
TAF9 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 GO:2001233 Not Cancer Driver No 25 0.095 203 19 0.094 0
TAF9B TAF9B Q9HBM6 Transcription initiation factor TFIID subunit 9B chrX GO:2001233 Not Cancer Driver No 48 0.191 189 34 0.18 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:2001233 Census Yes 110 0.097 212 16 0.075 31
THBS1 THBS1 P07996 Thrombospondin-1 chr15 GO:2001233 Not Cancer Driver No 188 0.161 320 58 0.181 0
TIMP3 TIMP3 P35625 Metalloproteinase inhibitor 3 chr22 GO:2001233 Not Cancer Driver No 43 0.204 3 1 0.333 5
TMBIM1_ENST00000396809 TMBIM1 Q969X1 Protein lifeguard 3 chr2 GO:2001233 Not Cancer Driver No 30 0.096 83 8 0.096 0
TMBIM6_ENST00000549385 TMBIM6 P55061 Bax inhibitor 1 chr12 GO:2001233 Not Cancer Driver No 16 0.068 3 0 0.0 0
TMC8 TMC8 Q8IU68 Transmembrane channel-like protein 8 chr17 GO:2001233 Not Cancer Driver No 61 0.084 107 10 0.093 0
TMEM14A TMEM14A Q9Y6G1 Transmembrane protein 14A chr6 GO:2001233 Not Cancer Driver No 10 0.101 0 0 0.0 0
TMEM161A TMEM161A Q9NX61 Transmembrane protein 161A chr19 GO:2001233 Not Cancer Driver No 49 0.102 22 8 0.364 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:2001233 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 GO:2001233 Census, Compendium Yes 98 0.124 231 33 0.143 1
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:2001233 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TPT1_ENST00000530705 TPT1 P13693 Translationally-controlled tumor protein chr13 GO:2001233 Not Cancer Driver No 17 0.099 43 6 0.14 0
TRAP1 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 GO:2001233 Not Cancer Driver No 74 0.105 110 11 0.1 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:2001233 Not Cancer Driver No 43 0.187 27 2 0.074 1
TRIAP1 TRIAP1 O43715 TP53-regulated inhibitor of apoptosis 1 chr12 GO:2001233 Not Cancer Driver No 9 0.118 20 1 0.05 0
TRIM32 TRIM32 Q13049 E3 ubiquitin-protein ligase TRIM32 chr9 GO:2001233 Not Cancer Driver No 82 0.126 87 10 0.115 3
TXNDC12 TXNDC12 O95881 Thioredoxin domain-containing protein 12 chr1 GO:2001233 Not Cancer Driver No 21 0.122 44 6 0.136 0
UBB_ENST00000614404 UBB P0CG47 Polyubiquitin-B chr17 GO:2001233 Not Cancer Driver No 20 0.087 102 8 0.078 0
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 GO:2001233 Not Cancer Driver No 64 0.109 543 58 0.107 0
UNC5B UNC5B Q8IZJ1 Netrin receptor UNC5B chr10 GO:2001233 Not Cancer Driver No 155 0.164 117 20 0.171 0
USP47 USP47 Q96K76 Ubiquitin carboxyl-terminal hydrolase 47 chr11 GO:2001233 Not Cancer Driver No 137 0.1 425 39 0.092 0
VNN1 VNN1 O95497 Pantetheinase chr6 GO:2001233 Not Cancer Driver No 88 0.172 20 5 0.25 0
WFS1_ENST00000503569 WFS1 O76024 Wolframin chr4 GO:2001233 Not Cancer Driver No 105 0.118 203 10 0.049 39
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 GO:2001233 Not Cancer Driver No 79 0.191 108 9 0.083 3
XBP1 XBP1 P17861 X-box-binding protein 1 chr22 GO:2001233 Not Cancer Driver No 19 0.073 169 9 0.053 0
YBX3 YBX3 P16989 Y-box-binding protein 3 chr12 GO:2001233 Not Cancer Driver No 49 0.132 359 47 0.131 0
ZC3HC1 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 GO:2001233 Not Cancer Driver No 70 0.139 250 34 0.136 0
ZNF385A ZNF385A Q96PM9 Zinc finger protein 385A chr12 GO:2001233 Not Cancer Driver No 43 0.111 312 34 0.109 0
ZSWIM2 ZSWIM2 Q8NEG5 E3 ubiquitin-protein ligase ZSWIM2 chr2 GO:2001233 Not Cancer Driver No 189 0.299 85 30 0.353 0