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Total number of protein in "GO:0050731" GO term:  136

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABI1 ABI1 Q8IZP0 Abl interactor 1 chr10 GO:0050731 Census, Compendium Yes 55 0.108 360 39 0.108 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0050731 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0050731 Not Cancer Driver No 201 0.154 86 8 0.093 0
ACVR1_ENST00000434821 ACVR1 Q04771 Activin receptor type-1 chr2 GO:0050731 Census, Compendium Yes 78 0.153 21 8 0.381 8
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0050731 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADIPOQ ADIPOQ Q15848 Adiponectin chr3 GO:0050731 Not Cancer Driver No 39 0.16 92 21 0.228 1
ADNP ADNP Q9H2P0 Activity-dependent neuroprotector homeobox protein chr20 GO:0050731 Not Cancer Driver No 130 0.118 615 66 0.107 0
ADORA1 ADORA1 P30542 Adenosine receptor A1 chr1 GO:0050731 Not Cancer Driver No 64 0.196 12 4 0.333 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0050731 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0050731 Not Cancer Driver No 67 0.144 161 10 0.062 0
AFAP1L2 AFAP1L2 Q8N4X5 Actin filament-associated protein 1-like 2 chr10 GO:0050731 Not Cancer Driver No 86 0.105 558 59 0.106 0
AGT AGT P01019 Angiotensinogen chr1 GO:0050731 Not Cancer Driver No 85 0.179 33 10 0.303 1
ALKAL1 ALKAL1 Q6UXT8 ALK and LTK ligand 1 chr8 GO:0050731 Not Cancer Driver No 18 0.14 49 3 0.061 0
ALKAL2 ALKAL2 Q6UX46 ALK and LTK ligand 2 chr2 GO:0050731 Not Cancer Driver No 7 0.046 31 0 0.0 0
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0050731 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANGPT4 ANGPT4 Q9Y264 Angiopoietin-4 chr20 GO:0050731 Not Cancer Driver No 104 0.207 150 32 0.213 0
AREG AREG P15514 Amphiregulin chr4 GO:0050731 Not Cancer Driver No 28 0.111 149 20 0.134 0
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0050731 Not Cancer Driver No 146 0.148 450 70 0.156 0
ARRB2_ENST00000269260 ARRB2 P32121 Beta-arrestin-2 chr17 GO:0050731 Not Cancer Driver No 46 0.112 122 22 0.18 0
BANK1 BANK1 Q8NDB2 B-cell scaffold protein with ankyrin repeats chr4 GO:0050731 Not Cancer Driver No 150 0.191 394 73 0.185 0
BMP6 BMP6 P22004 Bone morphogenetic protein 6 chr6 GO:0050731 Not Cancer Driver No 95 0.185 226 51 0.226 0
BTC BTC P35070 Probetacellulin chr4 GO:0050731 Not Cancer Driver No 29 0.163 12 5 0.417 0
CASS4 CASS4 Q9NQ75 Cas scaffolding protein family member 4 chr20 GO:0050731 Not Cancer Driver No 204 0.26 496 137 0.276 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0050731 Not Cancer Driver No 75 0.159 12 3 0.25 3
CD3E CD3E P07766 T-cell surface glycoprotein CD3 epsilon chain chr11 GO:0050731 Not Cancer Driver No 28 0.135 72 12 0.167 0
CD4 CD4 P01730 T-cell surface glycoprotein CD4 chr12 GO:0050731 Not Cancer Driver No 69 0.151 56 11 0.196 0
CD44 CD44 P16070 CD44 antigen chr11 GO:0050731 Not Cancer Driver No 75 0.101 542 60 0.111 0
CD74 CD74 P04233 HLA class II histocompatibility antigen gamma chain chr5 GO:0050731 Census Yes 31 0.105 185 20 0.108 0
CD80_ENST00000478182 CD80 P33681 T-lymphocyte activation antigen CD80 chr3 GO:0050731 Not Cancer Driver No 50 0.174 26 5 0.192 0
CD81 CD81 P60033 CD81 antigen chr11 GO:0050731 Not Cancer Driver No 28 0.119 0 0 0.0 0
CLEC6A CLEC6A Q6EIG7 C-type lectin domain family 6 member A chr12 GO:0050731 Not Cancer Driver No 41 0.196 7 0 0.0 0
CLEC7A CLEC7A Q9BXN2 C-type lectin domain family 7 member A chr12 GO:0050731 Not Cancer Driver No 43 0.174 46 2 0.043 0
CNTN1 CNTN1 Q12860 Contactin-1 chr12 GO:0050731 Not Cancer Driver No 265 0.26 220 50 0.227 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0050731 Census Yes 133 0.137 124 17 0.137 20
CSF3 CSF3 P09919 Granulocyte colony-stimulating factor chr17 GO:0050731 Not Cancer Driver No 20 0.097 7 0 0.0 0
CSPG4 CSPG4 Q6UVK1 Chondroitin sulfate proteoglycan 4 chr15 GO:0050731 Not Cancer Driver No 259 0.112 838 85 0.101 0
DGKQ DGKQ P52824 Diacylglycerol kinase theta chr4 GO:0050731 Not Cancer Driver No 56 0.059 264 11 0.042 0
DLG3 DLG3 Q92796 Disks large homolog 3 chrX GO:0050731 Not Cancer Driver No 94 0.115 322 30 0.093 0
DLG4_ENST00000399506 DLG4 P78352 Disks large homolog 4 chr17 GO:0050731 Not Cancer Driver No 116 0.16 232 55 0.237 0
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 GO:0050731 Not Cancer Driver No 365 0.18 458 69 0.151 0
DOK7 DOK7 Q18PE1 Protein Dok-7 chr4 GO:0050731 Not Cancer Driver No 52 0.103 286 27 0.094 19
DVL2 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 GO:0050731 Not Cancer Driver No 96 0.13 514 64 0.125 0
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0050731 Not Cancer Driver No 29 0.141 46 5 0.109 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 GO:0050731 Not Cancer Driver No 34 0.149 25 6 0.24 0
EGF EGF P01133 Pro-epidermal growth factor chr4 GO:0050731 Not Cancer Driver No 184 0.152 191 25 0.131 1
EHD4 EHD4 Q9H223 EH domain-containing protein 4 chr15 GO:0050731 Not Cancer Driver No 54 0.1 98 7 0.071 0
ENPP2_ENST00000075322 ENPP2 Q13822 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 chr8 GO:0050731 Not Cancer Driver No 168 0.195 81 16 0.198 0
EPGN EPGN Q6UW88 Epigen chr4 GO:0050731 Not Cancer Driver No 16 0.104 0 0 0.0 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0050731 Not Cancer Driver No 182 0.185 140 24 0.171 0
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:0050731 Census, Compendium Yes 298 0.222 396 70 0.177 3
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 GO:0050731 Not Cancer Driver No 211 0.141 829 117 0.141 9
EREG EREG O14944 Proepiregulin chr4 GO:0050731 Not Cancer Driver No 26 0.154 10 3 0.3 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 GO:0050731 Census, Compendium Yes 322 0.455 230 38 0.165 0
FCGR1A FCGR1A P12314 High affinity immunoglobulin gamma Fc receptor I chr1 GO:0050731 Not Cancer Driver No 62 0.166 37 5 0.135 0
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:0050731 Not Cancer Driver No 56 0.269 34 11 0.324 2
FGF7 FGF7 P21781 Fibroblast growth factor 7 chr15 GO:0050731 Not Cancer Driver No 38 0.196 22 4 0.182 0
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 GO:0050731 Not Cancer Driver No 30 0.129 79 9 0.114 6
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0050731 Not Cancer Driver No 82 0.121 42 6 0.143 0
GATA1 GATA1 P15976 Erythroid transcription factor chrX GO:0050731 Census, Compendium Yes 68 0.165 242 41 0.169 5
GFRA1 GFRA1 P56159 GDNF family receptor alpha-1 chr10 GO:0050731 Not Cancer Driver No 120 0.258 43 12 0.279 0
GH1 GH1 P01241 Somatotropin chr17 GO:0050731 Not Cancer Driver No 54 0.249 24 9 0.375 15
GHRL_ENST00000457360 GHRL Q9UBU3 Appetite-regulating hormone chr3 GO:0050731 Not Cancer Driver No 20 0.171 52 11 0.212 0
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0050731 Not Cancer Driver No 173 0.271 229 66 0.288 19
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 GO:0050731 Not Cancer Driver No 82 0.203 75 19 0.253 0
GREM1 GREM1 O60565 Gremlin-1 chr15 GO:0050731 Not Cancer Driver No 25 0.136 77 12 0.156 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 GO:0050731 Not Cancer Driver No 312 0.257 323 51 0.158 0
HAX1 HAX1 O00165 HCLS1-associated protein X-1 chr1 GO:0050731 Not Cancer Driver No 44 0.158 219 32 0.146 2
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 GO:0050731 Not Cancer Driver No 16 0.077 63 3 0.048 0
HCLS1 HCLS1 P14317 Hematopoietic lineage cell-specific protein chr3 GO:0050731 Not Cancer Driver No 103 0.212 446 94 0.211 0
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 GO:0050731 Compendium Yes 233 0.32 43 16 0.372 0
HTR2A HTR2A P28223 5-hydroxytryptamine receptor 2A chr13 GO:0050731 Not Cancer Driver No 105 0.223 44 8 0.182 0
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:0050731 Not Cancer Driver No 45 0.231 87 23 0.264 0
IGF2_ENST00000641326 IGF2 P01344 Insulin-like growth factor II chr11 GO:0050731 Not Cancer Driver No 39 0.217 44 12 0.273 0
IL11 IL11 P20809 Interleukin-11 chr19 GO:0050731 Not Cancer Driver No 19 0.095 69 8 0.116 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0050731 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL15_ENST00000320650 IL15 P40933 Interleukin-15 chr4 GO:0050731 Not Cancer Driver No 25 0.154 6 1 0.167 0
IL23A IL23A Q9NPF7 Interleukin-23 subunit alpha chr12 GO:0050731 Not Cancer Driver No 15 0.079 42 3 0.071 0
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0050731 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL3 IL3 P08700 Interleukin-3 chr5 GO:0050731 Not Cancer Driver No 25 0.164 22 3 0.136 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0050731 Not Cancer Driver No 22 0.091 42 6 0.143 0
IL5 IL5 P05113 Interleukin-5 chr5 GO:0050731 Not Cancer Driver No 13 0.097 0 0 0.0 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0050731 Not Cancer Driver No 35 0.165 58 7 0.121 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0050731 Not Cancer Driver No 55 0.118 165 23 0.139 1
ITGA5 ITGA5 P08648 Integrin alpha-5 chr12 GO:0050731 Not Cancer Driver No 127 0.121 201 29 0.144 0
ITGB3 ITGB3 P05106 Integrin beta-3 chr17 GO:0050731 Not Cancer Driver No 124 0.157 66 5 0.076 30
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0050731 Census, Compendium Yes 136 0.12 59 5 0.085 5
KITLG KITLG P21583 Kit ligand chr12 GO:0050731 Not Cancer Driver No 48 0.176 61 9 0.148 1
LACRT LACRT Q9GZZ8 Extracellular glycoprotein lacritin chr12 GO:0050731 Not Cancer Driver No 38 0.275 90 27 0.3 0
LIF LIF P15018 Leukemia inhibitory factor chr22 GO:0050731 Not Cancer Driver No 25 0.124 0 0 0.0 0
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0050731 Not Cancer Driver No 79 0.264 98 19 0.194 0
LRP4 LRP4 O75096 Low-density lipoprotein receptor-related protein 4 chr11 GO:0050731 Not Cancer Driver No 233 0.122 265 28 0.106 11
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0050731 Not Cancer Driver No 94 0.098 190 24 0.126 0
LRRK1 LRRK1 Q38SD2 Leucine-rich repeat serine/threonine-protein kinase 1 chr15 GO:0050731 Not Cancer Driver No 289 0.143 261 33 0.126 0
MIF MIF P14174 Macrophage migration inhibitory factor chr22 GO:0050731 Not Cancer Driver No 4 0.035 0 0 0.0 0
MLST8_ENST00000397124 MLST8 Q9BVC4 Target of rapamycin complex subunit LST8 chr16 GO:0050731 Not Cancer Driver No 37 0.113 45 3 0.067 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0050731 Census, Compendium Yes 379 0.149 296 37 0.125 18
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 GO:0050731 Not Cancer Driver No 37 0.095 181 12 0.066 1
NEDD9 NEDD9 Q14511 Enhancer of filamentation 1 chr6 GO:0050731 Not Cancer Driver No 106 0.127 516 72 0.14 0
NEURL1 NEURL1 O76050 E3 ubiquitin-protein ligase NEURL1 chr10 GO:0050731 Not Cancer Driver No 62 0.108 153 11 0.072 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0050731 Not Cancer Driver No 169 0.163 40 4 0.1 15
NOX4 NOX4 Q9NPH5 NADPH oxidase 4 chr11 GO:0050731 Not Cancer Driver No 123 0.213 0 0 0.0 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0050731 Census, Compendium Yes 159 0.248 528 132 0.25 0
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:0050731 Compendium Yes 146 0.158 211 31 0.147 0
NTF3_ENST00000331010 NTF3 P20783 Neurotrophin-3 chr12 GO:0050731 Not Cancer Driver No 52 0.202 99 21 0.212 0
OSM OSM P13725 Oncostatin-M chr22 GO:0050731 Not Cancer Driver No 43 0.171 114 24 0.211 0
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0050731 Compendium Yes 89 0.17 242 49 0.202 0
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0050731 Census Yes 37 0.154 99 22 0.222 2
PECAM1 PECAM1 P16284 Platelet endothelial cell adhesion molecule chr17 GO:0050731 Not Cancer Driver No 2 0.003 153 2 0.013 0
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:0050731 Not Cancer Driver No 248 0.196 142 30 0.211 1
PRNP PRNP P04156 Major prion protein chr20 GO:0050731 Not Cancer Driver No 36 0.142 115 7 0.061 18
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0050731 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 GO:0050731 Not Cancer Driver No 49 0.113 140 25 0.179 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 GO:0050731 Census, Compendium Yes 129 0.218 260 38 0.146 60
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0050731 Census, Compendium Yes 315 0.241 462 107 0.232 0
PTPRJ PTPRJ Q12913 Receptor-type tyrosine-protein phosphatase eta chr11 GO:0050731 Not Cancer Driver No 184 0.138 401 61 0.152 0
RELN RELN P78509 Reelin chr7 GO:0050731 Not Cancer Driver No 761 0.22 107 19 0.178 7
RICTOR_ENST00000357387 RICTOR Q6R327 Rapamycin-insensitive companion of mTOR chr5 GO:0050731 Not Cancer Driver No 212 0.124 366 50 0.137 0
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0050731 Not Cancer Driver No 63 0.117 143 20 0.14 0
SEMA4D SEMA4D Q92854 Semaphorin-4D chr9 GO:0050731 Not Cancer Driver No 117 0.136 132 15 0.114 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0050731 Census Yes 53 0.099 130 11 0.085 1
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0050731 Not Cancer Driver No 66 0.224 103 18 0.175 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0050731 Census Yes 96 0.151 131 27 0.206 5
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 GO:0050731 Not Cancer Driver No 39 0.207 25 2 0.08 0
TEC TEC P42680 Tyrosine-protein kinase Tec chr4 GO:0050731 Census, Compendium Yes 91 0.144 57 15 0.263 0
TGFA_ENST00000295400 TGFA P01135 Protransforming growth factor alpha chr2 GO:0050731 Not Cancer Driver No 20 0.125 0 0 0.0 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0050731 Not Cancer Driver No 41 0.105 41 4 0.098 10
THBS4 THBS4 P35443 Thrombospondin-4 chr5 GO:0050731 Not Cancer Driver No 137 0.143 281 40 0.142 0
TNFRSF14 TNFRSF14 Q92956 Tumor necrosis factor receptor superfamily member 14 chr1 GO:0050731 Census, Compendium Yes 33 0.117 54 8 0.148 0
TNK2_ENST00000333602 TNK2 Q07912 Activated CDC42 kinase 1 chr3 GO:0050731 Not Cancer Driver No 137 0.132 593 81 0.137 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0050731 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0050731 Not Cancer Driver No 43 0.187 27 2 0.074 1
UNC119 UNC119 Q13432 Protein unc-119 homolog A chr17 GO:0050731 Not Cancer Driver No 20 0.083 89 4 0.045 1
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0050731 Not Cancer Driver No 27 0.116 41 7 0.171 0
VTN VTN P04004 Vitronectin chr17 GO:0050731 Not Cancer Driver No 76 0.159 168 29 0.173 0
WNT3A WNT3A P56704 Protein Wnt-3a chr1 GO:0050731 Not Cancer Driver No 77 0.219 37 5 0.135 0
YES1_ENST00000314574 YES1 P07947 Tyrosine-protein kinase Yes chr18 GO:0050731 Not Cancer Driver No 65 0.12 62 10 0.161 0