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Total number of protein in "GO:0050729" GO term:  134

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCC1 ABCC1 P33527 Multidrug resistance-associated protein 1 chr16 GO:0050729 Not Cancer Driver No 199 0.13 123 22 0.179 1
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0050729 Not Cancer Driver No 201 0.154 86 8 0.093 0
ADAM8 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:0050729 Not Cancer Driver No 82 0.1 230 13 0.057 0
ADORA2B ADORA2B P29275 Adenosine receptor A2b chr17 GO:0050729 Not Cancer Driver No 23 0.069 0 0 0.0 0
AGT AGT P01019 Angiotensinogen chr1 GO:0050729 Not Cancer Driver No 85 0.179 33 10 0.303 1
AGTR1_ENST00000349243 AGTR1 P30556 Type-1 angiotensin II receptor chr3 GO:0050729 Not Cancer Driver No 95 0.265 0 0 0.0 1
ALOX5AP_ENST00000380490 ALOX5AP P20292 Arachidonate 5-lipoxygenase-activating protein chr13 GO:0050729 Not Cancer Driver No 17 0.106 1 0 0.0 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0050729 Not Cancer Driver No 128 0.166 418 71 0.17 17
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0050729 Census, Compendium Yes 147 0.223 114 27 0.237 110
C2CD4A C2CD4A Q8NCU7 C2 calcium-dependent domain-containing protein 4A chr15 GO:0050729 Not Cancer Driver No 13 0.035 223 4 0.018 0
C2CD4B C2CD4B A6NLJ0 C2 calcium-dependent domain-containing protein 4B chr15 GO:0050729 Not Cancer Driver No 5 0.014 191 0 0.0 0
C3 C3 P01024 Complement C3 chr19 GO:0050729 Not Cancer Driver No 337 0.203 287 50 0.174 12
CAMK2N1 CAMK2N1 Q7Z7J9 Calcium/calmodulin-dependent protein kinase II inhibitor 1 chr1 GO:0050729 Not Cancer Driver No 10 0.128 72 9 0.125 0
CASP1 CASP1 P29466 Caspase-1 chr11 GO:0050729 Not Cancer Driver No 79 0.196 87 18 0.207 0
CCL1 CCL1 P22362 C-C motif chemokine 1 chr17 GO:0050729 Not Cancer Driver No 27 0.281 0 0 0.0 0
CCL24_ENST00000222902 CCL24 O00175 C-C motif chemokine 24 chr7 GO:0050729 Not Cancer Driver No 25 0.21 23 3 0.13 0
CCN4 CCN4 O95388 CCN family member 4 chr8 GO:0050729 Not Cancer Driver No 93 0.253 20 8 0.4 0
CCR2_ENST00000400888 CCR2 P41597 C-C chemokine receptor type 2 chr3 GO:0050729 Not Cancer Driver No 81 0.217 23 1 0.043 0
CCR7 CCR7 P32248 C-C chemokine receptor type 7 chr17 GO:0050729 Census, Compendium Yes 50 0.132 0 0 0.0 0
CD28 CD28 P10747 T-cell-specific surface glycoprotein CD28 chr2 GO:0050729 Census Yes 42 0.191 18 10 0.556 0
CD47 CD47 Q08722 Leukocyte surface antigen CD47 chr3 GO:0050729 Not Cancer Driver No 37 0.115 0 0 0.0 0
CD81 CD81 P60033 CD81 antigen chr11 GO:0050729 Not Cancer Driver No 28 0.119 0 0 0.0 0
CDK19 CDK19 Q9BWU1 Cyclin-dependent kinase 19 chr6 GO:0050729 Not Cancer Driver No 63 0.125 191 28 0.147 8
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 GO:0050729 Census, Compendium Yes 12 0.034 342 12 0.035 1
CEBPB CEBPB P17676 CCAAT/enhancer-binding protein beta chr20 GO:0050729 Not Cancer Driver No 3 0.009 276 2 0.007 0
CLOCK CLOCK O15516 Circadian locomoter output cycles protein kaput chr4 GO:0050729 Not Cancer Driver No 83 0.098 458 38 0.083 0
CNR1_ENST00000549890 CNR1 P21554 Cannabinoid receptor 1 chr6 GO:0050729 Not Cancer Driver No 129 0.273 9 1 0.111 0
CREB3L3 CREB3L3 Q68CJ9 Cyclic AMP-responsive element-binding protein 3-like protein 3 chr19 GO:0050729 Not Cancer Driver No 96 0.208 338 67 0.198 1
CTSC CTSC P53634 Dipeptidyl peptidase 1 chr11 GO:0050729 Not Cancer Driver No 64 0.138 19 5 0.263 29
CX3CL1 CX3CL1 P78423 Fractalkine chr16 GO:0050729 Not Cancer Driver No 66 0.166 259 44 0.17 0
DDT_ENST00000350608 DDT P30046 D-dopachrome decarboxylase chr22 GO:0050729 Not Cancer Driver No 4 0.034 0 0 0.0 0
DEFB114 DEFB114 Q30KQ6 Beta-defensin 114 chr6 GO:0050729 Not Cancer Driver No 31 0.449 0 0 0.0 0
DHX9 DHX9 Q08211 ATP-dependent RNA helicase A chr1 GO:0050729 Compendium Yes 182 0.143 331 42 0.127 0
ETS1_ENST00000319397 ETS1 P14921 Protein C-ets-1 chr11 GO:0050729 Not Cancer Driver No 68 0.154 78 9 0.115 0
FABP4 FABP4 P15090 Fatty acid-binding protein, adipocyte chr8 GO:0050729 Not Cancer Driver No 14 0.106 4 0 0.0 0
FAM19A3_ENST00000361886 TAFA3 Q7Z5A8 Chemokine-like protein TAFA-3 chr1 GO:0050729 Not Cancer Driver No 17 0.128 6 0 0.0 0
FEM1A FEM1A Q9BSK4 Protein fem-1 homolog A chr19 GO:0050729 Not Cancer Driver No 68 0.102 162 22 0.136 0
FFAR2 FFAR2 O15552 Free fatty acid receptor 2 chr19 GO:0050729 Not Cancer Driver No 49 0.148 32 7 0.219 0
FFAR3 FFAR3 O14843 Free fatty acid receptor 3 chr19 GO:0050729 Not Cancer Driver No 78 0.225 29 6 0.207 0
GPR4 GPR4 P46093 G-protein coupled receptor 4 chr19 GO:0050729 Not Cancer Driver No 57 0.157 44 8 0.182 0
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 GO:0050729 Not Cancer Driver No 82 0.203 75 19 0.253 0
GPSM3_ENST00000375043 GPSM3 Q9Y4H4 G-protein-signaling modulator 3 chr6 GO:0050729 Not Cancer Driver No 26 0.163 160 26 0.163 0
GRN GRN P28799 Progranulin chr17 GO:0050729 Not Cancer Driver No 76 0.128 29 6 0.207 1
HLA-E HLA-E P13747 HLA class I histocompatibility antigen, alpha chain E chr6 GO:0050729 Not Cancer Driver No 63 0.176 138 39 0.283 0
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0050729 Not Cancer Driver No 52 0.11 8 1 0.125 0
IDO1_ENST00000522495 IDO1 P14902 Indoleamine 2,3-dioxygenase 1 chr8 GO:0050729 Not Cancer Driver No 82 0.203 41 8 0.195 0
IFI35_ENST00000415816 IFI35 P80217 Interferon-induced 35 kDa protein chr17 GO:0050729 Not Cancer Driver No 33 0.115 63 10 0.159 0
IFNG IFNG P01579 Interferon gamma chr12 GO:0050729 Not Cancer Driver No 51 0.307 23 6 0.261 0
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0050729 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL15_ENST00000320650 IL15 P40933 Interleukin-15 chr4 GO:0050729 Not Cancer Driver No 25 0.154 6 1 0.167 0
IL16 IL16 Q14005 Pro-interleukin-16 chr15 GO:0050729 Not Cancer Driver No 216 0.162 959 151 0.157 0
IL17RA IL17RA Q96F46 Interleukin-17 receptor A chr22 GO:0050729 Not Cancer Driver No 92 0.106 301 20 0.066 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0050729 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0050729 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL1RL1 IL1RL1 Q01638 Interleukin-1 receptor-like 1 chr2 GO:0050729 Not Cancer Driver No 119 0.214 24 8 0.333 0
IL2 IL2 P60568 Interleukin-2 chr4 GO:0050729 Census Yes 24 0.157 6 1 0.167 0
IL21 IL21 Q9HBE4 Interleukin-21 chr4 GO:0050729 Not Cancer Driver No 34 0.21 70 18 0.257 1
IL23A IL23A Q9NPF7 Interleukin-23 subunit alpha chr12 GO:0050729 Not Cancer Driver No 15 0.079 42 3 0.071 0
IL33 IL33 O95760 Interleukin-33 chr9 GO:0050729 Not Cancer Driver No 47 0.174 47 8 0.17 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0050729 Not Cancer Driver No 35 0.165 58 7 0.121 0
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0050729 Census, Compendium Yes 102 0.111 315 40 0.127 2
ITGA2 ITGA2 P17301 Integrin alpha-2 chr5 GO:0050729 Not Cancer Driver No 166 0.141 26 0 0.0 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0050729 Census, Compendium Yes 136 0.12 59 5 0.085 5
KARS_ENST00000302445 KARS1 Q15046 Lysine--tRNA ligase chr16 GO:0050729 Not Cancer Driver No 88 0.147 160 15 0.094 12
LBP LBP P18428 Lipopolysaccharide-binding protein chr20 GO:0050729 Not Cancer Driver No 84 0.175 6 0 0.0 0
LDLR LDLR P01130 Low-density lipoprotein receptor chr19 GO:0050729 Not Cancer Driver No 119 0.138 63 3 0.048 104
LGALS1 LGALS1 P09382 Galectin-1 chr22 GO:0050729 Not Cancer Driver No 16 0.119 0 0 0.0 0
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0050729 Not Cancer Driver No 79 0.264 98 19 0.194 0
LPL LPL P06858 Lipoprotein lipase chr8 GO:0050729 Not Cancer Driver No 94 0.198 23 3 0.13 70
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0050729 Not Cancer Driver No 519 0.205 90 17 0.189 23
LTA LTA P01374 Lymphotoxin-alpha chr6 GO:0050729 Not Cancer Driver No 37 0.18 20 5 0.25 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0050729 Not Cancer Driver No 51 0.14 50 15 0.3 0
MDK_ENST00000407067 MDK P21741 Midkine chr11 GO:0050729 Not Cancer Driver No 15 0.105 20 2 0.1 0
MGST2 MGST2 Q99735 Microsomal glutathione S-transferase 2 chr4 GO:0050729 Not Cancer Driver No 11 0.075 0 0 0.0 0
MMP8 MMP8 P22894 Neutrophil collagenase chr11 GO:0050729 Not Cancer Driver No 73 0.156 115 19 0.165 0
NAPEPLD NAPEPLD Q6IQ20 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D chr7 GO:0050729 Not Cancer Driver No 55 0.14 76 7 0.092 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 GO:0050729 Compendium Yes 37 0.117 102 9 0.088 1
NFKBIZ NFKBIZ Q9BYH8 NF-kappa-B inhibitor zeta chr3 GO:0050729 Not Cancer Driver No 96 0.134 443 53 0.12 0
NINJ1 NINJ1 Q92982 Ninjurin-1 chr9 GO:0050729 Not Cancer Driver No 17 0.112 29 0 0.0 0
NKG7 NKG7 Q16617 Protein NKG7 chr19 GO:0050729 Not Cancer Driver No 34 0.206 0 0 0.0 0
NLRP10 NLRP10 Q86W26 NACHT, LRR and PYD domains-containing protein 10 chr11 GO:0050729 Not Cancer Driver No 201 0.307 96 34 0.354 0
NLRP12_ENST00000324134 NLRP12 P59046 NACHT, LRR and PYD domains-containing protein 12 chr19 GO:0050729 Not Cancer Driver No 310 0.292 116 43 0.371 0
NLRP1_ENST00000572272 NLRP1 Q9C000 NACHT, LRR and PYD domains-containing protein 1 chr17 GO:0050729 Not Cancer Driver No 222 0.151 340 65 0.191 6
NMI NMI Q13287 N-myc-interactor chr2 GO:0050729 Not Cancer Driver No 34 0.111 104 12 0.115 0
NPY5R_ENST00000506953 NPY5R Q15761 Neuropeptide Y receptor type 5 chr4 GO:0050729 Not Cancer Driver No 144 0.324 44 16 0.364 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 GO:0050729 Not Cancer Driver No 10 0.122 82 10 0.122 0
OSM OSM P13725 Oncostatin-M chr22 GO:0050729 Not Cancer Driver No 43 0.171 114 24 0.211 0
OSMR OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 GO:0050729 Not Cancer Driver No 167 0.171 145 22 0.152 5
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0050729 Not Cancer Driver No 11 0.058 30 0 0.0 5
PDCD4 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 GO:0050729 Not Cancer Driver No 57 0.122 187 32 0.171 0
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 GO:0050729 Not Cancer Driver No 137 0.146 99 7 0.071 0
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0050729 Not Cancer Driver No 318 0.289 121 39 0.322 0
PLA2G2A_ENST00000375111 PLA2G2A P14555 Phospholipase A2, membrane associated chr1 GO:0050729 Not Cancer Driver No 25 0.174 0 0 0.0 0
PLA2G3 PLA2G3 Q9NZ20 Group 3 secretory phospholipase A2 chr22 GO:0050729 Not Cancer Driver No 115 0.226 175 39 0.223 0
PLA2G7 PLA2G7 Q13093 Platelet-activating factor acetylhydrolase chr6 GO:0050729 Not Cancer Driver No 70 0.159 27 7 0.259 2
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 GO:0050729 Not Cancer Driver No 248 0.196 142 30 0.211 1
PTGER3_ENST00000370931 PTGER3 P43115 Prostaglandin E2 receptor EP3 subtype chr1 GO:0050729 Not Cancer Driver No 79 0.203 17 2 0.118 0
PTGER4 PTGER4 P35408 Prostaglandin E2 receptor EP4 subtype chr5 GO:0050729 Not Cancer Driver No 81 0.166 118 17 0.144 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0050729 Not Cancer Driver No 105 0.174 30 5 0.167 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0050729 Not Cancer Driver No 16 0.082 39 4 0.103 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0050729 Compendium Yes 82 0.122 277 39 0.141 4
RPS19_ENST00000600467 RPS19 P39019 40S ribosomal protein S19 chr19 GO:0050729 Not Cancer Driver No 15 0.103 61 3 0.049 23
S100A12 S100A12 P80511 Protein S100-A12 chr1 GO:0050729 Not Cancer Driver No 18 0.196 1 0 0.0 0
S100A8 S100A8 P05109 Protein S100-A8 chr1 GO:0050729 Not Cancer Driver No 22 0.237 8 4 0.5 0
S100A9 S100A9 P06702 Protein S100-A9 chr1 GO:0050729 Not Cancer Driver No 18 0.158 76 7 0.092 0
SERPINE1 SERPINE1 P05121 Plasminogen activator inhibitor 1 chr7 GO:0050729 Not Cancer Driver No 78 0.194 7 2 0.286 0
SETD4 SETD4 Q9NVD3 SET domain-containing protein 4 chr21 GO:0050729 Not Cancer Driver No 51 0.116 27 2 0.074 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 GO:0050729 Not Cancer Driver No 21 0.15 107 13 0.121 5
SNX4 SNX4 O95219 Sorting nexin-4 chr3 GO:0050729 Not Cancer Driver No 31 0.069 101 5 0.05 0
STAP1_ENST00000396225 STAP1 Q9ULZ2 Signal-transducing adaptor protein 1 chr4 GO:0050729 Not Cancer Driver No 66 0.224 103 18 0.175 0
STAT5B STAT5B P51692 Signal transducer and activator of transcription 5B chr17 GO:0050729 Census, Compendium Yes 93 0.118 144 19 0.132 5
SUCNR1 SUCNR1 Q9BXA5 Succinate receptor 1 chr3 GO:0050729 Not Cancer Driver No 51 0.153 0 0 0.0 0
TLR10_ENST00000508334 TLR10 Q9BXR5 Toll-like receptor 10 chr4 GO:0050729 Not Cancer Driver No 122 0.15 9 1 0.111 0
TLR2 TLR2 O60603 Toll-like receptor 2 chr4 GO:0050729 Not Cancer Driver No 108 0.138 0 0 0.0 0
TLR3 TLR3 O15455 Toll-like receptor 3 chr4 GO:0050729 Not Cancer Driver No 123 0.136 0 0 0.0 1
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:0050729 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR7 TLR7 Q9NYK1 Toll-like receptor 7 chrX GO:0050729 Not Cancer Driver No 182 0.173 14 1 0.071 1
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 GO:0050729 Not Cancer Driver No 141 0.137 35 3 0.086 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0050729 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0050729 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFRSF1A TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 GO:0050729 Not Cancer Driver No 58 0.127 111 15 0.135 12
TNFSF11 TNFSF11 O14788 Tumor necrosis factor ligand superfamily member 11 chr13 GO:0050729 Not Cancer Driver No 52 0.164 56 1 0.018 1
TNFSF4 TNFSF4 P23510 Tumor necrosis factor ligand superfamily member 4 chr1 GO:0050729 Not Cancer Driver No 28 0.153 1 0 0.0 0
TNIP1_ENST00000522226 TNIP1 Q15025 TNFAIP3-interacting protein 1 chr5 GO:0050729 Not Cancer Driver No 85 0.134 625 83 0.133 0
TRADD TRADD Q15628 Tumor necrosis factor receptor type 1-associated DEATH domain protein chr16 GO:0050729 Not Cancer Driver No 26 0.083 74 5 0.068 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0050729 Not Cancer Driver No 43 0.187 27 2 0.074 1
TRPV4 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 chr12 GO:0050729 Not Cancer Driver No 142 0.163 231 34 0.147 44
TSLP TSLP Q969D9 Thymic stromal lymphopoietin chr5 GO:0050729 Not Cancer Driver No 27 0.17 16 0 0.0 0
TTBK1 TTBK1 Q5TCY1 Tau-tubulin kinase 1 chr6 GO:0050729 Not Cancer Driver No 193 0.146 1045 154 0.147 0
VAMP7_ENST00000286448 VAMP7 P51809 Vesicle-associated membrane protein 7 chrX GO:0050729 Not Cancer Driver No 38 0.173 4 1 0.25 0
VAMP8 VAMP8 Q9BV40 Vesicle-associated membrane protein 8 chr2 GO:0050729 Not Cancer Driver No 9 0.09 27 0 0.0 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 GO:0050729 Not Cancer Driver No 66 0.174 0 0 0.0 2
ZBP1 ZBP1 Q9H171 Z-DNA-binding protein 1 chr20 GO:0050729 Not Cancer Driver No 97 0.226 385 80 0.208 0
ZP3 ZP3 P21754 Zona pellucida sperm-binding protein 3 chr7 GO:0050729 Not Cancer Driver No 55 0.13 56 11 0.196 1