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Total number of protein in "GO:0045931" GO term:  116

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0045931 Census, Compendium Yes 139 0.123 604 73 0.121 2
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0045931 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADAMTS1 ADAMTS1 Q9UHI8 A disintegrin and metalloproteinase with thrombospondin motifs 1 chr21 GO:0045931 Not Cancer Driver No 135 0.14 272 32 0.118 0
AIF1 AIF1 P55008 Allograft inflammatory factor 1 chr6 GO:0045931 Not Cancer Driver No 14 0.095 61 6 0.098 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0045931 Census, Compendium Yes 108 0.225 158 24 0.152 4
ANAPC11_ENST00000579978 ANAPC11 Q9NYG5 Anaphase-promoting complex subunit 11 chr17 GO:0045931 Not Cancer Driver No 7 0.083 0 0 0.0 0
ANAPC4_ENST00000315368 ANAPC4 Q9UJX5 Anaphase-promoting complex subunit 4 chr4 GO:0045931 Not Cancer Driver No 70 0.087 54 1 0.019 0
ANAPC5 ANAPC5 Q9UJX4 Anaphase-promoting complex subunit 5 chr12 GO:0045931 Not Cancer Driver No 94 0.125 41 4 0.098 0
ANKRD17 ANKRD17 O75179 Ankyrin repeat domain-containing protein 17 chr4 GO:0045931 Not Cancer Driver No 312 0.12 1790 221 0.123 9
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 GO:0045931 Not Cancer Driver No 59 0.171 61 12 0.197 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0045931 Not Cancer Driver No 34 0.107 103 14 0.136 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0045931 Not Cancer Driver No 128 0.166 418 71 0.17 17
ASNS_ENST00000394308 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] chr7 GO:0045931 Not Cancer Driver No 81 0.144 11 0 0.0 3
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0045931 Census, Compendium Yes 457 0.134 1542 225 0.146 46
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 GO:0045931 Census, Compendium Yes 193 0.142 1182 172 0.146 0
CCDC57_ENST00000392347 CCDC57 Q2TAC2 Coiled-coil domain-containing protein 57 chr17 GO:0045931 Not Cancer Driver No 107 0.117 595 65 0.109 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 GO:0045931 Not Cancer Driver No 49 0.113 145 14 0.097 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0045931 Census, Compendium Yes 55 0.186 31 25 0.806 0
CCND2 CCND2 P30279 G1/S-specific cyclin-D2 chr12 GO:0045931 Census, Compendium Yes 39 0.135 29 7 0.241 5
CCND3 CCND3 P30281 G1/S-specific cyclin-D3 chr6 GO:0045931 Census, Compendium Yes 29 0.099 46 8 0.174 0
CDC16_ENST00000356221 CDC16 Q13042 Cell division cycle protein 16 homolog chr13 GO:0045931 Not Cancer Driver No 68 0.11 54 7 0.13 0
CDC23 CDC23 Q9UJX2 Cell division cycle protein 23 homolog chr5 GO:0045931 Not Cancer Driver No 57 0.095 45 6 0.133 0
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 GO:0045931 Not Cancer Driver No 63 0.12 313 35 0.112 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 GO:0045931 Not Cancer Driver No 80 0.138 328 43 0.131 0
CDC25C CDC25C P30307 M-phase inducer phosphatase 3 chr5 GO:0045931 Not Cancer Driver No 61 0.129 224 26 0.116 0
CDC27_ENST00000066544 CDC27 P30260 Cell division cycle protein 27 homolog chr17 GO:0045931 Not Cancer Driver No 179 0.217 289 75 0.26 0
CDC6 CDC6 Q99741 Cell division control protein 6 homolog chr17 GO:0045931 Not Cancer Driver No 57 0.102 170 15 0.088 1
CDC7 CDC7 O00311 Cell division cycle 7-related protein kinase chr1 GO:0045931 Not Cancer Driver No 72 0.125 185 24 0.13 0
CDCA5 CDCA5 Q96FF9 Sororin chr11 GO:0045931 Not Cancer Driver No 32 0.127 211 26 0.123 0
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 GO:0045931 Not Cancer Driver No 40 0.135 1 0 0.0 0
CDK10 CDK10 Q15131 Cyclin-dependent kinase 10 chr16 GO:0045931 Not Cancer Driver No 42 0.117 30 4 0.133 0
CDK4 CDK4 P11802 Cyclin-dependent kinase 4 chr12 GO:0045931 Census, Compendium Yes 52 0.172 52 5 0.096 3
CDT1 CDT1 Q9H211 DNA replication factor Cdt1 chr16 GO:0045931 Not Cancer Driver No 60 0.11 377 35 0.093 5
CENPJ CENPJ Q9HC77 Centromere protein J chr13 GO:0045931 Not Cancer Driver No 176 0.132 1176 158 0.134 1
CPSF3 CPSF3 Q9UKF6 Cleavage and polyadenylation specificity factor subunit 3 chr2 GO:0045931 Not Cancer Driver No 78 0.114 56 9 0.161 0
CUL3 CUL3 Q13618 Cullin-3 chr2 GO:0045931 Census, Compendium Yes 123 0.16 167 23 0.138 3
CUL4A CUL4A Q13619 Cullin-4A chr13 GO:0045931 Not Cancer Driver No 64 0.084 102 2 0.02 0
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0045931 Not Cancer Driver No 138 0.151 207 38 0.184 2
CYP1A1 CYP1A1 P04798 Cytochrome P450 1A1 chr15 GO:0045931 Not Cancer Driver No 81 0.158 17 2 0.118 0
DBF4B DBF4B Q8NFT6 Protein DBF4 homolog B chr17 GO:0045931 Not Cancer Driver No 68 0.111 311 22 0.071 0
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX GO:0045931 Census, Compendium Yes 133 0.201 301 47 0.156 18
DLGAP5 DLGAP5 Q15398 Disks large-associated protein 5 chr14 GO:0045931 Not Cancer Driver No 84 0.099 676 70 0.104 0
DTL DTL Q9NZJ0 Denticleless protein homolog chr1 GO:0045931 Not Cancer Driver No 73 0.1 331 49 0.148 0
DUSP3 DUSP3 P51452 Dual specificity protein phosphatase 3 chr17 GO:0045931 Not Cancer Driver No 21 0.114 4 1 0.25 0
DYNLT3 DYNLT3 P51808 Dynein light chain Tctex-type 3 chrX GO:0045931 Not Cancer Driver No 11 0.095 0 0 0.0 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0045931 Census, Compendium Yes 444 0.367 223 35 0.157 1
EIF4EBP1 EIF4EBP1 Q13541 Eukaryotic translation initiation factor 4E-binding protein 1 chr8 GO:0045931 Not Cancer Driver No 8 0.068 118 8 0.068 0
EIF4E_ENST00000450253 EIF4E P06730 Eukaryotic translation initiation factor 4E chr4 GO:0045931 Not Cancer Driver No 26 0.12 54 6 0.111 0
EIF4G1_ENST00000346169 EIF4G1 Q04637 Eukaryotic translation initiation factor 4 gamma 1 chr3 GO:0045931 Not Cancer Driver No 229 0.143 1079 153 0.142 2
ESPL1 ESPL1 Q14674 Separin chr12 GO:0045931 Not Cancer Driver No 211 0.1 380 39 0.103 0
FBXO5 FBXO5 Q9UKT4 F-box only protein 5 chr6 GO:0045931 Not Cancer Driver No 48 0.107 113 13 0.115 0
FGF10 FGF10 O15520 Fibroblast growth factor 10 chr5 GO:0045931 Not Cancer Driver No 56 0.269 34 11 0.324 2
FOXA1 FOXA1 P55317 Hepatocyte nuclear factor 3-alpha chr14 GO:0045931 Census, Compendium Yes 100 0.212 295 53 0.18 0
HES1 HES1 Q14469 Transcription factor HES-1 chr3 GO:0045931 Not Cancer Driver No 37 0.132 226 32 0.142 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0045931 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSPA2_ENST00000247207 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 GO:0045931 Not Cancer Driver No 93 0.146 286 38 0.133 0
HYAL1_ENST00000395144 HYAL1 Q12794 Hyaluronidase-1 chr3 GO:0045931 Not Cancer Driver No 47 0.108 9 0 0.0 1
KCNA5 KCNA5 P22460 Potassium voltage-gated channel subfamily A member 5 chr12 GO:0045931 Not Cancer Driver No 213 0.347 218 53 0.243 0
KLHL18 KLHL18 O94889 Kelch-like protein 18 chr3 GO:0045931 Not Cancer Driver No 82 0.143 31 10 0.323 0
KMT2E KMT2E Q8IZD2 Inactive histone-lysine N-methyltransferase 2E chr7 GO:0045931 Not Cancer Driver No 233 0.125 1613 198 0.123 4
LGMN_ENST00000334869 LGMN Q99538 Legumain chr14 GO:0045931 Not Cancer Driver No 57 0.132 112 19 0.17 0
LSM10 LSM10 Q969L4 U7 snRNA-associated Sm-like protein LSm10 chr1 GO:0045931 Not Cancer Driver No 21 0.171 12 5 0.417 0
LSM11 LSM11 P83369 U7 snRNA-associated Sm-like protein LSm11 chr5 GO:0045931 Not Cancer Driver No 34 0.094 266 17 0.064 1
MAD2L1BP_ENST00000372171 MAD2L1BP Q15013 MAD2L1-binding protein chr6 GO:0045931 Not Cancer Driver No 26 0.095 55 7 0.127 0
MBLAC1 MBLAC1 A4D2B0 Metallo-beta-lactamase domain-containing protein 1 chr7 GO:0045931 Not Cancer Driver No 26 0.098 175 22 0.126 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0045931 Census, Compendium Yes 56 0.114 297 37 0.125 0
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX GO:0045931 Not Cancer Driver No 75 0.154 483 74 0.153 46
MEIS2 MEIS2 O14770 Homeobox protein Meis2 chr15 GO:0045931 Not Cancer Driver No 94 0.197 358 76 0.212 0
MEPCE MEPCE Q7L2J0 7SK snRNA methylphosphate capping enzyme chr7 GO:0045931 Not Cancer Driver No 76 0.11 446 42 0.094 0
MTA3 MTA3 Q9BTC8 Metastasis-associated protein MTA3 chr2 GO:0045931 Not Cancer Driver No 48 0.081 169 18 0.107 0
MTBP MTBP Q96DY7 Mdm2-binding protein chr8 GO:0045931 Not Cancer Driver No 99 0.11 259 27 0.104 0
NEUROG1 NEUROG1 Q92886 Neurogenin-1 chr5 GO:0045931 Not Cancer Driver No 27 0.114 178 18 0.101 0
NKX3-1 NKX3-1 Q99801 Homeobox protein Nkx-3.1 chr8 GO:0045931 Not Cancer Driver No 35 0.15 171 16 0.094 0
NSMCE2_ENST00000522563 NSMCE2 Q96MF7 E3 SUMO-protein ligase NSE2 chr8 GO:0045931 Not Cancer Driver No 30 0.121 119 12 0.101 0
PAFAH1B1 PAFAH1B1 P43034 Platelet-activating factor acetylhydrolase IB subunit beta chr17 GO:0045931 Not Cancer Driver No 42 0.102 82 11 0.134 7
PBX1 PBX1 P40424 Pre-B-cell leukemia transcription factor 1 chr1 GO:0045931 Census Yes 82 0.191 290 57 0.197 0
PHB2 PHB2 Q99623 Prohibitin-2 chr12 GO:0045931 Not Cancer Driver No 31 0.104 26 4 0.154 0
PHOX2B PHOX2B Q99453 Paired mesoderm homeobox protein 2B chr4 GO:0045931 Census Yes 59 0.188 219 44 0.201 2
PKN2 PKN2 Q16513 Serine/threonine-protein kinase N2 chr1 GO:0045931 Not Cancer Driver No 123 0.125 415 48 0.116 0
PLCB1 PLCB1 Q9NQ66 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 chr20 GO:0045931 Not Cancer Driver No 313 0.257 481 104 0.216 0
PLRG1 PLRG1 O43660 Pleiotropic regulator 1 chr4 GO:0045931 Not Cancer Driver No 75 0.146 204 25 0.123 0
POLDIP2 POLDIP2 Q9Y2S7 Polymerase delta-interacting protein 2 chr17 GO:0045931 Not Cancer Driver No 36 0.098 94 13 0.138 0
PPP1R10 PPP1R10 Q96QC0 Serine/threonine-protein phosphatase 1 regulatory subunit 10 chr6 GO:0045931 Not Cancer Driver No 114 0.121 798 100 0.125 0
PRAP1 PRAP1 Q96NZ9 Proline-rich acidic protein 1 chr10 GO:0045931 Not Cancer Driver No 14 0.093 124 13 0.105 0
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 GO:0045931 Not Cancer Driver No 94 0.14 154 22 0.143 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 GO:0045931 Census, Compendium Yes 129 0.218 260 38 0.146 60
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 GO:0045931 Not Cancer Driver No 31 0.144 43 4 0.093 0
RAD51B_ENST00000487270 RAD51B O15315 DNA repair protein RAD51 homolog 2 chr14 GO:0045931 Census Yes 45 0.117 13 0 0.0 0
RAD51C RAD51C O43502 DNA repair protein RAD51 homolog 3 chr17 GO:0045931 Not Cancer Driver No 47 0.125 18 2 0.111 6
RB1 RB1 P06400 Retinoblastoma-associated protein chr13 GO:0045931 Census, Compendium Yes 140 0.151 282 32 0.113 22
RCC2 RCC2 Q9P258 Protein RCC2 chr1 GO:0045931 Not Cancer Driver No 63 0.121 194 27 0.139 0
RDX_ENST00000343115 RDX P35241 Radixin chr11 GO:0045931 Not Cancer Driver No 71 0.122 297 37 0.125 1
RGCC RGCC Q9H4X1 Regulator of cell cycle RGCC chr13 GO:0045931 Not Cancer Driver No 9 0.066 81 7 0.086 0
RPS6KB1 RPS6KB1 P23443 Ribosomal protein S6 kinase beta-1 chr17 GO:0045931 Not Cancer Driver No 45 0.086 226 26 0.115 0
RPTOR RPTOR Q8N122 Regulatory-associated protein of mTOR chr17 GO:0045931 Not Cancer Driver No 176 0.132 241 21 0.087 0
RRM1 RRM1 P23921 Ribonucleoside-diphosphate reductase large subunit chr11 GO:0045931 Not Cancer Driver No 74 0.093 41 7 0.171 0
RRM2B RRM2B Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B chr8 GO:0045931 Not Cancer Driver No 46 0.131 32 5 0.156 9
RRM2_ENST00000641198 RRM2 P31350 Ribonucleoside-diphosphate reductase subunit M2 chr2 GO:0045931 Not Cancer Driver No 40 0.103 48 0 0.0 0
SASS6 SASS6 Q6UVJ0 Spindle assembly abnormal protein 6 homolog chr1 GO:0045931 Not Cancer Driver No 82 0.125 331 37 0.112 1
SIN3A_ENST00000360439 SIN3A Q96ST3 Paired amphipathic helix protein Sin3a chr15 GO:0045931 Compendium Yes 172 0.135 617 73 0.118 0
SMOC2_ENST00000356284 SMOC2 Q9H3U7 SPARC-related modular calcium-binding protein 2 chr6 GO:0045931 Not Cancer Driver No 82 0.184 216 52 0.241 0
SPHK1_ENST00000545180 SPHK1 Q9NYA1 Sphingosine kinase 1 chr17 GO:0045931 Not Cancer Driver No 47 0.122 25 2 0.08 0
STAT5B STAT5B P51692 Signal transducer and activator of transcription 5B chr17 GO:0045931 Census, Compendium Yes 93 0.118 144 19 0.132 5
STIL_ENST00000360380 STIL Q15468 SCL-interrupting locus protein chr1 GO:0045931 Census, Compendium Yes 147 0.114 735 85 0.116 1
STOX1_ENST00000399169 STOX1 Q6ZVD7 Storkhead-box protein 1 chr10 GO:0045931 Not Cancer Driver No 121 0.122 659 83 0.126 2
TAL1 TAL1 P17542 T-cell acute lymphocytic leukemia protein 1 chr1 GO:0045931 Census Yes 54 0.163 305 53 0.174 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 GO:0045931 Census Yes 110 0.097 212 16 0.075 31
TFDP1 TFDP1 Q14186 Transcription factor Dp-1 chr13 GO:0045931 Not Cancer Driver No 82 0.2 245 47 0.192 0
TMOD3 TMOD3 Q9NYL9 Tropomodulin-3 chr15 GO:0045931 Not Cancer Driver No 40 0.114 190 24 0.126 0
TTL TTL Q8NG68 Tubulin--tyrosine ligase chr2 GO:0045931 Not Cancer Driver No 37 0.098 24 0 0.0 0
UBE2C UBE2C O00762 Ubiquitin-conjugating enzyme E2 C chr20 GO:0045931 Not Cancer Driver No 13 0.073 40 0 0.0 0
UBE2E2_ENST00000425792 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 GO:0045931 Not Cancer Driver No 28 0.139 90 15 0.167 0
USP2 USP2 O75604 Ubiquitin carboxyl-terminal hydrolase 2 chr11 GO:0045931 Not Cancer Driver No 88 0.145 213 39 0.183 0
USP22 USP22 Q9UPT9 Ubiquitin carboxyl-terminal hydrolase 22 chr17 GO:0045931 Not Cancer Driver No 64 0.122 50 1 0.02 0
VPS4B VPS4B O75351 Vacuolar protein sorting-associated protein 4B chr18 GO:0045931 Not Cancer Driver No 52 0.117 195 22 0.113 0
WNT10B WNT10B O00744 Protein Wnt-10b chr12 GO:0045931 Not Cancer Driver No 56 0.144 84 16 0.19 2