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Total number of protein in "GO:0045121" GO term:  288

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCA1 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 GO:0045121 Not Cancer Driver No 284 0.126 245 40 0.163 31
ABCB4 ABCB4 P21439 Phosphatidylcholine translocator ABCB4 chr7 GO:0045121 Not Cancer Driver No 243 0.189 74 14 0.189 72
ABCG2 ABCG2 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 chr4 GO:0045121 Not Cancer Driver No 124 0.189 35 10 0.286 0
ACE2 ACE2 Q9BYF1 Angiotensin-converting enzyme 2 chrX GO:0045121 Not Cancer Driver No 104 0.129 68 5 0.074 0
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0045121 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADCY1 ADCY1 Q08828 Adenylate cyclase type 1 chr7 GO:0045121 Not Cancer Driver No 244 0.218 99 19 0.192 0
ADCY2 ADCY2 Q08462 Adenylate cyclase type 2 chr5 GO:0045121 Not Cancer Driver No 303 0.278 95 24 0.253 0
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 GO:0045121 Not Cancer Driver No 419 0.335 215 38 0.177 0
ADCYAP1R1_ENST00000304166 ADCYAP1R1 P41586 Pituitary adenylate cyclase-activating polypeptide type I receptor chr7 GO:0045121 Not Cancer Driver No 127 0.271 0 0 0.0 0
ADGRG1 ADGRG1 Q9Y653 Adhesion G-protein coupled receptor G1 chr16 GO:0045121 Not Cancer Driver No 64 0.092 67 4 0.06 9
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0045121 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA1B ADRA1B P35368 Alpha-1B adrenergic receptor chr5 GO:0045121 Not Cancer Driver No 53 0.102 132 1 0.008 0
ADTRP_ENST00000414691 ADTRP Q96IZ2 Androgen-dependent TFPI-regulating protein chr6 GO:0045121 Not Cancer Driver No 41 0.178 2 0 0.0 0
AHNAK AHNAK Q09666 Neuroblast differentiation-associated protein AHNAK chr11 GO:0045121 Not Cancer Driver No 805 0.137 5777 794 0.137 0
AKAP5_ENST00000320636 AKAP5 P24588 A-kinase anchor protein 5 chr14 GO:0045121 Not Cancer Driver No 37 0.087 405 34 0.084 0
AKAP6 AKAP6 Q13023 A-kinase anchor protein 6 chr14 GO:0045121 Not Cancer Driver No 383 0.165 1456 240 0.165 0
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0045121 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANK2 ANK2 Q01484 Ankyrin-2 chr4 GO:0045121 Not Cancer Driver No 770 0.195 2844 566 0.199 4
ANO1 ANO1 Q5XXA6 Anoctamin-1 chr11 GO:0045121 Not Cancer Driver No 155 0.157 168 14 0.083 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 GO:0045121 Not Cancer Driver No 49 0.145 20 4 0.2 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0045121 Not Cancer Driver No 128 0.166 418 71 0.17 17
ARC ARC Q7LC44 Activity-regulated cytoskeleton-associated protein chr8 GO:0045121 Not Cancer Driver No 64 0.162 194 29 0.149 0
ARID3A ARID3A Q99856 AT-rich interactive domain-containing protein 3A chr19 GO:0045121 Not Cancer Driver No 55 0.093 432 37 0.086 0
ARID3C ARID3C A6NKF2 AT-rich interactive domain-containing protein 3C chr9 GO:0045121 Not Cancer Driver No 61 0.148 305 47 0.154 0
ASAH2 ASAH2 Q9NR71 Neutral ceramidase chr10 GO:0045121 Not Cancer Driver No 71 0.091 140 24 0.171 0
ATP1A1_ENST00000295598 ATP1A1 P05023 Sodium/potassium-transporting ATPase subunit alpha-1 chr1 GO:0045121 Census Yes 115 0.112 115 16 0.139 6
ATP1A2 ATP1A2 P50993 Sodium/potassium-transporting ATPase subunit alpha-2 chr1 GO:0045121 Not Cancer Driver No 230 0.225 161 34 0.211 8
ATP1A4 ATP1A4 Q13733 Sodium/potassium-transporting ATPase subunit alpha-4 chr1 GO:0045121 Not Cancer Driver No 195 0.19 117 24 0.205 0
ATP1B1 ATP1B1 P05026 Sodium/potassium-transporting ATPase subunit beta-1 chr1 GO:0045121 Not Cancer Driver No 38 0.125 55 9 0.164 0
ATP2B1_ENST00000261173 ATP2B1 P20020 Plasma membrane calcium-transporting ATPase 1 chr12 GO:0045121 Not Cancer Driver No 143 0.117 293 42 0.143 0
ATP2B2 ATP2B2 Q01814 Plasma membrane calcium-transporting ATPase 2 chr3 GO:0045121 Not Cancer Driver No 248 0.2 360 82 0.228 0
ATP5F1A_ENST00000282050 ATP5F1A P25705 ATP synthase subunit alpha, mitochondrial chr18 GO:0045121 Not Cancer Driver No 66 0.119 23 5 0.217 2
ATP7A ATP7A Q04656 Copper-transporting ATPase 1 chrX GO:0045121 Not Cancer Driver No 228 0.152 171 46 0.269 52
BAALC BAALC Q8WXS3 Brain and acute leukemia cytoplasmic protein chr8 GO:0045121 Not Cancer Driver No 22 0.152 145 22 0.152 0
BACE1 BACE1 P56817 Beta-secretase 1 chr11 GO:0045121 Not Cancer Driver No 55 0.11 53 5 0.094 0
BCL10 BCL10 O95999 B-cell lymphoma/leukemia 10 chr1 GO:0045121 Census, Compendium Yes 36 0.155 151 25 0.166 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 GO:0045121 Not Cancer Driver No 69 0.112 83 9 0.108 0
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 GO:0045121 Census, Compendium Yes 77 0.127 98 16 0.163 0
BMPR1A BMPR1A P36894 Bone morphogenetic protein receptor type-1A chr10 GO:0045121 Census, Compendium Yes 66 0.124 21 0 0.0 8
BMPR2 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 chr2 GO:0045121 Compendium Yes 141 0.136 601 70 0.116 19
BSG BSG P35613 Basigin chr19 GO:0045121 Not Cancer Driver No 43 0.112 123 17 0.138 0
BST2 BST2 Q10589 Bone marrow stromal antigen 2 chr19 GO:0045121 Not Cancer Driver No 19 0.106 20 0 0.0 0
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0045121 Census, Compendium Yes 147 0.223 114 27 0.237 110
BVES BVES Q8NE79 Blood vessel epicardial substance chr6 GO:0045121 Not Cancer Driver No 59 0.164 65 15 0.231 1
CAPN2 CAPN2 P17655 Calpain-2 catalytic subunit chr1 GO:0045121 Not Cancer Driver No 81 0.116 46 11 0.239 0
CARD11 CARD11 Q9BXL7 Caspase recruitment domain-containing protein 11 chr7 GO:0045121 Census, Compendium Yes 303 0.263 530 140 0.264 5
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0045121 Census Yes 32 0.116 62 5 0.081 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 GO:0045121 Census, Compendium Yes 142 0.296 106 12 0.113 1
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0045121 Not Cancer Driver No 30 0.169 2 0 0.0 0
CAV2 CAV2 P51636 Caveolin-2 chr7 GO:0045121 Not Cancer Driver No 20 0.123 5 2 0.4 0
CAV3 CAV3 P56539 Caveolin-3 chr3 GO:0045121 Not Cancer Driver No 27 0.179 0 0 0.0 25
CAVIN1 CAVIN1 Q6NZI2 Caveolae-associated protein 1 chr17 GO:0045121 Not Cancer Driver No 66 0.169 280 50 0.179 0
CAVIN2 CAVIN2 O95810 Caveolae-associated protein 2 chr2 GO:0045121 Not Cancer Driver No 109 0.256 393 99 0.252 0
CAVIN3 CAVIN3 Q969G5 Caveolae-associated protein 3 chr11 GO:0045121 Not Cancer Driver No 22 0.084 234 19 0.081 0
CAVIN4 CAVIN4 Q5BKX8 Caveolae-associated protein 4 chr9 GO:0045121 Not Cancer Driver No 59 0.162 286 45 0.157 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0045121 Census, Compendium Yes 115 0.127 512 56 0.109 4
CBLB CBLB Q13191 E3 ubiquitin-protein ligase CBL-B chr3 GO:0045121 Census Yes 160 0.163 562 104 0.185 0
CBLC_ENST00000647358 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 GO:0045121 Census Yes 60 0.127 128 21 0.164 0
CD14 CD14 P08571 Monocyte differentiation antigen CD14 chr5 GO:0045121 Not Cancer Driver No 42 0.112 60 5 0.083 0
CD19_ENST00000324662 CD19 P15391 B-lymphocyte antigen CD19 chr16 GO:0045121 Not Cancer Driver No 80 0.144 312 46 0.147 0
CD1A CD1A P06126 T-cell surface glycoprotein CD1a chr1 GO:0045121 Not Cancer Driver No 105 0.321 18 6 0.333 0
CD2 CD2 P06729 T-cell surface antigen CD2 chr1 GO:0045121 Not Cancer Driver No 75 0.214 126 35 0.278 0
CD226_ENST00000582621 CD226 Q15762 CD226 antigen chr18 GO:0045121 Not Cancer Driver No 79 0.235 47 11 0.234 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0045121 Not Cancer Driver No 75 0.159 12 3 0.25 3
CD4 CD4 P01730 T-cell surface glycoprotein CD4 chr12 GO:0045121 Not Cancer Driver No 69 0.151 56 11 0.196 0
CD48_ENST00000368046 CD48 P09326 CD48 antigen chr1 GO:0045121 Not Cancer Driver No 39 0.16 2 0 0.0 0
CD55_ENST00000367064 CD55 P08174 Complement decay-accelerating factor chr1 GO:0045121 Not Cancer Driver No 45 0.118 128 13 0.102 1
CD79A CD79A P11912 B-cell antigen receptor complex-associated protein alpha chain chr19 GO:0045121 Census Yes 32 0.142 28 3 0.107 0
CDH13_ENST00000567109 CDH13 P55290 Cadherin-13 chr16 GO:0045121 Not Cancer Driver No 168 0.236 235 59 0.251 0
CDH15 CDH15 P55291 Cadherin-15 chr16 GO:0045121 Not Cancer Driver No 105 0.129 405 57 0.141 3
CFLAR CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 GO:0045121 Not Cancer Driver No 40 0.083 44 2 0.045 0
CLIP3_ENST00000593074 CLIP3 Q96DZ5 CAP-Gly domain-containing linker protein 3 chr19 GO:0045121 Not Cancer Driver No 78 0.143 218 22 0.101 0
CLN3_ENST00000636147 CLN3 Q13286 Battenin chr16 GO:0045121 Not Cancer Driver No 58 0.132 69 10 0.145 9
CLN6 CLN6 Q9NWW5 Ceroid-lipofuscinosis neuronal protein 6 chr15 GO:0045121 Not Cancer Driver No 28 0.09 13 0 0.0 24
CNR1_ENST00000549890 CNR1 P21554 Cannabinoid receptor 1 chr6 GO:0045121 Not Cancer Driver No 129 0.273 9 1 0.111 0
CNTN1 CNTN1 Q12860 Contactin-1 chr12 GO:0045121 Not Cancer Driver No 265 0.26 220 50 0.227 0
CRK CRK P46108 Adapter molecule crk chr17 GO:0045121 Not Cancer Driver No 30 0.099 197 23 0.117 0
CSK_ENST00000439220 CSK P41240 Tyrosine-protein kinase CSK chr15 GO:0045121 Not Cancer Driver No 41 0.091 18 1 0.056 0
CTSD CTSD P07339 Cathepsin D chr11 GO:0045121 Not Cancer Driver No 57 0.138 6 1 0.167 2
CXADR CXADR P78310 Coxsackievirus and adenovirus receptor chr21 GO:0045121 Not Cancer Driver No 51 0.14 98 19 0.194 0
DLC1 DLC1 Q96QB1 Rho GTPase-activating protein 7 chr8 GO:0045121 Not Cancer Driver No 331 0.217 922 237 0.257 0
DLG1_ENST00000419354 DLG1 Q12959 Disks large homolog 1 chr3 GO:0045121 Not Cancer Driver No 120 0.133 460 67 0.146 0
DLL1 DLL1 O00548 Delta-like protein 1 chr6 GO:0045121 Not Cancer Driver No 115 0.159 145 24 0.166 1
DMD DMD P11532 Dystrophin chrX GO:0045121 Not Cancer Driver No 895 0.243 1399 329 0.235 14
DPP4 DPP4 P27487 Dipeptidyl peptidase 4 chr2 GO:0045121 Not Cancer Driver No 151 0.197 8 1 0.125 0
EDNRB_ENST00000334286 EDNRB P24530 Endothelin receptor type B chr13 GO:0045121 Not Cancer Driver No 112 0.253 56 19 0.339 6
EFHD2 EFHD2 Q96C19 EF-hand domain-containing protein D2 chr1 GO:0045121 Not Cancer Driver No 13 0.054 101 1 0.01 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 GO:0045121 Not Cancer Driver No 34 0.149 25 6 0.24 0
EFNB1 EFNB1 P98172 Ephrin-B1 chrX GO:0045121 Not Cancer Driver No 46 0.133 126 14 0.111 19
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0045121 Census, Compendium Yes 444 0.367 223 35 0.157 1
EHD2 EHD2 Q9NZN4 EH domain-containing protein 2 chr19 GO:0045121 Compendium Yes 85 0.157 125 12 0.096 0
EMP2_ENST00000536829 EMP2 P54851 Epithelial membrane protein 2 chr16 GO:0045121 Not Cancer Driver No 24 0.144 0 0 0.0 2
ENO2 ENO2 P09104 Gamma-enolase chr12 GO:0045121 Not Cancer Driver No 48 0.111 12 2 0.167 0
EPHB1 EPHB1 P54762 Ephrin type-B receptor 1 chr3 GO:0045121 Not Cancer Driver No 316 0.321 67 17 0.254 0
ERLIN2_ENST00000519638 ERLIN2 O94905 Erlin-2 chr8 GO:0045121 Not Cancer Driver No 38 0.112 22 3 0.136 0
F2R F2R P25116 Proteinase-activated receptor 1 chr5 GO:0045121 Not Cancer Driver No 73 0.172 19 2 0.105 0
FADD FADD Q13158 FAS-associated death domain protein chr11 GO:0045121 Not Cancer Driver No 26 0.125 45 10 0.222 1
FAIM2 FAIM2 Q9BWQ8 Protein lifeguard 2 chr12 GO:0045121 Not Cancer Driver No 37 0.117 54 11 0.204 0
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 GO:0045121 Census, Compendium Yes 55 0.164 62 18 0.29 22
FASLG FASLG P48023 Tumor necrosis factor ligand superfamily member 6 chr1 GO:0045121 Not Cancer Driver No 65 0.231 94 18 0.191 1
FLOT1 FLOT1 O75955 Flotillin-1 chr6 GO:0045121 Not Cancer Driver No 43 0.101 122 15 0.123 0
FLOT2 FLOT2 Q14254 Flotillin-2 chr17 GO:0045121 Not Cancer Driver No 56 0.131 20 3 0.15 0
FURIN_ENST00000610579 FURIN P09958 Furin chr15 GO:0045121 Not Cancer Driver No 93 0.117 283 35 0.124 0
FXYD1_ENST00000455515 FXYD1 O00168 Phospholemman chr19 GO:0045121 Not Cancer Driver No 10 0.109 22 4 0.182 0
FYB2 FYB2 Q5VWT5 FYN-binding protein 2 chr1 GO:0045121 Not Cancer Driver No 150 0.206 547 124 0.227 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0045121 Not Cancer Driver No 92 0.171 70 13 0.186 0
GABBR1 GABBR1 Q9UBS5 Gamma-aminobutyric acid type B receptor subunit 1 chr6 GO:0045121 Not Cancer Driver No 150 0.156 142 17 0.12 0
GASK1A GASK1A Q9UFP1 Golgi-associated kinase 1A chr3 GO:0045121 Not Cancer Driver No 25 0.043 235 10 0.043 0
GHSR GHSR Q92847 Growth hormone secretagogue receptor type 1 chr3 GO:0045121 Not Cancer Driver No 85 0.232 4 0 0.0 2
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 GO:0045121 Not Cancer Driver No 86 0.225 110 26 0.236 50
GLIPR1L1 GLIPR1L1 Q6UWM5 GLIPR1-like protein 1 chr12 GO:0045121 Not Cancer Driver No 32 0.132 0 0 0.0 0
GNAI2 GNAI2 P04899 Guanine nucleotide-binding protein G(i) subunit alpha-2 chr3 GO:0045121 Compendium Yes 50 0.141 24 0 0.0 0
GNAI3 GNAI3 P08754 Guanine nucleotide-binding protein G(i) subunit alpha-3 chr1 GO:0045121 Not Cancer Driver No 42 0.119 11 0 0.0 1
GP2 GP2 P55259 Pancreatic secretory granule membrane major glycoprotein GP2 chr16 GO:0045121 Not Cancer Driver No 144 0.268 25 4 0.16 0
GP6_ENST00000417454 GP6 Q9HCN6 Platelet glycoprotein VI chr19 GO:0045121 Not Cancer Driver No 57 0.168 122 21 0.172 2
GPC1 GPC1 P35052 Glypican-1 chr2 GO:0045121 Not Cancer Driver No 58 0.104 166 14 0.084 0
GPM6B_ENST00000356942 GPM6B Q13491 Neuronal membrane glycoprotein M6-b chrX GO:0045121 Not Cancer Driver No 39 0.147 14 3 0.214 0
HCK_ENST00000534862 HCK P08631 Tyrosine-protein kinase HCK chr20 GO:0045121 Not Cancer Driver No 112 0.213 124 25 0.202 0
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX GO:0045121 Not Cancer Driver No 178 0.147 409 59 0.144 0
HK1_ENST00000359426 HK1 P19367 Hexokinase-1 chr10 GO:0045121 Not Cancer Driver No 127 0.138 75 16 0.213 6
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:0045121 Not Cancer Driver No 46 0.16 81 13 0.16 0
HPSE HPSE Q9Y251 Heparanase chr4 GO:0045121 Not Cancer Driver No 90 0.166 16 2 0.125 0
HTR2A HTR2A P28223 5-hydroxytryptamine receptor 2A chr13 GO:0045121 Not Cancer Driver No 105 0.223 44 8 0.182 0
HYAL2_ENST00000357750 HYAL2 Q12891 Hyaluronidase-2 chr3 GO:0045121 Not Cancer Driver No 52 0.11 8 1 0.125 0
ICAM1 ICAM1 P05362 Intercellular adhesion molecule 1 chr19 GO:0045121 Not Cancer Driver No 61 0.115 251 28 0.112 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0045121 Not Cancer Driver No 183 0.134 265 37 0.14 6
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 GO:0045121 Census, Compendium Yes 106 0.14 211 31 0.147 1
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0045121 Census, Compendium Yes 102 0.111 315 40 0.127 2
INPP5D INPP5D Q92835 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 chr2 GO:0045121 Not Cancer Driver No 176 0.148 578 90 0.156 0
INSR INSR P06213 Insulin receptor chr19 GO:0045121 Not Cancer Driver No 190 0.137 280 57 0.204 64
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 GO:0045121 Not Cancer Driver No 161 0.13 1072 133 0.124 2
ITGA1 ITGA1 P56199 Integrin alpha-1 chr5 GO:0045121 Not Cancer Driver No 156 0.132 107 13 0.121 0
ITGB1_ENST00000302278 ITGB1 P05556 Integrin beta-1 chr10 GO:0045121 Not Cancer Driver No 103 0.129 84 10 0.119 0
ITLN1 ITLN1 Q8WWA0 Intelectin-1 chr1 GO:0045121 Not Cancer Driver No 72 0.23 13 4 0.308 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0045121 Census, Compendium Yes 136 0.12 59 5 0.085 5
KCNA3 KCNA3 P22001 Potassium voltage-gated channel subfamily A member 3 chr1 GO:0045121 Not Cancer Driver No 120 0.209 169 16 0.095 0
KCNA5 KCNA5 P22460 Potassium voltage-gated channel subfamily A member 5 chr12 GO:0045121 Not Cancer Driver No 213 0.347 218 53 0.243 0
KCNE1_ENST00000399284 KCNE1 P15382 Potassium voltage-gated channel subfamily E member 1 chr21 GO:0045121 Not Cancer Driver No 35 0.271 24 10 0.417 9
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 GO:0045121 Not Cancer Driver No 28 0.272 24 2 0.083 0
KCNMA1 KCNMA1 Q12791 Calcium-activated potassium channel subunit alpha-1 chr10 GO:0045121 Not Cancer Driver No 222 0.18 225 39 0.173 5
KCNQ1 KCNQ1 P51787 Potassium voltage-gated channel subfamily KQT member 1 chr11 GO:0045121 Not Cancer Driver No 78 0.115 219 20 0.091 132
KDR KDR P35968 Vascular endothelial growth factor receptor 2 chr4 GO:0045121 Census, Compendium Yes 357 0.263 275 55 0.2 2
KIF18A KIF18A Q8NI77 Kinesin-like protein KIF18A chr11 GO:0045121 Not Cancer Driver No 114 0.127 405 60 0.148 0
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 GO:0045121 Not Cancer Driver No 13 0.081 96 7 0.073 0
LAT2 LAT2 Q9GZY6 Linker for activation of T-cells family member 2 chr7 GO:0045121 Not Cancer Driver No 39 0.16 176 29 0.165 0
LAT_ENST00000360872 LAT O43561 Linker for activation of T-cells family member 1 chr16 GO:0045121 Not Cancer Driver No 37 0.141 213 29 0.136 0
LAX1 LAX1 Q8IWV1 Lymphocyte transmembrane adapter 1 chr1 GO:0045121 Not Cancer Driver No 61 0.153 228 32 0.14 0
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 GO:0045121 Census Yes 86 0.169 94 13 0.138 1
LDHB_ENST00000350669 LDHB P07195 L-lactate dehydrogenase B chain chr12 GO:0045121 Not Cancer Driver No 47 0.141 15 2 0.133 11
LIPE LIPE Q05469 Hormone-sensitive lipase chr19 GO:0045121 Not Cancer Driver No 123 0.114 496 65 0.131 0
LRP6 LRP6 O75581 Low-density lipoprotein receptor-related protein 6 chr12 GO:0045121 Not Cancer Driver No 206 0.128 255 30 0.118 5
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0045121 Not Cancer Driver No 94 0.098 190 24 0.126 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0045121 Not Cancer Driver No 519 0.205 90 17 0.189 23
LY6K LY6K Q17RY6 Lymphocyte antigen 6K chr8 GO:0045121 Not Cancer Driver No 35 0.212 14 5 0.357 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0045121 Census Yes 95 0.186 84 12 0.143 0
LYPD6_ENST00000409381 LYPD6 Q86Y78 Ly6/PLAUR domain-containing protein 6 chr2 GO:0045121 Not Cancer Driver No 17 0.099 8 0 0.0 0
MAG_ENST00000537831 MAG P20916 Myelin-associated glycoprotein chr19 GO:0045121 Not Cancer Driver No 118 0.188 65 7 0.108 1
MAL MAL P21145 Myelin and lymphocyte protein chr2 GO:0045121 Not Cancer Driver No 21 0.137 0 0 0.0 0
MAL2 MAL2 Q969L2 Protein MAL2 chr8 GO:0045121 Not Cancer Driver No 20 0.114 4 0 0.0 0
MALL MALL Q13021 MAL-like protein chr2 GO:0045121 Not Cancer Driver No 20 0.131 0 0 0.0 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0045121 Census, Compendium Yes 62 0.172 2 0 0.0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0045121 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0045121 Not Cancer Driver No 128 0.169 750 126 0.168 18
MLC1 MLC1 Q15049 Membrane protein MLC1 chr22 GO:0045121 Not Cancer Driver No 53 0.141 35 7 0.2 15
MME_ENST00000492661 MME P08473 Neprilysin chr3 GO:0045121 Not Cancer Driver No 189 0.252 40 17 0.425 4
MYADM MYADM Q96S97 Myeloid-associated differentiation marker chr19 GO:0045121 Not Cancer Driver No 73 0.227 0 0 0.0 0
MYO1C MYO1C O00159 Unconventional myosin-Ic chr17 GO:0045121 Not Cancer Driver No 110 0.103 66 11 0.167 0
MYOF MYOF Q9NZM1 Myoferlin chr10 GO:0045121 Not Cancer Driver No 269 0.131 401 55 0.137 0
NFAM1 NFAM1 Q8NET5 NFAT activation molecule 1 chr22 GO:0045121 Not Cancer Driver No 30 0.111 116 18 0.155 0
NOS1AP NOS1AP O75052 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein chr1 GO:0045121 Not Cancer Driver No 94 0.186 255 53 0.208 1
NOS1_ENST00000317775 NOS1 P29475 Nitric oxide synthase, brain chr12 GO:0045121 Not Cancer Driver No 405 0.282 342 99 0.289 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 GO:0045121 Not Cancer Driver No 168 0.14 347 38 0.11 0
NPC1 NPC1 O15118 NPC intracellular cholesterol transporter 1 chr18 GO:0045121 Not Cancer Driver No 155 0.121 24 0 0.0 150
NPHS2 NPHS2 Q9NP85 Podocin chr1 GO:0045121 Not Cancer Driver No 72 0.188 130 18 0.138 50
NTSR1 NTSR1 P30989 Neurotensin receptor type 1 chr20 GO:0045121 Not Cancer Driver No 85 0.203 23 1 0.043 0
OLR1 OLR1 P78380 Oxidized low-density lipoprotein receptor 1 chr12 GO:0045121 Not Cancer Driver No 38 0.139 75 8 0.107 0
OPRD1 OPRD1 P41143 Delta-type opioid receptor chr1 GO:0045121 Not Cancer Driver No 91 0.245 30 3 0.1 0
OPRM1_ENST00000330432 OPRM1 P35372 Mu-type opioid receptor chr6 GO:0045121 Not Cancer Driver No 107 0.268 58 27 0.466 0
ORAI1 ORAI1 Q96D31 Calcium release-activated calcium channel protein 1 chr12 GO:0045121 Not Cancer Driver No 26 0.086 101 9 0.089 5
P2RX1 P2RX1 P51575 P2X purinoceptor 1 chr17 GO:0045121 Not Cancer Driver No 59 0.148 14 1 0.071 0
P2RX3 P2RX3 P56373 P2X purinoceptor 3 chr11 GO:0045121 Not Cancer Driver No 85 0.214 15 6 0.4 0
PACSIN2_ENST00000402229 PACSIN2 Q9UNF0 Protein kinase C and casein kinase substrate in neurons protein 2 chr22 GO:0045121 Not Cancer Driver No 51 0.105 301 27 0.09 0
PAG1 PAG1 Q9NWQ8 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 chr8 GO:0045121 Not Cancer Driver No 58 0.134 394 54 0.137 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0045121 Not Cancer Driver No 11 0.058 30 0 0.0 5
PDPN_ENST00000621990 PDPN Q86YL7 Podoplanin chr1 GO:0045121 Not Cancer Driver No 37 0.228 96 24 0.25 0
PDZK1_ENST00000344770 PDZK1 Q5T2W1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 chr1 GO:0045121 Not Cancer Driver No 39 0.075 248 14 0.056 0
PECAM1 PECAM1 P16284 Platelet endothelial cell adhesion molecule chr17 GO:0045121 Not Cancer Driver No 2 0.003 153 2 0.013 0
PGK1 PGK1 P00558 Phosphoglycerate kinase 1 chrX GO:0045121 Not Cancer Driver No 61 0.146 40 5 0.125 9
PI4K2A PI4K2A Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha chr10 GO:0045121 Not Cancer Driver No 43 0.09 129 6 0.047 0
PIKFYVE PIKFYVE Q9Y2I7 1-phosphatidylinositol 3-phosphate 5-kinase chr2 GO:0045121 Not Cancer Driver No 278 0.133 848 101 0.119 1
PLLP PLLP Q9Y342 Plasmolipin chr16 GO:0045121 Not Cancer Driver No 16 0.088 0 0 0.0 0
PLPP1_ENST00000307259 PLPP1 O14494 Phospholipid phosphatase 1 chr5 GO:0045121 Not Cancer Driver No 28 0.099 27 1 0.037 0
PLPP2_ENST00000434325 PLPP2 O43688 Phospholipid phosphatase 2 chr19 GO:0045121 Not Cancer Driver No 47 0.163 0 0 0.0 0
PLPP3 PLPP3 O14495 Phospholipid phosphatase 3 chr1 GO:0045121 Not Cancer Driver No 48 0.154 10 1 0.1 0
PLSCR1 PLSCR1 O15162 Phospholipid scramblase 1 chr3 GO:0045121 Not Cancer Driver No 43 0.135 92 13 0.141 0
PLVAP PLVAP Q9BX97 Plasmalemma vesicle-associated protein chr19 GO:0045121 Not Cancer Driver No 96 0.217 174 39 0.224 1
PODXL PODXL O00592 Podocalyxin chr7 GO:0045121 Not Cancer Driver No 69 0.124 432 56 0.13 0
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 GO:0045121 Not Cancer Driver No 41 0.133 12 1 0.083 8
PPP2R1B_ENST00000527614 PPP2R1B P30154 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform chr11 GO:0045121 Not Cancer Driver No 72 0.12 17 1 0.059 0
PPT1 PPT1 P50897 Palmitoyl-protein thioesterase 1 chr1 GO:0045121 Not Cancer Driver No 37 0.121 0 0 0.0 23
PRKAR2B PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 GO:0045121 Not Cancer Driver No 60 0.144 125 4 0.032 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 GO:0045121 Not Cancer Driver No 70 0.118 116 11 0.095 0
PRNP PRNP P04156 Major prion protein chr20 GO:0045121 Not Cancer Driver No 36 0.142 115 7 0.061 18
PROM2_ENST00000403131 PROM2 Q8N271 Prominin-2 chr2 GO:0045121 Not Cancer Driver No 111 0.133 34 4 0.118 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0045121 Not Cancer Driver No 61 0.131 134 21 0.157 96
PSEN2 PSEN2 P49810 Presenilin-2 chr1 GO:0045121 Not Cancer Driver No 68 0.152 89 16 0.18 7
PTCH1 PTCH1 Q13635 Protein patched homolog 1 chr9 GO:0045121 Census, Compendium Yes 243 0.168 382 67 0.175 18
PTGIS PTGIS Q16647 Prostacyclin synthase chr20 GO:0045121 Not Cancer Driver No 102 0.204 18 3 0.167 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0045121 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0045121 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPRC PTPRC P08575 Receptor-type tyrosine-protein phosphatase C chr1 GO:0045121 Census, Compendium Yes 315 0.241 462 107 0.232 0
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 GO:0045121 Not Cancer Driver No 32 0.149 65 15 0.231 0
RANGRF RANGRF Q9HD47 Ran guanine nucleotide release factor chr17 GO:0045121 Not Cancer Driver No 10 0.054 42 5 0.119 0
RAP1B_ENST00000393436 RAP1B P61224 Ras-related protein Rap-1b chr12 GO:0045121 Not Cancer Driver No 26 0.141 14 3 0.214 0
RAP2B RAP2B P61225 Ras-related protein Rap-2b chr3 GO:0045121 Not Cancer Driver No 22 0.12 0 0 0.0 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:0045121 Census, Compendium Yes 208 0.187 105 12 0.114 139
RFTN1 RFTN1 Q14699 Raftlin chr3 GO:0045121 Not Cancer Driver No 87 0.151 319 44 0.138 0
RGMB_ENST00000513185 RGMB Q6NW40 Repulsive guidance molecule B chr5 GO:0045121 Not Cancer Driver No 42 0.096 84 12 0.143 0
RGS19_ENST00000332298 RGS19 P49795 Regulator of G-protein signaling 19 chr20 GO:0045121 Not Cancer Driver No 27 0.124 71 8 0.113 0
RGS7_ENST00000366563 RGS7 P49802 Regulator of G-protein signaling 7 chr1 GO:0045121 Census, Compendium Yes 196 0.396 150 50 0.333 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 GO:0045121 Not Cancer Driver No 25 0.122 0 0 0.0 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0045121 Compendium Yes 82 0.122 277 39 0.141 4
RIT2 RIT2 Q99578 GTP-binding protein Rit2 chr18 GO:0045121 Not Cancer Driver No 74 0.341 29 11 0.379 0
RTN4R RTN4R Q9BZR6 Reticulon-4 receptor chr22 GO:0045121 Not Cancer Driver No 38 0.08 148 17 0.115 5
RTN4RL1 RTN4RL1 Q86UN2 Reticulon-4 receptor-like 1 chr17 GO:0045121 Not Cancer Driver No 56 0.127 142 12 0.085 0
RTN4RL2 RTN4RL2 Q86UN3 Reticulon-4 receptor-like 2 chr11 GO:0045121 Not Cancer Driver No 38 0.09 121 5 0.041 0
S100A10 S100A10 P60903 Protein S100-A10 chr1 GO:0045121 Not Cancer Driver No 11 0.113 3 1 0.333 0
S1PR1 S1PR1 P21453 Sphingosine 1-phosphate receptor 1 chr1 GO:0045121 Not Cancer Driver No 86 0.225 29 6 0.207 0
SCARB1_ENST00000415380 SCARB1 Q8WTV0 Scavenger receptor class B member 1 chr12 GO:0045121 Not Cancer Driver No 53 0.096 6 1 0.167 0
SCN5A_ENST00000333535 SCN5A Q14524 Sodium channel protein type 5 subunit alpha chr3 GO:0045121 Not Cancer Driver No 491 0.244 550 144 0.262 190
SDC4 SDC4 P31431 Syndecan-4 chr20 GO:0045121 Census, Compendium Yes 34 0.172 110 25 0.227 0
SDCBP_ENST00000260130 SDCBP O00560 Syntenin-1 chr8 GO:0045121 Not Cancer Driver No 39 0.131 17 2 0.118 0
SELE SELE P16581 E-selectin chr1 GO:0045121 Not Cancer Driver No 137 0.225 12 0 0.0 0
SERPINH1_ENST00000358171 SERPINH1 P50454 Serpin H1 chr11 GO:0045121 Not Cancer Driver No 51 0.122 52 6 0.115 1
SGCA SGCA Q16586 Alpha-sarcoglycan chr17 GO:0045121 Not Cancer Driver No 58 0.15 82 9 0.11 29
SHH SHH Q15465 Sonic hedgehog protein chr7 GO:0045121 Not Cancer Driver No 56 0.121 139 14 0.101 81
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0045121 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC1A2 SLC1A2 P43004 Excitatory amino acid transporter 2 chr11 GO:0045121 Not Cancer Driver No 77 0.134 81 7 0.086 3
SLC22A6 SLC22A6 Q4U2R8 Solute carrier family 22 member 6 chr11 GO:0045121 Not Cancer Driver No 85 0.151 72 11 0.153 0
SLC25A5 SLC25A5 P05141 ADP/ATP translocase 2 chrX GO:0045121 Not Cancer Driver No 41 0.138 0 0 0.0 0
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0045121 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC2A4 SLC2A4 P14672 Solute carrier family 2, facilitated glucose transporter member 4 chr17 GO:0045121 Not Cancer Driver No 71 0.139 43 8 0.186 1
SLC34A1 SLC34A1 Q06495 Sodium-dependent phosphate transport protein 2A chr5 GO:0045121 Not Cancer Driver No 92 0.144 46 8 0.174 9
SLC6A2_ENST00000568943 SLC6A2 P23975 Sodium-dependent noradrenaline transporter chr16 GO:0045121 Not Cancer Driver No 127 0.206 23 8 0.348 1
SLC6A3 SLC6A3 Q01959 Sodium-dependent dopamine transporter chr5 GO:0045121 Not Cancer Driver No 150 0.242 31 8 0.258 2
SLC6A4_ENST00000401766 SLC6A4 P31645 Sodium-dependent serotonin transporter chr17 GO:0045121 Not Cancer Driver No 101 0.16 73 12 0.164 0
SLC9A1 SLC9A1 P19634 Sodium/hydrogen exchanger 1 chr1 GO:0045121 Not Cancer Driver No 89 0.109 251 29 0.116 1
SLC9A3R1 SLC9A3R1 O14745 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 chr17 GO:0045121 Not Cancer Driver No 19 0.053 318 16 0.05 4
SMO SMO Q99835 Smoothened homolog chr7 GO:0045121 Census, Compendium Yes 112 0.142 241 27 0.112 1
SMPD2 SMPD2 O60906 Sphingomyelin phosphodiesterase 2 chr6 GO:0045121 Not Cancer Driver No 45 0.106 48 5 0.104 0
SMURF2 SMURF2 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 chr17 GO:0045121 Not Cancer Driver No 87 0.116 242 28 0.116 0
SORBS1_ENST00000361941 SORBS1 Q9BX66 Sorbin and SH3 domain-containing protein 1 chr10 GO:0045121 Not Cancer Driver No 161 0.125 1111 133 0.12 0
SPRED1 SPRED1 Q7Z699 Sprouty-related, EVH1 domain-containing protein 1 chr15 GO:0045121 Not Cancer Driver No 71 0.16 194 35 0.18 2
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0045121 Census Yes 53 0.099 130 11 0.085 1
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 GO:0045121 Census, Compendium Yes 106 0.125 325 44 0.135 0
STOM STOM P27105 Stomatin chr9 GO:0045121 Not Cancer Driver No 23 0.08 44 3 0.068 0
STOML1 STOML1 Q9UBI4 Stomatin-like protein 1 chr15 GO:0045121 Not Cancer Driver No 48 0.121 82 14 0.171 0
STOML2 STOML2 Q9UJZ1 Stomatin-like protein 2, mitochondrial chr9 GO:0045121 Not Cancer Driver No 40 0.112 117 9 0.077 0
STOML3 STOML3 Q8TAV4 Stomatin-like protein 3 chr13 GO:0045121 Not Cancer Driver No 67 0.23 29 5 0.172 0
STX12 STX12 Q86Y82 Syntaxin-12 chr1 GO:0045121 Not Cancer Driver No 21 0.076 156 9 0.058 0
SULF1_ENST00000458141 SULF1 Q8IWU6 Extracellular sulfatase Sulf-1 chr8 GO:0045121 Not Cancer Driver No 246 0.282 269 71 0.264 0
SYNJ2 SYNJ2 O15056 Synaptojanin-2 chr6 GO:0045121 Not Cancer Driver No 189 0.126 545 70 0.128 0
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 GO:0045121 Not Cancer Driver No 39 0.207 25 2 0.08 0
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0045121 Not Cancer Driver No 219 0.195 126 22 0.175 10
TFPI TFPI P10646 Tissue factor pathway inhibitor chr2 GO:0045121 Not Cancer Driver No 47 0.155 28 2 0.071 0
TGFBR1_ENST00000374994 TGFBR1 P36897 TGF-beta receptor type-1 chr9 GO:0045121 Not Cancer Driver No 86 0.171 23 3 0.13 15
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:0045121 Census, Compendium Yes 106 0.187 60 16 0.267 25
THY1 THY1 P04216 Thy-1 membrane glycoprotein chr11 GO:0045121 Not Cancer Driver No 24 0.149 5 0 0.0 0
TLR1_ENST00000502213 TLR1 Q15399 Toll-like receptor 1 chr4 GO:0045121 Not Cancer Driver No 107 0.136 1 0 0.0 0
TLR2 TLR2 O60603 Toll-like receptor 2 chr4 GO:0045121 Not Cancer Driver No 108 0.138 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0045121 Not Cancer Driver No 99 0.124 1 0 0.0 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0045121 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF10A TNFRSF10A O00220 Tumor necrosis factor receptor superfamily member 10A chr8 GO:0045121 Not Cancer Driver No 55 0.118 174 17 0.098 0
TNFRSF1A TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 GO:0045121 Not Cancer Driver No 58 0.127 111 15 0.135 12
TNFRSF1B TNFRSF1B P20333 Tumor necrosis factor receptor superfamily member 1B chr1 GO:0045121 Not Cancer Driver No 48 0.104 229 28 0.122 0
TNR TNR Q92752 Tenascin-R chr1 GO:0045121 Not Cancer Driver No 496 0.365 358 128 0.358 0
TPP1 TPP1 O14773 Tripeptidyl-peptidase 1 chr11 GO:0045121 Not Cancer Driver No 67 0.119 92 7 0.076 37
TRADD TRADD Q15628 Tumor necrosis factor receptor type 1-associated DEATH domain protein chr16 GO:0045121 Not Cancer Driver No 26 0.083 74 5 0.068 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0045121 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRPC4_ENST00000379705 TRPC4 Q9UBN4 Short transient receptor potential channel 4 chr13 GO:0045121 Not Cancer Driver No 322 0.33 195 66 0.338 0
TRPC5 TRPC5 Q9UL62 Short transient receptor potential channel 5 chrX GO:0045121 Not Cancer Driver No 255 0.262 148 32 0.216 0
TRPM8 TRPM8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 chr2 GO:0045121 Not Cancer Driver No 206 0.187 43 11 0.256 0
TUBA1C_ENST00000301072 TUBA1C Q9BQE3 Tubulin alpha-1C chain chr12 GO:0045121 Not Cancer Driver No 39 0.087 50 5 0.1 0
TUBB TUBB P07437 Tubulin beta chain chr6 GO:0045121 Not Cancer Driver No 40 0.09 63 11 0.175 5
UNC5A UNC5A Q6ZN44 Netrin receptor UNC5A chr5 GO:0045121 Not Cancer Driver No 133 0.158 120 20 0.167 0
UNC5B UNC5B Q8IZJ1 Netrin receptor UNC5B chr10 GO:0045121 Not Cancer Driver No 155 0.164 117 20 0.171 0
VDAC1_ENST00000395047 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 chr5 GO:0045121 Not Cancer Driver No 38 0.134 36 4 0.111 0
ZAP70 ZAP70 P43403 Tyrosine-protein kinase ZAP-70 chr2 GO:0045121 Not Cancer Driver No 126 0.204 117 17 0.145 8